SCCOR in Thoracic Aortic Aneurysms and Dissections

Summary

Principal Investigator: Dianna Milewicz
Affiliation: Texas Medical Center
Country: USA
Abstract: Thoracic aortic disease is the fifteenth leading cause of death in the United States, with aortic dissections being the thirteenth leading cause of death for individuals between the ages of 55 and 64 years. The major manifestations of disease affecting the aorta in the thoracic cavity are aneurysms and dissections. The theme of the application, "Specialized Center for Clinically Oriented Research in Thoracic Aortic Aneurysms and Dissections" (SCCOR-TAAD), is to improve our understanding of the pathogenesis of these diseases in hopes of developing better methods to diagnose, treat, and predict outcome of thoracic aortic disease with the ultimate goal of preventing premature deaths. Project 1, Dysregulation of TGF(3 signaling in aortic aneurysms and dissections, Dianna Milewicz, M.D. Ph.D. Project Leader, focuses on elucidating the role that dysregulation of TGF-p signaling plays in both familial and non-familial cases of thoracic aortic aneurysms and dissections. Project 2, Apoptosis of Smooth Muscle Cells in Aortic Aneurysms, Yong-Jian Geng, M.D. Ph.D. Project Leader, addresses accelerated apoptosis of vascular cells as a major pathological change in the development of thoracic aortic aneurysms and dissections. Project 3, Inflammatory Biomarkers of Aortic Aneurysms, Allan Brasier, M.D. Project Leader, focuses on elucidating the role of angiotensin II (Ang II)- induced inflammation in aortic aneurysms. Project 4, Predictors of Outcomes after Acute Aortic Dissection, Chul Ahn, Ph.D., Project Leader, will explore the hypothesis that there are clinical, socioeconomic, genetic, and plasma markers that will predict which individuals will have an adverse outcome after an acute dissection. Project 5, Genetic Determinants of Thoracic Aortic Aneurysms and Dissections, Xing Li Wang, M.D., Ph.D. Project Leader, will explore the hypothesis that genetic variants contribute significantly to sporadic thoracic aortic aneurysms and dissections. Project 6, Computerized Ultrasound/MR Imaging for Thoracic Aortic Aneurysms and Dissections, Jeff Towbin, M.D. Project Leader, is focused on improving the ability to detect aortic disease using ultrasound and MRI. The proposed SCCOR-TAAD has been established to take advantage of the considerable clinical expertise, patient population, research talent and established centers in the Texas Medical Center, and represents a comprehensive research approach to understand the pathology, identify biomarkers that predict progression and outcome, and improve the methods to diagnose thoracic aortic disease.
Funding Period: 2006-05-05 - 2011-04-30
more information: NIH RePORT

Top Publications

  1. pmc ADAMTS-1 and ADAMTS-4 levels are elevated in thoracic aortic aneurysms and dissections
    Pingping Ren
    Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    Ann Thorac Surg 95:570-7. 2013
  2. doi Advanced atherosclerosis is associated with increased medial degeneration in sporadic ascending aortic aneurysms
    Paul T Albini
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Department of Adult Cardiothoracic Surgery, Texas Heart Institute, PO Box 20345, Houston, TX 77225, USA
    Atherosclerosis 232:361-8. 2014
  3. pmc TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome
    Catherine Boileau
    Institut National de la Santé et de la Recherche Médicale INSERM U698, Hopital Bichat, Paris, France
    Nat Genet 44:916-21. 2012
  4. pmc Thoracic aortic disease in two patients with juvenile polyposis syndrome and SMAD4 mutations
    Polakit Teekakirikul
    MassGeneral Hospital for Children, Boston, MA, USA
    Am J Med Genet A 161:185-91. 2013
