BIOMARKERS OF EXPOSURE TO HAZARDOUS SUBSTANCES

Summary

Principal Investigator: Bruce D Hammock
Abstract: Description (provided by applicant): The most important function of the Administrative core is to facilitate communication and thus interaction among research projects and cores. This exchange promotes a structure and atmosphere where interdisciplinary research and training takes place. Its procedural function is to provide fiscal and administrative support to the components of the program. It also serves to focus the individual projects on goals ofthe Superfund Program, and it serves as a conduit for program information to NIEHS, agencies, and citizens. It also serves as an interface with the University and other Superfund Programs in the nation. Four committees within the administrative core assist with these goals. The PI reports directly to the Vice Chancellor for Research at the University and is advised by an internal Executive Committee. An External Review Committee evaluates the relevance and quality of the research of individual projects and the integration of the entire program project. A Training Committee provides a rich interdisciplinary environment for pre and postdoctoral training. It coordinates the activities of the Training Core C, advises the Training Core Director and distributes funding from this core. Finally a Research Translation Advisory Committee guides the activities and goals of the Research Translation Core including program-government partnerships, technology transfer and communication of research information and products to broader audiences. It acts as a conduit to stake holders and advised the director of this core. The goals of the Administrative Core are accomplished through 3 specific objectives including: providing fiscal management and administrative support, facilitating scientific activities (research, training and communication), and disseminating information gained within the general framework of the Superfund Program.
Funding Period: 1997-04-01 - 2015-03-31
more information: NIH RePORT

Top Publications

  1. pmc In vitro glucuronidation of the antibacterial triclocarban and its oxidative metabolites
    N H Schebb
    University of Veterinary Medicine Hannover, Institute for Food Toxicology and Chemical Analysis, Hannover, Germany
    Drug Metab Dispos 40:25-31. 2012
  2. pmc Quantification of PCDD/Fs and dioxin-like PCBs in small amounts of human serum using the sensitive H1L7.5c1 mouse hepatoma cell line: optimization and analysis of human serum samples from adolescents of the Flemish human biomonitoring program FLEHS II
    K Croes
    Vrije Universiteit Brussel, Department of Analytical and Environmental Chemistry ANCH, Pleinlaan 2, 1050 Brussels, Belgium
    Talanta 85:2484-91. 2011
  3. pmc New aryl hydrocarbon receptor homology model targeted to improve docking reliability
    Ilaria Motto
    Dipartimento di Scienze dell Ambiente e del Territorio, Universita degli Studi di Milano Bicocca, Piazza della Scienza 1, 20126 Milano, Italy
    J Chem Inf Model 51:2868-81. 2011
  4. pmc Sex differences in the development of airway epithelial tolerance to naphthalene
    K M Sutherland
    Center for Health and Environment, Center School of Veterinary Medicine, University of California Davis, Davis, California 95616 8732, USA
    Am J Physiol Lung Cell Mol Physiol 302:L68-81. 2012
  5. pmc An immunoassay to evaluate human/environmental exposure to the antimicrobial triclocarban
    Ki Chang Ahn
    Department of Entomology and the UCD Cancer Center, University of California Davis, Davis, California 95616, United States
    Environ Sci Technol 46:374-81. 2012
  6. pmc Role of back diffusion and biodegradation reactions in sustaining an MTBE/TBA plume in alluvial media
    Ehsan Rasa
    Department of Civil and Environmental Engineering, University of California Davis, One Shields Avenue, Davis, California 95616, USA
    J Contam Hydrol 126:235-47. 2011
  7. ncbi Nutrigenomics and personalized diets: What will they mean for food?
    J Bruce German
    Foods for Health Institute, University of California, Davis, California 95616, USA
    Annu Rev Food Sci Technol 2:97-123. 2011
  8. pmc Isolation of alpaca anti-hapten heavy chain single domain antibodies for development of sensitive immunoassay
    Hee Joo Kim
    Department of Entomology and UCD Cancer Center, University of California, Davis, California 95616, United States
    Anal Chem 84:1165-71. 2012
  9. pmc Serum proteins prevent aggregation of Fe2O3 and ZnO nanoparticles
    Mark A Wells
    Department of Mechanical and Aerospace Engineering, University of California, Davis, CA 95616, USA
    Nanotoxicology 6:837-46. 2012
  10. pmc Juvenile hormone (JH) esterase of the mosquito Culex quinquefasciatus is not a target of the JH analog insecticide methoprene
    Shizuo G Kamita
    Department of Entomology, University of California Davis, Davis, California, United States of America
    PLoS ONE 6:e28392. 2011

Research Grants

  1. EPIDEMIOLOGY OF ALCOHOL PROBLEMS
    Thomas K Greenfield; Fiscal Year: 2013
  2. Elucidating Risks: From Exposure and Mechanism to Outcome
    James A Swenberg; Fiscal Year: 2013
  3. Puerto Rico Testsite for Exploring Contamination Threats (PRoTECT)
    Akram N Alshawabkeh; Fiscal Year: 2013

Detail Information

Publications495 found, 100 shown here

  1. pmc In vitro glucuronidation of the antibacterial triclocarban and its oxidative metabolites
    N H Schebb
    University of Veterinary Medicine Hannover, Institute for Food Toxicology and Chemical Analysis, Hannover, Germany
    Drug Metab Dispos 40:25-31. 2012
    ..These results present an anomaly where in vivo the predominant urinary metabolites of TCC are N and N'-glucuronides, but these compounds are slowly produced in vitro...
