Peripheral Nerve Function Decline in an Aged Cohort

Summary

Principal Investigator: Elsa Strotmeyer
Affiliation: University of Pittsburgh
Country: USA
Abstract: Although poor peripheral nerve function is common in older age, the rate of decline with aging is unknown. Diabetes and other known causes of neuropathy appear to account for very little of the loss of nerve function with advancing age. We conducted a cross-sectional epidemiologic study of the prevalence and risk factors or poor peripheral sensory and motor nerve function in the Health, Aging and Body Composition (Health ABC) cohort. The Health ABC baseline cohort included 3075 men and women (42 percent African-American and 52 percent women). Of these, 1462 survivors aged 80-89 years of age are expected for their eleventh year follow- up exam. Longitudinal data from 2000-01 to 2007-08 will make it possible to determine whether nerve function declines are related to prospective lower extremity disability in 2008-10 and whether or not these associations are mediated by changes in muscle, bone density, and strength. We have documented cross- sectionally that peripheral nerve function is critical to their lower extremity function and mobility and is associated with muscle strength and bone density, demonstrating the importance of the peripheral nerves in sarcopenia and age-related disability. Analyses of numerous potential risk factors in Health ABC have revealed that age itself remains strongly related to poorer peripheral nerve function, even when accounting for established risk factors such as diabetes, and novel risk factors such as subclinical peripheral arterial disease and Caucasian race. To date, no U.S. study has reported the rate of decline in these aspects of peripheral nerve function with aging or has determined whether they precede lower extremity disability. The specific aims are to determine 1) declines in peripheral sensory and motor nerve function over six years and risk factors for these declines (demographic factors, vitamin B12 status, impaired glucose metabolism, subclinical peripheral arterial disease) in Caucasian and African-American older adults; and 2) if the rate of decline in peripheral sensory and motor nerve function is prospectively related to rate of recurrent falls and a decline in self-reported walking ability over two years. This study addresses many goals of the NIA, defined in its strategic plan, including prevention of disability, understanding age-related change and evaluating ethnic disparities. The Health ABC Study provides a unique and cost-effective opportunity to quantify and identify risk factors for decline in sensory and motor nerve function and relate these declines to prospective disability for the first time among a large group of older adults.
Funding Period: 2007-09-15 - 2011-06-30
more information: NIH RePORT

Top Publications

  1. pmc Association of electrocardiogram abnormalities and incident heart failure events
    Baris Gencer
    Cardiology Division, Department of Medicine, Geneva University Hospital, Geneva, Switzerland
    Am Heart J 167:869-75.e3. 2014
  2. pmc Association between hypoglycemia and dementia in a biracial cohort of older adults with diabetes mellitus
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94121, USA
    JAMA Intern Med 173:1300-6. 2013
  3. pmc Unhealthy lifestyles do not mediate the relationship between socioeconomic status and incident depressive symptoms: the Health ABC study
    Danielle A I Groffen
    CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands
    Am J Geriatr Psychiatry 21:664-74. 2013
  4. ncbi Sex differences in the prevalence and clinical outcomes of subclinical peripheral artery disease in the Health, Aging, and Body Composition (Health ABC) study
    Jade S Hiramoto
    Department of Surgery, University of California, San Francisco, CA
    Vascular 22:142-8. 2014
  5. pmc White matter hyperintensity burden and disability in older adults: is chronic pain a contributor?
