PAHs: New Technologies and Emerging Health Risks

Summary

Principal Investigator: David E Williams
Abstract: The Oregon State University Superfund Research Program (SRP) is multi-investigator, multi-disciplinary and multi-institutional. In partnership wit Pacific Northwest National Laboratories, and other stakeholders and collaborators, we seek to develop new technologies to assess polycyclic aromatic hydrocarbons (PAHs) found at many of the nation's Superfund sites and assess the risk they pose for human health. The SRP consists of three biomedical research projects, two non-biomedical research projects, Administrative, Research Translation, Community Engagement, Training and two research support cores (Biostatistics and Modeling and Chemistry). Over the next five years of the program a number of innovative and high impact research goals will be pursued including: (1) the first ever study of how humans take-up and excrete carcinogenic PAHs at environmental levels of exposure;(2) produce Physiologically Based Pharmacokinetic (PBPK) models for risk assessment of PAH mixtures;(3) determine developmental toxicities of PAH mixtures and PAHs formed in the environment using a zebrafish model;(4) employ passive sampling devices to assess bioavailable PAHs at Superfund sites and the effectiveness of remediation strategies and;(5) employ new analytical approaches to assessing chemical changes in PAHs in soilds and sediments at Superfund sites over time. The cores will: (1) direct the activities of the SRP (Administrative);(2) pursue effective mechanisms for disseminating our findings to stakeholders (Research Translation), (3) work with communities impacted by PAH exposure to address concerns and pursue solutions for reduced risk (Community Engagement);(4) provide intensive multi-disciplinary training opportunities for the next generation of Environmental Health Scientists (Training) and;(5 and 6) provide Biostatistical and Modeling support for the design, conduct and interpretation of the research being conducted as well as using state-of the-art Chemistry instrumentation and approaches to assess the identity and quantity of hundreds of PAHs found in environmental and biological matrices. Accomplishing these goals will provide significant scientific advancement and improve the quality of life for impacted communities.
Funding Period: 2008-04-01 - 2018-03-31
more information: NIH RePORT

Top Publications

  1. pmc Passive sampling devices enable capacity building and characterization of bioavailable pesticide along the Niger, Senegal and Bani Rivers of Africa
    Kim A Anderson
    Environmental and Molecular Toxicology Department, Oregon State University, ALS 1007, Corvallis, OR 97331, USA
    Philos Trans R Soc Lond B Biol Sci 369:20130110. 2014
  2. pmc Naphthalene biomarkers and relationship with hemoglobin and hematocrit in White, Black, and Hispanic adults: results from the 2003-2004 National Health and Nutrition Examination Survey
    Daniel L Sudakin
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    J Med Toxicol 9:133-8. 2013
  3. pmc Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice
    Susan Ritger Crowell
    Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Toxicol Sci 135:48-62. 2013
  4. pmc Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish
    Britton C Goodale
    Department of Environmental and Molecular Toxicology, the Environmental Health Sciences Center, Oregon State University, Corvallis, OR, USA
    Toxicol Appl Pharmacol 272:656-70. 2013
  5. pmc Comparative developmental toxicity of environmentally relevant oxygenated PAHs
    Andrea L Knecht
    Department of Environmental and Molecular Toxicology, the Environmental Health Sciences Center, Oregon State University, Corvallis, OR, USA
    Toxicol Appl Pharmacol 271:266-75. 2013
  6. pmc Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane
    Lyndsey E Shorey
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 USA
    Toxicol Appl Pharmacol 270:60-9. 2013
  7. pmc Association of carcinogenic polycyclic aromatic hydrocarbon emissions and smoking with lung cancer mortality rates on a global scale
    Oleksii Motorykin
    Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States
    Environ Sci Technol 47:3410-6. 2013
  8. ncbi Extraction of fullerenes from environmental matrices as affected by solvent characteristics and analyte concentration
    Benjamin J Place
    Department of Chemistry, Oregon State University, Corvallis, OR 97331, USA
    J Sep Sci 36:953-8. 2013
  9. pmc Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin
    Andrew Larkin
    Department of Environmental and Molecular Toxicology, Oregon State University, USA
    Toxicol Appl Pharmacol 267:192-9. 2013
  10. pmc Non-coding RNAs--novel targets in neurotoxicity
    Tamara L Tal
    Department of Environmental and Molecular Toxicology and Environmental Health Sciences Center, Oregon State University, Corvallis, OR, United States
    Neurotoxicology 33:530-44. 2012

Detail Information

Publications78

  1. pmc Passive sampling devices enable capacity building and characterization of bioavailable pesticide along the Niger, Senegal and Bani Rivers of Africa
    Kim A Anderson
    Environmental and Molecular Toxicology Department, Oregon State University, ALS 1007, Corvallis, OR 97331, USA
    Philos Trans R Soc Lond B Biol Sci 369:20130110. 2014
    ..The joint study included sampling from 63 sites across six western African countries, generating a 9000 data point pesticide database with virtual access to all study participants. ..
