ENVIRONMENTAL HEALTH SCIENCES RESEARCH CENTER

Summary

Principal Investigator: Peter Thorne
Affiliation: University of Iowa
Country: USA
Abstract: DESCRIPTION (provided by applicant) Environmental health sciences has evolved from studies that link a single exposure with a disease, to a new understanding of complex mechanisms by which agents in the environment interact at the molecular level to induce disease in individuals who are susceptible by virtue of age, genetics, nutrition, underlying disease or concurrent exposures. While methods of characterizing exposure and disease have improved, challenges remain when there are multiple exposures and the pathogenesis involves complex genetic and host factors. This is particularly apparent among rural populations with a multiplicity of chemical and biological exposures. This application is to continue funding of the Iowa Environmental Health Sciences Research Center (EHSRC) which has as its overarching theme, research and outreach on the adverse health effects of environmental contaminants among rural and agricultural populations. The EHSRC is at the forefront of research on environmental health problems such as rural asthma and other environmental lung diseases, bioaerosol-induced inflammation, innate immune responses to inhaled microorganisms, mechanisms of oxidative stress, and pesticide metabolism. The Center's focus on the rural environment provides the opportunity to conduct innovative mechanistic and population-based research and to translate that research to prevention and treatment through public health initiatives and clinical advancements. Junior scientists are trained to characterize biological response mechanisms and elucidate gene-environment interactions underlying environmental disease. The interdisciplinary research is organized around three Research Clusters: Inflammation & Innate Immunity, Oxidative Stress & Metabolism, and Environmental Lung Disease. A new initiative is the formation of an Environmental Genomics Research Cluster. Three Facility Cores provide cutting edge services and equipment: Integrative Health Sciences Facility, Pulmonary Toxicology Facility, and Environmental Modeling & Exposure Assessment Facility. An Administrative Core manages a highly effective Pilot Grant Program, Career Development Program, and Community Outreach & Education Core. Center goals are: 1) To coordinate and nurture innovative interdisciplinary EHS research with a focus on reducing adverse health effects of environmental contaminants, especially among rural populations; 2) To promote and enhance multi-disciplinary collaborations among basic scientists and physician researchers; 3) To recruit investigators from within and outside EHS by providing support for Research Clusters and dedicated Facility Cores; 4) To provide mentoring, research resources, and salary support to stellar junior investigators to develop their research careers in EHS; and 5) To provide outreach and education to translate research findings to improve the health and environment of rural people. BACKGROUND The Environmental Health Science Research Center (EHSRC) is located in the upper Midwest at the University of Iowa. With its main activities focused in the Schools of Medicine and Public Health, the Center has concentrated on environmental health problems located primarily in Iowa and neighboring areas, although wider collaborations nationally and internationally have been features since the early beginnings of this Center. The EHSRC has been funded by the NIEHS since 1993. During that time it has had two Directors, Dr. James Merchant (1993-2003) and Dr. Peter Thorne (2003-present). The primary areas of research focus have been in areas of respiratory biology and airborne environmental exposures, environmental epidemiology and health surveys in relation to environmental exposures, exposure assessment, and the control of environmental exposures, primarily through engineering methods. An occupational medicine component was dropped in 2003. During the previous review, concerns in several areas of the Center were noted that resulted in only three years of funding. Significant changes in the Center's structure have occurred in over the past years, partly in response to the concerns of the previous review and from input from NIEHS staff. The structure of the Center's Research and Facility Cores since 2003 is well described in the application. The changes in structure were decided and implemented by the Director based on input from the Internal Advisory Committee and the External Advisory Committee. The most significant changes were a greater focus on environmental lung diseases and dropping the former Environmental Assessment and Control Core and the Exposure Assessment Facility. These latter components have been included in a new Iowa Superfund Program funded by the US EPA. The former Exposure Assessment Facility has been replaced by an Environmental Modeling and Exposure Assessment Facility that focuses on airborne exposures. In addition, elements of the Clinical Sciences Facility, with components of the Laboratory for Radiologic Imaging