  5. pmc AKT2 confers protection against aortic aneurysms and dissections
    Ying H Shen
    Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Circ Res 112:618-32. 2013
  6. pmc Notch signaling in descending thoracic aortic aneurysm and dissection
    Sili Zou
    Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e52833. 2012
  7. pmc Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β
    Christina L Papke
    Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 6 100, Houston, TX 77030, USA
    Hum Mol Genet 22:3123-37. 2013
  8. pmc Interleukin-6-signal transducer and activator of transcription-3 signaling mediates aortic dissections induced by angiotensin II via the T-helper lymphocyte 17-interleukin 17 axis in C57BL/6 mice
    Xiaoxi Ju
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA
    Arterioscler Thromb Vasc Biol 33:1612-21. 2013
  9. pmc IL-6 regulates extracellular matrix remodeling associated with aortic dilation in a fibrillin-1 hypomorphic mgR/mgR mouse model of severe Marfan syndrome
    Xiaoxi Ju
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX
    J Am Heart Assoc 3:e000476. 2014
  10. pmc Acute aortic dissections with pregnancy in women with ACTA2 mutations
    Ellen S Regalado
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas
    Am J Med Genet A 164:106-12. 2014

Scientific Experts

  • Anthony Estrera
  • Dianna Milewicz
  • Allan Brasier
  • C C Miller
  • Scott A LeMaire
  • Dong Chuan Guo
  • Joseph S Coselli
  • Ellen S Regalado
  • Ying H Shen
  • Shao Qing Kuang
  • Siddharth K Prakash
  • Hazim J Safi
  • Xiaoxi Ju
  • Callie S Kwartler
  • Katharine H Wrighton
  • Suzanne M Leal
  • Carlos Villamizar
  • Limin Gong
  • Jiumei Cao
  • Christina L Papke
  • Van Tran-Fadulu
  • Pingping Ren
  • Ming Xiang Zhang
  • Sili Zou
  • Wanda Lejeune
  • Adrian Recinos
  • Ronald G Tilton
  • Hong Sun
  • Ellen Regalado
  • Brian C Tieu
  • L Maximilian Buja
  • Xing Li Wang
  • Hariyadarshi Pannu
  • Xin Hua Feng
  • Cheng Zhang
  • Paul T Albini
  • Catherine Boileau
  • Deborah A Nickerson
  • Jay Shendure
  • Mark J Rieder
  • Chang Lee
  • John W Belmont
  • Yong Jian Geng
  • Yangxin Li
  • Nili Avidan
  • Dong H Kim
  • Sanjay S Shete
  • Robert K Yu
  • Chul Ahn
  • Yun Zhang
  • Xiao Nan Li
  • Chenmin Yang
  • Talha Ijaz
  • Polakit Teekakirikul
  • Lynn M Marshall
  • Lin Zhang
  • Darrell Wu
  • Guillaume Jondeau
  • John Pham
  • Katerina L Byanova
  • Jiu Mei Cao
  • Regie L Santos-Cortez
  • Alan C Braverman
  • James T Stull
  • Kristine E Kamm
  • Min Wang
  • Ludivine Russell
  • Hossein Golabbakhsh
  • Ralph J Johnson
  • Dawna Gilchrist
  • Sanjay Shete
  • Reed E Pyeritz
  • Song Zhang
  • Ariel Brautbar
  • Sakiko Inamoto
  • Van Tran Fadulu
  • Li Wang
  • Hazim Safi
  • Marcia C Willing
  • Senthil Duraisamy
  • V Tran-Fadulu
  • Xia Lin
  • Prateek Gupta
  • Marcia Willing
  • Elizabeth Sparks
  • Pallav J Shah
  • Elizabeth Pretzer
  • Rumin He
  • Jian Wang
  • C S Raman

Detail Information

Publications63

  1. pmc ADAMTS-1 and ADAMTS-4 levels are elevated in thoracic aortic aneurysms and dissections
    Pingping Ren
    Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    Ann Thorac Surg 95:570-7. 2013
    ..We hypothesized that ADAMTS-1 and ADAMTS-4 expression is increased in aortic tissues from patients with thoracic aortic aneurysms and dissections...
  2. doi Advanced atherosclerosis is associated with increased medial degeneration in sporadic ascending aortic aneurysms
    Paul T Albini
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Department of Adult Cardiothoracic Surgery, Texas Heart Institute, PO Box 20345, Houston, TX 77225, USA
    Atherosclerosis 232:361-8. 2014
    ..We evaluated the prevalence and severity of aortic atherosclerosis and its association with medial degeneration in SAAA...