  2. pmc Quantification of PCDD/Fs and dioxin-like PCBs in small amounts of human serum using the sensitive H1L7.5c1 mouse hepatoma cell line: optimization and analysis of human serum samples from adolescents of the Flemish human biomonitoring program FLEHS II
    K Croes
    Vrije Universiteit Brussel, Department of Analytical and Environmental Chemistry ANCH, Pleinlaan 2, 1050 Brussels, Belgium
    Talanta 85:2484-91. 2011
    ..1 (30.1-34.2) pg CALUX-BEQ/g fat for the dioxin-like PCBs...
  3. pmc New aryl hydrocarbon receptor homology model targeted to improve docking reliability
    Ilaria Motto
    Dipartimento di Scienze dell Ambiente e del Territorio, Universita degli Studi di Milano Bicocca, Piazza della Scienza 1, 20126 Milano, Italy
    J Chem Inf Model 51:2868-81. 2011
    ....
  4. pmc Sex differences in the development of airway epithelial tolerance to naphthalene
    K M Sutherland
    Center for Health and Environment, Center School of Veterinary Medicine, University of California Davis, Davis, California 95616 8732, USA
    Am J Physiol Lung Cell Mol Physiol 302:L68-81. 2012
    ..We conclude that, while females develop tolerance, sex differences exist in the tolerant state by airway level, and females remain more susceptible than males to repeated exposures to NA...
  5. pmc An immunoassay to evaluate human/environmental exposure to the antimicrobial triclocarban
    Ki Chang Ahn
    Department of Entomology and the UCD Cancer Center, University of California Davis, Davis, California 95616, United States
    Environ Sci Technol 46:374-81. 2012
    ..This immunoassay can be used as a rapid, inexpensive, and convenient tool to aid researchers monitoring human/environmental exposure to TCC to better understand the health effects...
  6. pmc Role of back diffusion and biodegradation reactions in sustaining an MTBE/TBA plume in alluvial media
    Ehsan Rasa
    Department of Civil and Environmental Engineering, University of California Davis, One Shields Avenue, Davis, California 95616, USA
    J Contam Hydrol 126:235-47. 2011
    ....
  7. ncbi Nutrigenomics and personalized diets: What will they mean for food?
    J Bruce German
    Foods for Health Institute, University of California, Davis, California 95616, USA
    Annu Rev Food Sci Technol 2:97-123. 2011
    ..The business models are also emerging to bring these assessment capabilities to industrial practice, in which consumers will know more about their personal health and seek personal solutions...
  8. pmc Isolation of alpaca anti-hapten heavy chain single domain antibodies for development of sensitive immunoassay
    Hee Joo Kim
    Department of Entomology and UCD Cancer Center, University of California, Davis, California 95616, United States
    Anal Chem 84:1165-71. 2012
    ..In conclusion, a highly specific and sensitive VHH for 3-PBA was developed using sequences from immunized alpaca and phage display technology for antibody selection...
  9. pmc Serum proteins prevent aggregation of Fe2O3 and ZnO nanoparticles
    Mark A Wells
    Department of Mechanical and Aerospace Engineering, University of California, Davis, CA 95616, USA
    Nanotoxicology 6:837-46. 2012
    ..Fluid shear at levels used in flow experiments breaks up iron oxide particle aggregates. These results enhance our understanding of nanoparticle aggregation and its consequences for research on the biological effects of nanomaterials...
  10. pmc Juvenile hormone (JH) esterase of the mosquito Culex quinquefasciatus is not a target of the JH analog insecticide methoprene
    Shizuo G Kamita
    Department of Entomology, University of California Davis, Davis, California, United States of America
    PLoS ONE 6:e28392. 2011
    ..Our findings indicated that JHE is not a molecular target of methoprene. Our findings also do not support the hypothesis that methoprene functions in part by inhibiting the action of JHE...