and the Asthma Center, were combined to form the Integrative Health Sciences Facility Core. The Inhalation Toxicology Facility was renamed the Pulmonary Toxicology Core. Reallocation of resources from five to three facility cores has provided three well funded cores that are responsive to the revised vision of the center. Over the same period, the Research Cores underwent some consolidation and restructuring also. Elements of the Environmental Epidemiology Core and Health Registry Facility were refocused and combined with other components to create the areas of pulmonary health outcomes research and the new Environmental Lung Disease Research Cluster. The basic science components were defined from several previous areas to create an Inflammation and Innate Immunity Cluster and an Oxidative Stress and Metabolism Cluster in order to take advantage of areas of growing expertise at the University of Iowa that complemented the new focus of the Center. The resulting redefinition of the EHSRC, in terms of its core research and facilities, now demonstrates a more focused and clearer vision, with better defined goals and objectives. ESSENTIAL CHARACTERISTICS Strategic Vision and Impact on Environmental Health
Funding Period: 1997-04-01 - 2012-03-31
more information: NIH RePORT

Top Publications

  1. pmc PLUNC is a novel airway surfactant protein with anti-biofilm activity
    Lokesh Gakhar
    Department of Biochemistry and Protein Crystallography Facility, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e9098. 2010
  2. pmc Identification of microdeletions in candidate genes for cleft lip and/or palate
    Min Shi
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Birth Defects Res A Clin Mol Teratol 85:42-51. 2009
  3. pmc Innovative application of fluoro tagging to trace airborne particulate and gas-phase polybrominated diphenyl ether exposures
    Johannes Klösener
    Department of Occupational and Environmental Health, High Resolution Mass Spectrometry Facility, and Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, 100 Oakdale Campus, Iowa City, Iowa 52242, USA
    Chem Res Toxicol 22:179-86. 2009
  4. doi Airborne monitoring to distinguish engineered nanomaterials from incidental particles for environmental health and safety
    Thomas M Peters
    Department of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa 52245, USA
    J Occup Environ Hyg 6:73-81. 2009
  5. pmc Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction
    Izabela Kania-Korwel
    Department of Occupational and Environmental Health, Collage of Public Health, University of Iowa, Iowa City, IA 52242, USA
    J Chromatogr A 1214:37-46. 2008
  6. pmc Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones
    Yang Song
    Department of Occupational and Environmental Health, The University of Iowa, 100 Oakdale Campus, 124 IREH, Iowa City, Iowa 52242 5000, USA
    J Org Chem 73:8296-304. 2008
  7. pmc Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip
    Fedik Rahimov
    Department of Pediatrics, University of Iowa, 2182 ML, S Grand Ave, Iowa City, Iowa 52242, USA
    Nat Genet 40:1341-7. 2008
  8. doi Real-time PCR quantification of Mycobacterium immunogenum in used metalworking fluids
    M Veillette
    Institut Universitaire de Cardiologie et de Pneumologie de l Hopital Laval, Universite Laval, Quebec, Canada
    J Occup Environ Hyg 5:755-60. 2008
  9. pmc Genetic contributions to the development of retinopathy of prematurity
    Shakir Mohamed
    Department of Pediatrics, University of Iowa, Iowa 52242, USA
    Pediatr Res 65:193-7. 2009
  10. pmc Evaluation of a low-cost electrostatic dust fall collector for indoor air endotoxin exposure assessment
    Ilka Noss
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Appl Environ Microbiol 74:5621-7. 2008

Scientific Experts

Detail Information

Publications62

  1. pmc PLUNC is a novel airway surfactant protein with anti-biofilm activity
    Lokesh Gakhar
    Department of Biochemistry and Protein Crystallography Facility, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e9098. 2010
    ....
  2. pmc Identification of microdeletions in candidate genes for cleft lip and/or palate
    Min Shi
    Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Birth Defects Res A Clin Mol Teratol 85:42-51. 2009
    ..The panels used for such analyses can detect single nucleotide polymorphisms and copy number variants, both of which may help to identify small deleted regions of the genome that may contribute to a particular disease...
  3. pmc Innovative application of fluoro tagging to trace airborne particulate and gas-phase polybrominated diphenyl ether exposures
    Johannes Klösener
    Department of Occupational and Environmental Health, High Resolution Mass Spectrometry Facility, and Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, 100 Oakdale Campus, Iowa City, Iowa 52242, USA
    Chem Res Toxicol 22:179-86. 2009
    ..Our study is of fundamental importance to the development of xenobiotic tracers for monitoring routes of human exposure to PBDEs and understanding uptake of PBDEs from particles and vapors...