    Neilly Buckalew
    Department of Geriatric Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    PM R 5:471-80; quiz 480. 2013
  6. pmc Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study
    Kristen M Beavers
    Department of Internal Medicine, National Institute on Aging, Baltimore, MD, USA
    Am J Clin Nutr 97:552-60. 2013
  7. pmc Hearing loss and cognitive decline in older adults
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    JAMA Intern Med 173:293-9. 2013
  8. pmc Pulse wave velocity and cognitive decline in elders: the Health, Aging, and Body Composition study
    Adina Zeki Al Hazzouri
    Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 185 Berry St, Lobby 5, Suite 5700, San Francisco, CA 94107, USA
    Stroke 44:388-93. 2013
  9. pmc Hypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: a collaborative study
    Michelle C Odden
    School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR, USA
    Ann Epidemiol 23:106-11. 2013
  10. pmc Prevalence and correlates of self-reported medication non-adherence among older adults with coronary heart disease, diabetes mellitus, and/or hypertension
    Zachary A Marcum
    Department of Medicine Geriatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA Electronic address
    Res Social Adm Pharm 9:817-27. 2013

Scientific Experts

  • Elsa Strotmeyer
  • ANN V contact SCHWARTZ
  • Matteo Cesari
  • W B Katzman
  • MARGARET B CONROY
  • Y Slinin
  • Kamil E Barbour
  • Aaron Vinik
  • Tamara B Harris
  • Anne B Newman
  • Suzanne Satterfield
  • Kristine Yaffe
  • Eleanor M Simonsick
  • Stephen B Kritchevsky
  • Douglas C Bauer
  • Caterina Rosano
  • Jane A Cauley
  • Tamara Harris
  • Denise K Houston
  • Annemarie Koster
  • Hilsa N Ayonayon
  • Nicolas Rodondi
  • Luigi Ferrucci
  • Anne Newman
  • Steven R Cummings
  • Eric Vittinghoff
  • Gregory J Tranah
  • Rachel A Murphy
  • Javed Butler
  • Andrea L Metti
  • Baris Gencer
  • Robert M Boudreau
  • Brenda W J H Penninx
  • Michael G Shlipak
  • Stephen Kritchevsky
  • Ronald I Shorr
  • Subashan Perera
  • Nathalie de Rekeneire
  • Trisha F Hue
  • Joseph T Hanlon
  • Yuri Milaneschi
  • Eleanor Simonsick
  • Catherine N Marti
  • Hassan Khan
  • Lisa C Barry
  • Ronit Katz
  • Cherie M Falvey
  • Todd M Manini
  • Jared W Magnani
  • Alka M Kanaya
  • Bret H Goodpaster
  • Marco Pahor
  • Stephanie A Studenski
  • Howard J Aizenstein
  • Michael A Nalls
  • Jennifer S Yokoyama
  • Shana M Katzman
  • Yongmei Liu
  • Zachary A Marcum
  • Vijay Venkatraman
  • Cherie Falvey
  • Reto Auer
  • Jeff D Williamson
  • Rebecca H Neiberg
  • M Kyla Shea
  • Gary G Schwartz
  • Janet A Tooze
  • Mary Ann Johnson
  • Dorothy B Hausman
  • Jacques Cornuz
  • Tinh Hai Collet
  • Frances A Tylavsky
  • Jasmine Nettiksimmons
  • Jade S Hiramoto
  • Valerie K Wilson
  • Andrea L Rosso
  • Andreas P Kalogeropoulos
  • Vasiliki V Georgiopoulou
  • Kaycee M Sink
  • William B Applegate
  • Pedro Marques-Vidal
  • Michael C Nevitt
  • Andrea Metti
  • Adina Zeki Al Hazzouri
  • Todd A Doyle
  • Alka Kanaya
  • Nancy Adler
  • Magdalena Madero
  • Chang Hyung Hong
  • Frank R Lin

Detail Information

Publications73

  1. pmc Association of electrocardiogram abnormalities and incident heart failure events
    Baris Gencer
    Cardiology Division, Department of Medicine, Geneva University Hospital, Geneva, Switzerland
    Am Heart J 167:869-75.e3. 2014
    ..Few data exist on whether baseline electrocardiographic (ECG) abnormalities can refine risk prediction for HF...
  2. pmc Association between hypoglycemia and dementia in a biracial cohort of older adults with diabetes mellitus
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94121, USA
    JAMA Intern Med 173:1300-6. 2013
    ..Hypoglycemia commonly occurs in patients with diabetes mellitus (DM) and may negatively influence cognitive performance. Cognitive impairment in turn can compromise DM management and lead to hypoglycemia...
