Baylor-UT Houston Center for AIDS Research

Summary

Principal Investigator: Janet S Butel
Abstract: This application requests renewal of support for the fourth funding period (years 16-20) of the Baylor- UT Houston Center for AIDS Research (CFAR). Both institutional partners are located in the vibrant Texas Medical Center in Houston, Texas. Houston is the fourth largest city in the US with a very diverse population and is ranked 7th in the US (2007) for cumulative number of AIDS cases. This current funding period (2004-2009) has proven the value of the synergistic partnership between Baylor College of Medicine and The University of Texas Health Science Center, raising CFAR efforts in HIV/AIDS research in Houston to a new level. Our historically successful Developmental grants program continued to foster HIV/AIDS research, with a lifetime record (1994-2008) of invested CFAR funds resulting in over 18-fold leveraging as reflected by new external funding to grantees. A comprehensive strategic planning process guided the CFAR in the development of visionary and proactive plans for the next 5 years that capitalize on unique strengths and opportunities. CFAR goals are supported by the expertise and services of six scientific cores: Immunology, Virology, Clinical Research, Design &Analysis, Behavioral Sciences, and International Research. New to this application, we propose to support a Scientific Program on HIV Associated Malignancies that builds upon opportunities provided by the recent development of an NCI designated Cancer Center at Baylor. Also new are identified Opportunity Areas that create a mechanism for Core Directors to provide proactive leadership in areas with potential to positively impact HIV/AIDS research at the CFAR. One opportunity to be pursued is developing ties with the Southwest National Primate Research Center in San Antonio, Texas, to facilitate CFAR member research involving nonhuman primates. Maturation of infrastructure and human capacity at international sites provides exciting possibilities for collaborative research which will be exploited in the next funding period. We will provide inter-CFAR leadership to support an innovative educational program on infectious diseases developed for middle schools. The unique environment of the Texas Medical Center creates many opportunities for scientific, clinical, and educational collaborations, of which the CFAR takes full advantage.
Funding Period: 1997-04-01 - 2015-07-31
more information: NIH RePORT

Top Publications

  1. pmc KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis
    Xueyou Hu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 287:4014-22. 2012
  2. pmc Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expression
    Sona Budhiraja
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Retrovirology 9:52. 2012
  3. ncbi Readiness, trust, and adherence: a clinical perspective
    Richard M Grimes
    Department of Medicine, The University of Texas Health Science Center, Houston, TX, USA
    J Int Assoc Provid AIDS Care 12:185-94. 2013
  4. pmc Utility of a partner communication scale and a personal meaning scale in newly diagnosed HIV-infected persons
    April Buscher
    Department of Medicine, Baylor College of Medicine, Houston Health Services Research and Development Center of Excellence, Houston, TX, USA
    J Assoc Nurses AIDS Care 24:126-34. 2013
  5. pmc Developing a web site for human immunodeficiency virus prevention in a middle income country: a pilot study from Thailand
    Nongyao Kasatpibal
    Faculty of Nursing, Chiang Mai University, Chiang Mai, Thailand
    Cyberpsychol Behav Soc Netw 15:560-3. 2012
  6. pmc Trimeric glycosylphosphatidylinositol-anchored HCDR3 of broadly neutralizing antibody PG16 is a potent HIV-1 entry inhibitor
    Lihong Liu
    Unit of Anti Viral Immunity and Genetic Therapy, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
    J Virol 87:1899-905. 2013
  7. pmc Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells
    Sona Budhiraja
    Department of Molecular Microbiology and Virology, Baylor College of Medicine, Houston, TX, USA
    J Virol 87:1211-20. 2013
  8. pmc An effective vaccination approach augments anti-HIV systemic and vaginal immunity in mice with decreased HIV-1 susceptible α4β7high CD4+ T cells
    Wei Zhu
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, The Methodist Hospital, Houston, TX, USA
    Curr HIV Res 11:56-66. 2013
  9. pmc MicroRNA-mediated restriction of HIV-1 in resting CD4+ T cells and monocytes
    Karen Chiang
    Interdepartmental Program in Translational Biology and Molecular Medicine, Houston, TX 77030, USA
    Viruses 4:1390-409. 2012
  10. ncbi Verifying quantitative stigma and medication adherence scales using qualitative methods among Thai youth living with HIV/AIDS
    Warunee Fongkaew
    Faculty of Nursing, Chiang Mai University, Chiang Mai, Thailand
    J Int Assoc Provid AIDS Care 13:69-77. 2014

Detail Information

Publications147 found, 100 shown here

  1. pmc KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis
    Xueyou Hu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 287:4014-22. 2012
    ..Our findings indicate a regulatory role of KCa1.1 channels in RA-FLS function and suggest this channel as a potential target for the treatment of RA...