  4. doi Airborne monitoring to distinguish engineered nanomaterials from incidental particles for environmental health and safety
    Thomas M Peters
    Department of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa 52245, USA
    J Occup Environ Hyg 6:73-81. 2009
    ..The methods presented here are applicable to any occupational or environmental setting in which one needs to distinguish incidental sources from engineered product...
  5. pmc Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction
    Izabela Kania-Korwel
    Department of Occupational and Environmental Health, Collage of Public Health, University of Iowa, Iowa City, IA 52242, USA
    J Chromatogr A 1214:37-46. 2008
    ..Comparable results were obtained with an established analysis method for PCBs, OH-PCBs and MeSO(2)-PCBs...
  6. pmc Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones
    Yang Song
    Department of Occupational and Environmental Health, The University of Iowa, 100 Oakdale Campus, 124 IREH, Iowa City, Iowa 52242 5000, USA
    J Org Chem 73:8296-304. 2008
    ..The greater the number of chlorines on the (hydro-)quinone (oxygenated) ring, the higher the steady-state level of the resulting semiquinone radical at near neutral pH...
  7. pmc Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip
    Fedik Rahimov
    Department of Pediatrics, University of Iowa, 2182 ML, S Grand Ave, Iowa City, Iowa 52242, USA
    Nat Genet 40:1341-7. 2008
    ..Our findings place IRF6 and AP-2alpha in the same developmental pathway and identify a high-frequency variant in a regulatory element contributing substantially to a common, complex disorder...
  8. doi Real-time PCR quantification of Mycobacterium immunogenum in used metalworking fluids
    M Veillette
    Institut Universitaire de Cardiologie et de Pneumologie de l Hopital Laval, Universite Laval, Quebec, Canada
    J Occup Environ Hyg 5:755-60. 2008
    ..The proposed qPCR approach could be routinely used in real-time PCR-equipped laboratories to provide early detection of M. immunogenum and to control proliferation that probably leads to hypersensitivity pneumonitis in exposed workers...
  9. pmc Genetic contributions to the development of retinopathy of prematurity
    Shakir Mohamed
    Department of Pediatrics, University of Iowa, Iowa 52242, USA
    Pediatr Res 65:193-7. 2009
    ..003), AGTR1 (p = 0.005), TBX5 (p = 0.003), CETP (p = 0.004), and GP1BA (p = 0.005). Our data suggest that genetic risk factors contribute to the development of ROP...
  10. pmc Evaluation of a low-cost electrostatic dust fall collector for indoor air endotoxin exposure assessment
    Ilka Noss
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Appl Environ Microbiol 74:5621-7. 2008
    ..We therefore conclude that measuring endotoxin levels with the EDC is a valid measure of average airborne endotoxin exposure, while reproducibility over time is at least equivalent to that of reservoir dust analyses...
  11. pmc Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1
    Hayrettin Ozan Gulcan
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA
    Chem Res Toxicol 21:1503-8. 2008
    ..Thus, the sulfation of polychlorinated phenols catalyzed by hSULT2A1 may be a significant component of their metabolism in humans...
  12. pmc Semiquinone radicals from oxygenated polychlorinated biphenyls: electron paramagnetic resonance studies
    Yang Song
    Department of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa 52242 1101, USA
    Chem Res Toxicol 21:1359-67. 2008
    ..Our data also point to futile redox cycling as being one mechanism by which oxygenated PCBs can lead to the formation of reactive oxygen species, but this is most efficient in the presence of SOD...
  13. pmc 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes
    Izabela Kania-Korwel
    Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus 124 IREH, Iowa City, Iowa 52242, USA
    Chem Res Toxicol 21:1295-303. 2008
    ....
  14. doi Blind testing of commercially available short-term radon detectors
    Kainan Sun
    Department of Occupational and Environmental Health, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Health Phys 94:548-57. 2008
    ..Nonetheless, the findings suggest the need for improved vigilance to assure that the public can rely on commercially available radon detectors to make an informed decision whether or not to perform additional testing or to mitigate...
  15. doi Concentrations of bioaerosols, odors, and hydrogen sulfide inside and downwind from two types of swine livestock operations
    Peter S Thorne
    Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa 52242 5000, USA
    J Occup Environ Hyg 6:211-20. 2009
    ..Both types of swine operations produced high airborne concentrations of endotoxin, odor, hydrogen sulfide, bacteria, and fungi. Endotoxin and odors were found downwind at concentrations previously associated with adverse health effects...