  2. pmc Naphthalene biomarkers and relationship with hemoglobin and hematocrit in White, Black, and Hispanic adults: results from the 2003-2004 National Health and Nutrition Examination Survey
    Daniel L Sudakin
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    J Med Toxicol 9:133-8. 2013
    ..The positive association between NAP1 with HCT and Hb is an unexpected finding. Further research is needed to understand the possible biological mechanisms or other explanations for this association...
  3. pmc Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice
    Susan Ritger Crowell
    Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Toxicol Sci 135:48-62. 2013
    ..Concentrations of DBC in fetuses were one to two orders of magnitude below maternal blood concentrations, whereas metabolite concentrations closely resembled those observed in maternal blood. ..
  4. pmc Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish
    Britton C Goodale
    Department of Environmental and Molecular Toxicology, the Environmental Health Sciences Center, Oregon State University, Corvallis, OR, USA
    Toxicol Appl Pharmacol 272:656-70. 2013
    ..These results indicate that systems approaches can be used to classify the toxicity of PAHs based on the networks perturbed following exposure, and may provide a path for unraveling the toxicity of complex PAH mixtures...
  5. pmc Comparative developmental toxicity of environmentally relevant oxygenated PAHs
    Andrea L Knecht
    Department of Environmental and Molecular Toxicology, the Environmental Health Sciences Center, Oregon State University, Corvallis, OR, USA
    Toxicol Appl Pharmacol 271:266-75. 2013
    ..Comprehensive in vivo characterization of 38 structurally diverse OPAHs indicated differential AHR dependency and a prominent role for oxidative stress in the toxicity mechanisms. ..
  6. pmc Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane
    Lyndsey E Shorey
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 USA
    Toxicol Appl Pharmacol 270:60-9. 2013
    ..These findings provide justification for further study of the safety and bioactivity of cruciferous vegetable phytochemicals at supplemental concentrations during the perinatal period...
  7. pmc Association of carcinogenic polycyclic aromatic hydrocarbon emissions and smoking with lung cancer mortality rates on a global scale
    Oleksii Motorykin
    Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States
    Environ Sci Technol 47:3410-6. 2013
    ....
  8. ncbi Extraction of fullerenes from environmental matrices as affected by solvent characteristics and analyte concentration
    Benjamin J Place
    Department of Chemistry, Oregon State University, Corvallis, OR 97331, USA
    J Sep Sci 36:953-8. 2013
    ..The usefulness of isotopically labeled surrogate is demonstrated and the study provides a quantitative assessment regarding the dependence of fullerene extraction efficiencies on the geochemical characteristics of solid matrices...
  9. pmc Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin
    Andrew Larkin
    Department of Environmental and Molecular Toxicology, Oregon State University, USA
    Toxicol Appl Pharmacol 267:192-9. 2013
    ..The aryl hydrocarbon receptor repressor (Ahrr) was determined to be the most significant input variable for model predictions using back-propagation and normalization of FNN weights...
