Advanced Centers for Interventions and Services Research

Summary

Principal Investigator: Robert Buchanan
Affiliation: University of Maryland
Country: USA
Abstract: The mission of this ACISR is to advance therapeutics for schizophrenia in order to reduce suffering and improve quality of life of persons afflicted with this group of diseases. We plan to advance therapeutic knowledge, and the application of this knowledge, by establishing core infrastructure functions that support a series of investigators in integrated research and dissemination activities. The research will advance knowledge on efficacy and effectiveness through clinical trials; effectiveness and the study of clinical practice through access to data from source categories (i.e., ACISR clinical trials; ACISR associated state-wide databases; industry data sets); and services research through integration with our Department's Center for Mental Health Services Research (CMHS) and the Mental Illness Research, Education, and Clinical Center (MIRECC). Dissemination of knowledge will be conducted in conjunction with the Schizophrenia Patient Outcomes Research Team (PORT) and the Research on Dissemination Core of the NIMH Center for Research on Services for Severe Mental Illness (SMI Center) and with Maryland's Mental Hygiene Administrations Services Training Center/Evidence-based Practices Center. The ACISR will support this work by: 1) developing and maintaining access to a variety of clinical sites for the conduct of clinical trials; 2) developing and maintaining databases reflecting general practice in Maryland with the ability to cross-reference findings across categorically discrete datasets; 3) fostering multi-disciplinary research in order to translate basic and clinical neuroscience knowledge into therapeutic research; 4) fostering multi-disciplinary research and planning in order to disseminate effectively therapeutic knowledge; 5) developing new technologies, methods, and designs for clinical studies; 6) assuring assessment, data management, statistical, and subject recruitment support for investigators; 7) developing innovative ethics methods; and 8) providing training for post-graduate trainees in clinical research.
Funding Period: 2003-08-05 - 2008-07-31
more information: NIH RePORT

Top Publications

  1. ncbi Old versus new: weighing the evidence between the first- and second-generation antipsychotics
    John M Davis
    Department of Psychiatry M C 912, University of Illinois at Chicago, University of Maryland Psychiatric Research Center, 1601 W Taylor Street, Chicago, IL, USA
    Eur Psychiatry 20:7-14. 2005
  2. pmc Lack of beneficial galantamine effect for smoking behavior: a double-blind randomized trial in people with schizophrenia
    Deanna L Kelly
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Box 22147 Baltimore, MD 21228, United States
    Schizophr Res 103:161-8. 2008
  3. pmc Cortical dopamine D2/D3 receptors are a common site of action for antipsychotic drugs--an original patient data meta-analysis of the SPECT and PET in vivo receptor imaging literature
    James M Stone
    King s College London Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, UK
    Schizophr Bull 35:789-97. 2009
  4. ncbi Maintaining informed consent validity during lengthy research protocols
    Kristen J Prentice
    University of Maryland School of Medicine, USA
    IRB 29:1-6. 2007
  5. pmc The evolution of drug development in schizophrenia: past issues and future opportunities
    William T Carpenter
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 33:2061-79. 2008
  6. ncbi Beta (~16 Hz) frequency neural oscillations mediate auditory sensory gating in humans
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Psychophysiology 45:197-204. 2008
  7. pmc Refining the predictive pursuit endophenotype in schizophrenia
    L Elliot Hong
    Maryland Psychiatric Research Center, Lions Vision Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 63:458-64. 2008
  8. pmc Identifying unmet therapeutic domains in schizophrenia patients: the early contributions of Wayne Fenton from Chestnut Lodge
    Thomas H McGlashan
    Department of Psychiatry, Yale University, USA
    Schizophr Bull 33:1086-92. 2007
  9. ncbi Issues that may determine the outcome of antipsychotic trials: industry sponsorship and extrapyramidal side effect
    John M Davis
    Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    Neuropsychopharmacology 33:971-5. 2008
  10. pmc Reward processing in schizophrenia: a deficit in the representation of value
    James M Gold
    Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Schizophr Bull 34:835-47. 2008

