Comprehensive NeuroAIDS Core Center

Summary

Principal Investigator: Kamel Khalili
Abstract: This revised application seeks support to establish a Comprehensive NeuroAIDS Core Center (CNACC) at the Temple University School of Medicine in order to bring highly needed infrastructure for basic scientists and clinicians involved in HIV-1/AIDS research and neurological, neurodegenerative, and neurobehavioral disorders. The central theme of CNACC is structured based on our hypothesis that understanding the mechanisms of HIV-1/CNS interactions at the molecular, cellular, and experimental animal model levels and bidirectional communication of laboratory findings and clinical observations to validate basic science discoveries are prerequisites for the development of effective, safe, and reliable approaches for early diagnostics and therapeutics for AIDS-associated neurological dysfunctions. The CNACC will provide unprecedented infrastructure to a large group of neuroAIDS investigators who plan to pursue their objectives using multidisciplinary approaches in cell culture, small animal models, and in the clinical setting for assessing gene expression and biomarker identification at the cellular and molecular levels. Further, through the Developmental Core, the CNACC will provide a unique opportunity for training and mentoring of junior and clinical investigators and attract and develop physician scientists in the field of neuroAIDS. Through CNACC, we will provide start-up funds for new and innovative pilot projects of newly recruited, independent investigators and will support feasibility studies for more established neuroAIDS investigators. The funding through this center will create a unique infrastructure that will serve to enhance and extend the effectiveness of ongoing HIV-1 investigations and promote translational research in neuroAIDS at Temple and other medical institutions in the greater Philadelphia area that are involved in basic science and clinical AIDS research. With its comprehensive structural organization encompassing broadly based cores ranging from molecular biology to experimental animals to the clinical arena directed by skilled and highly competent investigators from various disciplines, CNACC will support research in a variety of areas such as virology, basic and behavioral neuroscience, and clinical science, all of which are aimed toward the discovery of better diagnostics and effective therapeutic agents toward AIDS/CNS disorders.
Funding Period: 2011-08-05 - 2016-05-31
more information: NIH RePORT

Top Publications

  1. pmc Neurofibromatosis type 2 tumor suppressor protein, NF2, induces proteasome-mediated degradation of JC virus T-antigen in human glioblastoma
    Sarah Beltrami
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e53447. 2013
  2. pmc The rapidly expanding family of human polyomaviruses: recent developments in understanding their life cycle and role in human pathology
    Martyn K White
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA
    PLoS Pathog 9:e1003206. 2013
  3. pmc HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis
    Carlos A Barrero
    Department of Biochemistry, Temple University School of Medicine, Fels Institute, Philadelphia, Pennsylvania, USA
    PLoS ONE 8:e68376. 2013
  4. pmc Neuroprotective activity of pDING in response to HIV-1 Tat
    Nune Darbinian
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania
    J Cell Physiol 229:153-61. 2014
  5. pmc Epigenetic regulation of polyomavirus JC
    Hassen S Wollebo
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, USA
    Virol J 10:264. 2013
  6. pmc TNF-α/NF-κB signaling in the CNS: possible connection to EPHB2
    Paul D Pozniak
    Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Room 741 MERB, 3500N Broad Street, Philadelphia, PA, 19140, USA
    J Neuroimmune Pharmacol 9:133-41. 2014
  7. pmc CCAAT enhancer binding protein and nuclear factor of activated T cells regulate HIV-1 LTR via a novel conserved downstream site in cells of the monocyte-macrophage lineage
    Satinder Dahiya
    Department of Microbiology and Immunology, and Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e88116. 2014
  8. pmc Involvement of IRS-1 interaction with ADAM10 in the regulation of neurite extension
    Jin Ying Wang
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania
    J Cell Physiol 229:1039-46. 2014
  9. ncbi Cocaine alters cytokine profiles in HIV-1-infected African American individuals in the DrexelMed HIV/AIDS genetic analysis cohort
    Nirzari Parikh
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA Center for Clinical and Translational Medicine, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA and Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University College of Medicine, Philadelphia, PA
    J Acquir Immune Defic Syndr 66:256-64. 2014

