Chicago D-CFAR

Summary

Principal Investigator: Alan L Landay
Abstract: DESCRIPTION (provided by applicant): Chicago has the 6th highest HIV prevalence of large cities in the US;three medical institutions are located right in the middle of the communities with the highest prevalence of HIV in Chicago. More than 100 investigators in these institutions are currently involved in HIV/AIDS research. This proposal is to establish a Chicago Developmental Center for AIDS Research (D-CFAR) that will include Rush University Medical Center (RUMC), the University of Illinois at Chicago (UIC), and the Cook County Bureau of Health Services (Cook County) and will foster HIV/AIDS related research productivity. Dr. Alan Landay (RUMC) will be the Director and Dr. Robert Bailey (UIC) will be the Co-Director. The D-CFAR will build upon existing collaborative research efforts in basic, clinical, and behavioral science and will work toward expanding research opportunities for junior HIV investigators and to engage senior investigators from other disciplines in HIV/AIDS research. We plan to 1) develop an infrastructure that enhances HIV research across institutional boundaries, 2) work toward establishing interdisciplinary collaborations between investigators in the basic, social and behavioral and clinical areas of research, 3) encourage innovative research in HIV/AIDS, 4) improve communication between Chicago D-CFAR participants by creating a web site (www.ChicagoDCFAR. org), distributing a database of participants and emailing news of D-CFAR events to all participants, 5) develop access to HIV educational material, 6) develop a communication strategy for bringing advances in HIV/AIDS research to the community and 7) build an infrastructure to enable us to move from a D-CFAR to a CFAR. We will accomplish these goals by creating Cores and Emphasis Areas. There will be: an Administrative Core (Drs. Alan Landay and Linda Baum);a Developmental Core (Drs. Greg Spear and Ron Hershow);a Basic Science Core (Drs. Michael Caffrey and James Bremer);a Clinical Core (Drs. Audrey French and Richard Novak);and a Social and Behavioral Sciences Core (Drs. Judith Levy and Robert Bailey). We will actively promote research in: HIV and Women (Ms. Kathleen Weber);HIV and Aging (Dr. Pauline Maki) and Drug Abuse and HIV (Dr. Celeste Napier).
Funding Period: 2009-08-01 - 2014-07-31
more information: NIH RePORT

Top Publications

  1. pmc Regulatory B cell frequency correlates with markers of HIV disease progression and attenuates anti-HIV CD8⁺ T cell function in vitro
    Basile Siewe
    Rush University Medical Center, Departments of Immunology Microbiology and Internal Medicine, Chicago, Illinois 60612, USA
    J Leukoc Biol 93:811-8. 2013
  2. pmc Objective cognitive performance is related to subjective memory complaints in midlife women with moderate to severe vasomotor symptoms
    Lauren L Drogos
    From the Departments of 1Psychology, 2Psychiatry, and 3Obstetrics and Gynecology, University of Illinois, Chicago, IL and 4Department of Obstetrics and Gynecology and 5Feinberg School of Medicine, Northwestern University, Chicago, IL
    Menopause 20:1236-42. 2013
  3. pmc Microbial translocation and liver disease progression in women coinfected with HIV and hepatitis C virus
    Audrey L French
    Department of Medicine, CORE Center Stroger Hospital of Cook County, Chicago, IL 60612, USA
    J Infect Dis 208:679-89. 2013
  4. pmc Critical window hypothesis of hormone therapy and cognition: a scientific update on clinical studies
    Pauline M Maki
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Menopause 20:695-709. 2013
  5. pmc TLR2-activated B cells are phenotypically similar to the abnormal circulating B cells seen preceding the diagnosis of AIDS-related NHL diagnosis
    Yu Guo
    UCLA AIDS Institute, Los Angeles, CA The Institution of Viral disease Control and Prevention, CDC, Beijing, China Departments of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA Department of Epidemiology, UCLA Jonathan and Karin Fielding School of Public Health, Los Angeles, CA and Jonsson Comprehensive Cancer Center, Los Angeles, CA
    J Acquir Immune Defic Syndr 64:204-10. 2013
  6. pmc Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012"
    Paolo A Ascierto
    Istituto Nazionale Tumori, Fondazione G, Pascale, Naples, Italy
    J Transl Med 11:137. 2013
  7. pmc A role for TLR signaling during B cell activation in antiretroviral-treated HIV individuals
    Basile Siewe
    1 Rush University Medical Center, Chicago, Illinois
    AIDS Res Hum Retroviruses 29:1353-60. 2013
  8. pmc Facilitators and barriers to discussing HIV prevention with adolescents: perspectives of HIV-infected parents
    Laura L Edwards
    University of Illinois at Urbana Champaign, Department of Kinesiology and Community Health, Huff Hall, 1206 S Fourth Street, Champaign, IL 61820, USA
    Am J Public Health 103:1468-75. 2013
  9. pmc CenteringPregnancy-Africa: a pilot of group antenatal care to address Millennium Development Goals
    Crystal L Patil
    University of Illinois at Chicago, Department of Anthropology, 1007 W Harrison St MC 027, Chicago, IL 60607, USA Electronic address
    Midwifery 29:1190-8. 2013
  10. ncbi Double jeopardy through social marginalization: HIV risk among Tajik male labor migrants in Moscow
    Makhbatsho Bakhromov
    PRISMA Research Center, Dushanbe 734029, Tajikistan Electronic address
    Drug Alcohol Depend 132:S53-5. 2013

Research Grants

  1. The Miami Center for AIDS Research
    Savita Pahwa; Fiscal Year: 2013

Detail Information

Publications110 found, 100 shown here

  1. pmc Regulatory B cell frequency correlates with markers of HIV disease progression and attenuates anti-HIV CD8⁺ T cell function in vitro
    Basile Siewe
    Rush University Medical Center, Departments of Immunology Microbiology and Internal Medicine, Chicago, Illinois 60612, USA
    J Leukoc Biol 93:811-8. 2013
    ..4791; P=0.0443). Our data indicate that Bregs contribute to HIV-infection associated immune dysfunction by T cell impairment, via IL-10 and possibly PD-L1 expression...