  3. pmc TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome
    Catherine Boileau
    Institut National de la Santé et de la Recherche Médicale INSERM U698, Hopital Bichat, Paris, France
    Nat Genet 44:916-21. 2012
    ....
  4. pmc Thoracic aortic disease in two patients with juvenile polyposis syndrome and SMAD4 mutations
    Polakit Teekakirikul
    MassGeneral Hospital for Children, Boston, MA, USA
    Am J Med Genet A 161:185-91. 2013
    ..We propose that the thoracic aorta should be screened in patients with SMAD4 mutations to prevent untimely death from dissection. This report also confirms that SMAD4 mutations predispose to TAAD...
  5. pmc AKT2 confers protection against aortic aneurysms and dissections
    Ying H Shen
    Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Circ Res 112:618-32. 2013
    ..Although the overproduction of destructive factors promotes tissue damage and disease progression, the role of protective pathways is unknown...
  6. pmc Notch signaling in descending thoracic aortic aneurysm and dissection
    Sili Zou
    Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e52833. 2012
    ..The signaling pathways that control these processes in DTAAD are poorly understood. Because Notch signaling is a critical pathway for cell survival, proliferation, and tissue repair, we examined its activation in DTAAD...
  7. pmc Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β
    Christina L Papke
    Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 6 100, Houston, TX 77030, USA
    Hum Mol Genet 22:3123-37. 2013
    ..Loss of α-SMA leads to SMC hyperplasia in vivo and in vitro through a mechanism involving FAK, p53 and Pdgfr-β, supporting the hypothesis that SMC hyperplasia contributes to occlusive lesions in patients with ACTA2 missense mutations. ..
  8. pmc Interleukin-6-signal transducer and activator of transcription-3 signaling mediates aortic dissections induced by angiotensin II via the T-helper lymphocyte 17-interleukin 17 axis in C57BL/6 mice
    Xiaoxi Ju
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA
    Arterioscler Thromb Vasc Biol 33:1612-21. 2013
    ..Here, we tested the relationship of IL-6-signal transducer and activator of transcription-3 signaling with Th17-induced inflammation in the formation of Ang II-induced dissections in C57BL/6 mice...
  9. pmc IL-6 regulates extracellular matrix remodeling associated with aortic dilation in a fibrillin-1 hypomorphic mgR/mgR mouse model of severe Marfan syndrome
    Xiaoxi Ju
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX
    J Am Heart Assoc 3:e000476. 2014
    ....
  10. pmc Acute aortic dissections with pregnancy in women with ACTA2 mutations
    Ellen S Regalado
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas
    Am J Med Genet A 164:106-12. 2014
    ..Women with ACTA2 mutations who are planning to get pregnant should be counseled about this risk of aortic dissection, and proper clinical management should be initiated to reduce this risk...
  11. doi Simvastatin-enhanced expression of promyogenic nuclear factors and cardiomyogenesis of murine embryonic stem cells
    Chenmin Yang
    The Center for Cardiovascular Biology and Atherosclerosis Research, The University of Texas Medical School at Houston, Houston, TX USA The Department of Obstetrics and Gynecology, Ruijin Hospital, Jiao Tong University Medical School, Shanghai, China Texas Heart Institute, Houston, TX, USA
    Vascul Pharmacol 60:8-16. 2014
    ..Thus, simvastatin treatment enhances ESC myogenesis during early development perhaps via a mechanism inhibiting the mevalonate-FPP/GGPP pathway. ..
  12. doi Thoracic aortic aneurysm frequency and dissection are associated with fibrillin-1 fragment concentrations in circulation
    Lynn M Marshall
    From the Departments of Orthopedics and Rehabilitation
    Circ Res 113:1159-68. 2013
    ..Genome-wide association studies also implicate fibrillin-1 in sporadic TAA. Fragmentation of the aortic elastic lamellae is characteristic of TAA...
  13. pmc Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections
    Dong Chuan Guo
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Am J Hum Genet 93:398-404. 2013
    ....