  16. pmc Structure-activity relationships for hydroxylated polychlorinated biphenyls as substrates and inhibitors of rat sulfotransferases and modification of these relationships by changes in thiol status
    Yungang Liu
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    Drug Metab Dispos 37:1065-72. 2009
    ..This alteration in specificity of rSULT1A1 for certain OH-PCBs suggests that conditions of oxidative stress may significantly alter the sulfation of some OH-PCBs in the rat...
  17. pmc Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip
    Satoshi Suzuki
    Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, Chikusa ku, Nagoya, Japan
    Am J Hum Genet 84:406-11. 2009
    ..Furthermore, we suggest a role for BMP4 in wound healing...
  18. doi Room model based Monte Carlo simulation study of the relationship between the airborne dose rate and the surface-deposited radon progeny
    Kainan Sun
    Department of Occupational and Environmental Health, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Health Phys 98:29-36. 2010
    ..14 (95% CI 1.03-1.27) and 1.13 (95% CI 1.05-1.22) in the mean dose rates were found for large room sizes relative to small room sizes in the different dose models...
  19. pmc Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure
    Yueming Zhu
    Free Radical and Radiation Biology Program, B180 Medical Laboratories, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA
    Free Radic Biol Med 47:1762-71. 2009
    ....
  20. pmc CFD simulation of contaminant decay for high reynolds flow in a controlled environment
    Andrew R Lambert
    Department of Mechanical and Industrial Engineering, University of Iowa, Center for the Engineering Arts and Sciences, Iowa City, IA 52242, USA
    Ann Occup Hyg 54:88-99. 2010
    ..Furthermore, percent error between computational and experimental data as low as -5.32% shows that CFD is a useful tool for studying ventilation phenomena...
  21. pmc Field investigation of surface-deposited radon progeny as a possible predictor of the airborne radon progeny dose rate
    Kainan Sun
    Department of Occupational and Environmental Health, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Health Phys 97:132-44. 2009
    ..08-2.79) after adjusting for the radon and radon progeny effects as well as other environmental factors. Fireplace usage was found to significantly increase the mean Pdose to 1.71 (90% CI 1.20-2.45) after adjusting for other factors...
  22. pmc Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite, is dependent on both the aldehyde and the catechol
    Jennifer N Rees
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242, USA
    Chem Res Toxicol 22:1256-63. 2009
    ..These data indicate that DOPAL is highly reactive toward protein nucleophiles with the potential for protein cross-linking...
  23. pmc Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones
    Yang Song
    Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus, 124 IREH, Iowa City, IA 52242 5000, USA
    Proc Natl Acad Sci U S A 106:9725-30. 2009
    ..Our discovery that chlorinated quinones undergo a rapid, nonenzymatic dechlorination upon reaction with GSH opens a different view on mechanisms of metabolism and the toxicity of this class of compounds...
  24. pmc Predictors of endotoxin levels in U.S. housing
    Peter S Thorne
    Environmental Health Sciences Research Center, College of Public Health, University of Iowa, Iowa City, Iowa 52242 5000, USA
    Environ Health Perspect 117:763-71. 2009
    ..However, few studies have evaluated predictors of household endotoxin, and none have done so for multiple locations within homes and on a national scale...
  25. pmc Field and wind tunnel comparison of four aerosol samplers using agricultural dusts
    Stephen J Reynolds
    Department of Environmental and Radiological Health Sciences, Colorado State University, Ft Collins, CO 80523, USA
    Ann Occup Hyg 53:585-94. 2009
    ..Suggested conversion factors for the Button/IOM are swine (0.57), chicken (0.80), turkey (0.53), and dairy (0.67). Any attempt to apply a conversion factor between the Cyclone and inhalable samplers is not recommended...
  26. pmc Genetic determinants of facial clefting: analysis of 357 candidate genes using two national cleft studies from Scandinavia
    Astanand Jugessur
    Craniofacial Development, Musculoskeletal Disorders, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Australia
    PLoS ONE 4:e5385. 2009
    ....
  27. pmc Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate
    Yunden Jinsmaa
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242, USA
    Chem Res Toxicol 22:835-41. 2009
    ....