  2. pmc Objective cognitive performance is related to subjective memory complaints in midlife women with moderate to severe vasomotor symptoms
    Lauren L Drogos
    From the Departments of 1Psychology, 2Psychiatry, and 3Obstetrics and Gynecology, University of Illinois, Chicago, IL and 4Department of Obstetrics and Gynecology and 5Feinberg School of Medicine, Northwestern University, Chicago, IL
    Menopause 20:1236-42. 2013
    ..We predicted that subjective memory complaints would be related to affective symptoms and lower performance on tests of memory and attention...
  3. pmc Microbial translocation and liver disease progression in women coinfected with HIV and hepatitis C virus
    Audrey L French
    Department of Medicine, CORE Center Stroger Hospital of Cook County, Chicago, IL 60612, USA
    J Infect Dis 208:679-89. 2013
    ..We sought to determine whether markers of microbial translocation are associated with liver disease progression during coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV)...
  4. pmc Critical window hypothesis of hormone therapy and cognition: a scientific update on clinical studies
    Pauline M Maki
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Menopause 20:695-709. 2013
    ..This article reviews clinical studies that bear on this hypothesis...
  5. pmc TLR2-activated B cells are phenotypically similar to the abnormal circulating B cells seen preceding the diagnosis of AIDS-related NHL diagnosis
    Yu Guo
    UCLA AIDS Institute, Los Angeles, CA The Institution of Viral disease Control and Prevention, CDC, Beijing, China Departments of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA Department of Epidemiology, UCLA Jonathan and Karin Fielding School of Public Health, Los Angeles, CA and Jonsson Comprehensive Cancer Center, Los Angeles, CA
    J Acquir Immune Defic Syndr 64:204-10. 2013
    ....
  6. pmc Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012"
    Paolo A Ascierto
    Istituto Nazionale Tumori, Fondazione G, Pascale, Naples, Italy
    J Transl Med 11:137. 2013
    ....
  7. pmc A role for TLR signaling during B cell activation in antiretroviral-treated HIV individuals
    Basile Siewe
    1 Rush University Medical Center, Chicago, Illinois
    AIDS Res Hum Retroviruses 29:1353-60. 2013
    ....
  8. pmc Facilitators and barriers to discussing HIV prevention with adolescents: perspectives of HIV-infected parents
    Laura L Edwards
    University of Illinois at Urbana Champaign, Department of Kinesiology and Community Health, Huff Hall, 1206 S Fourth Street, Champaign, IL 61820, USA
    Am J Public Health 103:1468-75. 2013
    ..We examined HIV-infected parents' conversations about HIV prevention with their uninfected children, including what facilitated or hindered communication...
  9. pmc CenteringPregnancy-Africa: a pilot of group antenatal care to address Millennium Development Goals
    Crystal L Patil
    University of Illinois at Chicago, Department of Anthropology, 1007 W Harrison St MC 027, Chicago, IL 60607, USA Electronic address
    Midwifery 29:1190-8. 2013
    ..Group ANC, specifically CenteringPregnancy (CP), may offer an innovative approach to enable midwives to offer higher quality ANC...
  10. ncbi Double jeopardy through social marginalization: HIV risk among Tajik male labor migrants in Moscow
    Makhbatsho Bakhromov
    PRISMA Research Center, Dushanbe 734029, Tajikistan Electronic address
    Drug Alcohol Depend 132:S53-5. 2013
    ....
  11. pmc Medical male circumcision and herpes simplex virus 2 acquisition: posttrial surveillance in Kisumu, Kenya
    Supriya D Mehta
    Division of Epidemiology and Biostatistics, University of Illinois at Chicago School of Public Health
    J Infect Dis 208:1869-76. 2013
    ..We estimated the 72-month efficacy of medical male circumcision (MMC) against herpes simplex virus 2 (HSV-2) incidence among men in the Kisumu MMC randomized trial...