  11. pmc Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts, USA
    J Clin Invest 122:178-91. 2012
    ..Thus, our data indicate a central role for EETs in tumorigenesis, offering a mechanistic link between lipid signaling and cancer and emphasizing the critical importance of considering possible effects of EET-modulating drugs on cancer...
  12. pmc Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs
    Jackie K W Chan
    Center for Health and the Environment, University of California, Davis, Davis, California 95616, USA
    Toxicol Sci 124:472-86. 2011
    ..We conclude that neonates have an impaired ability to respond to environmental exposures that increases lung cytotoxicity and results in enhanced susceptibility to PFP, which may lead to abnormal airway growth...
  13. pmc Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor
    Michael S Denison
    Department of Environmental Toxicology, University of California, Davis, California 95616, USA
    Toxicol Sci 124:1-22. 2011
    ....
  14. pmc Vitamin D enhances corneal epithelial barrier function
    Zhaohong Yin
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Invest Ophthalmol Vis Sci 52:7359-64. 2011
    ....
  15. pmc Immunochemical analysis of 3-phenoxybenzoic acid, a biomarker of forestry worker exposure to pyrethroid insecticides
    Ki Chang Ahn
    Department of Entomology, University of California, Davis, CA 95616, USA
    Anal Bioanal Chem 401:1285-93. 2011
    ..This ELISA method using a 96-well plate was performed as a high-throughput tool for analyzing around 300 urine samples measured in triplicate to provide data for workers exposure assessment...
  16. pmc Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model
    Jun Yan Liu
    Department of Entomology and Cancer Center, University of California, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 255:200-6. 2011
    ..It may be a promising starting point for developing new low volume high value applications of TCC. However these biological effects also caution against the general over use of TCC in PCPs...
  17. pmc Channelopathies: summary of the hot topic keynotes session
    Jason P Magby
    Joint Graduate Program in Toxicology, Rutgers University University of Medicine and Dentistry New Jersey, Piscataway, NJ 08854, United States
    Neurotoxicology 32:661-5. 2011
    ..It then explored the available evidence that individuals with channelopathies may or may not be more sensitive to effects of chemicals...
  18. pmc Upconversion in NaYF(4):Yb, Er nanoparticles amplified by metal nanostructures
    Wei Deng
    Department of Physics and Astronomy, Macquarie University, North Ryde 2112 NSW, Australia
    Nanotechnology 22:325604. 2011
    ..However, the Au shell coating extended the red emission by a factor of 1.5 and did not obviously change the lifetime of green emission. The responsible mechanisms such as plasmonic enhancement and surface effects are discussed...
  19. pmc Third-generation Ah receptor-responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness
    Guochun He
    Department of Environmental Toxicology, University of California, Davis, California 95616, USA
    Toxicol Sci 123:511-22. 2011
    ..The new G3 CALUX cell lines provide a highly responsive and sensitive bioassay system for the detection and relative quantitation of very low levels of dioxin-like chemicals in sample extracts...
  20. pmc Mobilization of endocrine-disrupting chemicals and estrogenic activity in simulated rainfall runoff from land-applied biosolids
    Ben D Giudice
    Department of Civil and Environmental Engineering, University of California Davis, Davis, California, USA
    Environ Toxicol Chem 30:2220-8. 2011
    ..The ER-CALUX results were mostly explained by background bisphenol A contamination and octylphenol in runoff, although unknown contributors or matrix effects were also found...
  21. pmc Competitive selection from single domain antibody libraries allows isolation of high-affinity antihapten antibodies that are not favored in the llama immune response
    Sofia Tabares-da Rosa
    Cátedra de Inmunología, Facultad de Química, Instituto de Higiene, Universidad de la República, Montevideo, Uruguay
    Anal Chem 83:7213-20. 2011
    ..Despite the modest overall antihapten sdAbs response in llamas, a small subpopulation of high-affinity VHHs is generated that can be isolated by careful design of the selection process...
  22. pmc Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception
    Karen Wagner
    Department of Entomology and UC Davis Cancer Center, University of California Davis, Davis, CA 95616, USA
    Prostaglandins Other Lipid Mediat 96:76-83. 2011
    ....
  23. pmc Bioconcentration, metabolism and excretion of triclocarban in larval Qurt medaka (Oryzias latipes)
    Nils Helge Schebb
    University of Veterinary Medicine Hannover, Institute of Food Toxicology and Analytical Chemistry, Bischofsholer Damm 15, 30173 Hannover, Germany
    Aquat Toxicol 105:448-54. 2011
    ..This study shows that larval medaka metabolize TCC similarly to mammals. The rapid rate of metabolism results in a lower bioconcentration than calculated from the octanol-water coefficient of TCC...