  3. pmc Unhealthy lifestyles do not mediate the relationship between socioeconomic status and incident depressive symptoms: the Health ABC study
    Danielle A I Groffen
    CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands
    Am J Geriatr Psychiatry 21:664-74. 2013
    ....
  4. ncbi Sex differences in the prevalence and clinical outcomes of subclinical peripheral artery disease in the Health, Aging, and Body Composition (Health ABC) study
    Jade S Hiramoto
    Department of Surgery, University of California, San Francisco, CA
    Vascular 22:142-8. 2014
    ..33, 1.44-7.70) and incident stroke (2.45, 1.38-4.35) only in women. Subclinical PAD was strongly associated with adverse CV events in both women and men, but women had a higher prevalence of subclinical PAD. ..
  5. pmc White matter hyperintensity burden and disability in older adults: is chronic pain a contributor?
    Neilly Buckalew
    Department of Geriatric Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    PM R 5:471-80; quiz 480. 2013
    ..To secondarily compare WMH of the participants with CLBP with the pain-free controls...
  6. pmc Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study
    Kristen M Beavers
    Department of Internal Medicine, National Institute on Aging, Baltimore, MD, USA
    Am J Clin Nutr 97:552-60. 2013
    ..In older adults, every 0.1-m/s slower gait speed is associated with a 12% higher mortality. However, little research has identified risk factors for gait-speed decline...
  7. pmc Hearing loss and cognitive decline in older adults
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    JAMA Intern Med 173:293-9. 2013
    ..Further studies are needed to investigate what the mechanistic basis of this association is and whether hearing rehabilitative interventions could affect cognitive decline...
  8. pmc Pulse wave velocity and cognitive decline in elders: the Health, Aging, and Body Composition study
    Adina Zeki Al Hazzouri
    Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 185 Berry St, Lobby 5, Suite 5700, San Francisco, CA 94107, USA
    Stroke 44:388-93. 2013
    ..Arterial stiffness is a measure of subclinical cardiovascular disease and increases with age. This study examines the association between arterial stiffness and cognitive decline in a cohort of older adults...
  9. pmc Hypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: a collaborative study
    Michelle C Odden
    School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR, USA
    Ann Epidemiol 23:106-11. 2013
    ..To determine if the associations among established risk factors and reduced kidney function vary by age...
  10. pmc Prevalence and correlates of self-reported medication non-adherence among older adults with coronary heart disease, diabetes mellitus, and/or hypertension
    Zachary A Marcum
    Department of Medicine Geriatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA Electronic address
    Res Social Adm Pharm 9:817-27. 2013
    ..Information about the prevalence and correlates of self-reported medication nonadherence using multiple measures in older adults with chronic cardiovascular conditions is needed...
  11. pmc Association of arterial rigidity with incident kidney disease and kidney function decline: the Health ABC study
    Magdalena Madero
    Department of Medicine, Division of Nephrology, National Heart Institute, Mexico City, Mexico
    Clin J Am Soc Nephrol 8:424-33. 2013
    ..This study evaluated the association of aortic pulse wave velocity (aPWV) and pulse pressure (PP) with rapid kidney function decline and incident CKD in the Health, Aging and Body Composition study...
  12. pmc Electrocardiographic PR interval and adverse outcomes in older adults: the Health, Aging, and Body Composition study
    Jared W Magnani
    Cardiology Section, Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Circ Arrhythm Electrophysiol 6:84-90. 2013
    ..We sought to determine the associations between PR interval and heart failure, AF, and mortality in a biracial cohort of older adults...
  13. pmc Aortic pulse wave velocity predicts focal white matter hyperintensities in a biracial cohort of older adults
    Caterina Rosano
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Hypertension 61:160-5. 2013
    ....