  14. doi Aortic remodeling after transverse aortic constriction in mice is attenuated with AT1 receptor blockade
    Shao Qing Kuang
    Department of Internal Medicine, University of Texas Health Science Center at Houston, University of Texas Medical Branch, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 33:2172-9. 2013
    ..We investigated the role of angiotensin II type 1 receptor activation in ascending aortic remodeling in response to increased biomechanical forces using a transverse aortic constriction (TAC) mouse model...
  15. pmc Rare copy number variants disrupt genes regulating vascular smooth muscle cell adhesion and contractility in sporadic thoracic aortic aneurysms and dissections
    Siddharth K Prakash
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 87:743-56. 2010
    ..03). Our findings suggest that rare CNVs disrupting smooth muscle adhesion or contraction contribute to both sporadic and familial disease...
  16. pmc Mutations in myosin light chain kinase cause familial aortic dissections
    Li Wang
    Department of Internal Medicine, University of Texas Medical School at Houston, TX 77030, USA
    Am J Hum Genet 87:701-7. 2010
    ..Thus, genetic and functional studies support the conclusion that heterozygous loss-of-function mutations in MYLK are associated with aortic dissections...
  17. pmc De novo ACTA2 mutation causes a novel syndrome of multisystemic smooth muscle dysfunction
    Dianna M Milewicz
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Am J Med Genet A 152:2437-43. 2010
    ....
  18. pmc TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections
    Sakiko Inamoto
    Department of Internal Medicine and Cardiothoracic and Vascular Surgery, University of Texas Medical School at Houston, MSB 6 100, 6431, Fannin St, Houston, TX 77030, USA
    Cardiovasc Res 88:520-9. 2010
    ..The aim of this study is to determine the molecular mechanism by which TGFBR2 mutations cause TAADs...
  19. pmc Genetic testing in aortic aneurysm disease: PRO
    Dianna M Milewicz
    Department of Internal Medicine, University of Texas Health Science Center at Houston, 6431 Fannin Street MSB 6 100, Houston, TX 77030, USA
    Cardiol Clin 28:191-7. 2010
    ..Genetic testing for TAAD and the phenotype and management of patients harboring mutations in these genes are addressed in this article...
  20. pmc Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells
    Shao Qing Kuang
    Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Circ Res 110:1411-22. 2012
    ....
  21. pmc Familial thoracic aortic aneurysms and dissections: identification of a novel locus for stable aneurysms with a low risk for progression to aortic dissection
    Dong Chuan Guo
    University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Circ Cardiovasc Genet 4:36-42. 2011
    ....
  22. doi Epidemiology of thoracic aortic dissection
    Scott A LeMaire
    The Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Nat Rev Cardiol 8:103-13. 2011
    ..Specific nonsyndromic genetic mutations in families and single nucleotide polymorphisms have also been identified as possible risk factors for TAD...
  23. pmc Recurrent chromosome 16p13.1 duplications are a risk factor for aortic dissections
    Shao Qing Kuang
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA
    PLoS Genet 7:e1002118. 2011
    ....
  24. pmc Exome sequencing identifies SMAD3 mutations as a cause of familial thoracic aortic aneurysm and dissection with intracranial and other arterial aneurysms
    Ellen S Regalado
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA
    Circ Res 109:680-6. 2011
    ....
  25. pmc Autosomal dominant inheritance of a predisposition to thoracic aortic aneurysms and dissections and intracranial saccular aneurysms
    Ellen Regalado
    Department of Internal Medicine and Neurosurgery, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Am J Med Genet A 155:2125-30. 2011
    ..In these families, routine cerebral and aortic imaging for at risk members could prevent cerebral hemorrhages and aortic dissections...
  26. doi Susceptibility to acute thoracic aortic dissections in patients dying outside the hospital: an autopsy study
    Siddharth K Prakash
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Am Heart J 162:474-9. 2011
    ..The objectives of this study were to identify the incidence and predictors of death from acute thoracic aortic dissections (AoDs) and to describe their associated clinical findings...
  27. pmc Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1
    Scott A LeMaire
    Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    Nat Genet 43:996-1000. 2011
    ..This study shows that common genetic variants at 15q21.1 that probably act via FBN1 are associated with STAAD, suggesting a common pathogenesis of aortic disease in Marfan syndrome and STAAD...