  24. pmc Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy
    Hiromi Inoue
    Division of Nephrology Department of Internal Medicine, University of California, Davis, CA, USA
    Cancer Biol Ther 12:827-36. 2011
    ....
  25. pmc Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys
    A Ulu
    Department of Entomology and Cancer Center, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Br J Pharmacol 165:1401-12. 2012
    ..Development of a sEHI for use in NHPs will facilitate investigations on the role of sEH in numerous chronic inflammatory conditions...
  26. pmc Nitrate removal, communities of denitrifiers and adverse effects in different carbon substrates for use in denitrification beds
    Sören Warneke
    Department of Earth and Ocean Sciences, University of Waikato, Hamilton, New Zealand
    Water Res 45:5463-75. 2011
    ..Therefore we recommend the combination of maize cobs and woodchips to enhance NO(3)(-) removal while minimizing adverse effects in denitrification beds...
  27. pmc Corncob bedding alters the effects of estrogens on aggressive behavior and reduces estrogen receptor-α expression in the brain
    Rosalina Villalon Landeros
    Department of Psychology and Center for Neuroscience, University of California, Davis, Davis, California 95616, USA
    Endocrinology 153:949-53. 2012
    ..Our observations on the effects of corncob bedding on behavior and brain function should draw attention to the importance that cage bedding can exert on neuroendocrine research...
  28. ncbi Dioxin analysis in water by using a passive sampler and CALUX bioassay
    Amr Addeck
    Department of Analytical and Environmental Chemistry, Vrije Universiteit Brussel VUB, Pleinlaan 2, 1050 Brussels, Belgium
    Talanta 88:73-8. 2012
    ..The mean effective molecular diffusion coefficient of TCDD in the toximeter amounts to 11.9×10(-6)m(2)d(-1) while the minimum concentration detectable in an aquatic system after 30 days of exposure amounts to 0.89 pg-TCDDL(-1)...
  29. pmc Reduction of inflammatory bowel disease-induced tumor development in IL-10 knockout mice with soluble epoxide hydrolase gene deficiency
    Wanying Zhang
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Carcinog 52:726-38. 2013
    ..These results indicate that sEH plays an important role in IBD and its-induced carcinogenesis and could serve as a highly potential target of chemoprevention and treatment for IBD...
  30. pmc Inhibition of soluble epoxide hydrolase limits niacin-induced vasodilation in mice
    Ahmet B Inceoglu
    Department of Entomology, University of California, Davis, CA, USA
    J Cardiovasc Pharmacol 60:70-5. 2012
    ..Arachidonic acid is also metabolized by the cytochrome P450 system, which is regulated, in part, by the enzyme soluble epoxide hydrolase (sEH)...
  31. pmc PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms
    Gary A Wayman
    Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington, USA
    Environ Health Perspect 120:997-1002. 2012
    ..Ca(2+) signaling is a predominant factor in shaping dendritic arbors, but whether PCB potentiation of RyR activity influences dendritic growth is not known...
  32. pmc PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth
    Gary A Wayman
    Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington, USA
    Environ Health Perspect 120:1003-9. 2012
    ..RyRs regulate the spatiotemporal dynamics of intracellular Ca(2+) signals, but whether RyRs promote dendritic growth via modulation of this signaling pathway is not known...
  33. ncbi Analysis of PCDD/Fs and dioxin-like PCBs in atmospheric deposition samples from the Flemish measurement network: correlation between the CALUX bioassay and GC-HRMS
    K Croes
    Vrije Universiteit Brussel VUB, Department of Analytical and Environmental Chemistry ANCH, Pleinlaan 2, 1050 Brussels, Belgium
    Chemosphere 88:881-7. 2012
    ..The results show that the CALUX bioassay is a valuable alternative tool for the classic GC-HRMS analysis of atmospheric deposition samples in the Flemish measurement network...
  34. pmc Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients
    Jun Yang
    Department of Entomology, University of California at Davis, Davis, CA 95616, USA
    Free Radic Biol Med 53:160-71. 2012
    ....
  35. pmc Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-/-) mice
    Wanying Zhang
    Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Dig Dis Sci 57:2580-91. 2012
    ..Soluble epoxide hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids (EETs) into their much less active dihydroxy derivatives dihydroxyeicosatrienoic acids. Thus, targeting sEH would be important for inflammation...
  36. pmc Enhancement of vitamin D metabolites in the eye following vitamin D3 supplementation and UV-B irradiation
    Yanping Lin
    Department of Entomology and Cancer Center, University of California, Davis, CA, USA
    Curr Eye Res 37:871-8. 2012
    ..We also determined if the corneal epithelium can synthesize vitamin D following UV-B exposure...