  28. pmc An efficient approach to sulfate metabolites of polychlorinated biphenyls
    Xueshu Li
    Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Environ Int 36:843-8. 2010
    ..To aid with future quantitative structure activity relationship studies, the structures of two 2,2,2-trichloroethyl-protected PCB sulfates were verified by X-ray diffraction...
  29. pmc Determination of genetic predisposition to patent ductus arteriosus in preterm infants
    John M Dagle
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Pediatrics 123:1116-23. 2009
    ..Our major goal was to determine if genetic risk factors play a role in patent ductus arteriosus seen in preterm infants...
  30. pmc Causes of mortality and risk factors for injury mortality among children in the agricultural health study
    Kori B Flower
    Charles Drew Community Health Center, Piedmont Health Services, Burlington, NC 27217, USA
    J Agromedicine 11:47-59. 2006
    ..Farm children face unique health risks due to sharing their residential environment with hazardous machinery and materials. Causes of mortality among farm children have not been comprehensively described...
  31. pmc MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: effect of acylation state
    Suzana Hadina
    Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA 52242 5000, USA
    Am J Respir Cell Mol Biol 38:647-54. 2008
    ..Hyporesponsiveness in MD-2-null mice after nasal aspiration of wild-type LOS indicate its essential role in airway responsiveness to endotoxin...
  32. pmc Surfactant-associated protein A provides critical immunoprotection in neonatal mice
    Caroline L S George
    Department of Pediatrics, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    Infect Immun 76:380-90. 2008
    ....
  33. pmc Endotoxin in inner-city homes: associations with wheeze and eczema in early childhood
    Matthew S Perzanowski
    Columbia s Center for Children s Environmental Health, Columbia University, New York, NY 10032, USA
    J Allergy Clin Immunol 117:1082-9. 2006
    ..The relevance of this aspect of the hygiene hypothesis to US inner-city communities that have disproportionately high asthma prevalence has not been determined...
  34. ncbi Dosimetric challenges for residential radon epidemiology
    Daniel J Steck
    Physics Department, St John s University, Collegeville, Minnesota 56321, USA
    J Toxicol Environ Health A 69:655-64. 2006
    ..New technologies that use surface-deposited and implanted radon progeny activities make more accurate dose estimates available for future epidemiologic studies...
  35. ncbi A combined analysis of North American case-control studies of residential radon and lung cancer
    Daniel Krewski
    Department of Epidemiology and Community Medicine, Faculty of Medicine, McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, Ontario, Canada
    J Toxicol Environ Health A 69:533-97. 2006
    ..Collectively, these results provide direct evidence of an association between residential radon and lung cancer risk, a finding predicted by extrapolation of results from occupational studies of radon-exposed underground miners...
  36. ncbi Indoor and outdoor air quality assessment of four wastewater treatment plants
    Joung Ae Lee
    Department of Occupational and Environmental Health, The University of Iowa, Iowa City 52242, USA
    J Occup Environ Hyg 3:36-43. 2006
    ..The results showed that the factors analyzed affected concentrations of H2S and endotoxin differently. Therefore, different control methods for endotoxin and H2S need to be considered to effectively reduce their concentrations at WWTPs...
  37. pmc Metalworking fluid with mycobacteria and endotoxin induces hypersensitivity pneumonitis in mice
    Peter S Thorne
    The University of Iowa, College of Public Health, 100 Oakdale Campus, IREH Iowa City, IA 52242 5000, USA
    Am J Respir Crit Care Med 173:759-68. 2006
    ..Other constituents of in-use metalworking fluids (MWFs) may also contribute to the development of lung disease. We investigated the potential for Mycobacterium immunogenum (MI) in MWFs to induce HP...
  38. ncbi Interlaboratory evaluation of endotoxin analyses in agricultural dusts--comparison of LAL assay and mass spectrometry
    Stephen J Reynolds
    Department of Environmental and Radiological Health Sciences, Colorado State University, Ft Collins, CO 80523 1681, USA
    J Environ Monit 7:1371-7. 2005
    ..GC-MS may be of use when comparing across heterogeneous environments and should be considered for inclusion in future studies of human health outcomes...
