ENVIRONMENTAL HEALTH SCIENCES RESEARCH CENTER

Summary

Principal Investigator: Peter Thorne
Affiliation: University of Iowa
Country: USA
Abstract: DESCRIPTION (provided by applicant) Environmental health sciences has evolved from studies that link a single exposure with a disease, to a new understanding of complex mechanisms by which agents in the environment interact at the molecular level to induce disease in individuals who are susceptible by virtue of age, genetics, nutrition, underlying disease or concurrent exposures. While methods of characterizing exposure and disease have improved, challenges remain when there are multiple exposures and the pathogenesis involves complex genetic and host factors. This is particularly apparent among rural populations with a multiplicity of chemical and biological exposures. This application is to continue funding of the Iowa Environmental Health Sciences Research Center (EHSRC) which has as its overarching theme, research and outreach on the adverse health effects of environmental contaminants among rural and agricultural populations. The EHSRC is at the forefront of research on environmental health problems such as rural asthma and other environmental lung diseases, bioaerosol-induced inflammation, innate immune responses to inhaled microorganisms, mechanisms of oxidative stress, and pesticide metabolism. The Center's focus on the rural environment provides the opportunity to conduct innovative mechanistic and population-based research and to translate that research to prevention and treatment through public health initiatives and clinical advancements. Junior scientists are trained to characterize biological response mechanisms and elucidate gene-environment interactions underlying environmental disease. The interdisciplinary research is organized around three Research Clusters: Inflammation & Innate Immunity, Oxidative Stress & Metabolism, and Environmental Lung Disease. A new initiative is the formation of an Environmental Genomics Research Cluster. Three Facility Cores provide cutting edge services and equipment: Integrative Health Sciences Facility, Pulmonary Toxicology Facility, and Environmental Modeling & Exposure Assessment Facility. An Administrative Core manages a highly effective Pilot Grant Program, Career Development Program, and Community Outreach & Education Core. Center goals are: 1) To coordinate and nurture innovative interdisciplinary EHS research with a focus on reducing adverse health effects of environmental contaminants, especially among rural populations; 2) To promote and enhance multi-disciplinary collaborations among basic scientists and physician researchers; 3) To recruit investigators from within and outside EHS by providing support for Research Clusters and dedicated Facility Cores; 4) To provide mentoring, research resources, and salary support to stellar junior investigators to develop their research careers in EHS; and 5) To provide outreach and education to translate research findings to improve the health and environment of rural people. BACKGROUND The Environmental Health Science Research Center (EHSRC) is located in the upper Midwest at the University of Iowa. With its main activities focused in the Schools of Medicine and Public Health, the Center has concentrated on environmental health problems located primarily in Iowa and neighboring areas, although wider collaborations nationally and internationally have been features since the early beginnings of this Center. The EHSRC has been funded by the NIEHS since 1993. During that time it has had two Directors, Dr. James Merchant (1993-2003) and Dr. Peter Thorne (2003-present). The primary areas of research focus have been in areas of respiratory biology and airborne environmental exposures, environmental epidemiology and health surveys in relation to environmental exposures, exposure assessment, and the control of environmental exposures, primarily through engineering methods. An occupational medicine component was dropped in 2003. During the previous review, concerns in several areas of the Center were noted that resulted in only three years of funding. Significant changes in the Center's structure have occurred in over the past years, partly in response to the concerns of the previous review and from input from NIEHS staff. The structure of the Center's Research and Facility Cores since 2003 is well described in the application. The changes in structure were decided and implemented by the Director based on input from the Internal Advisory Committee and the External Advisory Committee. The most significant changes were a greater focus on environmental lung diseases and dropping the former Environmental Assessment and Control Core and the Exposure Assessment Facility. These latter components have been included in a new Iowa Superfund Program funded by the US EPA. The former Exposure Assessment Facility has been replaced by an Environmental Modeling and Exposure Assessment Facility that focuses on airborne exposures. In addition, elements of the Clinical Sciences Facility, with components of the Laboratory for Radiologic Imaging and the Asthma Center, were combined to form the Integrative Health Sciences Facility Core. The Inhalation Toxicology Facility was renamed the Pulmonary Toxicology Core. Reallocation of resources from five to three facility cores has provided three well funded cores that are responsive to the revised vision of the center. Over the same period, the Research Cores underwent some consolidation and restructuring also. Elements of the Environmental Epidemiology Core and Health Registry Facility were refocused and combined with other components to create the areas of pulmonary health outcomes research and the new Environmental Lung Disease Research Cluster. The basic science components were defined from several previous areas to create an Inflammation and Innate Immunity Cluster and an Oxidative Stress and Metabolism Cluster in order to take advantage of areas of growing expertise at the University of Iowa that complemented the new focus of the Center. The resulting redefinition of the EHSRC, in terms of its core research and facilities, now demonstrates a more focused and clearer vision, with better defined goals and objectives. ESSENTIAL CHARACTERISTICS Strategic Vision and Impact on Environmental Health