  12. pmc Changes in plasma viral load and penile viral shedding after circumcision among HIV-positive men in Kisumu, Kenya
    Elijah Odoyo-June
    Nyanza Reproductive Health Society, Kisumu, Kenya University of Nairobi, Nairobi, Kenya and Division of Epidemiology and Biostatistics University of Illinois at Chicago, Illinois
    J Acquir Immune Defic Syndr 64:511-7. 2013
    ..We conducted a prospective cohort study of HIV-positive men aged 18-35 years in Kisumu, Kenya to determine if medical circumcision of ART-naive HIV-positive men leads to increased viral load and penile viral shedding...
  13. pmc Vitamin D and insulin resistance in non-diabetic women's interagency HIV study participants
    Oluwatoyin M Adeyemi
    CORE Center and John H Stroger Hospital, Chicago, IL 60612, USA
    AIDS Patient Care STDS 27:320-5. 2013
    ..We found a marginally significant association between vitamin D insufficiency and insulin resistance among nondiabetic HIV-infected WIHS women...
  14. pmc Correctional facilities as partners in reducing HIV disparities
    Josiah D Rich
    Brown University Medical School, Providence, RI 02906, USA
    J Acquir Immune Defic Syndr 63:S49-53. 2013
    ....
  15. pmc IL-22 levels are associated with Trichomonas vaginalis infection in the lower genital tract
    Hadijat Moradeke Makinde
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Am J Reprod Immunol 70:38-44. 2013
    ..IL-22 has important functions at mucosal surfaces, including the induction of antimicrobial peptides and maintenance of epithelium. However, IL-22 has not been investigated in the genital tract during TV infection...
  16. pmc Sex work venue and condom use among female sex workers in Senggigi, Indonesia
    Iko Safika
    AIDS Research Centre, Atmajaya Catholic University, Jakarta, Indonesia
    Cult Health Sex 15:598-613. 2013
    ..Future research into the effects of social context on HIV risk should also be considered...
  17. pmc Measuring prevalence and correlates of concurrent sexual partnerships among young sexually active men in Kisumu, Kenya
    Nelli Westercamp
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, 1603 W Taylor St, MC 923, Chicago, IL, 60612, USA
    AIDS Behav 17:3124-32. 2013
    ..Estimates of concurrency were influenced by methods for definition and measurement. Regardless of definition, concurrent partnerships are frequent in this population of young, sexually active men in high HIV prevalence Kisumu, Kenya...
  18. pmc Incident hepatitis C virus infection in men who have sex with men: a prospective cohort analysis, 1984-2011
    Mallory D Witt
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Clin Infect Dis 57:77-84. 2013
    ..Prospective characterization of hepatitis C virus (HCV) transmission in both human immunodeficiency virus (HIV)-infected and -uninfected men who have sex with men (MSM) over the entire HIV epidemic has not been comprehensively conducted...
  19. pmc The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial
    Peter W Hunt
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
    Blood 121:4635-46. 2013
    ..These results may have relevance for trials of maraviroc for HIV preexposure prophylaxis and graft-versus-host disease. This trial was registered at www.clinicaltrials.gov as #NCT00735072...
  20. pmc Empowering peer group leaders for HIV prevention in Malawi
    Linda L McCreary
    Alpha Lambda, Research Assistant Professor, University of Illinois at Chicago College of Nursing, Chicago, IL, USA
    J Nurs Scholarsh 45:288-97. 2013
    ..This study describes how participants felt being a peer group leader affected their lives...
  21. pmc Time to complete wound healing in HIV-positive and HIV-negative men following medical male circumcision in Kisumu, Kenya: a prospective cohort study
    John H Rogers
    University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 8:e61725. 2013
    ..This prospective cohort study evaluates post-circumcision wound healing to determine whether the 42-day post-circumcision abstinence period, recommended by the World Health Organization and adopted by VMMC programs, is optimal...
  22. pmc Hepatitis C viremia is associated with cytomegalovirus IgG antibody levels in HIV-infected women
    Mark H Kuniholm
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 8:e61973. 2013
    ..Individuals with HIV infection exhibit high cytomegalovirus (CMV) IgG levels, but there are few data regarding the association of hepatitis C virus (HCV) with the immune response against CMV...
  23. pmc Cognition in perimenopause: the effect of transition stage
    MIRIAM T WEBER
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Menopause 20:511-7. 2013
    ....
  24. pmc Using the Rasch measurement model in psychometric analysis of the Family Effectiveness Measure
    Linda L McCreary
    College of Nursing, University of Illinois at Chicago, Chicago, Illinois 60612 7350, USA
    Nurs Res 62:149-59. 2013
    ..The Family Effectiveness Measure was developed to address this limitation...
  25. pmc Virological and immunological characteristics of human cytomegalovirus infection associated with Alzheimer disease
    Nell S Lurain
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Infect Dis 208:564-72. 2013
    ..HSV-1 infection of HFFs did not induce amyloid-β. These data support an association between CMV and the development of Alzheimer disease. ..
  26. ncbi Oral rapid test: an alternative to traditional HIV screening in Chile
    Lisette Paola Irarrazábal
    University of Illinois at Chicago, Chicago, Illinois, USA
    Rev Panam Salud Publica 33:427-32. 2013
    ....
  27. pmc Computational modeling reveals distinct effects of HIV and history of drug use on decision-making processes in women
    Jasmin Vassileva
    Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 8:e68962. 2013
    ..In this study, we use this approach to investigate the effects of HIV and drug use on decision-making processes in women, who remain a relatively understudied population...