  37. pmc Analysis of naphthalene adduct binding sites in model proteins by tandem mass spectrometry
    Nathalie T Pham
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Chem Biol Interact 199:120-8. 2012
    ....
  38. pmc Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia
    Hong Qiu
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Cardiovasc Res 95:336-45. 2012
    ..However, the key question that remains unanswered is whether cardiac-generated eicosanoids are the cause or the consequence of cardiac cell damage in MI...
  39. pmc Metabolism of the antibacterial triclocarban by human epidermal keratinocytes to yield protein adducts
    Nils Helge Schebb
    Institute of Food Toxicology and Chemical Analysis, University of Veterinary Medicine Hannover, Hannover 30173, Germany
    J Biochem Mol Toxicol 26:230-4. 2012
    ..Exploiting the sensitivity of the method, we demonstrated that a substantial portion of triclocarban forms adducts with keratinocyte protein under the P450 inducing conditions employed...
  40. pmc Role of epoxide hydrolases in lipid metabolism
    Christophe Morisseau
    Department of Entomology and U C D Comprehensive Cancer Center, One Shields Avenue, University of California, Davis, CA 95616, USA
    Biochimie 95:91-5. 2013
    ..This review will discuss the biological activity of key lipid epoxides in mammals. In addition, the use of EH specific inhibitors will be highlighted as possible therapeutic disease interventions...
  41. pmc Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes
    Bora Inceoglu
    Department of Entomology, University of California Davis and UC Davis Cancer Center, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 109:11390-5. 2012
    ..Overall, these results argue that further efforts in understanding the spectrum of effects of EpFAs will yield novel opportunities in treating neuropathic pain...
  42. pmc Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context
    Richard J Wall
    School of Biology, University Park, University of Nottingham, Nottingham NG7 2RD, UK
    Toxicology 297:26-33. 2012
    ....
  43. pmc Monitoring of total type ii pyrethroid pesticides in citrus oils and water by converting to a common product 3-phenoxybenzoic acid
    Mark R McCoy
    Department of Entomology and UCD Cancer Center, University of California Davis, Davis, California 95616, USA
    J Agric Food Chem 60:5065-70. 2012
    ..8 μM when detected by LC-MS/MS, gas chromatography-mass spectrometry, and immunoassay, respectively. The limit of detection for pyrethroids in water when detected by immunoassay was 2 nM...
  44. pmc Whole blood is the sample matrix of choice for monitoring systemic triclocarban levels
    Nils Helge Schebb
    Institute of Toxicology and Chemical Analysis, University of Veterinary Medicine, Hannover, Germany
    Chemosphere 87:825-7. 2012
    ..Utilizing whole blood sampling, a low but significant absorption of TCC from soap during showering is demonstrated for a small group of human subjects...
  45. pmc Microbial biosafety of pilot-scale bioreactor treating MTBE and TBA-contaminated drinking water supply
    Radomir Schmidt
    Land Air and Water Resources Department, One Shields Ave, University of California, Davis, CA 95616, USA
    J Hazard Mater 209:524-8. 2012
    ..hydrophila, numbers were usually lower in treated water than influent samples, suggesting removal during treatment. The detection of particular bacterial species reflected their presence or absence in the influent waters...
  46. pmc Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension
    Jan Neckar
    Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Clin Sci (Lond) 122:513-25. 2012
    ..These findings indicate that chronic inhibition of sEH exhibits antihypertensive and cardioprotective actions in this transgenic model of angiotensin II-dependent hypertension...
  47. pmc Mass discharge in a tracer plume: evaluation of the Theissen Polygon Method
    Douglas M Mackay
    Department of Land, Air and Water Resources, University of California, Davis, CA 95616, USA
    Ground Water 50:895-907. 2012
    ....
  48. pmc Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine
    Dorota Zolkowska
    Department of Neurology, School of Medicine, University of California Davis, Sacramento, California, USA
    J Pharmacol Exp Ther 341:435-46. 2012
    ....
  49. pmc Bovine milk as a source of functional oligosaccharides for improving human health
    Angela M Zivkovic
    Department of Food Science and Technology, University of California, Davis, CA 95616, USA
    Adv Nutr 2:284-9. 2011
    ....
  50. pmc Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids
    Christophe Morisseau
    Department of Entomology and UCD Cancer Center, One Shields Avenue, University of California, Davis, CA 95616, USA
    Biochem Biophys Res Commun 419:796-800. 2012
    ..These findings also underline possible cellular mechanisms by which both activities of sEH (EH and phosphatase) may have complementary or opposite roles...
  51. pmc Identification and characterization of complex bioactive oligosaccharides in white and red wine by a combination of mass spectrometry and gas chromatography
    Matteo Bordiga
    Dipartimento di Scienze del Farmaco, Universita degli Studi del Piemonte Orientale A Avogadro, Novara, Italy
    J Agric Food Chem 60:3700-7. 2012
    ..The coupled gas chromatography and accurate mass spectrometry approach revealed an effective method to characterize and quantify complex functional oligosaccharides in both red and white wine...