  2. pmc Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expression
    Sona Budhiraja
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Retrovirology 9:52. 2012
    ..We investigated the role of phosphatase PPM1A in regulating CDK9 T-loop phosphorylation and its effect on HIV-1 proviral transcription...
  3. ncbi Readiness, trust, and adherence: a clinical perspective
    Richard M Grimes
    Department of Medicine, The University of Texas Health Science Center, Houston, TX, USA
    J Int Assoc Provid AIDS Care 12:185-94. 2013
    ..This paper examines the scientific bases for the recommendations on readiness, trust, and adherence that were contained in 5 HIV treatment guidelines...
  4. pmc Utility of a partner communication scale and a personal meaning scale in newly diagnosed HIV-infected persons
    April Buscher
    Department of Medicine, Baylor College of Medicine, Houston Health Services Research and Development Center of Excellence, Houston, TX, USA
    J Assoc Nurses AIDS Care 24:126-34. 2013
    ..The quality of HIV-infected individuals' discussions of HIV with their partners and positive constructed meaning were associated with better mental health and could be targets for improving medication adherence...
  5. pmc Developing a web site for human immunodeficiency virus prevention in a middle income country: a pilot study from Thailand
    Nongyao Kasatpibal
    Faculty of Nursing, Chiang Mai University, Chiang Mai, Thailand
    Cyberpsychol Behav Soc Netw 15:560-3. 2012
    ..In conclusion, the study showed that the combination of nurses and MSMs from a middle income country could develop a usable HIV prevention Web site that instructed and changed behavior...
  6. pmc Trimeric glycosylphosphatidylinositol-anchored HCDR3 of broadly neutralizing antibody PG16 is a potent HIV-1 entry inhibitor
    Lihong Liu
    Unit of Anti Viral Immunity and Genetic Therapy, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
    J Virol 87:1899-905. 2013
    ....
  7. pmc Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells
    Sona Budhiraja
    Department of Molecular Microbiology and Virology, Baylor College of Medicine, Houston, TX, USA
    J Virol 87:1211-20. 2013
    ....
  8. pmc An effective vaccination approach augments anti-HIV systemic and vaginal immunity in mice with decreased HIV-1 susceptible α4β7high CD4+ T cells
    Wei Zhu
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, The Methodist Hospital, Houston, TX, USA
    Curr HIV Res 11:56-66. 2013
    ..Hence this study provides a unique and effective strategy to induce α4β7(low) anti-HIV immune responses...
  9. pmc MicroRNA-mediated restriction of HIV-1 in resting CD4+ T cells and monocytes
    Karen Chiang
    Interdepartmental Program in Translational Biology and Molecular Medicine, Houston, TX 77030, USA
    Viruses 4:1390-409. 2012
    ..In this review we will discuss the resting state and the causes behind viral restriction in resting cells, with emphasis on the role of microRNAs...
  10. ncbi Verifying quantitative stigma and medication adherence scales using qualitative methods among Thai youth living with HIV/AIDS
    Warunee Fongkaew
    Faculty of Nursing, Chiang Mai University, Chiang Mai, Thailand
    J Int Assoc Provid AIDS Care 13:69-77. 2014
    ..The differences between the quantitative and the qualitative results highlight the importance of validating psychometric scales when they are translated and used in other cultures. ..
  11. pmc miR-132 enhances HIV-1 replication
    Karen Chiang
    Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 438:1-4. 2013
    ..Knockdown of MeCP2, a previously identified target of miR-132, also increases HIV-1 replication. To the best of our knowledge, miR-132 is the first miRNA reported to enhance HIV-1 replication...
  12. ncbi Advances in basic and clinical immunology in 2012
    Javier Chinen
    Immunology, Allergy and Rheumatology Section, Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, TX 77030, USA
    J Allergy Clin Immunol 131:675-82. 2013
    ..The use of anti-IL-6 mAbs showed promise as an alternative treatment in patients with Schnitzler syndrome...
  13. ncbi Why Thailand should consider promoting neonatal circumcision?