  14. pmc Macro- and microstructural magnetic resonance imaging indices associated with diabetes among community-dwelling older adults
    Cherie M Falvey
    Department of Psychiatry, University of California, San Francisco, and San Francisco Veteran s Administration Medical Center, San Francisco, CA, USA
    Diabetes Care 36:677-82. 2013
    ....
  15. pmc 25-hydroxyvitamin D status and change in physical performance and strength in older adults: the Health, Aging, and Body Composition Study
    Denise K Houston
    Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1207, USA
    Am J Epidemiol 176:1025-34. 2012
    ..Older adults with low 25(OH)D concentrations had poorer physical performance over 4 years of follow-up, but low 25(OH)D concentrations were not associated with a faster rate of decline in physical performance or strength...
  16. pmc Trajectories of gait speed predict mortality in well-functioning older adults: the Health, Aging and Body Composition study
    Daniel K White
    Department of Physical Therapy and Athletic Training, Boston University, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 68:456-64. 2013
    ..Although gait speed slows with age, the rate of slowing varies greatly. To date, little is known about the trajectories of gait speed, their correlates, and their risk for mortality in older adults...
  17. pmc Modifiable risk factors for pneumonia requiring hospitalization of community-dwelling older adults: the Health, Aging, and Body Composition Study
    Manisha Juthani-Mehta
    Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
    J Am Geriatr Soc 61:1111-8. 2013
    ..To identify novel modifiable risk factors, focusing on oral hygiene, for pneumonia requiring hospitalization of community-dwelling older adults...
  18. pmc Lipid peroxidation and depressed mood in community-dwelling older men and women
    Yuri Milaneschi
    Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center GGZ inGeest, Amsterdam, The Netherlands
    PLoS ONE 8:e65406. 2013
    ..Further studies are needed to explore whether the modulation of oxidative stress may break down the link between late-life depression and its deleterious health consequences...
  19. pmc Association of total adiposity and computed tomographic measures of regional adiposity with incident cancer risk: a prospective population-based study of older adults
    Rachel A Murphy
    a Laboratory of Epidemiology, and Population Sciences, Intramural Research Program, National Institute on Aging, 7201 Wisconsin Ave, 3C 309, Bethesda, MD 20814, USA
    Appl Physiol Nutr Metab 39:687-92. 2014
    ..40, 95% CI 1.08-1.82 per SD increase). These findings provide insight into relationships between specific adipose depots and cancer risk and suggest differential relationships among men and women. ..
  20. pmc Higher step length variability indicates lower gray matter integrity of selected regions in older adults
    Andrea L Rosso
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA Electronic address
    Gait Posture 40:225-30. 2014
    ..These findings support previous research indicating a role for cognitive function in motor control. Higher SLV may indicate focal neuropathology in those without diagnosed neurologic disease. ..
  21. pmc The associations between serum brain-derived neurotrophic factor, potential confounders, and cognitive decline: a longitudinal study
    Jasmine Nettiksimmons
    Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e91339. 2014
    ..Our results suggest that serum BDNF may have limited utility as a biomarker of prospective cognitive decline. ..
  22. pmc Relationship between 25-hydroxyvitamin d and cognitive function in older adults: the health, aging and body composition study
    Valerie K Wilson
    Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina
    J Am Geriatr Soc 62:636-41. 2014
    ..To examine the relationship between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance over time in older adults in the Health, Aging and Body Composition (Health ABC) Study...
  23. ncbi Incident heart failure in relation to vascular disease: insights from the Health, Aging, and Body Composition Study
    Hassan Khan
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Eur J Heart Fail 16:526-34. 2014
    ..The contribution of heart failure (HF) unrelated to vascular disease to the overall HF burden in older adults is not well characterized. This was investigated in this study...