Scientific Experts

Detail Information

Publications40

  1. ncbi Old versus new: weighing the evidence between the first- and second-generation antipsychotics
    John M Davis
    Department of Psychiatry M C 912, University of Illinois at Chicago, University of Maryland Psychiatric Research Center, 1601 W Taylor Street, Chicago, IL, USA
    Eur Psychiatry 20:7-14. 2005
    ..Choice of antipsychotic, in our opinion, is probably the most important decision that the clinician makes for the psychotic patient. This involves the choice of drug, its dose, balancing efficacy, side-effects and cost...
  2. pmc Lack of beneficial galantamine effect for smoking behavior: a double-blind randomized trial in people with schizophrenia
    Deanna L Kelly
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Box 22147 Baltimore, MD 21228, United States
    Schizophr Res 103:161-8. 2008
    ..53, df=1, p=0.019), for an effect size of 0.4. These results suggest that galantamine has no effect on cigarette smoking and that during galantamine treatment nicotine dependency scores worsen...
  3. pmc Cortical dopamine D2/D3 receptors are a common site of action for antipsychotic drugs--an original patient data meta-analysis of the SPECT and PET in vivo receptor imaging literature
    James M Stone
    King s College London Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, UK
    Schizophr Bull 35:789-97. 2009
    ..We found no evidence for 5HT(2A) blockade involvement in antipsychotic action, although we cannot exclude this possibility...
  4. ncbi Maintaining informed consent validity during lengthy research protocols
    Kristen J Prentice
    University of Maryland School of Medicine, USA
    IRB 29:1-6. 2007
  5. pmc The evolution of drug development in schizophrenia: past issues and future opportunities
    William T Carpenter
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 33:2061-79. 2008
    ..Success in drug discovery for cognition and negative symptom pathologies may bring forth issues in ethics as the potential for enhancing normal function is explored...
  6. ncbi Beta (~16 Hz) frequency neural oscillations mediate auditory sensory gating in humans
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Psychophysiology 45:197-204. 2008
    ..The results suggested that beta oscillation indexed a neural process associated with the strength of sensory gating...
  7. pmc Refining the predictive pursuit endophenotype in schizophrenia
    L Elliot Hong
    Maryland Psychiatric Research Center, Lions Vision Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 63:458-64. 2008
    ..Previous work has shown a reduced predictive pursuit response to a briefly masked (i.e., invisible) moving object in schizophrenia. However, the overt awareness of target removal can confound the measurement...
  8. pmc Identifying unmet therapeutic domains in schizophrenia patients: the early contributions of Wayne Fenton from Chestnut Lodge
    Thomas H McGlashan
    Department of Psychiatry, Yale University, USA
    Schizophr Bull 33:1086-92. 2007
    ..The results have radically changed the paradigm for discovery with emphasis on impaired cognition and negative symptom psychopathology...
  9. ncbi Issues that may determine the outcome of antipsychotic trials: industry sponsorship and extrapyramidal side effect
    John M Davis
    Department of Psychiatry, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
    Neuropsychopharmacology 33:971-5. 2008
    ..We were unable to confirm that the drug's EPS properties or antiparkinsonian management altered actual efficacy...
  10. pmc Reward processing in schizophrenia: a deficit in the representation of value
    James M Gold
    Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Schizophr Bull 34:835-47. 2008
    ..In contrast, patients often (but not always) approach normal performance levels on the slow learning achieved by the integration of reinforcement signals over many trials, thought to be mediated by the basal ganglia...
  11. pmc Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Arch Gen Psychiatry 65:1008-16. 2008
    ..Frequency-specific sensory gating may be less complex than the P50 response, and therefore closer to the direct genetic effects, and thus a more valid endophenotype...
  12. doi Second-generation antipsychotics for schizophrenia: can we resolve the conflict?
    S Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Germany
    Psychol Med 39:1591-602. 2009
    ..However, these drugs are important contributions to treatment, and most psychiatrists, let alone patients, would probably not want to do without them...
  13. pmc Impaired visual working memory consolidation in schizophrenia
    Rebecca L Fuller
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, MD, USA
    Neuropsychology 23:71-80. 2009