  10. pmc Non-coding RNAs--novel targets in neurotoxicity
    Tamara L Tal
    Department of Environmental and Molecular Toxicology and Environmental Health Sciences Center, Oregon State University, Corvallis, OR, United States
    Neurotoxicology 33:530-44. 2012
    ..Finally, we identify a number of outstanding questions regarding ncRNAs and neurotoxicity...
  11. pmc Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse
    Lisbeth K Siddens
    Department of Environmental and Molecular Toxicology, Oregon State University, USA
    Toxicol Appl Pharmacol 264:377-86. 2012
    ..BaP and mixtures up-regulated phase 1 and phase 2 metabolizing enzymes while DBC did not. The carcinogenicity with DBC and two of the mixtures was much greater than would be predicted based on published Relative Potency Factors (RPFs)...
  12. pmc Conducting research with tribal communities: sovereignty, ethics, and data-sharing issues
    Anna Harding
    School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA
    Environ Health Perspect 120:6-10. 2012
    ....
  13. pmc Emissions of parent, nitro, and oxygenated polycyclic aromatic hydrocarbons from residential wood combustion in rural China
    Guofeng Shen
    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Sci Technol 46:8123-30. 2012
    ..The gas-particle partitioning of freshly emitted pPAHs, nPAHs, and oPAHs was primarily controlled by organic carbon absorption...
  14. pmc Inhalation cancer risk associated with exposure to complex polycyclic aromatic hydrocarbon mixtures in an electronic waste and urban area in South China
    Jing Wang
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China
    Environ Sci Technol 46:9745-52. 2012
    ..On average, the inhalation cancer risk in the e-waste area was 1.6 times higher than in the urban area. The e-waste dismantling activities in South China led to higher inhalation cancer risk due to PAH exposure than the urban area...
  15. pmc Automated zebrafish chorion removal and single embryo placement: optimizing throughput of zebrafish developmental toxicity screens
    David Mandrell
    Oregon State University, Corvallis, OR, USA
    J Lab Autom 17:66-74. 2012
    ..9%) as from manual pipetting (9 of 864; 1%). There was no statistical difference between the success of performing the embryo placement robotically or manually...
  16. pmc Occurrence and exposure to polycyclic aromatic hydrocarbons and their derivatives in a rural Chinese home through biomass fuelled cooking
    Junnan Ding
    Laboratory for Earth Surface Processes, College of Urban and Environmental Science, Peking University, Beijing, China
    Environ Pollut 169:160-6. 2012
    ..The daily mean benzo(a)pyrene equivalent exposure concentration was as high as 200 ± 160 ng/m(3) in the winter for the housewife who did the cooking compared to 59 ± 37 ng/m(3) for the control group that did not cook...
  17. pmc MicroRNAs control neurobehavioral development and function in zebrafish
    Tamara L Tal
    Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, 28645 East HWY 34, Corvallis, OR 97333, USA
    FASEB J 26:1452-61. 2012
    ..Together, these data support an integral role for miRNAs in the establishment of vertebrate neurobehavioral and skeletal systems...
  18. pmc Bridging environmental mixtures and toxic effects
    Sarah E Allan
    Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, OR, USA
    Environ Toxicol Chem 31:2877-87. 2012
    ..Although the present study highlights the complexity of discerning specific bioactive compounds in complex mixtures, it demonstrates methods for associating toxic effects with chemical characteristics of environmental samples...
  19. pmc Formation of nitro-PAHs from the heterogeneous reaction of ambient particle-bound PAHs with N2O5/NO3/NO2
    Kathryn Zimmermann
    Air Pollution Research Center, University of California, Riverside, California 92521, United States
    Environ Sci Technol 47:8434-42. 2013
    ....
  20. ncbi Influence of fuel mass load, oxygen supply and burning rate on emission factor and size distribution of carbonaceous particulate matter from indoor corn straw burning
    Guofeng Shen
    Jiangsu Academy of Environmental Sciences, Nanjing 210036, China
    J Environ Sci (China) 25:511-9. 2013
    ..05), but they were not significantly correlated with the EF of co-emitted CO, suggesting that special attention should be paid to the use of CO as a surrogate for other incomplete combustion pollutants...