Research Grants

Detail Information

Publications9

  1. pmc Neurofibromatosis type 2 tumor suppressor protein, NF2, induces proteasome-mediated degradation of JC virus T-antigen in human glioblastoma
    Sarah Beltrami
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e53447. 2013
    ..Collectively, these results demonstrate that NF2 negatively regulates JCV T-antigen expression by proteasome-mediated degradation, and suggest a novel role for NF2 as a suppressor of JCV T-antigen-induced cell cycle regulation...
  2. pmc The rapidly expanding family of human polyomaviruses: recent developments in understanding their life cycle and role in human pathology
    Martyn K White
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, PA, USA
    PLoS Pathog 9:e1003206. 2013
    ..We summarize what is known so far about their distribution, life cycle, tissue tropism, their associated pathologies (if any), and future research directions in the field...
  3. pmc HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis
    Carlos A Barrero
    Department of Biochemistry, Temple University School of Medicine, Fels Institute, Philadelphia, Pennsylvania, USA
    PLoS ONE 8:e68376. 2013
    ..Furthermore, dysregulation of mitochondrial glutamate metabolism in macrophages can contribute to neurodegeneration via neuroexcitotoxic mechanisms in the context of NeuroAIDS. ..
  4. pmc Neuroprotective activity of pDING in response to HIV-1 Tat
    Nune Darbinian
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania
    J Cell Physiol 229:153-61. 2014
    ..These observations suggest that pDING, through its phosphatase activity, has the ability to manipulate the state of phosphorylation and activity of several factors involved in neuronal cell health in response to HIV-1...
  5. pmc Epigenetic regulation of polyomavirus JC
    Hassen S Wollebo
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, USA
    Virol J 10:264. 2013
    ..Thus a central question in PML pathogenesis is the nature of the molecular mechanisms maintaining JCV in a latent state and then allowing reactivation...
  6. pmc TNF-α/NF-κB signaling in the CNS: possible connection to EPHB2
    Paul D Pozniak
    Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Room 741 MERB, 3500N Broad Street, Philadelphia, PA, 19140, USA
    J Neuroimmune Pharmacol 9:133-41. 2014
    ....
  7. pmc CCAAT enhancer binding protein and nuclear factor of activated T cells regulate HIV-1 LTR via a novel conserved downstream site in cells of the monocyte-macrophage lineage
    Satinder Dahiya
    Department of Microbiology and Immunology, and Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e88116. 2014
    ..Thus, the events at DS3 positively regulate the HIV-1 promoter in cells of the monocyte-macrophage lineage. ..
  8. pmc Involvement of IRS-1 interaction with ADAM10 in the regulation of neurite extension
    Jin Ying Wang
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania
    J Cell Physiol 229:1039-46. 2014
    ..Altogether, these observations suggest a role for ADAM10 in the mechanism for IGF1/IRS-1 signaling pathway in sustaining the stability of neuronal processes...
  9. ncbi Cocaine alters cytokine profiles in HIV-1-infected African American individuals in the DrexelMed HIV/AIDS genetic analysis cohort
    Nirzari Parikh
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA Center for Clinical and Translational Medicine, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA and Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University College of Medicine, Philadelphia, PA
    J Acquir Immune Defic Syndr 66:256-64. 2014
    ....

Research Grants30

  1. Defining and Treating Written Language Disabilities
    VIRGINIA WISE BERNINGER; Fiscal Year: 2013
    ..The proposed multidisciplinary research has practical significance for improving diagnosis and providing more effective services which may lower such risks. ..
  2. OUHSC Specific Pathogen Free Baboon Research Resource
    Roman F Wolf; Fiscal Year: 2013
    ..The long term objective is for the SPF baboon colony to be a stable, self-sustaining breeding colony that produces ~100 SPF baboons/year for use in NIH-funded biomedical research. ..
  3. COBRE Center for Central Nervous System Function
    Jerome N Sanes; Fiscal Year: 2013
    ..The COBRE Center will leverage the administrative resources available through the Brown Institute for Brain Science to ensure efficient operation and coordinate with other brain science research activities at Brown. ..
  4. Early Experience, Stress and Neurobehavioral Development Center
    Megan R Gunnar; Fiscal Year: 2013
    ..Our Center also includes a cross-training program in basic developmental science and developmental psychopathology &prevention science. ..
  5. Early Phase Psychosis: Informing Treatment Decisions
    John M Kane; Fiscal Year: 2013
    ..Our ability to intervene appropriately, effectively and consistently in this population can have profound long-term public health consequences. ..
  6. Substance Abuse Research - Medications Development Center
    JOY MARIE SCHMITZ; Fiscal Year: 2013
    ..abstract_text> ..