Funding Period: 1997-04-01 - 2012-03-31
more information: NIH RePORT

Top Publications

  1. pmc The concentration of glutathione in human erythrocytes is a heritable trait
    Thomas J van 't Erve
    Interdisciplinary Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, USA
    Free Radic Biol Med 65:742-9. 2013
  2. pmc A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting
    Adam P Ross
    Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento, California, United States of America
    PLoS ONE 8:e69333. 2013
  3. pmc The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis
    Gitanjali M Singh
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS ONE 8:e65174. 2013
  4. pmc Development of quantitative computed tomography lung protocols
    John D Newell
    Advanced Pulmonary Physiomics Imaging Laboratory, Department of Radiology, University of Iowa, Iowa City, IA 52242, USA
    J Thorac Imaging 28:266-71. 2013
  5. pmc Damage control: management of cellular stress by the NLRP3 inflammasome
    Stefanie Haasken
    Inflammation Program, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Eur J Immunol 43:2003-5. 2013
  6. pmc ATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites
    Christoph O Randak
    From the Departments of Pediatrics
    J Biol Chem 288:27692-701. 2013
  7. pmc Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3
    Mitchell C Coleman
    1 Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, The University of Iowa, Iowa City, Iowa
    Antioxid Redox Signal 20:1423-35. 2014
  8. doi Person-to-Person Spread of the MERS Coronavirus - An Evolving Picture
    Stanley Perlman
    From the Departments of Microbiology and Pediatrics, University of Iowa, Iowa City
    N Engl J Med 369:466-7. 2013
  9. doi CaMKII is essential for the proasthmatic effects of oxidation
    Philip N Sanders
    Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Sci Transl Med 5:195ra97. 2013
  10. doi Iron dissolution of dust source materials during simulated acidic processing: the effect of sulfuric, acetic, and oxalic acids
    Haihan Chen
    Departments of Chemical and Biochemical Engineering and Chemistry, University of Iowa, Iowa City, Iowa 52242, United States
    Environ Sci Technol 47:10312-21. 2013

Scientific Experts

Detail Information

Publications298 found, 100 shown here

  1. pmc The concentration of glutathione in human erythrocytes is a heritable trait
    Thomas J van 't Erve
    Interdisciplinary Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, USA
    Free Radic Biol Med 65:742-9. 2013
    ..Understanding the genetic determinants of these inherited traits may allow personalized approaches to relevant therapies. ..
  2. pmc A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting
    Adam P Ross
    Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento, California, United States of America
    PLoS ONE 8:e69333. 2013
    ..No deleterious variants in the PAK1IP1 gene coding region were recognized, however, we identified a borderline association effect for SNP rs494723 suggesting a possible role for the PAK1IP1 gene in human orofacial clefting. ..
  3. pmc The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis
    Gitanjali M Singh
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS ONE 8:e65174. 2013
    ....
  4. pmc Development of quantitative computed tomography lung protocols
    John D Newell
    Advanced Pulmonary Physiomics Imaging Laboratory, Department of Radiology, University of Iowa, Iowa City, IA 52242, USA
    J Thorac Imaging 28:266-71. 2013
    ....
  5. pmc Damage control: management of cellular stress by the NLRP3 inflammasome
    Stefanie Haasken
    Inflammation Program, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Eur J Immunol 43:2003-5. 2013
    ....
  6. pmc ATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites
    Christoph O Randak
    From the Departments of Pediatrics
    J Biol Chem 288:27692-701. 2013
    ..They further indicate that the active center of the adenylate kinase comprises ATP-binding site 2. ..
  7. pmc Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3
    Mitchell C Coleman
    1 Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, The University of Iowa, Iowa City, Iowa
    Antioxid Redox Signal 20:1423-35. 2014
    ..Antioxid. Redox Signal. 20, 1423-1435. ..
  8. doi Person-to-Person Spread of the MERS Coronavirus - An Evolving Picture
    Stanley Perlman
    From the Departments of Microbiology and Pediatrics, University of Iowa, Iowa City
    N Engl J Med 369:466-7. 2013
    ..Since this coronavirus is a close relative of the virus that caused the severe acute respiratory syndrome (SARS), a short-lived but . . . ..
  9. doi CaMKII is essential for the proasthmatic effects of oxidation
    Philip N Sanders
    Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Sci Transl Med 5:195ra97. 2013
    ..Our findings support the view that CaMKII is a ROS-responsive, pluripotent proasthmatic signal and provide proof-of-concept evidence that CaMKII is a therapeutic target in asthma. ..
  10. doi Iron dissolution of dust source materials during simulated acidic processing: the effect of sulfuric, acetic, and oxalic acids
    Haihan Chen
    Departments of Chemical and Biochemical Engineering and Chemistry, University of Iowa, Iowa City, Iowa 52242, United States
    Environ Sci Technol 47:10312-21. 2013
    ..The role of atmospheric organic acids should be taken into account in global-biogeochemical modeling to better access dissolved atmospheric Fe deposition flux at the ocean surface. ..