    KriengKrai Srithanaviboonchai
    Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Thailand
    Southeast Asian J Trop Med Public Health 43:1218-26. 2012
    ..NC is an efficacious HIV prevention strategy that should be considered by those involved in HIV/AIDS prevention planning in Thailand. Further studies are needed to determine whether NC should be promoted in Thailand...
  14. pmc A variant macaque-tropic human immunodeficiency virus type 1 is resistant to alpha interferon-induced restriction in pig-tailed macaque CD4+ T cells
    Rajesh Thippeshappa
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 87:6678-92. 2013
    ..However, variants with resistance to IFN-α-induced restriction factors in PTM CD4(+) T cells may enhance viral replication by overcoming a barrier early in the viral replication cycle...
  15. pmc T-cell therapies for HIV
    Sharon Lam
    Center for Cell and Gene Therapy, 1102 Bates Street, Ste 1770 01, Houston, TX 77030, USA
    Immunotherapy 5:407-14. 2013
    ....
  16. pmc Complete absence of the αGal xenoantigen and isoglobotrihexosylceramide in α1,3galactosyltransferase knock-out pigs
    Gisella L Puga Yung
    Division of Clinical Immunology and Allergology, Department of Internal Medicine, University Hospital and Medical Faculty Geneva, Geneva, Switzerland
    Xenotransplantation 19:196-206. 2012
    ..The present work determined whether the terminal Galα1,3Gal disaccharide is completely absent in Immerge pigs lacking the GalT using several different highly sensitive methods...
  17. pmc Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection
    Samuel B Foster
    Baylor College of Medicine, Department of Pediatrics and Texas Children s Hospital, Houston, TX 77030, USA
    Clin Immunol 144:13-23. 2012
    ....
  18. pmc Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents
    George K Siberry
    Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Clin Immunol 142:201-8. 2012
    ..29%, p = 0.010). HIV-infected children and adolescents in this study had an increased incidence of asthma and AD, a finding critical for millions of HIV-infected children worldwide...
  19. pmc Epstein-Barr virus BART9 miRNA modulates LMP1 levels and affects growth rate of nasal NK T cell lymphomas
    Rajesh Ramakrishnan
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e27271. 2011
    ..Our findings may have direct application for improving NKTCL diagnosis and for developing possible novel treatment approaches for this tumor, for which current chemotherapeutic drugs have limited effectiveness...
  20. pmc Causes of hospitalization and perceived access to care among persons newly diagnosed with HIV infection: implications for HIV testing programs
    Lokesh Shahani
    University of Texas Health Science Center at Houston School of Public Health, Houston, Texas, USA
    AIDS Patient Care STDS 26:81-6. 2012
    ....
  21. pmc Validity of self-report measures in assessing antiretroviral adherence of newly diagnosed, HAART-naïve, HIV patients
    April Buscher
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    HIV Clin Trials 12:244-54. 2011
    ..To compare the performance of self-report instruments assessing adherence to antiretroviral therapy (ART) in patients starting ART for the first time and in a predominately Hispanic population...
  22. pmc The role of trust in delayed HIV diagnosis in a diverse, urban population
    James L Graham
    Legacy Community Health Services, Houston, TX, USA
    AIDS Behav 17:266-73. 2013
    ..Hispanics had the highest trust scores, followed by Blacks and Whites. Low trust is likely not a barrier to timely diagnosis of HIV infection...
  23. pmc Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes
    Karen Chiang
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 86:3244-52. 2012
    ..These results implicate miR-27b as a novel regulator of cyclin T1 protein levels and HIV-1 replication, while miR-29b, miR-223, and miR-150 may regulate cyclin T1 indirectly...
  24. pmc Advances in basic and clinical immunology in 2011
    Javier Chinen
    Allergy and Immunology Section, Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, Tex 77030, USA
    J Allergy Clin Immunol 129:342-8. 2012
    ....
  25. pmc Absence of XMRV in peripheral blood mononuclear cells of ARV-treatment naïve HIV-1 infected and HIV-1/HCV coinfected individuals and blood donors
    Cosmina Gingaras
    Section of Retrovirology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 7:e31398. 2012
    ..Based on evidence suggesting common transmission routes between XMRV and HIV-1, HIV-1 infected individuals may represent a high-risk group for XMRV infection and spread...