  21. pmc Quantification of complex polycyclic aromatic hydrocarbon mixtures in standard reference materials using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry
    Carlos Manzano
    Department of Chemistry, Oregon State University, Corvallis, OR, USA
    J Chromatogr A 1307:172-9. 2013
    ....
  22. pmc Novel nitro-PAH formation from heterogeneous reactions of PAHs with NO2, NO3/N2O5, and OH radicals: prediction, laboratory studies, and mutagenicity
    Narumol Jariyasopit
    Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, United States
    Environ Sci Technol 48:412-9. 2014
    ....
  23. pmc Passive sampling methods for contaminated sediments: risk assessment and management
    Marc S Greenberg
    USEPA Office of Superfund Remediation and Technology Innovation, Edison, New Jersey
    Integr Environ Assess Manag 10:224-36. 2014
    ..Research and communication needs for encouraging broader use are discussed...
  24. pmc Bioaccessibility of metals in alloys: evaluation of three surrogate biofluids
    Wendy E Hillwalker
    Chemical Regulatory and Food Safety Center, Exponent, 1150 Connecticut Ave, Suite 1100, Washington, DC 22036, USA Electronic address
    Environ Pollut 185:52-8. 2014
    ..The large variability of bioaccessibility indicates the relevancy of assessing alloys as toxicologically distinct relative to individual metals. ..
  25. ncbi Field measurement on the emissions of PM, OC, EC and PAHs from indoor crop straw burning in rural China
    Siye Wei
    Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Pollut 184:18-24. 2014
    ..The field measured EFPM, EFOC, and EFEC were significantly affected by stove age and the EFs of carbonaceous particles for the 15-year old stove were approximately 2.5 times of those for the 1-year old stove. ..
  26. pmc Passive sampling coupled to ultraviolet irradiation: a useful analytical approach for studying oxygenated polycyclic aromatic hydrocarbon formation in bioavailable mixtures
    Norman D Forsberg
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, USA
    Environ Toxicol Chem 33:177-81. 2014
    ..A reduction in PAH levels and simultaneous formation of several oxygenated PAHs were measured. Site-specific differences were observed with UVB-exposed PSD mixtures...
  27. pmc Chronic exposure of killifish to a highly polluted environment desensitizes estrogen-responsive reproductive and biomarker genes
    Sean M Bugel
    Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, United States Electronic address
    Aquat Toxicol 152:222-31. 2014
    ....
  28. pmc Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish
    Cory V Gerlach
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA
    Aquat Toxicol 154:71-9. 2014
    ..Overall, these results suggest that, while mITP is an AHR agonist, mITP causes AHR-independent cardiotoxicity through a pathway that is also antagonized by CH223191. ..
  29. ncbi In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes
    S R Crowell
    Systems Toxicology and Exposure Science, Pacific Northwest National Laboratory, Richland, WA, United States Electronic address
    Toxicol Lett 228:48-55. 2014
    ..These findings suggest that rats are a more appropriate model organism for human PAH metabolism, and that pregnancy's effects on metabolism should be further explored. ..
  30. pmc A rapid throughput approach identifies cognitive deficits in adult zebrafish from developmental exposure to polybrominated flame retardants
    Lisa Truong
    Department of Environmental and Molecular Toxicology, The Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, United States
    Neurotoxicology 43:134-42. 2014
    ..Active avoidance response in zebrafish is an effective model of learning that, combined with automated shuttle box testing, will provide a highly efficient platform for evaluating persistent neurotoxic hazard from many chemicals. ..
  31. pmc Early life perfluorooctanesulphonic acid (PFOS) exposure impairs zebrafish organogenesis
    Jiangfei Chen
    Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou 325035, China
    Aquat Toxicol 150:124-32. 2014
    ..Taken together, early life stage exposure to PFOS perturbs various molecular pathways potentially resulting in observed defects in swim bladder and gut development...