  52. pmc Cellular changes that accompany shedding of human corneocytes
    Tzu Kai Lin
    Department of Veterans Affairs Medical Center and Department of Dermatology, Dermatology Service, University of California, San Francisco, San Francisco, California, USA
    J Invest Dermatol 132:2430-9. 2012
    ..Hydration also provoked degradation of membranes by activating contiguous acidic ceramidase activity. Together, these studies identify several parallel mechanisms that orchestrate exfoliation from the surface of normal human skin...
  53. pmc The anti-inflammatory effects of soluble epoxide hydrolase inhibitors are independent of leukocyte recruitment
    Benjamin B Davis
    Center for Health and the Environment, University of California, Davis, CA 95616, USA
    Biochem Biophys Res Commun 410:494-500. 2011
    ..This demonstrates that the widely held belief that sEH inhibition prevents leukocyte recruitment via EET prevention of adhesion molecule expression is not consistently reproducible...
  54. pmc Formulation effects and the off-target transport of pyrethroid insecticides from urban hard surfaces
    Brant C Jorgenson
    Agricultural and Environmental Chemistry Graduate Group and Department of Civil and Environmental Engineering, University of California at Davis, Davis, California 95616, USA
    Environ Sci Technol 44:4951-7. 2010
    ....
  55. pmc Age specific responses to acute inhalation of diffusion flame soot particles: cellular injury and the airway antioxidant response
    Laura S Van Winkle
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, California 95616 8732, USA
    Inhal Toxicol 22:70-83. 2010
    ..We conclude that key airway antioxidant enzymes undergo changes in expression in response to a moderate PM exposure that does not cause frank epithelial injury and that neonates have a different response pattern than adults...
  56. pmc Modeling and predicting competitive sorption of organic compounds in soil
    Isabel R Faria
    Agricultural and Environmental Chemistry and Department of Civil and Environmental Engineering, University of California Davis, One Shields Avenue, Davis, California 95616, USA
    Environ Toxicol Chem 29:2676-84. 2010
    ..A significant relationship between competitor structure and the degree of competition was observed at environmentally relevant sorbed competitor concentrations for the soil containing the highest fraction of hard carbon (Forbes soil)...
  57. pmc Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension
    Zuzana Honetschlägerová
    Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    J Physiol 589:207-19. 2011
    ..These data suggest that the oral administration of c-AUCB displays antihypertensive effects in Ren-2 transgenic rats with inducible malignant hypertension via an improvement of renal function...
  58. pmc Immunoassays and biosensors for monitoring environmental and human exposure to pyrethroid insecticides
    Ki Chang Ahn
    Department of Entomology, University of California, Davis, Davis, California 95616, United States
    J Agric Food Chem 59:2792-802. 2011
    ..These new technologies alone and in combination result in an improved ability to both determine if effective levels of pyrethroids are being used in the field and evaluate possible contamination...
  59. pmc Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity
    Kyung Ho Kim
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
    Environ Health Perspect 119:519-26. 2011
    ..Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants that bioaccumulate in human tissues. Their neurotoxicity involves dysregulation of calcium ion (Ca(2+))signaling; however, specific mechanisms have yet to be defined...
  60. pmc Soil nitrogen transformations under elevated atmospheric CO₂ and O₃ during the soybean growing season
    Engil Isadora Pujol Pereira
    Department of Plant Sciences, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Environ Pollut 159:401-7. 2011
    ..However, elevated O(3) can lead to a decrease in soil N availability in both bulk and rhizosphere soils, and this likely also affects ecosystem productivity by reducing the mineralization rates of plant-derived residues...
  61. pmc Mathematical model of Chlorella minutissima UTEX2341 growth and lipid production under photoheterotrophic fermentation conditions
    Jinshui Yang
    Department of Land, Air and Water Resources, University of California, Davis, CA 95616, USA
    Bioresour Technol 102:3077-82. 2011
    ..This model is applicable for prediction of other single cell algal species but model testing is recommended before scaling up the fermentation of process...
  62. pmc Noncompetitive phage anti-immunocomplex real-time polymerase chain reaction for sensitive detection of small molecules
    Hee Joo Kim
    Department of Entomology and UCD Cancer Center, University of California, Davis, California 95616, United States
    Anal Chem 83:246-53. 2011
    ..The assay was validated with both agricultural drain water and human urine samples, showing its robustness for rapid monitoring of human exposure or environmental contamination...