  11. pmc Cancer risk in children and adolescents with birth defects: a population-based cohort study
    Lorenzo D Botto
    Division of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA
    PLoS ONE 8:e69077. 2013
    ..Excess cancer risk may be an added burden in this vulnerable group of children, but studies to date have provided inconsistent findings. This study assessed the risk for cancer in children and young adolescents with major birth defects...
  12. pmc Abundant DNase I-sensitive bacterial DNA in healthy porcine lungs and its implications for the lung microbiome
    Alejandro A Pezzulo
    Departments of Internal Medicine
    Appl Environ Microbiol 79:5936-41. 2013
    ..This approach and conceptual framework will improve analysis of the lung microbiome in disease. ..
  13. ncbi Maternal periconceptional occupational exposure to pesticides and selected musculoskeletal birth defects
    Christine Kielb
    NYS Department of Health, Center for Environmental Health, Troy, NY, United States Electronic address
    Int J Hyg Environ Health 217:248-54. 2014
    ..16-3.05), but not for women under age 20 (aOR=0.48; 95% CI: 0.20-1.16). We found no significant associations for the other defects. Additional research is needed to validate these findings in a separate population. ..
  14. doi Microparticles prepared from sulfenamide-based polymers
    Sheetal R D'Mello
    Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA and
    J Microencapsul 31:137-46. 2014
    ..Confocal laser scanning microscopy was used to qualitatively observe the cellular uptake of PSN microparticles and indicated localization of the particles in both the cytoplasm and the nucleus...
  15. pmc Postentry processing of recombinant adeno-associated virus type 1 and transduction of the ferret lung are altered by a factor in airway secretions
    Ziying Yan
    Department of Anatomy and Cell Biology, University of Iowa School of Medicine, Iowa City, IA 52242 1009, USA
    Hum Gene Ther 24:786-96. 2013
    ..These findings demonstrate that a factor in lung secretions can influence intracellular processing of rAAV1 in a proteasome-dependent fashion...
  16. pmc Search for genetic modifiers of IRF6 and genotype-phenotype correlations in Van der Woude and popliteal pterygium syndromes
    Elizabeth J Leslie
    Department of Pediatrics, University of Iowa, Iowa City, Iowa
    Am J Med Genet A 161:2535-44. 2013
    ..We also show that families with the Van de Woude phenotype but in whom no mutations have been identified have a lower frequency of cleft lip, suggesting there may be locus and/or mutation class differences in Van de Woude syndrome...
  17. pmc Human Melanoma cells over-express extracellular matrix 1 (ECM1) which is regulated by TFAP2C
    Geeta Lal
    Department of Surgery, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 8:e73953. 2013
    ..Our investigations show an as yet unrecognized role for TFAP2C in melanoma via its regulation of ECM1. ..
  18. doi Quantification of ventilation distribution in regional lung injury by electrical impedance tomography and xenon computed tomography
    Gunnar Elke
    Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 3 Haus 12, D 24105 Kiel, Germany
    Physiol Meas 34:1303-18. 2013
    ..This study shows that EIT is able to reliably discern even small ventilation changes on sub-lobar level. ..
  19. pmc Residential culturable fungi, (1-3, 1-6)-β-d-glucan, and ergosterol concentrations in dust are not associated with asthma, rhinitis, or eczema diagnoses in children
    H Choi
    Department of Environmental Health Sciences, School of Public Health, University at Albany, Rensselaer, NY, USA
    Indoor Air 24:158-70. 2014
    ..Furthermore, these agents in dust samples were not associated with any health outcomes in the children...
  20. pmc Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction
    Yassaman Niknam
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616
    Toxicol Sci 136:500-13. 2013
    ..NDL-PCBs and their 5-OH and 4-OH metabolites differentially influence RyR1 channel activity and ECC in embryonic skeletal muscle...
  21. pmc Chitosan coating of copper nanoparticles reduces in vitro toxicity and increases inflammation in the lung
    Kristan L S Worthington
    Department of Chemical and Biochemical Engineering, College of Engineering, University of Iowa, Iowa City, IA 52242, USA Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    Nanotechnology 24:395101. 2013
    ..g. chitosan) could increase their potential for use in controlled release of copper ions to cells, but will result in a higher inflammatory response if administered via the lung. ..
  22. pmc Cultural identity and patient trust among older American Indians
    Vanessa W Simonds
    Department of Community and Behavioral Health, College of Public Health, University of Iowa, 105 River Street, N428 CPHB, Iowa City, IA, 52242, USA
    J Gen Intern Med 29:500-6. 2014
    ..The likely influence of patients' cultural characteristics on trust is widely acknowledged but inadequately explored...
  23. pmc Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma
    Michael E Wechsler
    Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, Colo Electronic address
    J Allergy Clin Immunol 132:1295-302. 2013
    ..Bronchial thermoplasty (BT) has previously been shown to improve asthma control out to 2 years in patients with severe persistent asthma...