  28. pmc Stem cells in thoracic aortic aneurysms and dissections: potential contributors to aortic repair
    Ying H Shen
    Texas Heart Institute at St Luke s Episcopal Hospital, and Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann Thorac Surg 93:1524-33. 2012
    ..We sought to determine whether SCs are more abundant in TAAD tissue than in control tissues, and whether SCs within the diseased aortic wall differentiate into functionally relevant cell types...
  29. pmc The nuclear factor-kappaB-interleukin-6 signalling pathway mediating vascular inflammation
    Allan R Brasier
    Division of Endocrinology, Department of Internal Medicine, Sealy Center for Molecular Medicine and Institute for Translational Sciences, University of Texas Medical Branch, MRB 8 122, 301 University Blvd, Galveston, TX 77555 1060, USA
    Cardiovasc Res 86:211-8. 2010
    ..These new discoveries further our understanding for the important role of the NF-kappaB-IL-6 signalling pathway in the process of vascular inflammation...
  30. pmc Thoracic aortic disease in tuberous sclerosis complex: molecular pathogenesis and potential therapies in Tsc2+/- mice
    Jiumei Cao
    Department of Internal Medicine, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Hum Mol Genet 19:1908-20. 2010
    ..These findings provide insights into the molecular pathogenesis of aortic disease in TSC patients and identify a potential therapeutic target for treatment of this complication of the disease...
  31. pmc Effects of correlation and missing data on sample size estimation in longitudinal clinical trials
    Song Zhang
    Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Pharm Stat 9:2-9. 2010
    ..A simulation study is conducted to investigate the performance of GEE sample size formula with small sample sizes, damped exponential family of correlation structure and non-ignorable missing data...
  32. pmc Aortic adventitial fibroblasts participate in angiotensin-induced vascular wall inflammation and remodeling
    Brian C Tieu
    Department of Biochemistry, University of Texas Medical Branch, Galveston, TX 77555 1060, USA
    J Vasc Res 48:261-72. 2011
    ..Our objective was to explore the contribution of these cells to angiotensin II (Ang II)-induced aortic inflammation and adventitial expansion...
  33. pmc Postoperative renal function preservation with nonischemic femoral arterial cannulation for thoracoabdominal aortic repair
    Charles C Miller
    Department of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso Paul L Foster School of Medicine, El Paso, Tex 79905, USA
    J Vasc Surg 51:38-42. 2010
    ..After this finding, we modified our perfusion technique to eliminate leg ischemia from cannulation. In this article, we present the effects of this change on postoperative renal function...
  34. doi Paucity of skeletal manifestations in Hispanic families with FBN1 mutations
    Carlos Villamizar
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA
    Eur J Med Genet 53:80-4. 2010
    ..We recommend that echocardiogram, ocular examination and FBN1 molecular testing be considered for any patients with possible MFS even in the absence of skeletal features, including Hispanic patients...
  35. ncbi Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction
    Dianna M Milewicz
    Department of Internal Medicine, University of Texas, Houston, Texas 77030, USA
    Annu Rev Genomics Hum Genet 9:283-302. 2008
    ....
  36. pmc Effect of 27nt small RNA on endothelial nitric-oxide synthase expression
    Ming Xiang Zhang
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University, Qilu Hospital, Jinan, Shandong 250012, China
    Mol Biol Cell 19:3997-4005. 2008
    ..Our study demonstrates that 27nt small RNA may suppress eNOS expression by altering histone acetylation and DNA methylation in regions adjacent to the 27nt repeat element and core promoter...
  37. pmc Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha1
    Cheng Zhang
    Division of Cardiovascular Surgery, the Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas, USA
    Biochim Biophys Acta 1783:1517-28. 2008
    ..Defining this cytokine-mediated regulatory pathway may provide novel molecular targets for therapeutic intervention in preventing plaque rupture and acute coronary occlusion...
  38. pmc Biogenesis of short intronic repeat 27-nucleotide small RNA from endothelial nitric-oxide synthase gene
    Ming Xiang Zhang
    Adult Section of Cardiothoracic Surgery, Texas Heart Institute at St Luke s Episcopal Hospital, Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Biol Chem 283:14685-93. 2008
    ..This novel molecular model may be responsible for quantitative differences between individuals carrying different numbers of the polymorphic repeats hence the cardiovascular risk...