  28. pmc Comparison of antibodies that mediate HIV type 1 gp120 antibody-dependent cell-mediated cytotoxicity in asymptomatic HIV type 1-positive men and women
    Mariana M Mata
    1 Department of Immunology and Microbiology, Rush University Medical Center, Chicago, Illinois
    AIDS Res Hum Retroviruses 30:50-7. 2014
    ..Both sexes had significant cross-clade reactivity. Differences between men and women may become evident as disease progresses; this should be evaluated at later stages of HIV-1 infection...
  29. pmc The longitudinal and interactive effects of HIV status, stimulant use, and host genotype upon neurocognitive functioning
    Andrew J Levine
    Department of Neurology, National Neurological AIDS Bank, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    J Neurovirol 20:243-57. 2014
    ..Being consistent with findings from another cohort, dopamine (DA)-related genetic differences do not appear to impact the longitudinal neurocognitive functioning of HIV+ individuals. ..
  30. ncbi Human α-amylase present in lower-genital-tract mucosal fluid processes glycogen to support vaginal colonization by Lactobacillus
    Gregory T Spear
    Department of Immunology Microbiology
    J Infect Dis 210:1019-28. 2014
    ..These studies show that human α-amylase is present in the female lower genital tract and elucidates how epithelial glycogen can support Lactobacillus colonization in the genital tract. ..
  31. pmc Regulatory B cells inhibit cytotoxic T lymphocyte (CTL) activity and elimination of infected CD4 T cells after in vitro reactivation of HIV latent reservoirs
    Basile Siewe
    Rush University Medical Center, Department of Immunology and Microbiology, Chicago, Illinois, United States of America
    PLoS ONE 9:e92934. 2014
    ..Our data suggest that, possibly, via an IL-10 and PD-L1 synergistic mechanism; Bregs likely inhibit APC function and CD4+ T-cell proliferation, leading to anti-HIV CTL attenuation, hindering viral eradication. ..
  32. pmc Smoking cessation and recidivism in the Women's Interagency Human Immunodeficiency Virus Study
    Nancy A Hessol
    Department of Clinical Pharmacy, University of California, San Francisco Electronic address
    Am J Prev Med 47:53-69. 2014
    ..Smoking increases the risk of morbidity and mortality and is particularly harmful to HIV-infected people...
  33. pmc Crack cocaine use impairs anterior cingulate and prefrontal cortex function in women with HIV infection
    Vanessa J Meyer
    University of Illinois at Chicago, Chicago, IL, USA
    J Neurovirol 20:352-61. 2014
    ..05. The verbal learning and memory deficits associated with cocaine use in women with HIV may be partially accounted for by alterations in ACC and PFC function...
  34. pmc Safety, effectiveness and acceptability of the PrePex device for adult male circumcision in Kenya
    Paul J Feldblum
    Clinical Sciences Unit, FHI 360, Durham, North Carolina, United States of America
    PLoS ONE 9:e95357. 2014
    ..To assess the safety, effectiveness and acceptability of the PrePex device for adult medical male circumcision (MMC) in routine service delivery in Kenya...
  35. ncbi Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment
    Allan R Tenorio
    Department of Medicine
    J Infect Dis 210:1248-59. 2014
    ....
  36. pmc Comparison of lower genital tract microbiota in HIV-infected and uninfected women from Rwanda and the US
    Lorie Benning
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 9:e96844. 2014
    ..We assessed geographic differences in types of genital microbiota between HIV-infected and uninfected women from Rwanda and the United States...
  37. ncbi The barrier to HIV transmission provided by genital tract Lactobacillus colonization
    Paria Mirmonsef
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL, USA
    Am J Reprod Immunol 71:531-6. 2014
    ..This article reviews selected recent research on genital tract microbiota in women including how microbiota impacts HIV resistance and factors affecting Lactobacillus colonization. ..
  38. pmc Macrophage inflammatory markers are associated with subclinical carotid artery disease in women with human immunodeficiency virus or hepatitis C virus infection
    Iftach Shaked
    From the Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA I S, K L Department of Epidemiology and Population Health, Department of Medicine D B H, D T, K A, R K, and Department of Obstetrics and Gynecology and Women s Health K A, and Department of Microbiology and Immunology V P, Albert Einstein College of Medicine, Bronx, NY Department of Immunology Microbiology, Rush University, Chicago, IL J P, M C, A L L Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD E T G Division of Infectious Disease, Georgetown University Medical Center, Washington, DC M A Y Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY J L Atherosclerosis Research Unit, University of Southern California, Los Angeles, CA R K Department of Medicine, University of California, San Francisco P C T Department of Cardiology, Angiology and Pneumonology, University of Heidelberg, Germany C G and Department of Medicine, University of California, San Diego B M
    Arterioscler Thromb Vasc Biol 34:1085-92. 2014
    ..Our goal was to identify plasma biomarkers that reflect macrophage inflammation and are associated with subclinical atherosclerosis...