  24. pmc Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system
    Swati Shah
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742
    J Immunol 191:3514-8. 2013
    ..In conclusion, we report a novel immune evasion mechanism of M. tuberculosis that involves the ESX-1-dependent, direct or indirect, suppression of the host cell AIM2 inflammasome activation during infection. ..
  25. pmc A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11)
    Yueming Zhu
    Free Radical and Radiation Biology Program, B180 Medical Laboratories, Department of Radiation Oncology, Holden Comprehensive Cancer Center
    Toxicol Sci 136:39-50. 2013
    ..Furthermore, antioxidant treatments following PCBs exposure could significantly mitigate the PCB-induced cytotoxicity in exponentially growing human prostate epithelial cells...
  26. pmc Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis
    Bjarke Feenstra
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    JAMA 310:714-21. 2013
    ..Infantile hypertrophic pyloric stenosis shows strong familial aggregation and heritability, but knowledge about specific genetic risk variants is limited...
  27. ncbi Interaction of dipalmitoyl phosphatidylcholine monolayers with a particle-laden subphase
    Amir M Farnoud
    Department of Chemical and Biochemical Engineering, The University of Iowa, 4133 Seamans Center, Iowa City, Iowa 52242, United States
    J Phys Chem B 117:12124-34. 2013
    ..These studies may partially explain the varying results reported in previous studies. ..
  28. ncbi Biodegradable particles as vaccine antigen delivery systems for stimulating cellular immune responses
    Vijaya B Joshi
    Department of Pharmaceutical Sciences and Experimental Therapeutics College of Pharmacy University of Iowa Iowa City, IA USA
    Hum Vaccin Immunother 9:2584-90. 2013
    ..Our attention is focused on, but not limited to, the generation of antitumor immunity where we stress the importance of particle size and co-delivery of antigen and adjuvant. ..
  29. ncbi Glucocorticoid receptor antagonist and siRNA prevent senescence of human bone marrow mesenchymal stromal cells in vitro
    Na Wei
    Dows Institute for Dental Research, College of Dentistry, University of Iowa, 405N, DSB, 801 Newton Ave, Iowa City, IA, 52242, USA
    Cell Tissue Res 354:461-70. 2013
    ..Our data suggest that the blocking of the effects mediated by GCs might extend the lifespan of endogenous MSCs in patients who have elevated GC levels as a consequence of advancing age or estrogen depletion...
  30. doi Nongenetic risk factors and congenital heart defects
    Sonali S Patel
    Department of Pediatrics, Division of Pediatric Cardiology, Carver College of Medicine, University of Iowa, Children s Hospital, 200 Hawkins Drive, Iowa City, IA, 52242, USA
    Pediatr Cardiol 34:1535-55. 2013
    ..These factors also are broken down by specific defect type. Although additional investigations are needed in this area, many of the discussed risk factors present an opportunity for prevention of potential disease. ..
  31. pmc Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation
    Shankar S Iyer
    Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Immunity 39:311-23. 2013
    ..Together these data suggest that mitochondria play a critical role in the activation of the Nlrp3 inflammasome through the direct binding of Nlrp3 to cardiolipin. ..
  32. ncbi The dairy industry: a brief description of production practices, trends, and farm characteristics around the world
    David I Douphrate
    School of Public Health, University of Texas, San Antonio Regional Campus, San Antonio, Texas 78229, USA
    J Agromedicine 18:187-97. 2013
    ....
  33. pmc Risk factors for metastatic disease at presentation with osteosarcoma: an analysis of the SEER database
    Benjamin J Miller
    Department of Orthopaedics and Rehabilitation, University of Iowa, 200 Hawkins Drive, 01015 JPP, Iowa City, IA 52242, USA
    J Bone Joint Surg Am 95:e89. 2013
    ..Our goal was to examine potential risk factors predictive of metastatic disease at presentation...
  34. doi Surface modification of Al30 Keggin-type polyaluminum molecular clusters
    Samangi Abeysinghe
    Department of Chemistry, University of Iowa, W374 Chemistry Building, Iowa City, Iowa 52242, United States
    Inorg Chem 52:5991-9. 2013
    ....
  35. pmc Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro
    Shyam Ramachandran
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 305:L23-32. 2013
    ....
  36. pmc Bringing the ocean into the laboratory to probe the chemical complexity of sea spray aerosol
    Kimberly A Prather
    Department of Chemistry and Biochemistry and Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 110:7550-5. 2013
    ....
  37. pmc Privacy and security of patient data in the pathology laboratory
    Ioan C Cucoranu
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
    J Pathol Inform 4:4. 2013
    ..Importantly, security failures often lead to privacy breaches, invoking the HIPAA privacy rule as well. Therefore, this review also highlights key aspects of HIPAA and its impact on the pathology laboratory in the United States...
  38. doi Identification and environmental implications of photo-transformation products of trenbolone acetate metabolites
    Edward P Kolodziej
    Department of Civil and Environmental Engineering, University of Nevada, Reno, Mail Stop 258, Reno, Nevada 89557, United States
    Environ Sci Technol 47:5031-41. 2013
    ..These data indicate that environmental transformation processes do not necessarily reduce steroid hormone ecotoxicity...