  39. pmc To (TGF)beta or not to (TGF)beta: fine-tuning of Smad signaling via post-translational modifications
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Signal 20:1579-91. 2008
    ..Recent progress, discussed herein, illustrates the critical roles of Smad post-translational modifications in the cellular outcome to TGF-beta signaling...
  40. doi Ascending and transverse aortic arch repair: the impact of glomerular filtration rate on mortality
    Anthony L Estrera
    Department of Cardiothoracic and Vascular Surgery, The University of Texas at Houston Medical School, Memorial Hermann Heart and Vascular Institute, Houston, TX 77030, USA
    Ann Surg 247:524-9. 2008
    ..We studied the impact of GFR on mortality following repair of ascending and arch aneurysms...
  41. doi Outcomes of delayed sternal closure after complex aortic surgery
    Anthony L Estrera
    Department of Cardiothoracic and Vascular Surgery, University of Texas Medical School and Memorial Hermann Hospital, Houston, TX 77030, United States
    Eur J Cardiothorac Surg 33:1039-42. 2008
    ..The objective of this study was to report our experience with open chest management and delayed sternal closure after complex proximal aortic surgery...
  42. doi Intraoperative skeletal muscle ischemia contributes to risk of renal dysfunction following thoracoabdominal aortic repair
    Charles C Miller
    Department of Cardiothoracic and Vascular Surgery, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Eur J Cardiothorac Surg 33:691-4. 2008
    ..Lacking complete historical laboratory data on myoglobinemia, we studied somatosensory evoked potential (SSEP) changes in the leg (a functional marker of leg ischemia), as a surrogate predictor of acute postoperative renal failure...
  43. pmc Saturation fluorescence labeling of proteins for proteomic analyses
    Elizabeth Pretzer
    Bayer HealthCare Pharmaceuticals, Berkeley, CA 94710, USA
    Anal Biochem 374:250-62. 2008
    ..We also showed that the dye exhibits little to no effect on the two-dimensional mobilities of labeled proteins derived from cells...
  44. ncbi Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections
    Dong Chuan Guo
    Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Nat Genet 39:1488-93. 2007
    ..These data, along with the previously reported MYH11 mutations causing familial TAAD, indicate the importance of SMC contraction in maintaining the structural integrity of the ascending aorta...
  45. ncbi Involvement of a novel Rac/RhoA guanosine triphosphatase-nuclear factor-kappaB inducing kinase signaling pathway mediating angiotensin II-induced RelA transactivation
    Sanjeev Choudhary
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    Mol Endocrinol 21:2203-17. 2007
    ..RelA complex formation and inducible Ser(536) RelA phosphorylation...
  46. ncbi Analysis of ascending and transverse aortic arch repair in octogenarians
    Pallav J Shah
    Cardiothoracic and Vascular Surgery, University of Texas Medical School at Houston, Houston, Texas, USA
    Ann Thorac Surg 86:774-9. 2008
    ..Increasing numbers of older patients are requiring complex thoracic aortic surgery. This retrospective study analyzed early and late outcomes after ascending and transverse arch surgery using hypothermic circulatory arrest (HCA)...
  47. pmc Expanding role of cyclin dependent kinases in cytokine inducible gene expression
    Allan R Brasier
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    Cell Cycle 7:2661-6. 2008
    ..The potential of inhibiting P-TEFb as an anti-inflammatory therapy in innate immunity and systemic inflammation will be discussed...
  48. ncbi An FBN1 pseudoexon mutation in a patient with Marfan syndrome: confirmation of cryptic mutations leading to disease
    Dong Chuan Guo
    The Department of Internal Medicine, The University of Texas Medical School at Houston, 6431 Fannin, MSB 6 100, Houston, TX 77030, USA
    J Hum Genet 53:1007-11. 2008
    ..Identification of a novel pseudoexon mutation in FBN1, in association with a clinical diagnosis of MFS, confirms that cryptic mutations that are missed by the current DNA-based diagnostic methods have a causative role...