  39. pmc Scaling up routine HIV testing at specialty clinics: assessing the effectiveness of an academic detailing approach
    Ronald J Lubelchek
    Division of Infectious Diseases, John H Stroger, Jr Hospital of Cook County, Chicago, IL Department of Medicine, Rush University Medical Center, Chicago, IL Chicago Developmental Center for AIDS Research D CFAR, Chicago, IL Chicago Consortium, Women s Interagency HIV Study Department of Prevention and Education, Ruth M Rothstein CORE Center, Chicago, IL and STI HIV Services Division, Chicago Department of Public Health
    J Acquir Immune Defic Syndr 64:S14-9. 2013
    ..We report on use of a survey of barriers to routine testing coupled with academic detailing-type educational sessions to increase routine testing at specialty clinics in Chicago's main safety-net health system...
  40. pmc Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques
    Monica Vaccari
    1 Animal Models and Retroviral Vaccines Section, NCI, NIH, Bethesda, Maryland
    AIDS Res Hum Retroviruses 30:355-62. 2014
    ..Our findings confirm recent results observed in asymptomatic HIV-infected patients and suggest that CQ does not provide an obvious benefit in the absence of antiretroviral therapy...
  41. pmc Epigenetic regulation of HIV-1 latency in astrocytes
    Srinivas D Narasipura
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, Illinois, USA
    J Virol 88:3031-8. 2014
    ..Our studies add to a growing body of evidence demonstrating that astrocytes are a reservoir for HIV. ..
  42. doi Past hormone therapy in older women: does the brain recover from adverse effects?
    Kejal Kantarci
    From the Department of Radiology K K, Mayo Clinic, Rochester, MN and Department of Psychiatry P M M, University of Illinois, Chicago
    Neurology 82:380-1. 2014
    ..1) Unopposed CEE (i.e., without medroxyprogesterone acetate) did not increase the incidence of dementia, but a pooled analysis of both treatments arms revealed a 76% increased incidence of dementia.(2.) ..
  43. ncbi Opt-out screening for Chlamydia trachomatis and Neisseria gonorrhoeae in female detainees at Cook County jail in Chicago, IL
    Joanna Cole
    From the Rush University Medical Center, Chicago, IL John H Stroger Hospital Cook County Health and Hospital Systems, Chicago Center for AIDS Research, Chicago, IL and Cermak Health Services, Cook County Jail, Chicago, IL
    Sex Transm Dis 41:161-5. 2014
    ..In this retrospective review, we assess the impact of opt-out protocol on rates of testing, diagnoses, and successful treatment...
  44. pmc Systematic review of the performance of HIV viral load technologies on plasma samples
    Kimberly A Sollis
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 9:e85869. 2014
    ..Since 2010 the World Health Organization has recommended a phase-in approach to VL monitoring in resource-limited settings. We conducted a systematic review of the accuracy and precision of HIV VL technologies for treatment monitoring...
  45. pmc Effects of cryopreservation on effector cells for antibody dependent cell-mediated cytotoxicity (ADCC) and natural killer (NK) cell activity in (51)Cr-release and CD107a assays
    Mariana M Mata
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, United States
    J Immunol Methods 406:1-9. 2014
    ..Clinical studies of antibodies that mediate ADCC would benefit from using effector cells that have been frozen, thawed and rested overnight prior to assay. ..
  46. pmc Abuse and resilience in relation to HAART medication adherence and HIV viral load among women with HIV in the United States
    Sannisha Dale
    1 Department of Psychology, Boston University, Boston, Massachusetts
    AIDS Patient Care STDS 28:136-43. 2014
    ..Interventions to improve coping strategies that promote resilience among HIV+ women may be beneficial for achieving higher HAART adherence and viral suppression...
  47. pmc Listeria monocytogenes virulence factor secretion: don't leave the cell without a chaperone
    Laty A Cahoon
    Department of Microbiology and Immunology, University of Illinois at Chicago Chicago, IL, USA
    Front Cell Infect Microbiol 4:13. 2014
    ....
  48. pmc A compositional look at the human gastrointestinal microbiome and immune activation parameters in HIV infected subjects
    Ece A Mutlu
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Rush University Medical Center, Chicago, Illinois, United States of America
    PLoS Pathog 10:e1003829. 2014
    ..This is the first report characterizing the terminal ileal and colonic mucosal microbiome in HIV patients with next generation sequencing. Limitations include use of HIV-infected subjects on HAART therapy. ..
  49. pmc Systematic review of the use of dried blood spots for monitoring HIV viral load and for early infant diagnosis
    Pieter W Smit
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 9:e86461. 2014
    ..We systematically reviewed evidence on the performance of DBS compared to plasma for VL monitoring and EID...
  50. pmc Women's beliefs about male circumcision, HIV prevention, and sexual behaviors in Kisumu, Kenya
    Thomas H Riess
    School of Public Health, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 9:e97748. 2014
    ....
  51. pmc Dynamics of SARS-coronavirus HR2 domain in the prefusion and transition states
    Susanna McReynolds
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA
    J Magn Reson 201:218-21. 2009
    ....