    ..These data demonstrate abnormally prolonged WM consolidation in schizophrenia. This impairment may slow the formation of stable representations of the visual environment, impacting everyday visually guided behavior...
  14. pmc CNTRICS final task selection: control of attention
    Keith H Nuechterlein
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behaviour, University of California, LA, CA, USA
    Schizophr Bull 35:182-96. 2009
    ....
  15. doi Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Lancet 373:31-41. 2009
    ....
  16. pmc Is motion perception deficit in schizophrenia a consequence of eye-tracking abnormality?
    L Elliot Hong
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 65:1079-85. 2009
    ..However, eye movement closely interacts with motion perception. The known eye-tracking difficulties in schizophrenia patients may interact with their motion perception...
  17. pmc Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers
    James A Waltz
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 34:1567-77. 2009
    ..These results provide evidence that SZ patients show abnormal brain responses associated with the processing of a primary reinforcer, which may be a source of motivational deficits...
  18. pmc White matter alterations in deficit schizophrenia
    Laura M Rowland
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 34:1514-22. 2009
    ..These findings provide further support for altered frontal-parietal network in deficit schizophrenia...
  19. doi A meta-analysis of head-to-head comparisons of second-generation antipsychotics in the treatment of schizophrenia
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munchen, Germany
    Am J Psychiatry 166:152-63. 2009
    ..The authors conducted a systematic review and meta-analysis of blinded studies comparing second-generation antipsychotics head-to-head...
  20. ncbi Tardive dyskinesia in children treated with atypical antipsychotic medications
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Mov Disord 22:1777-82. 2007
    ..Ethnicity might also be a risk factor for dyskinesia in children. Side-effect profile of the atypical antipsychotic drugs in children may be much different than that in adults...
  21. ncbi Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia
    Dwight Dickinson
    VISN 5 Mental Illness Research, Education and Clinical Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arch Gen Psychiatry 64:532-42. 2007
    ..In focusing on potentially localizable cognitive impairments, the schizophrenia meta-analytic literature has overlooked the largest single impairment: on digit symbol coding tasks...
  22. ncbi Psychopathological and cognitive correlates of tardive dyskinesia in patients treated with neuroleptics
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Motor Disorders Clinic, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Adv Neurol 96:336-49. 2005
    ..No effective treatments for TD are available. This lack of effective therapy is problematic, especially in the few patients in whom the disorder causes functional impairment and other complications, and in whom it may be irreversible...
  23. ncbi No, it is not possible to be schizophrenic yet neuropsychologically normal
    Christopher M Wilk
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Department of Psychiatry, Baltimore, MD 21228 0747, and Mental Illness Research, Education, and Clinical Center, Veterans Affairs Capital Health Care Network, USA
    Neuropsychology 19:778-86. 2005
    ..Thus, scoring in the normal range does not preclude neuropsychological abnormality in schizophrenia, confirming that neuropsychological impairment is a core feature of the illness...
  24. ncbi Reliability of a portable head-mounted eye tracking instrument for schizophrenia research
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD 21228, USA
    Behav Res Methods 37:133-8. 2005
    ..96). This result suggests that the portable device is comparable with a lab-based system, which makes possible the collection of eye movement data in community-based and multicenter familial studies of schizophrenia...
  25. ncbi Association between polymorphism of the SNAP29 gene promoter region and schizophrenia
    Ikwunga Wonodi
    Schizophr Res 78:339-41. 2005
  26. ncbi Response to unexpected target changes during sustained visual tracking in schizophrenic patients
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Exp Brain Res 165:125-31. 2005
    ..Data suggest that at-risk individuals for schizophrenia depend less on extraretinal and more on retinal motion signals to maintain pursuit than healthy individuals...
  27. ncbi Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia
    L Elliot Hong
    Department of Psychiatry, Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore, 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 136:8-11. 2005