  32. pmc Silicone wristbands as personal passive samplers
    Steven G O'Connell
    Department of Environmental and Molecular Toxicology and College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon 97331, United States
    Environ Sci Technol 48:3327-35. 2014
    ..05, power =0.85). Additionally, the amount of PAH sequestered differed between worksites (p < 0.05, power = 0.99), suggesting spatial sensitivity using this novel application...
  33. ncbi Emissions of parent, nitrated, and oxygenated polycyclic aromatic hydrocarbons from indoor corn straw burning in normal and controlled combustion conditions
    Guofeng Shen
    Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    J Environ Sci (China) 25:2072-80. 2013
    ..The results from the stepwise regression model showed that fuel burning rate, air supply amount, and modified combustion efficiency were the three most significant influencing factors, explaining 72%-85% of the total variations...
  34. pmc An analytical investigation of 24 oxygenated-PAHs (OPAHs) using liquid and gas chromatography-mass spectrometry
    Steven G O'Connell
    Environmental and Molecular Toxicology Department, Agricultural and Life Sciences Building, Oregon State University, Rm 1007, Corvallis, OR, 97331, USA
    Anal Bioanal Chem 405:8885-96. 2013
    ..Overall, this work improves upon OPAH analytical methods and provides some considerations and strategies for OPAHs as focus continues to expand on this emerging chemical class. ..
  35. ncbi Stainless steel leaches nickel and chromium into foods during cooking
    Kristin L Kamerud
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, United States
    J Agric Food Chem 61:9495-501. 2013
    ..Stainless steel cookware can be an overlooked source of nickel and chromium, where the contribution is dependent on stainless steel grade, cooking time, and cookware usage. ..
  36. pmc Retinoic acid-dependent regulation of miR-19 expression elicits vertebrate axis defects
    Jill A Franzosa
    3Department of Environmental and Molecular Toxicology, Oregon State University, 28645 East HWY 34 Corvallis, OR 97333, USA
    FASEB J 27:4866-76. 2013
    ..This highlights a previously unidentified role of miR-19 in facilitating vertebrate axis development via regulation of RA signaling...
  37. ncbi Influence of fuel moisture, charge size, feeding rate and air ventilation conditions on the emissions of PM, OC, EC, parent PAHs, and their derivatives from residential wood combustion
    Guofeng Shen
    Jiangsu Academy of Environmental Sciences, Nanjing 210036, China
    J Environ Sci (China) 25:1808-16. 2013
    ....
  38. pmc Polystyrene plastic: a source and sink for polycyclic aromatic hydrocarbons in the marine environment
    Chelsea M Rochman
    Department of Biology and Coastal and Marine Institute, and Graduate School of Public Health, San Diego State University, San Diego, California 92182, United States
    Environ Sci Technol 47:13976-84. 2013
    ..The combination of greater PAHs in virgin pellets and large sorption suggests that PS may pose a greater risk of exposure to PAHs upon ingestion. ..
  39. pmc Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish
    Katerine S Saili
    Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97333, USA
    Toxicology 291:83-92. 2012
    ..Exposure to 0.1μM 17β-estradiol or GSK4716 also led to larval hyperactivity. This study demonstrates the efficacy of using the zebrafish model for studying the neurobehavioral effects of low-dose developmental BPA exposure...
  40. pmc Surface functionalities of gold nanoparticles impact embryonic gene expression responses
    Lisa Truong
    Department of Environmental and Molecular Toxicology, The Sinnhuber Aquatic Research Laboratory and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR 97333, USA
    Nanotoxicology 7:192-201. 2013
    ..Additionally, transport mechanisms were misregulated after exposure to TMAT and MES-AuNPs, demonstrating that surface functionalisation influences many molecular pathways...