  63. pmc Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures
    Emun Abdu
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon, USA
    J Neurochem 117:632-42. 2011
    ..These data indicate that EETs enhance axon outgrowth and suggest that axonal sEH activity regulates EETs-induced axon outgrowth. These findings suggest a novel therapeutic use of sEH inhibitors in promoting nerve regeneration...
  64. pmc Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice
    Wei Feng
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Mol Pharmacol 79:420-31. 2011
    ..Dysregulated R163C channels produce a more overt phenotype in myotubes than in adult fibers in the absence of triggering agents, suggesting tighter negative regulation of R163C-RyR1 within the Ca(2+) release unit of adult fibers...
  65. ncbi Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation
    Petra Kleinbongard
    FRCP, Institut fur Pathophysiologie, Universitatsklinikum Essen, Hufelandstr 55, 45122 Essen, Germany
    Circ Res 108:344-52. 2011
    ..Stent implantation into atherosclerotic plaques releases, apart from particulate debris, soluble substances that contribute to impaired microvascular perfusion...
  66. pmc Pyrethroid sorption to Sacramento River suspended solids and bed sediments
    Tessa L Fojut
    Department of Civil and Environmental Engineering, University of California, Davis, Davis, California 95616, USA
    Environ Toxicol Chem 30:787-92. 2011
    ..16) to 10(6.68) at an equilibrium aqueous concentration of 0.1 µg/L. Higher than expected sorption of pyrethroids to the tested materials may be explained by sorption to black carbon and/or mineral surfaces...
  67. pmc Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction
    Karen Wagner
    Department of Entomology and University of California Davis Cancer Center, University of California Davis, Davis, California 95616, United States
    J Agric Food Chem 59:2816-24. 2011
    ..This paper provides a brief history of the discovery of the sEH enzyme and argues that inhibitors of sEH through several independent mechanisms display pain-reducing effects...
  68. pmc Proteomic analysis of human nail plate
    Robert H Rice
    Department of Environmental Toxicology, University of California, Davis, California 95616, United States
    J Proteome Res 9:6752-8. 2010
    ..Analyses of samples from an arsenic-exposed population revealed few proteins whose levels were altered substantially but raised the possibility of detecting sensitive individuals in this way...
  69. pmc CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor
    Bin Zhao
    Department of Environmental Toxicology, University of California, Davis, California 95616 8588, USA
    Toxicol Sci 117:393-403. 2010
    ....
  70. pmc Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids
    Christophe Morisseau
    Department of Entomology and Cancer Center, School of Medicine, University of California, Davis, CA 95616, USA
    J Lipid Res 51:3481-90. 2010
    ..Consequently, the DHA and eicosapentaenoic acid epoxides may be responsible for some of the beneficial effects associated with dietary n-3 fatty acid intake...
  71. pmc Reactivity versus steric effects in fluorinated ketones as esterase inhibitors: a quantum mechanical and molecular dynamics study
    Josep Rayo
    Department of Biological Chemistry and Molecular Modeling, IQAC CSIC, Jordi Girona 18 26, 08034, Barcelona, Spain
    J Mol Model 16:1753-64. 2010
    ..Overall, the results sustain a subtle balance between reactivity and steric effects in modulating the inhibitory activity of TFMK inhibitors...
  72. pmc Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
    Anthony E Boitano
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 329:1345-8. 2010
    ..Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR). The identification of SR1 and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy...
  73. pmc Neutral and acidic oligosaccharides in Holstein-Friesian colostrum during the first 3 days of lactation measured by high performance liquid chromatography on a microfluidic chip and time-of-flight mass spectrometry
    D Barile
    Department of Food Science and Technology, University of California, Davis 95616, USA
    J Dairy Sci 93:3940-9. 2010
    ..This investigation revealed that colostrum milk from Holstein-Friesian cows is a rich source of neutral and acidic OS for the food and pharmaceutical industries...
  74. pmc Comparing linear free energy relationships for organic chemicals in soils: effects of soil and solute properties
    Isabel R Faria
    Department of Civil and Environmental Engineering, University of California Davis, One Shields Avenue, Davis, California 95616, USA
    Environ Sci Technol 44:6971-7. 2010
    ....
  75. pmc 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain
    Tristan E Rose
    Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue, Davis, California 95616, USA
    J Med Chem 53:7067-75. 2010
    ..This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model...
  76. pmc The antimicrobial triclocarban stimulates embryo production in the freshwater mudsnail Potamopyrgus antipodarum
    Ben D Giudice
    Department of Civil and Environmental Engineering, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Environ Toxicol Chem 29:966-70. 2010
    ..Furthermore, the present study indicates that environmental risk from a new class of endocrine-disrupting chemicals (EDCs) is both qualitatively and quantitatively similar to risk from existing classes of EDCs...