  24. pmc Associations of BMI and adipose tissue area and density with incident mobility limitation and poor performance in older adults
    Rachel A Murphy
    Laboratory of Epidemiology, and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD RAM, IR, and TBH the Sections on Comparative Medicine Pathology, Radiology TCR, and Gerontology and Geriatrics SBK, Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, NC the Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA HNA the Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA ABN the Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN SS the Center for Aging and Population Health, Department of Medicine, University of Pittsburgh, Pittsburgh, PA BHG and the Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, Baltimore, MD EMS
    Am J Clin Nutr 99:1059-65. 2014
    ..Obesity is a risk factor for disability, but risk of specific adipose depots is not completely understood...
  25. pmc Effect of socioeconomic disparities on incidence of dementia among biracial older adults: prospective study
    Kristine Yaffe
    Neurology, Epidemiology and Biostatistics, University of California, San Francisco, 4150 Clement Street Box 181, San Francisco, CA 94121, USA
    BMJ 347:f7051. 2013
    ....
  26. pmc Soluble tumor necrosis factor receptors and heart failure risk in older adults: Health, Aging, and Body Composition (Health ABC) Study
    Catherine N Marti
    Cardiology Division, Emory University, Atlanta, GA
    Circ Heart Fail 7:5-11. 2014
    ..The soluble TNF type 1 (sTNF-R1) and type 2 (sTNF-R2) receptors are elevated in patients with manifest HF, but whether they are associated with risk for incident HF is unclear...
  27. pmc Snoring, daytime sleepiness, and incident cardiovascular disease in the health, aging, and body composition study
    Yohannes Endeshaw
    Department of Medicine, Morehouse School of Medicine, Atlanta, GA
    Sleep 36:1737-45. 2013
    ..To examine the association between snoring and incident cardiovascular disease (CVD)...
  28. pmc Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans
    Gregory J Tranah
    California Pacific Medical Center Research Institute San Francisco, San Francisco, CA, USA Electronic address
    Neurobiol Aging 35:442.e1-8. 2014
    ....
  29. pmc Elevated HbA1c and fasting plasma glucose in predicting diabetes incidence among older adults: are two better than one?
    Kasia J Lipska
    Corresponding author Kasia J Lipska
    Diabetes Care 36:3923-9. 2013
    ..To determine which measures-impaired fasting glucose (IFG), elevated HbA1c, or both-best predict incident diabetes in older adults...
  30. pmc Diabetes and risk of hospitalized fall injury among older adults
    Rebecca K Yau
    Corresponding author Rebecca K Yau
    Diabetes Care 36:3985-91. 2013
    ..To determine whether older adults with diabetes are at increased risk of an injurious fall requiring hospitalization...
  31. pmc Race-related differences in depression onset and recovery in older persons over time: the health, aging, and body composition study
    Lisa C Barry
    Center on Aging, University of Connecticut, Farmington, CT Electronic address
    Am J Geriatr Psychiatry 22:682-91. 2014
    ..To evaluate race-related differences in depression onset and recovery in older persons, overall and by sex, and examine race-related differences in mortality according to depression...
  32. pmc Anemia and risk of dementia in older adults: findings from the Health ABC study
    Chang Hyung Hong
    Department of Psychiatry and Institute on Aging, Ajou University School of Medicine, Suwon, Republic of Korea
    Neurology 81:528-33. 2013
    ..To determine whether anemia is associated with incident dementia in older adults...
  33. pmc The QT interval and risk of incident atrial fibrillation
    Mala C Mandyam
    Electrophysiology Section, Division of Cardiology, University of California, San Francisco, California
    Heart Rhythm 10:1562-8. 2013
    ..Abnormal atrial repolarization is important in the development of atrial fibrillation (AF), but no direct measurement is available in clinical medicine...
  34. pmc Changes in cholesterol-lowering medications use over a decade in community-dwelling older adults
    Wei Hsuan Lo-Ciganic
    School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Pharmacother 47:984-92. 2013
    ..The impact of evidence-based guidelines and controlled trial data on use of cholesterol-lowering medications in older adults is unclear...