  39. pmc Endotoxin exposure is a risk factor for asthma: the national survey of endotoxin in United States housing
    Peter S Thorne
    Department of Occupational and Environmental Health, College of Public Health, University of Iowa, 100 Oakdale Campus, 176 IREH, Iowa City, IA 52242 5000, USA
    Am J Respir Crit Care Med 172:1371-7. 2005
    ..We assayed 2,552 house dust samples in a representative nationwide sam- ple to explore relationships between endotoxin exposures and risk factors for asthma, asthma symptoms, and medication use...
  40. ncbi Evaluation of perfluorooctane surfactants in a wastewater treatment system and in a commercial surface protection product
    Bryan Boulanger
    Department of Civil and Environmental Engineering, University of Iowa, SC 4105, Iowa City, Iowa 52240, USA
    Environ Sci Technol 39:5524-30. 2005
    ..These findings suggest transformation of precursors within wastewater treatment is not an important source of these compounds compared to direct use and disposal of products containing the end products as residual amounts...
  41. ncbi Nitrogen dioxide prediction in Southern California using land use regression modeling: potential for environmental health analyses
    Zev Ross
    ZevRoss Spatial Analysis, 303 Fairmount Ave, Ithaca, New York 14850, USA
    J Expo Sci Environ Epidemiol 16:106-14. 2006
    ..These models may be useful tools in evaluating health effects of long-term exposure to traffic-related pollution...
  42. ncbi Comparison of farmers in the agricultural health study to the 1992 and the 1997 censuses of agriculture
    Charles F Lynch
    Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA 52242, USA
    J Agromedicine 10:13-22. 2005
    ....
  43. ncbi Test-retest of self-reported exposure to artificial tanning devices, self-tanning creams, and sun sensitivity showed consistency
    Laura E Beane Freeman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Occupational and Environmental Epidemiology Branch, 6120, Executive Boulevard, Suite 511, MSC 7240, Bethesda, MD 20892 7344, USA
    J Clin Epidemiol 58:430-2. 2005
    ..Although the reliability of self-report of many sun exposure factors has been previously described in several studies, self-report of use of artificial tanning devices and self-tanning creams has been less well characterized...
  44. ncbi Surface sampling for endotoxin assessment using electrostatic wiping cloths
    Peter S Thorne
    Occupational and Environmental Health, College of Public Health, The University of Iowa, 100 Oakdale Campus, IREH, Iowa City, IA 52242 5000, USA
    Ann Occup Hyg 49:401-6. 2005
    ..Thus, we evaluated the feasibility of wipe sampling for endotoxin environmental assessment using electrostatic wipes with or without the use of disposable examination gloves...
  45. ncbi Mass budget of perfluorooctane surfactants in Lake Ontario
    Bryan Boulanger
    Department of Civil and Environmental Engineering, University of Iowa, Iowa City, Iowa 52240, USA
    Environ Sci Technol 39:74-9. 2005
    ..Using the mass budget data, the steady state and measured mean concentrations in the lake water are the same at the 95% confidence level...
  46. ncbi Characterization of endotoxin and mouse allergen exposures in mouse facilities and research laboratories
    Karin A Pacheco
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Ann Occup Hyg 50:563-72. 2006
    ..Endotoxin and mouse allergen are derived from the same animal source, but have different physicochemical attributes. It is not known if airborne exposures to these agents are correlated in the laboratory animal workplace...
  47. ncbi School proximity to concentrated animal feeding operations and prevalence of asthma in students
    Sigurdur T Sigurdarson
    Division of Critical Care, and Occupational Medicine, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, Iowa City, IA, USA
    Chest 129:1486-91. 2006
    ..We compared the prevalence of asthma in two Iowa elementary schools, one adjacent to a CAFO, and the other distant from any large-scale farming operations...
  48. pmc Distribution of chiral PCBs in selected tissues in the laboratory rat
    Izabela Kania-Korwel
    Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA
    Environ Sci Technol 40:3704-10. 2006
    ....
  49. pmc Influence of dietary fat on the enantioselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in female mice
    I Kania-Korwel
    Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus, 124 IREH, Iowa City, IA 52242, United States
    Food Chem Toxicol 46:637-44. 2008
    ..Higher EF values in feces excreted after two and three days are due to excretion of previously absorbed PCBs. Overall, our study suggests that the EF value may be a good tool to investigate the absorption and excretion of PCBs in vivo...