  39. pmc Aberrant free radical biology is a unifying theme in the etiology and pathogenesis of major human diseases
    Frederick E Domann
    Departments of Radiation Oncology, Surgery, and Pathology Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Int J Mol Sci 14:8491-5. 2013
    ..Together with this deeper understanding, opportunities will arise to devise rational therapeutic interventions to decrease the incidence and severity of these diseases and positively impact the human healthspan...
  40. pmc Manganese superoxide dismutase regulates a redox cycle within the cell cycle
    Ehab H Sarsour
    Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, Iowa
    Antioxid Redox Signal 20:1618-27. 2014
    ..Therefore, MnSOD and mitochondria-generated reactive oxygen species (ROS) are believed to be critical regulators of quiescent cells' entry into the cell cycle and exit from the proliferative cycle back to the quiescent state...
  41. pmc Recent advances in RNA interference therapeutics for CNS diseases
    Pavitra S Ramachandran
    Interdisciplinary Program in Genetics, University of Iowa, Iowa City, IA 52242, USA
    Neurotherapeutics 10:473-85. 2013
    ..We also highlight outstanding questions or concerns that have emerged as a result of an improved (and ever advancing) understanding of the technologies employed. ..
  42. pmc Sulfated metabolites of polychlorinated biphenyls are high-affinity ligands for the thyroid hormone transport protein transthyretin
    Fabian A Grimm
    Interdisciplinary Graduate Program in Human Toxicology, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, College of Public Health, The University of Iowa, Iowa City, Iowa 52246, USA
    Environ Health Perspect 121:657-62. 2013
    ..Previous research has discovered hydroxylated PCB metabolites (OH-PCBs) as high-affinity ligands for TTR, but the binding potential of conjugated PCB metabolites such as PCB sulfates has not been explored...
  43. pmc Elimination of inhaled 3,3'-dichlorobiphenyl and the formation of the 4-hydroxylated metabolite
    Xin Hu
    Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, Iowa 52242, USA
    Environ Sci Technol 47:4743-51. 2013
    ..4 h half-life. This study demonstrates rapid metabolism of CB11 and elimination of 4-OH-CB11 and suggests that the metabolite is not retained in the body but is susceptible to further biotransformation...
  44. pmc Optimization of dual-energy xenon-computed tomography for quantitative assessment of regional pulmonary ventilation
    Matthew K Fuld
    Department of Radiology, University of Iowa, Iowa City, IA 52242, USA
    Invest Radiol 48:629-37. 2013
    ....
  45. pmc Characterization of an ntrX mutant of Neisseria gonorrhoeae reveals a response regulator that controls expression of respiratory enzymes in oxidase-positive proteobacteria
    John M Atack
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
    J Bacteriol 195:2632-41. 2013
    ....
  46. pmc Cyclic siloxanes in air, including identification of high levels in Chicago and distinct diurnal variation
    Rachel A Yucuis
    Department of Civil and Environmental Engineering, IIHR Hydroscience and Engineering, University of Iowa, Iowa City, IA 52242, USA
    Chemosphere 92:905-10. 2013
    ..D5 was the dominant siloxane in both indoor and outdoor air. Ratios of D5 to D4 averaged 91 and 3.2 for indoor and outdoor air respectively...
  47. pmc Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction
    Surya P Bhatt
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Thorax 69:410-5. 2014
    ..70 with LLN in diagnosing smoking-related airflow obstruction using CT-defined emphysema and gas trapping as the disease gold standard...
  48. doi Validating whole slide imaging for diagnostic purposes in pathology: guideline from the College of American Pathologists Pathology and Laboratory Quality Center
    Liron Pantanowitz
    From the Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Drs Pantanowitz, Contis, and Parwani the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut Dr Sinard the Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio Dr Henricks the College of American Pathologists, Northfield, Illinois Ms Fatheree the Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia Dr Carter the Department of Pathology, North Shore Medical Center, Salem, Massachusetts Dr Beckwith the Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada Dr Evans the Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts Dr Otis and University Hospital, London Health Science Center, London, Ontario, Canada Dr Lal
    Arch Pathol Lab Med 137:1710-22. 2013
    ..Currently, there are no standard guidelines regarding validation of WSI for diagnostic use...
  49. pmc Laxative use and incident falls, fractures and change in bone mineral density in postmenopausal women: results from the Women's Health Initiative
    Bernhard Haring
    Department of Internal Medicine I, Comprehensive Heart Failure Center, University of Wurzburg, Oberdurrbacher Strasse 6, Wurzburg 97080, Germany
    BMC Geriatr 13:38. 2013
    ..Associations between laxative use and risk for fractures and change in bone mineral density [BMD] have not previously been investigated...
  50. ncbi Size-dependent changes in sea spray aerosol composition and properties with different seawater conditions
    Andrew P Ault
    Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States
    Environ Sci Technol 47:5603-12. 2013
    ..These changes with size and seawater composition have important implications for atmospheric processes such as cloud droplet activation and heterogeneous reactivity...