  35. pmc Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioid analgesics
    Christine K O'Neil
    Department of Pharmacy Practice, School of Pharmacy, Duquesne University, Pittsburgh, PA, USA
    Am J Geriatr Pharmacother 10:331-42. 2012
    ..Osteoarthritis (OA) is the most common cause of disability in older adults, and although analgesic use can be helpful, it can also result in adverse drug events...
  36. pmc Adherence to mediterranean diet and decline in walking speed over 8 years in community-dwelling older adults
    Danit R Shahar
    S Daniel International Center for Health and Nutrition, Department of Epidemiology and Health Evaluation, Faculty of Health Sciences, Ben Gurion University of the Negev, Negev, Israel
    J Am Geriatr Soc 60:1881-8. 2012
    ..To determine the association between Mediterranean diet (MedDiet) score and 20-m walking speed over 8 years...
  37. pmc Mitochondrial DNA sequence variation is associated with free-living activity energy expenditure in the elderly
    Gregory J Tranah
    California Pacific Medical Center Research Institute, San Francisco, San Francisco, CA 94107, USA
    Biochim Biophys Acta 1817:1691-700. 2012
    ....
  38. pmc Low 25-hydroxyvitamin D predicts the onset of mobility limitation and disability in community-dwelling older adults: the Health ABC Study
    Denise K Houston
    Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1207, USA
    J Gerontol A Biol Sci Med Sci 68:181-7. 2013
    ....
  39. pmc Association of a Modified Physiologic Index with mortality and incident disability: the Health, Aging, and Body Composition study
    Jason L Sanders
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Bellefield Professional Building 4th Floor, 130 North Bellefield Avenue, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 67:1439-46. 2012
    ..We studied the associations of a Modified Physiologic Index (systolic blood pressure, forced vital capacity, Digit Symbol Substitution Test score, serum cystatin-C, serum fasting glucose) with mortality and incident disability...
  40. pmc Bone mineral density and fracture risk in older individuals with CKD
    Robert H Yenchek
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin J Am Soc Nephrol 7:1130-6. 2012
    ..We assessed whether BMD is associated with fractures in participants with and without CKD in the Health, Aging, and Body Composition study, a prospective study of well functioning older individuals...
  41. pmc Plasma beta amyloid level and depression in older adults
    Andrea L Metti
    Center for Aging and Population Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 68:74-9. 2013
    ..Older adults with depression have an increased risk of developing dementia. Low plasma beta-amyloid 42 (Aβ42) and Aβ42/Aβ40 have emerged as promising biomarkers of dementia. The association between depression and plasma Aβ is unclear...
  42. pmc Patterns of focal gray matter atrophy are associated with bradykinesia and gait disturbances in older adults
    Caterina Rosano
    Department of Epidemiology, Graduate School of Public Health, 130 North Bellefield Street, Room 512, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 67:957-62. 2012
    ..Identify the neuroimaging correlates of parkinsonian signs in older adults living in the community...
  43. pmc Diabetes, depressive symptoms, and inflammation in older adults: results from the health, aging, and body composition study
    Todd A Doyle
    Psychology Department, Ohio University, Athens, OH, United States Electronic address
    J Psychosom Res 75:419-24. 2013
    ..This study examined the association between inflammation and both T2DM and elevated depressive symptoms...
  44. pmc Dietary patterns and survival of older adults
    Amy L Anderson
    Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA
    J Am Diet Assoc 111:84-91. 2011
    ..Recent research has linked overall dietary patterns to survival in older adults...
  45. pmc Association of lower limb cutaneous sensitivity with gait speed in the elderly: the health ABC study
    Nandini Deshpande
    Department of Physical Therapy and Rehabilitation Sciences, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Phys Med Rehabil 87:921-8. 2008
    ....
  46. pmc Leptin, abdominal obesity, and onset of depression in older men and women
    Yuri Milaneschi
    Department of Psychiatry, VU University Medical Center GGZ inGeest, A J Ernststraat 1187, 1081 HL Amsterdam, The Netherlands
    J Clin Psychiatry 73:1205-11. 2012
    ..We tested whether high circulatory concentration of leptin, alone and in combination with visceral adiposity, is associated with onset of depression in a sample of older persons...