  50. ncbi Variation in yearly residential radon concentrations in the upper midwest
    Zugui Zhang
    Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Health Phys 93:288-97. 2007
    ....
  51. pmc The three-dimensional structure of 3,3',4,4'-tetrachlorobiphenyl, a dioxin-like polychlorinated biphenyl (PCB)
    Nadim S Shaikh
    The University of Iowa, Department of Occupational and Environmental Health, 100 Oakdale Campus, 124 IREH, Iowa City, IA 52242 5000, USA
    Chemosphere 70:1694-8. 2008
    ..The dihedral angle of PCB 77 is 43.94(6) degrees, which is slightly larger than calculated or experimental dihedral angles of biphenyl derivatives in solution but smaller than experimental dihedral angles in the gas phase...
  52. pmc Community health and socioeconomic issues surrounding concentrated animal feeding operations
    Kelley J Donham
    College of Public Health, The University of Iowa, Iowa City, Iowa 52242, USA
    Environ Health Perspect 115:317-20. 2007
    ....
  53. pmc The potential role of concentrated animal feeding operations in infectious disease epidemics and antibiotic resistance
    Mary J Gilchrist
    University Hygienic Laboratory, Iowa City, Iowa 52242, USA
    Environ Health Perspect 115:313-6. 2007
    ....
  54. pmc Impacts of waste from concentrated animal feeding operations on water quality
    JoAnn Burkholder
    North Carolina State University, Raleigh, North Carolina, USA
    Environ Health Perspect 115:308-12. 2007
    ..Last, there is a need to promote and enforce best practices to minimize inputs of nutrients and toxicants from CAFOs into freshwater and marine ecosystems...
  55. pmc Monitoring and modeling of emissions from concentrated animal feeding operations: overview of methods
    Bryan Bunton
    Iowa Department of Natural Resources, Des Moines, Iowa, USA
    Environ Health Perspect 115:303-7. 2007
    ..Additional data are needed to obtain reliable emission rates from CAFOs...
  56. pmc Health effects of airborne exposures from concentrated animal feeding operations
    Dick Heederik
    University of Utrecht, Utrecht, The Netherlands
    Environ Health Perspect 115:298-302. 2007
    ....
  57. pmc Environmental health impacts of concentrated animal feeding operations: anticipating hazards--searching for solutions
    Peter S Thorne
    College of Public Health, The University of Iowa, Iowa City, Iowa 52242, USA
    Environ Health Perspect 115:296-7. 2007
    ....
  58. ncbi Iowa radon leukaemia study: a hierarchical population risk model for spatially correlated exposure measured with error
    Brian J Smith
    Department of Biostatistics, The University of Iowa, Iowa City, IA 52242 1009, U S A
    Stat Med 26:4619-42. 2007
    ..91 (0.78-1.03), 1.01 (0.92-1.12), 1.06 (0.96-1.16), and 1.12 (0.98-1.27), respectively...
  59. pmc Characterization of airborne molds, endotoxins, and glucans in homes in New Orleans after Hurricanes Katrina and Rita
    Carol Y Rao
    Epidemic Intelligence Service, Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS C09, Atlanta, GA 30333, USA
    Appl Environ Microbiol 73:1630-4. 2007
    ..The species and concentrations were different from those previously reported for non-water-damaged buildings in the southeastern United States...
  60. pmc Dog ownership enhances symptomatic responses to air pollution in children with asthma
    Rob McConnell
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    Environ Health Perspect 114:1910-5. 2006
    ..Experimental data suggest that asthma exacerbation by ambient air pollutants is enhanced by exposure to endotoxin and allergens; however, there is little supporting epidemiologic evidence...
  61. ncbi Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1
    Yungang Liu
    Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA
    Chem Res Toxicol 19:1420-5. 2006
    ..Thus, the interactions of OHPCBs with human SULT2A1 represent both a potential route of metabolism and a possible source of interference with sulfation reactions catalyzed by this enzyme...
  62. ncbi Milwaukee, WI, as a source of atmospheric PCBs to Lake Michigan
    David M Wethington
    Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, Iowa 52242, USA
    Environ Sci Technol 39:57-63. 2005
    ..We calculated that Milwaukee air contributes about 120 kg of PCBs to Lake Michigan each year. This is about 10 times larger than the discharge of PCBs from the Milwaukee River...