  77. pmc Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events
    Jun Yan Liu
    Department of Entomology and University of California Davis Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 107:17017-22. 2010
    ....
  78. pmc Electrochemistry-mass spectrometry unveils the formation of reactive triclocarban metabolites
    A Baumann
    Institute of Inorganic and Analytical Chemistry, University of Munster, Munster, Germany
    Drug Metab Dispos 38:2130-8. 2010
    ..Moreover, the occurrence of reactive metabolites is compared with findings from earlier in vivo studies and their relevance in vivo is argued...
  79. pmc Magnetic scanometric DNA microarray detection of methyl tertiary butyl ether degrading bacteria for environmental monitoring
    Mei Lin Chan
    Department of Mechanical and Aeronautical Engineering, University of California at Davis, Davis, CA 95616, United States
    Biosens Bioelectron 26:2060-6. 2011
    ....
  80. pmc Effects of triclocarban on intact immature male rat: augmentation of androgen action
    Antoni J Duleba
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Davis, CA 95817, USA
    Reprod Sci 18:119-27. 2011
    ..In conclusion, TCC significantly affects intact male reproductive organs and potentiates androgen effects in prostate cancer cells...
  81. pmc Osmoprotective proteome adjustments in mouse kidney papilla
    B J Gabert
    Department of Animal Science, University of Califonia, Davis, CA, USA
    Biochim Biophys Acta 1814:435-48. 2011
    ....
  82. pmc Considerations for potency equivalent calculations in the Ah receptor-based CALUX bioassay: normalization of superinduction results for improved sample potency estimation
    David S Baston
    Department of Environmental Toxicology, University of California, Davis, CA 95616 8588, USA
    Talanta 83:1415-21. 2011
    ....
  83. pmc Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats
    Maarten P Koeners
    Dept of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands
    Am J Physiol Endocrinol Metab 300:E691-8. 2011
    ....
  84. ncbi Growth hormone enhances arachidonic acid metabolites in a growth hormone transgenic mouse
    A M Oberbauer
    Department of Animal Science, University of California, Davis, CA 95616, USA
    Lipids 46:495-504. 2011
    ....
  85. pmc Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors
    Nils Helge Schebb
    Department of Entomology and Cancer Research Center, University of California, One Shields Avenue, Davis, CA 95616 8584, USA
    Anal Bioanal Chem 400:1359-66. 2011
    ..Therefore, enzyme assays using natural substrate, as described here, are indispensable for reliable determination of structure-activity relationships for sEH inhibition...
  86. pmc Competitive immunochromatographic assay for the detection of the organophosphorus pesticide chlorpyrifos
    Young Ah Kim
    Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea
    Anal Chim Acta 693:106-13. 2011
    ..The assay time for the ICA test was less than 10 min, suitable for rapid on-site testing of chlorpyrifos...
  87. pmc Profiling the regulatory lipids: another systemic way to unveil the biological mystery
    Jun Yang
    Department of Entomology, UCD Cancer Center, University of California, Davis, California 95616, USA
    Curr Opin Lipidol 22:197-203. 2011
    ..This review highlights the development of methods to profile these regulatory lipids and the recent publications employing these profiling methods...
  88. pmc Desorption of pyrethroids from suspended solids
    Tessa L Fojut
    Civil and Environmental Engineering, University of California, Davis, California, USA
    Environ Toxicol Chem 30:1760-6. 2011
    ....
  89. pmc Perinatal exposure to environmental polychlorinated biphenyls sensitizes hippocampus to excitotoxicity ex vivo
    Kyung Ho Kim
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Neurotoxicology 32:981-5. 2011
    ..Developmental exposure to PCBs may sensitize seizure susceptibility postnatally, especially in susceptible populations with GABA(A) receptor signaling deficits...

Research Grants30

  1. EPIDEMIOLOGY OF ALCOHOL PROBLEMS
    Thomas K Greenfield; Fiscal Year: 2013
    ..We plan to build research capacity in the Center and other organizations, enhance careers of new investigators, and make key findings accessible to researchers, policy makers, practitioners, and the public. ..
  2. Elucidating Risks: From Exposure and Mechanism to Outcome
    James A Swenberg; Fiscal Year: 2013
    ..This Program is highly relevant to Superfund by addressing high-priority chemicals and by focusing on mechanisms underlying health effects, exposure assessment, and remediation to mitigate exposure and toxicity. ..
  3. Puerto Rico Testsite for Exploring Contamination Threats (PRoTECT)
    Akram N Alshawabkeh; Fiscal Year: 2013
    ..The cross-disciplinary approach will employ the data-rich centralized data repository and integrated modeling/analysis capabilities to better understand complex interrelationships between multiple risk factors. ..