Neuroscience Center for Biomedical Research Excellence

Summary

Principal Investigator: FRANCIS FLYNN
Abstract: This COBRE application builds on the foundation laid by the initial COBRE (RR15640). The Neuroscience COBRE has as its programmatic objective the establishment of a sustainable Center for Neuroscience. Significant progress has been made. Neuroscience was identified as one of four Areas of Distinction in the University Academic Plan. A critical mass of Neuroscience Center faculty is developing by the augmentation of existing faculty with the addition of three recent hires and the approval for 3-4 more Neuroscience faculty to be recruited during the next support period. Core research facilities have been established that have enhanced the biomedical research capability of investigators and which are necessary for the continued growth of the Neuroscience Center. Innovative research programs have developed as a result of COBRE established Core facilities for imaging the brain, and analysis of the genetic and protein structure of the nervous system. Multidisciplinary teams have formed that are comprised of electrical engineers, electro physiologists, and behavioral neuroscientists. Collectively these teams have as their thematic focus the study of activity dependent changes in neuronal function which are essential for the survival of the animal and normal brain function. The Neuroscience COBRE investigators will work on interrelated projects that seek to understand how central nervous system circuitry and neural pathways adapt to changes in sensory information. The model systems used by investigators will explore mechanisms underlying activity dependent changes in neural systems due to alterations in visual (including photoperiod), somatosensory, and nociceptive input. Approaches to these functional questions will be multidisciplinary with the investigators sharing electrophysiological, pharmacological, molecular, and neuroanatomical techniques. Through collaborative efforts, computational processing algorithms may be developed to model activity dependent changes in mature, functional systems. Collectively, the projects will show the degree to which inhibitory circuits shape the neuronal architecture of incoming sensory inputs at multiple levels of the nervous system and in multiple sensory systems. The overall scientific objective is to advance our understanding of neural systems controlling sensory processing, neurochemical and neuroendocrine signaling and behavior, so as to facilitate prevention and treatment of: pathological states resulting from sensory restriction, neuroendocrine dysfunction, and chronic pain.
Funding Period: ----------------2000 - ---------------2011-
more information: NIH RePORT

Top Publications

  1. pmc Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis
    Asli F Ceylan-Isik
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
    J Mol Cell Cardiol 48:367-78. 2010
  2. ncbi Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models
    Jun Ren
    Centerfor Cardiovascular Research and Alternative Medicne, University of Wyoming, 1000 E University Avenue, Department 3375, Laramie, WY 82071, USA
    Novartis Found Symp 285:69-76; discussion 76-9, 198-9. 2007
  3. ncbi Novel heme-based oxygen sensor with a revealing evolutionary history
    Oleg V Moskvin
    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Biol Chem 282:28740-8. 2007
  4. ncbi Selective inhibition of cyclooxygenase-2 exacerbates methamphetamine-induced dopamine depletion in the striatum in rats
    X Zhang
    Division of Pharmaceutical Sciences, Graduate Neuroscience Program and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071 3375, USA
    Neuroscience 150:950-8. 2007
  5. pmc The missing piece in the 'use it or lose it' puzzle: is inhibition regulated by activity or does it act on its own accord?
    Qian Quan Sun
    Laboratory of Neural Development and Learning, Department of Zoology and Physiology and Neuroscience Program, University of Wyoming, Laramie, WY, USA
    Rev Neurosci 18:295-310. 2007
  6. ncbi Myelinated skin sensory neurons project extensively throughout adult mouse substantia gelatinosa
    M Danilo Boada
    Department of Zoology and Physiology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Neurosci 28:2006-14. 2008
  7. pmc Cleavage of Mcd1 by caspase-like protease Esp1 promotes apoptosis in budding yeast
    Hui Yang
    Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA
    Mol Biol Cell 19:2127-34. 2008
  8. ncbi Tachykinin neurokinin 3 receptor signaling in cholecystokinin-elicited release of oxytocin and vasopressin
    Gwendolen E Haley
    Neuroscience Program, University of Wyoming, Laramie, WY 82071, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1760-7. 2008
  9. pmc Immunoreactive GnRH type I receptors in the mouse and sheep brain
    Asher J Albertson
    Department of Zoology and Physiology and Neurobiology Program, University of Wyoming, Dept 3166, 1000 E University Avenue, Laramie, WY 82071, USA
    J Chem Neuroanat 35:326-33. 2008
  10. ncbi Musca domestica inspired machine vision sensor with hyperacuity
    D T Riley
    Sensors and Platform Branch, Naval Air Warfare Center, China Lake, CA, USA
    Bioinspir Biomim 3:026003. 2008