  47. pmc Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adults
    Kira Leishear
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 60:1057-63. 2012
    ..To examine whether deficient B12 status or low serum B12 levels are associated with worse sensory and motor peripheral nerve function in older adults...
  48. pmc Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia
    Kristine Yaffe
    Departments of Psychiatry, University of California, San Francisco, and San Francisco, VA, USA
    Arch Neurol 69:1170-5. 2012
    ..To determine if prevalent and incident diabetes mellitus (DM) increase risk of cognitive decline and if, among elderly adults with DM, poor glucose control is related to worse cognitive performance. DESIGN Prospective cohort study...
  49. pmc 25-Hydroxyvitamin D, parathyroid hormone, and mortality in black and white older adults: the health ABC study
    Stephen B Kritchevsky
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1207, USA
    J Clin Endocrinol Metab 97:4156-65. 2012
    ..Whether the relationship is similar in Blacks and to what extent differences in 25(OH)D explain racial disparities in mortality is unclear...
  50. pmc Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts
    Baris Gencer
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    Circulation 126:1040-9. 2012
    ..Limited prospective data exist on the association between subclinical thyroid dysfunction and heart failure events...
  51. pmc The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease
    Bram van den Borst
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    Am J Clin Nutr 96:516-26. 2012
    ..Although altered body composition, especially increased visceral fat (VF) mass, could be a significant contributor to low-grade systemic inflammation, this remains unexplored in COPD...
  52. pmc Educational attainment and late life telomere length in the Health, Aging and Body Composition Study
    Nancy Adler
    University of California, San Francisco, USA
    Brain Behav Immun 27:15-21. 2013
    ..10). This study provides the first demonstration of an association between educational attainment and LTL in a US population where higher education appears to have a protective effect against telomere shortening, particularly in blacks...
  53. pmc Reproducibility of peroneal motor nerve conduction measurement in older adults
    Rachel E Ward
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Clin Neurophysiol 124:603-9. 2013
    ..While neuropathy is common in the elderly, nerve conduction (NC) reproducibility in older adults is not well-established. We sought to evaluate intraobserver reproducibility of peroneal motor NC measures in a diverse sample of older adults...
  54. pmc Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly
    Gregory J Tranah
    California Pacific Medical Center Research Institute, San Francisco, CA, USA
    J Alzheimers Dis 32:357-72. 2012
    ....
  55. pmc Individual magnetic resonance imaging and radiographic features of knee osteoarthritis in subjects with unilateral knee pain: the health, aging, and body composition study
    M K Javaid
    University of Oxford, Oxford, UK
    Arthritis Rheum 64:3246-55. 2012
    ..This study was undertaken to compare radiographic and magnetic resonance imaging (MRI) features of knee OA and assess their ability to discriminate between painful and nonpainful knees in persons with unilateral symptoms...
  56. pmc The demographic and medical correlates of plasma aβ40 and aβ42
    Andrea L Metti
    Department of Epidemiology, Center for Aging and Population Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Alzheimer Dis Assoc Disord 27:244-9. 2013
    ....
  57. pmc Antihypertensive drug class use and differential risk of urinary incontinence in community-dwelling older women
    Emily P Peron
    Department of Pharmacotherapy and Outcomes Science, School of Pharmacy, Virginia Commonwealth University, 410 North 12th Street, P O Box 980533, Richmond, VA 23298, USA
    J Gerontol A Biol Sci Med Sci 67:1373-8. 2012
    ..The objective of this longitudinal cohort study was to evaluate whether self-reported UI in community-dwelling older women is associated with the use of different classes of antihypertensive agents...
  58. pmc Adipokines and the risk of fracture in older adults
    Kamil E Barbour
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Bone Miner Res 26:1568-76. 2011
    ..More research is needed to understand the physiologic basis underlying these sex differences...