  41. pmc Mobilization of soil-bound residue of organochlorine pesticides and polycyclic aromatic hydrocarbons in an in vitro gastrointestinal model
    Shu Tao
    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Sci Technol 45:1127-32. 2011
    ..The mobilization process followed typical first-order kinetics. The calculated rate constants suggest that mobilization was fast and 90% of extracted bound residues of OCPs and PAHs were mobilized within 2.4 and 4.8 h, respectively...
  42. pmc Atmospheric concentrations and air-soil gas exchange of polycyclic aromatic hydrocarbons (PAHs) in remote, rural village and urban areas of Beijing-Tianjin region, North China
    Wentao Wang
    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Sci Total Environ 409:2942-50. 2011
    ..However, in winter, more gaseous PAHs deposited from air to soil due to higher PAH emissions and lower temperatures. The soil TOC concentration had no significant influence on the air-soil gas exchange of PAHs...
  43. pmc Estimated reduction in cancer risk due to PAH exposures if source control measures during the 2008 Beijing Olympics were sustained
    Yuling Jia
    Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Environ Health Perspect 119:815-20. 2011
    ..The 2008 Beijing Olympic Games provided a unique case study to investigate the effect of source control measures on the reduction in air pollution, and associated inhalation cancer risk, in a Chinese megacity...
  44. ncbi Sequestration of organochlorine pesticides in soils of distinct organic carbon content
    Na Zhang
    Laboratory for Earth Surface Processing, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Pollut 159:700-5. 2011
    ....
  45. pmc Emission of oxygenated polycyclic aromatic hydrocarbons from indoor solid fuel combustion
    Guofeng Shen
    Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Sci Technol 45:3459-65. 2011
    ..7-2.1 μm for crop residues and high caking coals and <0.7 μm for the tested low caking briquettes...
  46. pmc Emission factors of particulate matter and elemental carbon for crop residues and coals burned in typical household stoves in China
    Guofeng Shen
    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Sci Technol 44:7157-62. 2010
    ..It was also found that EC emissions were significantly correlated with emissions of PM with size less than 0.4 μm...
  47. pmc Polycyclic aromatic hydrocarbons in water, sediment, soil, and plants of the Aojiang River waterway in Wenzhou, China
    Jianwang Li
    Institute of Watershed Science and Environmental Ecology, Wenzhou Medical College, Wenzhou 325035, PR China
    J Hazard Mater 173:75-81. 2010
    ..The general observation of elevated PAH concentrations in all matrix suggests a possible contribution by the local leather industry on the PAH concentrations in the Aojiang watershed...
  48. ncbi Dynamic changes of α-hexachlorocyclohexane and its enantiomers in various tissues of Japanese Rabbits (Oyctolagus cuniculus) after oral or dermal exposure
    Miao Xue
    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Chemosphere 81:1486-91. 2010
    ..The EFs for other tissues also increased dramatically after the exposure and the EFs in brain reached as high as 0.99 due to enantioselective transport across the blood brain barrier...
  49. pmc Concentrations, sources and spatial distribution of polycyclic aromatic hydrocarbons in soils from Beijing, Tianjin and surrounding areas, North China
    Wentao Wang
    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Pollut 158:1245-51. 2010
    ..In addition, the PAH concentration was well correlated with the total organic carbon (TOC) concentration of the soil. The PAH profile suggested that coal combustion and biomass burning were primary PAH sources...
  50. pmc Ketone and quinone-substituted polycyclic aromatic hydrocarbons in mussel tissue, sediment, urban dust, and diesel particulate matrices
    Julie A Layshock
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA
    Environ Toxicol Chem 29:2450-60. 2010
    ..Of the OPAHs tested, the most frequently occurring in the environmental matrices were 9-fluorenone, 9,10-anthraquinone, benzofluorenone, and 7,12-benz[a]anthracenequinone...
  51. pmc Sources and deposition of polycyclic aromatic hydrocarbons to Western U.S. national parks
    Sascha Usenko
    Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA
    Environ Sci Technol 44:4512-8. 2010
    ....