  52. pmc Role of β-catenin/TCF-4 signaling in HIV replication and pathogenesis: insights to informing novel anti-HIV molecular therapeutics
    Lisa J Henderson
    Department of Immunology Microbiology and Center for AIDS Research, Rush University Medical Center, Chicago, IL 60607, USA
    J Neuroimmune Pharmacol 6:247-59. 2011
    ..This review highlights the role of the Wnt/β-catenin pathway as a host factor that represses HIV replication in multiple targets, especially those relevant to HIV in the central nervous system...
  53. pmc HIV in young men who have sex with men: a review of epidemiology, risk and protective factors, and interventions
    Brian S Mustanski
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60608, USA
    J Sex Res 48:218-53. 2011
    ....
  54. pmc IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner
    Wei Li
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 186:6771-8. 2011
    ....
  55. pmc Probing the HIV gp120 envelope glycoprotein conformation by NMR
    Jessica Celigoy
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Biol Chem 286:23975-81. 2011
    ..In addition, we show a subtle difference in the binding mode of 12p1 in the presence of gp41 domains, i.e. the trimeric state, which we interpret as small differences in the gp120 structure in the presence of gp41...
  56. pmc Methamphetamine and HIV-1 Tat down regulate β-catenin signaling: implications for methampetamine abuse and HIV-1 co-morbidity
    Amit Sharma
    Department of Immunology Microbiology, Rush University Medical Center, 1735 W Harrison Street, 614 Cohn, Chicago, IL 60612, USA
    J Neuroimmune Pharmacol 6:597-607. 2011
    ..The consequences of which may contribute to the pathophysiologic effects of HIV-1 and Meth co-morbidity in the CNS...
  57. pmc HIV-related research in correctional populations: now is the time
    Josiah D Rich
    Brown University Medical School, Providence, RI, USA
    Curr HIV/AIDS Rep 8:288-96. 2011
    ..This is especially relevant given recent evidence of the effectiveness of antiretroviral therapy in reducing HIV transmission...
  58. pmc Risk factors for oral HPV infection among a high prevalence population of HIV-positive and at-risk HIV-negative adults
    Daniel C Beachler
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 n Wolfe St E6132B, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 21:122-33. 2012
    ..Individuals with human immunodeficiency virus (HIV) have higher oral HPV prevalence but the risk factors for oral HPV infection are not well understood for either HIV-positive or HIV-negative individuals...
  59. pmc Role of β-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes
    Srinivas D Narasipura
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, Illinois, USA
    J Virol 86:1911-21. 2012
    ....
  60. pmc Longitudinal assessment of pigtailed macaque lower genital tract microbiota by pyrosequencing reveals dissimilarity to the genital microbiota of healthy humans
    Gregory T Spear
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, Illinois 60612, USA
    AIDS Res Hum Retroviruses 28:1244-9. 2012
    ..The polymicrobial makeup of the macaque bacterial populations, the paucity of lactobacilli, and the specific types of bacteria present suggest that the pigtailed macaque microbiota could influence vaginal retrovirus infection...
  61. pmc Interferon-alpha administration enhances CD8+ T cell activation in HIV infection
    Maura Manion
    Division of Infectious Diseases, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 7:e30306. 2012
    ..In HIV infection, type I interferons may delay disease progression by inhibiting viral replication while at the same time accelerating disease progression by contributing to chronic immune activation...
  62. pmc Maternal models of risk: links between substance use and risky sexual behavior in African American female caregivers and daughters
    Tiffany Brakefield
    Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    J Adolesc 35:959-68. 2012
    ..These findings suggest that female caregivers' sexual behavior and substance use both relate to girls' sexual risk. Thus, results emphasize the role of female caregivers in transmitting risk...
  63. pmc HIV envelope: challenges and opportunities for development of entry inhibitors
    Michael Caffrey
    Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, IL 60607, USA
    Trends Microbiol 19:191-7. 2011
    ..In this review, the challenges, strategies and progress to date for developing novel entry inhibitors directed at disrupting HIV gp120 and gp41 function are discussed...
  64. pmc A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers
    Peter W Hunt
    Departments of Medicine and Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e15924. 2011
    ..These data support a model in which low frequencies of Tregs in HIV controllers may contribute to an effective adaptive immune response, but may also contribute to generalized immune activation, potentially contributing to CD4 depletion...
  65. pmc The relationship of CCR5 antagonists to CD4+ T-cell gain: a meta-regression of recent clinical trials in treatment-experienced HIV-infected patients
    Timothy J Wilkin
    Division of Infectious Diseases, Weill Cornell Medical College, New York, New York 10011, USA
    HIV Clin Trials 11:351-8. 2010
    ..CCR5 antagonists are associated with robust CD4+ T-cell responses. We examined the relationship of CCR5 antagonists to CD4+ T-cell gains...
  66. pmc Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared with other antiretrovirals
    David W Ouyang
    Division of Maternal Fetal Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    AIDS 24:109-14. 2010
    ..To estimate whether HIV-infected pregnant women were at an increased risk of hepatotoxicity when taking nevirapine (NVP)-containing regimens compared with HIV-infected pregnant women taking antiretroviral therapy (ART) not containing NVP...