  59. pmc Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry St, Lobby 5, Ste 5700, San Francisco, CA 94107 1762, USA
    JAMA 305:2184-92. 2011
    ..It is not known if low BMD, central to fracture prediction in older adults, identifies fracture risk in patients with DM...
  60. pmc The effects of adiponectin and leptin on changes in bone mineral density
    K E Barbour
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Osteoporos Int 23:1699-710. 2012
    ..Results suggest that adiponectin, but not leptin, is a risk factor for bone loss in women...
  61. pmc Association of spinal muscle composition and prevalence of hyperkyphosis in healthy community-dwelling older men and women
    Wendy Katzman
    Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, 1500 Owens, Suite 400, San Francisco, CA 94143, USA
    J Gerontol A Biol Sci Med Sci 67:191-5. 2012
    ..Our objective was to determine whether spinal muscle area and density are associated with hyperkyphosis, independent of age, race, sex, bone mineral density, and trunk fat...
  62. pmc Thyroid function and prevalent and incident metabolic syndrome in older adults: the Health, Ageing and Body Composition Study
    Avantika C Waring
    Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Clin Endocrinol (Oxf) 76:911-8. 2012
    ..We sought to determine the association between thyroid function and the prevalence and incidence of the metabolic syndrome in a cohort of older adults...
  63. pmc Subclinical hyperthyroidism and the risk of coronary heart disease and mortality
    Tinh Hai Collet
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    Arch Intern Med 172:799-809. 2012
    ..We aimed to assess the risks of total and coronary heart disease (CHD) mortality, CHD events, and atrial fibrillation (AF) associated with endogenous subclinical hyperthyroidism among all available large prospective cohorts...
  64. pmc Association of major and minor ECG abnormalities with coronary heart disease events
    Reto Auer
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    JAMA 307:1497-505. 2012
    ..Electrocardiographic (ECG) abnormalities are common in older adults and might be of value for CHD prediction...
  65. pmc Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the health aging and body composition study
    Matteo Cesari
    Institut du vieillissement, Universite de Toulouse, 37 Allees Jules Guesde, 31000 Toulouse, France
    J Gerontol A Biol Sci Med Sci 67:671-6. 2012
    ..The aim of the present study is to assess whether biomarkers representing these mechanisms predicted major adverse health-related events in older persons...
  66. pmc Calciotropic hormones and the risk of hip and nonspine fractures in older adults: the Health ABC Study
    Kamil E Barbour
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Bone Miner Res 27:1177-85. 2012
    ..We found limited evidence to support an association between calciotropic hormones and hip and nonspine fractures in older men and women...
  67. pmc Muscle strength, mass, and quality in older men and women with knee osteoarthritis
    Molly B Conroy
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Arthritis Care Res (Hoboken) 64:15-21. 2012
    ..To examine the relationship between knee osteoarthritis (OA) and muscle parameters in a biracial cohort of older adults...
  68. pmc 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men
    Y Slinin
    One Veterans Dr 111J, Minneapolis, MN 55417, USA
    Neurology 74:33-41. 2010
    ..To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline...
  69. pmc Sensory and motor peripheral nerve function and lower-extremity quadriceps strength: the health, aging and body composition study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 57:2004-10. 2009
    ..To determine whether sensory and motor nerve function is associated cross-sectionally with quadriceps or ankle dorsiflexion strength in an older community-based population...
  70. pmc Diabetic neuropathy in older adults
    Aaron I Vinik
    Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    Clin Geriatr Med 24:407-35, v. 2008
    ..Ultimately agents that address large fiber dysfunction will be essential to reduce the gross impairment of quality of life and activities of daily living that neuropathy visits older people who have diabetes...
  71. pmc The relationship of reduced peripheral nerve function and diabetes with physical performance in older white and black adults: the Health, Aging, and Body Composition (Health ABC) study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 31:1767-72. 2008
    ..Poor peripheral nerve function is prevalent in diabetes and older populations, and it has great potential to contribute to poor physical performance...