    ..2%, P =0.050) forms of schizophrenia compared to controls (allele frequency 25.0%). We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia...
  28. ncbi Specific motion processing pathway deficit during eye tracking in schizophrenia: a performance-matched functional magnetic resonance imaging study
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA
    Biol Psychiatry 57:726-32. 2005
    ....
  29. ncbi Optimistic bias in the perception of personal risk: patterns in schizophrenia
    Kristen J Prentice
    Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    Am J Psychiatry 162:507-12. 2005
    ..The authors investigated whether schizophrenia patients share the same optimistic biases frequently demonstrated by non-ill adults in their perceptions of personal risk...
  30. pmc Review of clinical correlates of P50 sensory gating abnormalities in patients with schizophrenia
    David Potter
    University of Maryland School of Medicine, Department of Psychiatry, Baltimore, Maryland, USA
    Schizophr Bull 32:692-700. 2006
    ..These results suggest that considerably more work needs to be done to understand and validate the clinical significance of this impairment...
  31. ncbi Familial aggregation of eye-tracking endophenotypes in families of schizophrenic patients
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA
    Arch Gen Psychiatry 63:259-64. 2006
    ..Recent studies have suggested that deficit in predictive pursuit, a specific component of the SPEMs, marks schizophrenia susceptibility...
  32. pmc Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunction
    James A Waltz
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, United States
    Schizophr Res 93:296-303. 2007
    ..Further studies are required to investigate the roles of dopaminergic systems in these impairments...
  33. ncbi Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study
    Joseph R Hibbeln
    Laboratory of Membrane Biophysics and Biochemistry, US National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, MD 20952, USA
    Lancet 369:578-85. 2007
    ..We used the Avon Longitudinal Study of Parents and Children (ALSPAC) to assess the possible benefits and hazards to a child's development of different levels of maternal seafood intake during pregnancy...
  34. ncbi Independent domains of inhibitory gating in schizophrenia and the effect of stimulus interval
    L Elliot Hong
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Am J Psychiatry 164:61-5. 2007
    ..The authors hypothesized that the relationship of the two measures may vary as a function of interstimulus intervals of stimulus presentations...
  35. pmc Neuropsychology of the deficit syndrome: new data and meta-analysis of findings to date
    Alex S Cohen
    Department of Psychology, University of Maryland, College Park, USA
    Schizophr Bull 33:1201-12. 2007
    ..The question of whether deficit patients exhibit a unique cognitive impairment profile will require a more sophisticated and rigorous examination of the neuropsychology of the deficit syndrome...
  36. pmc Functional connectivity in fMRI: A modeling approach for estimation and for relating to local circuits
    Ransom Winder
    Department of Computer Science, University of Maryland at College Park, MD, USA
    Neuroimage 34:1093-107. 2007
    ..Furthermore, our results suggest how fronto-temporal functional disconnection in schizophrenia can result from reduced local synaptic connections within frontal cortex rather than compromised interregional connections...
  37. pmc The burden of depressive symptoms in the long-term treatment of patients with schizophrenia
    Robert R Conley
    Maryland Psychiatric Research Center, University of Maryland at Baltimore, School of Medicine, USA
    Schizophr Res 90:186-97. 2007
    ..To prospectively measure the link between depressive symptoms and functional outcomes in the long-term treatment of people with schizophrenia...
  38. ncbi Impaired control of visual attention in schizophrenia
    Rebecca L Fuller
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Abnorm Psychol 115:266-75. 2006
    ..This pattern of results indicates that the primary impairment of attention in schizophrenia lies in the control of attention and not in the selection processes that operate once attention has been directed to an object...
  39. ncbi The speed of visual attention in schizophrenia: electrophysiological and behavioral evidence
    Steven J Luck
    Department of Psychology, University of Iowa, Iowa City, 52242 1407, USA
    Schizophr Res 85:174-95. 2006
    ....
  40. pmc Turning it upside down: areas of preserved cognitive function in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychol Rev 19:294-311. 2009
    ..The documentation of preserved cognitive function in schizophrenia may serve to sharpen hypotheses about the biological mechanisms that are implicated in the illness...