  51. doi Size-resolved sea spray aerosol particles studied by vibrational sum frequency generation
    Carlena J Ebben
    Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States
    J Phys Chem A 117:6589-601. 2013
    ..Needs for additional research activities are discussed in the context of the results presented. ..
  52. ncbi Synthetic tracheal mucus with native rheological and surface tension properties
    R Hamed
    Department of Pharmaceutical Sciences and Experimental Therapeutics, The University of Iowa, Iowa City, Iowa, 52242 Faculty of Pharmacy, Al Zaytoonah University of Jordan, Amman, 11733, Jordan
    J Biomed Mater Res A 102:1788-98. 2014
    ..However, surfactant spreading on the more viscoelastic mimetics was hindered, suggesting that the bulk properties of the mimetics dictate the range of surface properties that can be achieved...
  53. pmc Site-specific acylation changes in the lipid A of Escherichia coli lpxL mutants grown at high temperatures
    Birgit Schilling
    1The Buck Institute for Research on Aging, Novato, CA, USA
    Innate Immun 20:269-82. 2014
    ..This study indicates that E. coli (lpxL) lipid A biosynthesis, and specifically the 'late' acylation of lipid A, is temperature dependent, thus suggesting a highly regulated process. ..
  54. pmc Regulation of CuZnSOD and its redox signaling potential: implications for amyotrophic lateral sclerosis
    Michael J Hitchler
    1 Department of Radiation Oncology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
    Antioxid Redox Signal 20:1590-8. 2014
    ....
  55. doi Agreement between fixed-ratio and lower limit of normal spirometry interpretation protocols decreases with age: is there a need for a new GOLD standard?
    Marek A Mikulski
    Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA
    J Occup Environ Med 55:802-8. 2013
    ..To assess concordance between the fixed 70% ratio cutoff point with the fixed percent predicted values (Fixed-ratio) and the lower limit of normal (LLN) algorithms in interpreting spirometry results in an older population...
  56. pmc Diabetes, metformin use, and colorectal cancer survival in postmenopausal women
    Furha Iram Cossor
    Tufts Medical Center, 800 Washington Street, Box 245, Boston, MA 02111, USA
    Cancer Epidemiol 37:742-9. 2013
    ..We examined the relationships among metformin use, diabetes, and survival in postmenopausal women with CRC in the Women's Health Initiative (WHI) clinical trials and observational study...
  57. pmc Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation
    Malvika Rawal
    Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Cancer Res 73:5232-41. 2013
    ..Finally, tumor growth in vivo was inhibited more effectively by combining MnT4MPyP with AscH-. We concluded that MnPs increase the rate of oxidation of AscH- to leverage H2O2 flux and ascorbate-induced cytotoxicity...
  58. doi Cellular localization of dieldrin and structure-activity relationship of dieldrin analogues in dopaminergic cells
    Erin M G Allen
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, United States
    Chem Res Toxicol 26:1043-54. 2013
    ..Comparisons of the toxicity profiles for each dieldrin analogue indicated a structure-specific effect important for elucidating the mechanisms of dieldrin neurotoxicity. ..
  59. pmc Chronic chlorpyrifos exposure does not promote prostate cancer in prostate specific PTEN mutant mice
    Robert U Svensson
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
    J Environ Pathol Toxicol Oncol 32:29-39. 2013
    ....
  60. doi Chlorinated solvent transformation by palladized zerovalent iron: mechanistic insights from reductant loading studies and solvent kinetic isotope effects
    Yang Xie
    Department of Chemical and Environmental Engineering, University of California, A242 Bourns Hall, Riverside, California 92521, USA
    Environ Sci Technol 47:7940-8. 2013
    ..During anaerobic aging of Pd/NZVI, decreases in the SKIE for 1,1,1,2-TeCA reduction suggest that atomic hydrogen will contribute to reactivity for only approximately 1 week after application...
  61. pmc Longer lived parents: protective associations with cancer incidence and overall mortality
    Ambarish Dutta
    MBBCh, Medical School, Barrack Road, Exeter, EX2 5DW, UK
    J Gerontol A Biol Sci Med Sci 68:1409-18. 2013
    ..Children of centenarians have lower cardiovascular disease prevalence and live longer. We aimed to estimate associations between the full range of parental attained ages and health status in a middle-aged U.S. representative sample...
  62. pmc Passive monitors to measure hydrogen sulfide near concentrated animal feeding operations
    Brian T Pavilonis
    Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Environ Sci Process Impacts 15:1271-8. 2013
    ..Measured values in excess of an Iowa state limit of 30 ppb (24 h average) suggest that enforcement actions are needed to mitigate H2S migration from swine CAFOs...
  63. pmc Community-based participatory research: its role in future cancer research and public health practice
    Vanessa W Simonds
    University of Iowa, Iowa City, IA, USA
    Prev Chronic Dis 10:E78. 2013
    ....