  67. pmc Role of humoral immunity in host defense against HIV
    Linda L Baum
    Department of Immunology Microbiology, Rush University Medical Center, 1735 West Harrison Street, 622 Cohn Building, Chicago, IL, 60612, USA
    Curr HIV/AIDS Rep 7:11-8. 2010
    ....
  68. ncbi Alanine scanning mutagenesis of HIV-1 gp41 heptad repeat 1: insight into the gp120-gp41 interaction
    Jayita Sen
    Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607, USA
    Biochemistry 49:5057-65. 2010
    ....
  69. pmc Intracellular Casp8p41 content is inversely associated with CD4 T cell count
    Nathan W Cummins
    Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Infect Dis 202:386-91. 2010
    ..This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection...
  70. pmc Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells
    Jason M Schenkel
    Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 185:2013-9. 2010
    ..Collectively, these data demonstrate that beta-catenin is critical in inducing CD4 expression on mature CD8(+) T cells, suggesting that it is a common pathway for CD4 upregulation among thymocytes and mature CD8(+) T cells...
  71. pmc HIV+ men and women show different performance patterns on procedural learning tasks
    Eileen Martin
    University of Illinois College of Medicine Chicago, Chicago, IL 60612, USA
    J Clin Exp Neuropsychol 33:112-20. 2011
    ..Additional studies are needed to address directly the possibility of sex differences in HAND and the possibility that women might be more vulnerable to the effects of HIV and substance dependence on some neurocognitive functions...
  72. pmc Biomarkers of immune dysfunction in HIV
    Daniel E Nixon
    Virginia Commonwealth University, Richmond, Virginia 23298 0049, USA
    Curr Opin HIV AIDS 5:498-503. 2010
    ..This review will highlight recent developments using plasma and cellular biomarkers of immune system activation and dysfunction to predict mortality and opportunistic disease in HIV-infected individuals...
  73. pmc Pyrosequencing of the genital microbiotas of HIV-seropositive and -seronegative women reveals Lactobacillus iners as the predominant Lactobacillus Species
    Gregory T Spear
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Appl Environ Microbiol 77:378-81. 2011
    ..Lactobacillus iners sequences were the predominant lactobacillus sequences in 66% of HIV(+) women and 90% of HIV(-) women. This has implications for resistance of HIV(+) and HIV(-) women to genital colonization by pathogenic organisms...
  74. pmc Mirtazapine alters cue-associated methamphetamine seeking in rats
    Steven M Graves
    Department of Pharmacology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Biol Psychiatry 69:275-81. 2011
    ..This pharmacologic profile prompted our interest in its potential for preventing relapse to METH-taking. This study tested the hypothesis that mirtazapine would attenuate METH-seeking in rats trained to self-administer METH...
  75. pmc Associations between use of crack cocaine and HIV-1 disease progression: research findings and implications for mother-to-infant transmission
    Judith A Cook
    Department of Psychiatry, University of Illinois at Chicago, United States
    Life Sci 88:931-9. 2011
    ....
  76. pmc T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    J Infect Dis 203:452-63. 2011
    ..It is unknown whether T cell activation and senescence, 2 immunologic sequelae of HIV infection, are associated with vascular disease among HIV-infected adults...
  77. pmc Neurocognitive performance in drug-dependent males and females with posttraumatic stress disorder symptoms
    Jessica L Paxton
    Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA
    J Clin Exp Neuropsychol 34:521-30. 2012
    ..These results represent progress in efforts to delineate sex-specific risk factors for neurocognitive deficits among SDIs...
  78. pmc Association among vitamin D, oral candidiasis, and calprotectinemia in HIV
    H Y Sroussi
    Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, University of Illinois at Chicago, 801 S Paulina, M C 838, Chicago, IL 60612, USA
    J Dent Res 91:666-70. 2012
    ..These findings support studies to examine the effect of vitamin D status on calprotectinemia, neutrophil functions, and opportunistic mucosal infections in HIV...
  79. ncbi Seroprevalence study using oral rapid HIV testing in a large urban emergency department
    Sachin Jain
    Department of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Emerg Med 43:e269-75. 2012
    ..1%. Rapid HIV testing has several advantages; however, recent studies have raised concerns about false positives in populations with low seroprevalence...
  80. pmc Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription through its intact core and cysteine-rich domains inhibits Wnt/β-catenin signaling in astrocytes: relevance to HIV neuropathogenesis
    Lisa J Henderson
    Department of Immunology Microbiology, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Neurosci 32:16306-13. 2012
    ..The consequences of this interaction include alleviation of Wnt/β-catenin-mediated suppression of HIV and possible astrocyte dysregulation contributing to HIV neuropathogenesis...
  81. pmc Should male circumcision be advocated for genital cancer prevention?
    Brian J Morris
    Molecular Medical Sciences, University of Sydney, Australia
    Asian Pac J Cancer Prev 13:4839-42. 2012
    ..Male circumcision can reduce cervical, penile and possibly prostate cancer. Promotion of both HPV vaccination and male circumcision will synergistically maximize genital cancer prevention...