  26. pmc Genetic divergence of rotavirus nonstructural protein 4 results in distinct serogroup-specific viroporin activity and intracellular punctate structure morphologies
    Joseph M Hyser
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 86:4921-34. 2012
    ..These data suggest that elevated cytosolic calcium is a common critical process for all rotavirus strains...
  27. pmc High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients
    Zheng Wang
    Institutes of Biology and Medical Sciences, First Affiliated Hospital, Soochow University, Suzhou, China
    Glycobiology 22:930-8. 2012
    ..05). Our results suggest that AML-associated GSLs Lc3, GM3 and nLc4 are possibly involved in initiation and differentiation of AML...
  28. pmc Autoregulation of the Drosophila Noncoding roX1 RNA Gene
    Chiat Koo Lim
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, USA
    PLoS Genet 8:e1002564. 2012
    ..We offer a model describing how the production of roX1 and msl2, two key components of the MSL complex, are coordinated to meet the dosage compensation demands of the male cell...
  29. pmc Evaluation of the effectiveness of an outreach clinical mentoring programme in support of paediatric HIV care scale-up in Botswana
    Gelane Workneh
    Botswana Baylor Children s Clinical Centre of Excellence, Princess Marina Hospital, Gaborone, Botswana
    AIDS Care 25:11-9. 2013
    ..Further study will help refine approaches to clinical mentoring, including assuring mentoring translates into improved clinical outcomes for HIV-infected children...
  30. pmc Impact of antiretroviral dosing frequency and pill burden on adherence among newly diagnosed, antiretroviral-naive HIV patients
    A Buscher
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Int J STD AIDS 23:351-5. 2012
    ..Pill burden among once-daily regimens did not predict adherence, suggesting that factors other than pill burden should drive regimen selection...
  31. pmc Transmitted HIV drug resistance in treatment-naive Romanian patients
    Aura Temereanca
    Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    J Med Virol 85:1139-47. 2013
    ..The recent increase of HIV-1 infections which involve other subtypes impose a continuous surveillance of the genetic composition of the epidemic...
  32. ncbi Measurement issues in using pharmacy records to calculate adherence to antiretroviral drugs
    Deanna E Grimes
    Department of Nursing Systems, School of Nursing, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    HIV Clin Trials 14:68-74. 2013
    ..Researchers often use pharmacy records to calculate adherence to antiretrovirals. Variability in the findings may be due to inconsistent methods of calculating adherence...
  33. pmc The VP8* domain of neonatal rotavirus strain G10P[11] binds to type II precursor glycans
    Sasirekha Ramani
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 87:7255-64. 2013
    ..These studies provide the first molecular basis for understanding neonatal rotavirus infections, indicating that glycan modification during neonatal development may mediate the age-restricted infectivity of neonatal viruses...
  34. pmc The adaptor protein Crk in immune response
    Dongfang Liu
    1 Center for Human Immunobiology, Texas Children s Hospital, Baylor College of Medicine, Houston, TX, USA 2 Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA
    Immunol Cell Biol 92:80-9. 2014
    ..The aim of this review is to summarize recent key findings regarding the role of Crk in immune responses mediated by T, B and natural killer (NK) cells. In particular, the roles of Crk in NK cell functions are discussed. ..
  35. pmc Inflammasome activation by altered proteostasis
    Jin Na Shin
    From the Department of Medicine, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 288:35886-95. 2013
    ..Our results suggest that altered proteostasis results in inflammasome activation and thus provide mechanisms for the association of altered proteostasis with inflammatory disorders. ..
  36. ncbi HIV-1 circulating subtypes in Romania
    Loredana Sabina Cornelia Manolescu
    Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    Roum Arch Microbiol Immunol 72:121-34. 2013
    ..In this context, it is of outmost importance to follow the spreading of new emerging subtypes in the predictable setting of new infection waves in the Romanian HIV epidemic...
  37. pmc Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease
    Terry G Coursey
    Ocular Surface Center, Dept of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e78508. 2013
    ....
  38. pmc Regulation of IL-4 receptor signaling by STUB1 in lung inflammation
    Qin Wei
    1 Department of Medicine, Baylor College of Medicine, Houston, Texas and
    Am J Respir Crit Care Med 189:16-29. 2014
    ..However, the regulatory mechanisms underlying IL-4Rα turnover and its signal termination remain elusive...
  39. pmc Mammary cells with active Wnt signaling resist ErbB2-induced tumorigenesis
    Wen Bu
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas, United States of America Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e78720. 2013
    ....