  64. pmc Adapting Western research methods to indigenous ways of knowing
    Vanessa W Simonds
    Vanessa W Simonds is with the Department of Community and Behavioral Health, College of Public Health, University of Iowa, Iowa City Suzanne Christopher is with the Department of Health and Human Development at Montana State University, Bozeman
    Am J Public Health 103:2185-92. 2013
    ..Currently, examples of Indigenous methods and theories are not widely available in academic texts or published articles, and are often not perceived as valid. ..
  65. doi Development of metal-organic nanotubes exhibiting low-temperature, reversible exchange of confined "ice channels"
    Daniel K Unruh
    Department of Chemistry, University of Iowa, Chemistry Building W374, Iowa City, Iowa 52242, USA
    J Am Chem Soc 135:7398-401. 2013
    ..Similar properties have not been reported for other inorganic or hybrid compounds and indicate the potential of MONs as advanced materials...
  66. ncbi Composition and sources of fine particulate matter across urban and rural sites in the Midwestern United States
    Shuvashish Kundu
    Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA
    Environ Sci Process Impacts 16:1360-70. 2014
    ..This study presents the first source apportionment results from the state of Iowa and is broadly applicable to understanding the differences in anthropogenic and natural sources in the urban-rural continuum of particle air pollution. ..
  67. ncbi Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation
    Pieter J Bakker
    Department of Pathology, Academical Medical Center, Amsterdam, The Netherlands
    Kidney Int 85:1112-22. 2014
    ..Thus, Nlrp3 may mediate renal pathology in the context of diet-induced MetSyn. ..
  68. pmc Integrin α6β4 Identifies Human Distal Lung Epithelial Progenitor Cells with Potential as a Cell-Based Therapy for Cystic Fibrosis Lung Disease
    Xiaopeng Li
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 8:e83624. 2013
    ..Therefore, targeting the α6β4(+) epithelial population via either gene delivery or progenitor cell-based reconstitution represents a potential new strategy to treat CF lung disease. ..
  69. pmc Associations between cigarette smoking, hormone therapy, and folate intake with incident colorectal cancer by TP53 protein expression level in a population-based cohort of older women
    Lori S Tillmans
    Authors Affiliations Departments of Laboratory Medicine and Pathology and Health Sciences Research Division of Epidemiology Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester Department of Epidemiology, University of Minnesota, Minneapolis, Minnesota Department of Medicine Gastroenterology, Huntsman Cancer Institute and University of Utah, Salt Lake City, Utah Department of Epidemiology, University of Iowa, Iowa City, Iowa Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
    Cancer Epidemiol Biomarkers Prev 23:350-5. 2014
    ..50; 95% CI, 0.27-0.94). No other statistically significant associations were observed. These data support possible heterogeneous effects from HT on TP53-related pathways of colorectal carcinogenesis in older women...
  70. doi Transition metal associations with primary biological particles in sea spray aerosol generated in a wave channel
    Timothy L Guasco
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, 92093
    Environ Sci Technol 48:1324-33. 2014
    ..This study highlights the potential for transition metals, in combination with specific biomarkers, to serve as unique indicators for the presence of marine PBAP, especially in metal-impacted coastal regions. ..
  71. pmc Early airway structural changes in cystic fibrosis pigs as a determinant of particle distribution and deposition
    Maged Awadalla
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, C33GH, Iowa City, IA, 52242, USA
    Ann Biomed Eng 42:915-27. 2014
    ..The irregular particle distribution and increased deposition in newborn CF pig airways suggest that early airway structural abnormalities might contribute to CF disease pathogenesis. ..
  72. ncbi Developing a public health-tracking system for follow-up of newborn screening metabolic conditions: a four-state pilot project structure and initial findings
    Cynthia F Hinton
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 16:484-90. 2014
    ....
  73. ncbi Surface photochemistry of adsorbed nitrate: the role of adsorbed water in the formation of reduced nitrogen species on α-Fe2O3 particle surfaces
    Charith E Nanayakkara
    Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States
    J Phys Chem A 118:158-66. 2014
    ..The atmospheric implications of these results are discussed. ..
  74. pmc Noninvasive positive pressure ventilation in subjects with stable COPD: a randomized trial
    Surya P Bhatt
    Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Internal Medicine, Roy J and Lucille A, Carver College of Medicine, University of Iowa Hospital, Iowa City, IA, USA
    Int J Chron Obstruct Pulmon Dis 8:581-9. 2013
    ..We hypothesized that use of NPPV in stable COPD and partial pressure of carbon dioxide (PaCO2) <52 mmHg might result in improvement in quality of life and dyspnea...
  75. pmc Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern
    Amanda R Decker
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242, United States
    Dev Biol 386:428-39. 2014
    ..In summary, a forward genetic screen in zebrafish has revealed that both melanocytes and dopaminergic neurons depend on the ion channel Trpm7. The mechanistic underpinning of this dependence requires further investigation. ..