  82. pmc Racial/ethnic differences in spontaneous HCV clearance in HIV infected and uninfected women
    Monika Sarkar
    Department of Medicine, Division of Gastroenterology and Hepatology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0358, USA
    Dig Dis Sci 58:1341-8. 2013
    ..Few studies report racial/ethnic differences in acute HCV in HIV infected, or Hispanic women. We examined racial/ethnic differences in spontaneous HCV clearance in a population of HCV mono- and co-infected women...
  83. pmc GB virus C infection is associated with altered lymphocyte subset distribution and reduced T cell activation and proliferation in HIV-infected individuals
    Jack T Stapleton
    Research and Medical Services, Iowa City VA Medical Center, Iowa City, Iowa, United States of America
    PLoS ONE 7:e50563. 2012
    ..Furthermore, since cART therapy does not reduce T cell activation to levels seen in HIV-uninfected people, GBV-C infection may be beneficial for HIV-related diseases in those effectively treated with anti-HIV therapy...
  84. pmc Factors associated with resumption of sex before complete wound healing in circumcised HIV-positive and HIV-negative men in Kisumu, Kenya
    Elijah Odoyo-June
    Nyanza Reproductive Health Society, Kisumu, Kenya University of Nairobi, Nairobi, Kenya University of Illinois, Chicago, IL
    J Acquir Immune Defic Syndr 62:465-70. 2013
    ..The purpose was to assess factors associated with adherence to the WHO recommendation of 42-days postcircumcision sexual abstinence and with engaging in sex before complete healing...
  85. pmc In captive rhesus macaques, cervicovaginal inflammation is common but not associated with the stable polymicrobial microbiome
    Gregory Spear
    Department Immunology Microbiology, Rush University Medical Center, Chicago, Illinois, United States of America
    PLoS ONE 7:e52992. 2012
    ..It seems likely that results of published vaginal SIV transmission experiments in RM have been influenced by pre-existing inflammation in the animals used for the experiments...
  86. pmc Community-associated methicillin-resistant Staphylococcus aureus colonization burden in HIV-infected patients
    Kyle J Popovich
    Rush University Medical Center, Stroger Hospital of Cook County, and University of Illinois at Chicago Medical Center, Chicago, Illinois 60612, USA
    Clin Infect Dis 56:1067-74. 2013
    ..The epidemic of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has had a disproportionate impact on patients with human immunodeficiency virus (HIV)...
  87. pmc The PrePex device is unlikely to achieve cost-savings compared to the forceps-guided method in male circumcision programs in sub-Saharan Africa
    Walter Obiero
    Nyanza Reproductive Health Society, Kisumu, Kenya
    PLoS ONE 8:e53380. 2013
    ..The PrePex male circumcision (PMC) method could replace FGMC and potentially reduce MC programming costs. We compared the potential costs of introducing the PrePex device into MC programming to the cost of the forceps-guided method...
  88. pmc Age-associated changes in monocyte and innate immune activation markers occur more rapidly in HIV infected women
    Genevieve E Martin
    Centre for Virology, Burnet Institute, Melbourne, Australia
    PLoS ONE 8:e55279. 2013
    ..Whilst sex differences in innate immunity are recognized, little research into innate immune aging has been performed on women...
  89. pmc Factors associated with the safety of voluntary medical male circumcision in Nyanza province, Kenya
    Amy Herman-Roloff
    University of Illinois, 1603 W Taylor Street M C 923, Office 959, Chicago, IL, 60612, United States of America
    Bull World Health Organ 90:773-81. 2012
    ..To determine factors associated with the incidence of adverse events associated with voluntary medical male circumcision (VMMC) for the prevention of HIV infection in Nyanza province, Kenya...
  90. pmc Biology of mucosally transmitted sexual infection-translating the basic science into novel HIV intervention: a workshop summary
    Damian Purcell
    University of Melbourne, Parkville, Australia
    AIDS Res Hum Retroviruses 28:1389-96. 2012
    ..The workshop raised important questions that we need to answer to further our basic understanding of host and viral factors influencing HIV transmission to inform the development of novel prevention strategies...
  91. pmc Alcohol consumption trajectory patterns in adult women with HIV infection
    Robert L Cook
    Department of Epidemiology, University of Florida, PO Box 100231, Gainesville, FL 32610, USA
    AIDS Behav 17:1705-12. 2013
    ..Clinicians and those providing alcohol-related interventions might target those with depression, current use of tobacco or illicit drugs, HCV infection, or a previous history of drinking problems...
  92. pmc Potential cardiovascular disease risk markers among HIV-infected women initiating antiretroviral treatment
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Acquir Immune Defic Syndr 60:359-68. 2012
    ..We examined atherogenic biomarkers and subclinical atherosclerosis in HIV-infected adults before and after beginning highly active antiretroviral therapy (HAART)...
  93. pmc Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates
    Ivona Pandrea
    Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Blood 120:1357-66. 2012
    ..Our results demonstrate that hypercoagulation and cardiovascular pathology are at least in part a consequence of excessive immune activation and MT in SIV infection...

Research Grants30

  1. The Miami Center for AIDS Research
    Savita Pahwa; Fiscal Year: 2013
    ..The Miami CFAR will play to the research strengths contained within the institution and accelerate the pace of research at UM, so that we can truly make a mark towards elimination of the HIV/AIDS epidemic. ..