  40. pmc HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation
    Neeti Agarwal
    Translational Metabolism Unit, Diabetes Research Center, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
    Sci Transl Med 5:213ra164. 2013
    ..Confirmation of these mechanisms in HIV patients could lead to targeted treatment of the metabolic complications with Vpr inhibitors, GR antagonists, or PPARγ/PPARα agonists. ..
  41. pmc FGFR1-WNT-TGF-β signaling in prostate cancer mouse models recapitulates human reactive stroma
    Julienne L Carstens
    Authors Affiliations Departments of Pathology and Immunology and Molecular and Cellular Biology and Dan L Duncan Cancer Center, Baylor College of Medicine, Houston M E DeBakey, Department of Veterans Affairs Medical Center, Houston, Texas
    Cancer Res 74:609-20. 2014
    ..Our findings establish the importance of the FGFR1-WNT-TGF-β signaling axes as driving forces behind reactive stroma in aggressive prostate adenocarcinomas, deepening their relevance as therapeutic targets...
  42. pmc Hemogenic endothelial cell specification requires c-Kit, Notch signaling, and p27-mediated cell-cycle control
    Kathrina L Marcelo
    Interdepartmental Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Children s Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Cell 27:504-15. 2013
    ..Thus, RA regulation of hemogenic endothelial cell specification requires c-Kit, notch signaling, and p27-mediated cell-cycle control...
  43. pmc Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin
    Oh Joon Kwon
    Departments of Molecular and Cellular Biology and Pathology and Immunology and the Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030
    Proc Natl Acad Sci U S A 111:E592-600. 2014
    ....
  44. pmc Ocular surface disease and dacryoadenitis in aging C57BL/6 mice
    Andrew J McClellan
    Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Houston, Texas
    Am J Pathol 184:631-43. 2014
    ..Taken together, our results indicate that age-related autoimmunity contributes to development of DED with aging. ..
  45. pmc Physician barriers to successful implementation of US Preventive Services Task Force routine HIV testing recommendations
    Micha Yin Zheng
    University of California, Berkeley, School of Public Health, Berkeley, CA, USA
    J Int Assoc Provid AIDS Care 13:200-5. 2014
    ..In April 2013, the US Preventive Services Task Force released a recommendation supporting routine HIV testing; strategies are needed to help address ongoing physician barriers to testing. ..
  46. pmc Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses
    Felix W Santiago
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
    J Virol 88:4572-85. 2014
    ....
  47. pmc Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation
    Jasmina Ziva Cerne
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States
    Invest Ophthalmol Vis Sci 55:2130-9. 2014
    ..In this study, we investigated the impact of small-molecule PKC inhibitors bisindolylmaleimide I (BIM) and sotrastaurin (AEB071), combined with ionizing radiation (IR), on survival in melanoma cell lines...
  48. pmc Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes
    Shyny Koshy
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e76740. 2013
    ..This results in a TRAM-34-induced increased ability of A-NK cells to reduce in vivo tumor growth. Taken together, our results suggest that targeting KCa3.1 on NK cells with selective blockers may be beneficial in cancer immunotherapy. ..
  49. pmc Computed tomography in patients with abdominal pain and diarrhoea: does the benefit outweigh the drawbacks?
    G M Aisenberg
    Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    Intern Med J 43:1141-4. 2013
    ..The probability of CT causing such a change does not outweigh the cost, radiation risk or potential for contrast-induced nephropathy...
  50. ncbi Capability of Thailand to implement newborn male circumcision: a nation-wide survey
    KriengKrai Srithanaviboonchai
    a Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    AIDS Care 26:20-5. 2014
    ..More information on the opinions of health authorities, health-care personnel and parents as well as cost-effectiveness studies are needed before a proper policy can be implemented. ..
  51. pmc Correctional facilities as partners in reducing HIV disparities
    Josiah D Rich
    Brown University Medical School, Providence, RI 02906, USA
    J Acquir Immune Defic Syndr 63:S49-53. 2013
    ....
  52. pmc Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death
    Giedre Krenciute
    Center for Molecular Discovery, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 288:20547-57. 2013
    ..Together our results suggest that the nuclear BAG6 complex is an effector in DNA damage response pathway and its phosphorylation and nuclear localization are important determinants for its function. ..