  49. pmc FBN1 mutations in patients with descending thoracic aortic dissections
    Ariel Brautbar
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Med Genet A 152:413-6. 2010
    ....
  50. pmc An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice
    Brian C Tieu
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA
    J Clin Invest 119:3637-51. 2009
    ....
  51. doi Acute type A intramural hematoma: analysis of current management strategy
    Anthony Estrera
    Department of Cardiothoracic and Vascular Surgery, Memorial Hermann Heart and Vascular Institute, University of Texas at Houston Medical School, 77030, USA
    Circulation 120:S287-91. 2009
    ..Management of acute type A intramural hematoma (IMH) remains controversial, varying from immediate surgery to medical management only. Conversion to typical dissection remains a concern. We analyzed our experience managing acute type A IMH...
  52. ncbi Cerebrospinal fluid drainage during thoracic aortic repair: safety and current management
    Anthony L Estrera
    Department of Cardiothoracic and Vascular Surgery, University of Texas Medical School Houston, Houston, Texas, USA
    Ann Thorac Surg 88:9-15; discussion 15. 2009
    ..The benefit of cerebrospinal fluid (CSF) drainage during thoracic aortic repair has been established. Few studies, however, report management and safety of CSF drainage...
  53. ncbi Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations
    V Tran-Fadulu
    Department of Internal Medicine and Department of Neurosurgery, University of Texas Health Science Center at Houston, Texas, USA
    J Med Genet 46:607-13. 2009
    ..TGFBR2 mutations can also cause TAAD in the absence of features of LDS in large multigenerational families, yet only sporadic LDS cases or parent-child pairs with TGFBR1 mutations have been reported to date...
  54. pmc Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease
    Dong Chuan Guo
    The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Am J Hum Genet 84:617-27. 2009
    ....
  55. doi Serum myoglobin and renal morbidity and mortality following thoracic and thoraco-abdominal aortic repair: does rhabdomyolysis play a role?
    C C Miller
    Department of Cardiothoracic and Vascular Surgery, University of Texas Medical School at Houston, Memorial Hermann Heart and Vascular Institute, Houston, TX 77030, USA
    Eur J Vasc Endovasc Surg 37:388-94. 2009
    ..We studied postoperative myoglobinaemia and renal dysfunction following aortic surgery...
  56. pmc Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 284:9755-63. 2009
    ..Thus, TGFbeta-mediated Smad1 phosphorylation appears to occur via different receptor complexes in a cell type-specific manner...
  57. pmc Phospho-control of TGF-beta superfamily signaling
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery, Department of Molecular and Cellular Biology and Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Res 19:8-20. 2009
    ..This article illustrates the essential roles of reversible phosphorylation in controlling the strength and duration of TGF-beta signaling and the ensuing physiological responses...
  58. pmc Characterization of the inflammatory cells in ascending thoracic aortic aneurysms in patients with Marfan syndrome, familial thoracic aortic aneurysms, and sporadic aneurysms
    Rumin He
    Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Thorac Cardiovasc Surg 136:922-9, 929.e1. 2008
    ..This study sought to characterize the inflammatory infiltrate in ascending thoracic aortic aneurysm in patients with Marfan syndrome, familial thoracic aortic aneurysm, or nonfamilial thoracic aortic aneurysm...
  59. doi Ascending and transverse aortic arch repair: the impact of retrograde cerebral perfusion
    Anthony L Estrera
    Department of Cardiothoracic and Vascular Surgery, The University of Texas Houston Medical School, 6410 Fannin, Suite 425, Houston, TX 77030, USA
    Circulation 118:S160-6. 2008
    ..We examined our experience with ascending and transverse arch repairs to determine the impact of retrograde cerebral perfusion on stroke and mortality...
  60. pmc Apolipoprotein-J prevention of fetal cardiac myoblast apoptosis induced by ethanol
    Yangxin Li
    Texas Heart Institute and The University of Texas Health Science Center, Houston, TX 77030, USA
    Biochem Biophys Res Commun 357:157-61. 2007
    ..Thus, ApoJ serves as a cytoprotective protein that protects cardiac stem cells against EtOH cytotoxicity...