  76. doi An employee total health management-based survey of Iowa employers
    James A Merchant
    From the Healthier Workforce Center for Excellence Drs Merchant, Kelly, and Hall, Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City and David P Lind Benchmark Mr Lind, Clive, Iowa
    J Occup Environ Med 55:S73-7. 2013
    ..To implement an Employee Total Health Management (ETHM) model-based questionnaire and provide estimates of model program elements among a statewide sample of Iowa employers...
  77. doi Characterizing the needs of a young working population: making the case for total worker health in an emerging workforce
    Diane S Rohlman
    From the Center for Research on Occupational and Environmental Toxicology Dr Rohlman, Ms Parish, and Ms Montgomery and Health Promotion and Sports Medicine Dr Elliot, Oregon Health and Science University, Portland Occupational and Environmental Health Dr Rohlman, University of Iowa, Iowa City and Kaiser Permanente Northwest Dr Hanson, Center for Health Research, Portland, Ore
    J Occup Environ Med 55:S69-72. 2013
    ..This article aimed to identify the content and process for an on-line total worker health training for young workers...
  78. doi The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram
    Fionn E O'Brien
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland
    Behav Brain Res 261:17-25. 2014
    ....
  79. pmc The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo
    Xin Hu
    Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA 52242, USA Electronic address
    Environ Int 63:92-100. 2014
    ..Some lower-chlorinated PCBs are still being produced and contaminate both indoor and ambient air...
  80. pmc Minimal Change in the cytoplasmic calcium dynamics in striatal GABAergic neurons of a DYT1 dystonia knock-in mouse model
    Sadahiro Iwabuchi
    Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
    PLoS ONE 8:e80793. 2013
    ..Given that calcium dynamics reflect neuronal excitability, these results suggest that the mutation only slightly increases the excitability of striatal GABAergic neurons in DYT1 dystonia. ..
  81. pmc Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines
    Sabine U Vorrink
    Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA, USA Department of Radiation Oncology, The University of Iowa, Iowa City, IA, USA
    Toxicol Appl Pharmacol 274:408-16. 2014
    ..Our results show that AhR activation and CYP1A1 expression induced by PCB 126 were significantly inhibited by hypoxia and hypoxia might therefore play an important role in PCB metabolism and toxicity. ..
  82. pmc Polymorphisms of CYP51A1 from Cholesterol Synthesis: Associations with Birth Weight and Maternal Lipid Levels and Impact on CYP51 Protein Structure
    Monika Lewinska
    Center for Functional Genomics and Bio Chips, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    PLoS ONE 8:e82554. 2013
    ..042 and p = 0.046 respectively). Our results indicate a new link between a cholesterol synthesis gene CYP51A1 and pregnancy pathologies. ..
  83. ncbi Characterization of N-glycosylation sites on the extracellular domain of NOX1/NADPH oxidase
    Misaki Matsumoto
    Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan Electronic address
    Free Radic Biol Med 68:196-204. 2014
    ..As is true for NOX2, the contribution of glycosylation in NOX1 to its biologic function(s) merits further study. ..
  84. pmc Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models
    Andrea Adamcakova-Dodd
    Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA 52242, USA
    Part Fibre Toxicol 11:15. 2014
    ..We sought to determine whether ZnO NPs induce pulmonary toxicity in mice following sub-acute or sub-chronic inhalation exposure to realistic exposure doses...
  85. pmc A comparison of winter short-term and annual average radon measurements in basements of a radon-prone region and evaluation of further radon testing indicators
    Nirmalla G Barros
    Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242 Department of Physics, St John s University, Collegeville, MN 56321
    Health Phys 106:535-44. 2014
    ....
  86. pmc A microRNA processing defect in smokers' macrophages is linked to SUMOylation of the endonuclease DICER
    Thomas J Gross
    From the Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242
    J Biol Chem 289:12823-34. 2014
    ..This massive down-regulation of miRNAs (driven in part by alterations in DICER) may be an important regulator of the disease-promoting macrophage phenotype found in the lungs of smokers. ..
  87. pmc Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1
    Edugie J Ekuase
    Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, United States
    Chem Biol Interact 212:56-64. 2014
    ..These results have implications for the roles of SULTs in the toxicology of OHPCBs, while also providing molecular probes of the complexity of substrate/inhibitor interactions with hSULT2A1. ..
  88. pmc Inositol-requiring enzyme 1 inhibits respiratory syncytial virus replication
    Ihab Hassan
    From the Department of Internal Medicine, Carver College of Medicine and
    J Biol Chem 289:7537-46. 2014
    ..Our data characterize, for the first time, the nature of the ER stress response in the setting of RSV infection and identify the IRE1 stress pathway as a novel cellular anti-RSV defense mechanism. ..
  89. pmc Epigenetic Silencing of the Human NOS2 Gene: Rethinking the Role of Nitric Oxide in Human Macrophage Inflammatory Responses
    Thomas J Gross
    Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242
    J Immunol 192:2326-38. 2014
    ..Taken together, our findings suggest there are significant and underappreciated differences in how murine and human macrophages respond to inflammatory stimuli. ..