  53. pmc Heritable change caused by transient transcription errors
    Alasdair J E Gordon
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    PLoS Genet 9:e1003595. 2013
    ..Thus, like DNA mutations, transcriptional epimutations can instigate heritable changes that increase phenotypic diversity, which drives both evolution and disease. ..
  54. pmc Kin recognition protects cooperators against cheaters
    Hsing I Ho
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Biol 23:1590-5. 2013
    ..These findings provide direct evidence for the role of kin recognition in cheater control and suggest a mechanism for the maintenance of stable cooperative systems...
  55. pmc Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18
    Erin Leishman
    Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, One Baylor Plaza, BCM 505, Houston, TX 77030, USA
    Development 140:3809-18. 2013
    ....
  56. pmc Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress
    Niral B Gandhi
    1 Baylor College of Medicine, 6565 Fannin St, NC 505, Houston, TX 77030, USA
    J Leukoc Biol 94:1293-301. 2013
    ..Reconstitution of TSP-1KO mice with WT DCs prior to DS reversed the resistance of the TSP-1KO to DS-induced immunopathology. In conclusion, DC-derived TSP-1 is critical for generating the Th17 ocular surface response to DS. ..
  57. pmc Mutations in FBXL4 cause mitochondrial encephalopathy and a disorder of mitochondrial DNA maintenance
    Penelope E Bonnen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 93:471-81. 2013
    ..Together our data demonstrate that mutations in FBXL4 are disease causing and establish FBXL4 as a mitochondrial protein with a possible role in maintaining mtDNA integrity and stability. ..
  58. ncbi Autophagy regulates phagocytosis by modulating the expression of scavenger receptors
    Diana L Bonilla
    Department of Medicine Pulmonary and Critical Care Section, Baylor College of Medicine, Houston, TX 77030, USA
    Immunity 39:537-47. 2013
    ..These insights increase our understanding of the host-pathogen relationship and suggest that therapeutic strategies should be designed to include modulation of both phagocytosis and autophagy...
  59. pmc A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)
    Brandi L Carofino
    Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dis Model Mech 6:1494-506. 2013
    ..Furthermore, breeding R26PR to additional Cre lines will allow for the continued development of novel cancer models. ..
  60. pmc Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients
    Dan Nguyen
    Translational Metabolism Unit D N, R V S, Division of Diabetes, Endocrinology, and Metabolism Diabetes and Endocrinology Research Center D N, R V S and Department of Medicine J W H, F J, U S Department of Agriculture Agricultural Research Service, Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030
    J Clin Endocrinol Metab 99:169-77. 2014
    ....
  61. pmc FoxP3+ regulatory T cells are not important for rotavirus clearance or the early antibody response to rotavirus
    Amber D Miller
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Microbes Infect 16:67-72. 2014
    ..These data suggest FoxP3(+) regulatory T cells are not critical for the early antibody response to rotavirus infection. ..
  62. pmc Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine
    Scott M Hammer
    The authors affiliations are listed in the Appendix
    N Engl J Med 369:2083-92. 2013
    ..We tested the efficacy of a DNA prime-recombinant adenovirus type 5 boost (DNA/rAd5) vaccine regimen in persons at increased risk for HIV-1 infection in the United States...
  63. pmc Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity
    Joseph M Hyser
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Virol 87:13579-88. 2013
    ..This is the first report of viroporin-mediated activation of SOCE, reinforcing NSP4 as a robust model to understand dysregulation of calcium homeostasis during virus infections. ..
  64. pmc Assessing HIV testing and linkage to care activities and providing academic support to public health authorities in Houston, TX
    Thomas P Giordano
    Health Services Research Center of Excellence, Michael E DeBakey VA Medical Center, Houston, TX Department of Medicine, Baylor College of Medicine, Houston, TX and Houston Department of Health and Human Services, Houston, TX
    J Acquir Immune Defic Syndr 64:S7-13. 2013
    ..Health departments often have little knowledge of HIV testing and linkage activities outside of those they directly fund. Many health departments also have limited access to outside academic expertise...
  65. pmc Physiological IgM class catalytic antibodies selective for transthyretin amyloid
    Stephanie A Planque
    From the Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030
    J Biol Chem 289:13243-58. 2014
    ..Excess misTTR was dissolved by a hydrolytic mIgM. The studies reveal a novel antibody property, the innate ability of IgMs to selectively degrade and dissolve toxic misTTR species as a first line immune function. ..