  52. pmc Exploiting lipid-free tubing passive samplers and embryonic zebrafish to link site specific contaminant mixtures to biological responses
    Wendy E Hillwalker
    Environmental and Molecular Toxicology Department, Oregon State University, ALS 1007, Corvallis, OR 97331, USA
    Chemosphere 79:1-7. 2010
    ..This demonstrates the sensitivity of the bio-analytical tool for detecting spatially distinct toxicity in aquatic systems; bridging environmental exposure to biological response...
  53. pmc Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands
    William H Bisson
    Cancer Biology Laboratory, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon 97331, USA
    J Med Chem 52:5635-41. 2009
    ....
  54. pmc Quantitative analysis of fullerene nanomaterials in environmental systems: a critical review
    Carl W Isaacson
    Department of Chemistry, Oregon State University, Corvallis, Oregon, USA
    Environ Sci Technol 43:6463-74. 2009
    ..Finally, the benefits of quantitative and validated analytical methods for advancing the knowledge on fullerene occurrence, fate, and behavior are indicated...
  55. pmc Inhalation exposure to ambient polycyclic aromatic hydrocarbons and lung cancer risk of Chinese population
    Yanxu Zhang
    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Proc Natl Acad Sci U S A 106:21063-7. 2009
    ..An extremely high PAF of >44% was estimated in isolated locations near small-scale coke oven operations...
  56. pmc Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents
    Susan Ritger Crowell
    Biological Monitoring and Modeling Group, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Toxicol Appl Pharmacol 257:365-76. 2011
    ..The preliminary PBPK models were able to describe many, but not all, of the available data sets, comprising multiple routes of exposure (oral, intravenous) and nominal doses spanning several orders of magnitude...
  57. ncbi Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons
    Zdenek Andrysik
    Department of Cytokinetics, Institute of Biophysics AS CR, Kralovopolska 135, 61265 Brno, Czech Republic
    Mutat Res 714:53-62. 2011
    ..Taken together, our data suggest that more attention should be paid to the AhR-dependent nongenotoxic events elicited by urban PM constituents, especially PAHs and their derivatives...
  58. pmc Comparison of lichen, conifer needles, passive air sampling devices, and snowpack as passive sampling media to measure semi-volatile organic compounds in remote atmospheres
    Jill E Schrlau
    Department of Chemistry, Oregon State University, Corvallis, Oregon, 97331, United States
    Environ Sci Technol 45:10354-61. 2011
    ..Lichen accumulated more SOCs with log K(OA) > 10 relative to needles and showed a greater accumulation of particle-phase PAHs...
  59. pmc Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): timing of maternal exposures determines target tissue response in offspring
    Lyndsey E Shorey
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Cancer Lett 317:49-55. 2012
    ..This study highlights the importance of developmental stage in susceptibility to environmental carcinogens...
  60. pmc Emission factors, size distributions, and emission inventories of carbonaceous particulate matter from residential wood combustion in rural China
    Shen Guofeng
    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Sci Technol 46:4207-14. 2012
    ..On the basis of the measured EFs, total emissions of PM, OC, and EC from residential wood combustion in rural China in 2007 were estimated at about 303, 75.7, and 92.0 Gg...
  61. ncbi The use of cellular diagnostics for identifying sub-lethal stress in reef corals
    Craig A Downs
    Haereticus Environmental Laboratory, PO Box 92, Clifford, VA 24533, USA
    Ecotoxicology 21:768-82. 2012
    ....
  62. pmc Integration of data systems and technology improves research and collaboration for a superfund research center
    Kevin A Hobbie
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA
    J Lab Autom 17:275-83. 2012
    ....
  63. pmc Bioinformatics Resource Manager v2.3: an integrated software environment for systems biology with microRNA and cross-species analysis tools
    Susan C Tilton
    Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, USA
    BMC Bioinformatics 13:311. 2012
    ..3 is a software environment for data management, mining, integration and functional annotation of HTP biological data. In this study, we report recent updates to BRM for miRNA data analysis and cross-species comparisons across datasets...
