A CHEMICALLY SYNTHETIC ANTI-TOXIC VACCINE AGAINST MALARI
Principal Investigator: L Schofield
Abstract: DESCRIPTION (Adapted from the Applicant's Abstract): Plasmodium falciparum is a global health problem because of the morbidity and mortality associated with infection. Much of this morbidity and mortality is believed to arise from the actions of a malaria toxin. The toxin initiates a systemic inflammatory cascade involving cytokine excess, which may result in disseminated intravascular coagulation, hepatic dysfunction, acute renal failure, multi-organ inflammation, hypoglycemia, lactic acidosis and death. The toxin may further contribute to organ-specific and cerebral disease syndromes by hyperactivation of the vascular endothelium. Clinical immunity to malaria is acquired considerably earlier than anti-parasite immunity, and it is possible that this is mediated by anti-toxin mechanisms.
Funding Period: 2000-09-15 - 2003-08-31
more information: NIH RePORT
- gammadelta-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-gamma response to Plasmodium falciparum malariaDiana S Hansen
Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
Eur J Immunol 37:1864-73. 2007..Applied to longitudinal cohort studies in endemic regions, similar comparative phenotyping should allow assessment of the contribution of diverse cell populations and regulatory receptors to risk of infection and disease...
- The role of leukocytes bearing Natural Killer Complex receptors and Killer Immunoglobulin-like Receptors in the immunology of malariaDiana S Hansen
The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville 3050, Victoria, Australia
Curr Opin Immunol 19:416-23. 2007..Population-based immunogenetic analyses should allow the identification of NKC and KIR loci controlling innate and adaptive immune responses to malaria and associated with altered risk of infection and disease...