  66. ncbi Activation of refractory T cell responses against hepatitis C virus core protein by ablation of interfering hydrophobic domains
    Helen A Andersson
    Center for Cell and Gene Therapy, Baylor College of Medicine Texas Children s Hospital The Methodist Hospital, Baylor College of Medicine, Houston, 77030, USA
    Mol Ther 13:338-46. 2006
    ..These results suggest that more potent HCV vaccines can be achieved by targeting the core protein for proteasomal degradation by deletion of its C-terminal hydrophobic domain...
  67. ncbi Seropositive human subjects produce interferon gamma after stimulation with recombinant Cryptosporidium hominis gp15
    Geoffrey A Preidis
    Translational Biology and Molecular Medicine Program, Infectious Disease Section Department of Medicine, Department of Immunology, and Department of Pathology, Baylor College of Medicine, Houston, Texas, USA
    Am J Trop Med Hyg 77:583-5. 2007
    ..parvum gp15 or either gp40 preparation. IFNgamma production in response to C. hominis gp15 was noted in both CD4(+) and CD8(+) cells. This highlights the potential for C. hominis gp15 as a vaccine candidate for human cryptosporidiosis...
  68. ncbi Long-term follow-up of patients with primary immunodeficiencies
    Javier Chinen
    Department of Pediatrics, Allergy and Immunology Section, Baylor College of Medicine, Houston, TX 77030, USA
    J Allergy Clin Immunol 120:795-7. 2007
    ..Patients with immunodeficiency are at high risk for the development of malignancy and autoimmune diseases and should be evaluated by a trained specialist with a frequency of not less than every 6 months...
  69. pmc Changes in simian immunodeficiency virus reverse transcriptase alleles that appear during infection of macaques enhance infectivity and replication in CD4+ T cells
    Tasha Biesinger
    Department of Molecular Virology and Microbiology, BCM385, Room 811D, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Virology 370:184-93. 2008
    ..Taken together, our data underscore the importance of RT determinants for pathogenicity of SIV and for the capacity to replicate in CD4(+) T cell populations...
  70. ncbi CD4/CD8 T-cell ratio predicts HIV infection in infants: the National Heart, Lung, and Blood Institute P2C2 Study
    William T Shearer
    Department of Pediatrics, Section of Allergy and Immunology, Baylor College of Medicine, Houston, TX, USA
    J Allergy Clin Immunol 120:1449-56. 2007
    ..In resource-poor regions of the world, HIV virologic testing is not available...
  71. ncbi Primary immunodeficiency: meeting the challenges
    William T Shearer
    J Allergy Clin Immunol 120:753-5. 2007
  72. ncbi Images in immunodeficiency
    William T Shearer
    Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, TX 77030, USA
    J Allergy Clin Immunol 120:982-4. 2007
  73. pmc Oral immunization of rhesus macaques with adenoviral HIV vaccines using enteric-coated capsules
    George T Mercier
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital, Texas Children s Hospital, Houston, TX, USA
    Vaccine 25:8687-701. 2007
    ....
  74. ncbi Diagnosis and management of HIV drug hypersensitivity
    Carla M Davis
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2399, USA
    J Allergy Clin Immunol 121:826-832.e5. 2008
    ....
  75. ncbi 6. Secondary immunodeficiencies, including HIV infection
    Javier Chinen
    Department of Pediatrics, Allergy and Immunology Section, Baylor College of Medicine, Texas Children s Hospital, 1102 Bates St Houston, TX 77030, USA
    J Allergy Clin Immunol 121:S388-92; quiz S417. 2008
    ....
  76. pmc Proposal for the development of a standardized protocol for assessing the economic costs of HIV prevention interventions
    Steven D Pinkerton
    Center for AIDS Intervention Research, Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, WI 53202, USA
    J Acquir Immune Defic Syndr 47:S10-4. 2008
    ....
  77. doi Breastfeeding and HIV infection
    William T Shearer
    Department of Pediatrics, Section of Allergy and Immunology, Baylor College of Medicine, Houston, Texa, USA
    Pediatrics 121:1046-7. 2008
  78. pmc Increased incidence of asthma in HIV-infected children treated with highly active antiretroviral therapy in the National Institutes of Health Women and Infants Transmission Study
    Samuel B Foster
    Department of Pediatrics, Allergy and Immunology Section, Baylor College of Medicine and Texas Children s Hospital, Houston, Tex 77030, USA
    J Allergy Clin Immunol 122:159-65. 2008
    ..Immunoreconstitution of HIV(+) patients after treatment with highly active antiretroviral therapy (HAART) appears to provoke inflammatory diseases...