  64. pmc Reductions in emissions of carbonaceous particulate matter and polycyclic aromatic hydrocarbons from combustion of biomass pellets in comparison with raw fuel burning
    Guofeng Shen
    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Sci Technol 46:6409-16. 2012
    ....
  65. pmc Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout
    Abby D Benninghoff
    Department of Animal, Dairy and Veterinary Sciences and Graduate Program in Toxicology, Utah State University, Logan, Utah 84322, USA
    Toxicol Sci 125:69-78. 2012
    ..Overall, these data suggest that multiple PFAAs can promote liver cancer and that the mechanism of promotion may be similar to that of E2...
  66. pmc An approach for calculating a confidence interval from a single aquatic sample for monitoring hydrophobic organic contaminants
    Melissa M Matzke
    Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, USA
    Environ Toxicol Chem 31:2888-92. 2012
    ..e., n = 1) using an estimate of sample variance derived from a pilot study is presented. Coverage probabilities are explored over a range of variance values using a Monte Carlo simulation...
  67. pmc AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish
    Britton C Goodale
    Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon, United States of America
    PLoS ONE 7:e29346. 2012
    ....
  68. pmc Improved separation of complex polycyclic aromatic hydrocarbon mixtures using novel column combinations in GC × GC/ToF-MS
    Carlos Manzano
    Department of Chemistry, Oregon State University, Corvallis, Oregon, USA
    Environ Sci Technol 46:7677-84. 2012
    ....
  69. pmc Impact of the deepwater horizon oil spill on bioavailable polycyclic aromatic hydrocarbons in Gulf of Mexico coastal waters
    Sarah E Allan
    Environmental and Molecular Toxicology Department, Oregon State University, ALS 1007, Corvallis, Oregon 97331, United States
    Environ Sci Technol 46:2033-9. 2012
    ..Chemical forensic modeling demonstrated that elevated PAH concentrations are associated with distinctive chemical profiles...
  70. pmc Emissions of PAHs from indoor crop residue burning in a typical rural stove: emission factors, size distributions, and gas-particle partitioning
    Guofeng Shen
    Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China
    Environ Sci Technol 45:1206-12. 2011
    ..5, and the mass percentage of PAHs in fine particles increased as the molecular weight increased. For freshly emitted PAHs, absorption into organic carbon, rather than adsorption, dominated the gas-particle partitioning...
  71. pmc Determination of parent and substituted polycyclic aromatic hydrocarbons in high-fat salmon using a modified QuEChERS extraction, dispersive SPE and GC-MS
    Norman D Forsberg
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, United States
    J Agric Food Chem 59:8108-16. 2011
    ..With this method, a single analyst could extract and clean up ≥60 samples for PAH analysis in an 8 h work day...
  72. pmc Estimating risk at a Superfund site using passive sampling devices as biological surrogates in human health risk models
    Sarah E Allan
    Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, OR, USA
    Chemosphere 85:920-7. 2011
    ..Incorporating PSD data into Public Health Assessments provides specific spatial and temporal contaminant exposure information that can assist public health professionals in evaluating human health risks...
  73. pmc Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games
    Wentao Wang
    College of Urban and Environmental Science, Peking University, Beijing, China
    Environ Sci Technol 45:6887-95. 2011
    ..This suggests that NPAH and OPAH make up a significant portion of the overall mutagenicity of PM(2.5) in Beijing...
  74. pmc PAH intermediates: Links between the atmosphere and biological systems
    Staci L Massey Simonich
    Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Chem Biol Interact 192:26-9. 2011
    ....
  75. pmc Spatial distribution and seasonal variation of atmospheric bulk deposition of polycyclic aromatic hydrocarbons in Beijing-Tianjin region, North China
    Wentao Wang
    Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Pollut 159:287-93. 2011
    ....
  76. pmc Atmospheric particulate matter pollution during the 2008 Beijing Olympics
    Wentao Wang
    College of Urban and Environmental Science, Peking University, Beijing, China 100871
    Environ Sci Technol 43:5314-20. 2009
    ....