  79. pmc Continuous improvement in the immune system of HIV-infected children on prolonged antiretroviral therapy
    Adriana Weinberg
    University of Colorado Denver School of Medicine, Denver, Colorado, USA
    AIDS 22:2267-77. 2008
    ..The goal of HAART is to promote reconstitution of CD4+ T cells and other immune responses. We evaluated the extent and the kinetics of immune reconstitution in HIV-infected children over 144 weeks of successful HAART...
  80. pmc SV40 lymphomagenesis in Syrian golden hamsters
    Adrienne L McNees
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Virology 384:114-24. 2009
    ....
  81. ncbi The Pediatric AIDS Corps: responding to the African HIV/AIDS health professional resource crisis
    Mark W Kline
    Baylor International Pediatric AIDS Initiative, Baylor College of Medicine and Texas Children s Hospital, Houston, Texas, USA
    Pediatrics 123:134-6. 2009
    ..We believe that this pilot program can serve as a model for larger-scale efforts to immediately expand access for African children and families to life-saving HIV/AIDS care and treatment...
  82. ncbi Advances in basic and clinical immunology in 2006
    Javier Chinen
    Department of Pediatrics, Allergy and Immunology Section, Baylor College of Medicine, Texas Children s Hospital, Houston, TX 77030, USA
    J Allergy Clin Immunol 120:263-70. 2007
    ..The modern understanding of immunologic concepts is helping to elucidate the mechanisms of defense against viruses, bacteria, and parasites; as a result, strategies to improve management and prevention continue to emerge...
  83. pmc ICAM-3 influences human immunodeficiency virus type 1 replication in CD4(+) T cells independent of DC-SIGN-mediated transmission
    Julia E Biggins
    Department of Molecular Virology and Microbiology, BCM385, Room 811D, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Virology 364:383-94. 2007
    ..Together, these data indicate that while ICAM-3 may influence HIV-1 replication, it does so independent of DC-SIGN-mediated virus transmission or activation of CD4(+) T cells...
  84. ncbi Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein
    Victor V Keasler
    Department of Molecular Virology and Microbiology, Baylor College of Medicine BCM 385, One Baylor Plaza, Houston, TX 77030 3411, USA
    Virology 347:466-75. 2006
    ..These results indicate that HBx expression contributes to increased liver pathogenesis in HCV transgenic mice by a mechanism that involves an imbalance in hepatocyte death and regeneration within the context of severe steatosis...
  85. ncbi Biologic and social determinants of sequelae and long-term survival of pediatric HIV in Romania
    Claudia A Kozinetz
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Ann Epidemiol 16:593-9. 2006
    ....
  86. ncbi Perspectives on the pediatric HIV/AIDS pandemic: catalyzing access of children to care and treatment
    Mark W Kline
    The Baylor International Pediatric AIDS Initiative, Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas, USA
    Pediatrics 117:1388-93. 2006
    ....
  87. ncbi The last 80 years in primary immunodeficiency: how far have we come, how far need we go?
    William T Shearer
    J Allergy Clin Immunol 117:748-52. 2006
  88. ncbi Community outreach with weekly delivery of anti-retroviral drugs compared to cognitive-behavioural health care team-based approach to improve adherence among indigent women newly starting HAART
    F Visnegarwala
    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, Room 465 EC, Houston, TX 77030, USA
    AIDS Care 18:332-8. 2006
    ....
  89. pmc Integration of human immunodeficiency virus type 1 in untreated infection occurs preferentially within genes
    Hongbing Liu
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Virol 80:7765-8. 2006
    ..Taken together, our data indicate that HIV-1 preferentially integrates within genes during untreated infection...
  90. ncbi Deficiencies in myeloid antigen-presenting cells in women with cervical squamous intraepithelial lesions
    Bang Ning Lee
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 107:999-1007. 2006
    ..In the current study the functions of dendritic cells in the development of T-cell immunity in women with cervical SILs were assessed...
  91. ncbi Simian virus 40 in posttransplant lymphoproliferative disorders
    Regis A Vilchez
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Pathol 37:1130-6. 2006
    ..These results suggest that SV40 may be associated with a small subset of PTLD cases. Additional studies are needed to determine the role of SV40 in EBV-negative PTLD...