Scientific Experts

  • D C Skinner
  • Catherine S Hubbard
  • FRANCIS FLYNN
  • QIANQUAN SUN
  • CELIA SLADEK
  • Jonathan H Fox
  • Gwendolen E Haley
  • Asher J Albertson
  • Oleg V Moskvin
  • Shawna M McBride
  • Mark Gomelsky
  • Jun Ren
  • X Zhang
  • M Danilo Boada
  • Steven F Barrett
  • ChunZhao Zhang
  • F Dong
  • C Jeffery Woodbury
  • Cameron H G Wright
  • John B Benson
  • A W Smith
  • W Andrew Taylor
  • Yi Ye
  • D D Jensen
  • Asli F Ceylan-Isik
  • Andrew Young
  • J D Davis
  • J Ren
  • Marie Alda Gilles-Gonzalez
  • C H G Wright
  • S F Barrett
  • Hui Yang
  • B Culver
  • Alain Caraty
  • D T Riley
  • Larissa Gomelsky
  • D Jensen
  • Leah Selby
  • Bruce Culver
  • Jeffrey R Anderson
  • Travis M Anderson
  • Tanja Zeller
  • Gavin R Philips
  • Shi Yan Li
  • Yuanyuan Jiao
  • Mark H Harpster
  • Thu T Dinh
  • Jinhong Duan
  • W J Murdoch
  • B S Edwards
  • C S Asa
  • Carole Hertz
  • T John Wu
  • Neil P Evans
  • Xiaoyan Xiao
  • Bingfang Zhang
  • K Sundstrom
  • Guohai Su
  • Peng Zhao
  • M J Driscoll
  • K A Ryff
  • M Wilcox
  • W T Malik
  • K J Luhrs
  • Timothy J Donohue
  • W M Harmann
  • Denise F Jones
  • Heather Talbott
  • Laurence Dufourny
  • Zhaojie Zhang
  • Rachel A Stenzel
  • Amy Navratil
  • Mallory Mignot
  • Z Zhang
  • Qun Ren
  • Qi Wang
  • Brian Cherrington
  • Dane Jensen
  • Gabriele Klug
  • D C Bruch
  • Samuel Kaplan
  • G E Mayer
  • Kuanyu Li
  • Mobarak A Mraheil
  • Andrew A Catellier
  • Shaik Shavali
  • Yizhen Liu
  • Mark M Stayton
  • Manuchair Ebadi
  • Jacque A Keele

Detail Information

Publications54

  1. pmc Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis
    Asli F Ceylan-Isik
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
    J Mol Cell Cardiol 48:367-78. 2010
    ..LPS activated AMPK and its downstream signaling ACC in conjunction with an elevated AMP/ATP ratio, which was unaffected by MT. Taken together, our data favor a beneficial effect of MT in the management of cardiac dysfunction in sepsis...
  2. ncbi Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models
    Jun Ren
    Centerfor Cardiovascular Research and Alternative Medicne, University of Wyoming, 1000 E University Avenue, Department 3375, Laramie, WY 82071, USA
    Novartis Found Symp 285:69-76; discussion 76-9, 198-9. 2007
    ....
  3. ncbi Novel heme-based oxygen sensor with a revealing evolutionary history
    Oleg V Moskvin
    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Biol Chem 282:28740-8. 2007
    ..A phylogenetic analysis revealed that SCHIC domain proteins form a distinct cluster within a superfamily that includes vitamin B(12)-binding proteins and other proteins that may bind other kinds of tetrapyrroles...
  4. ncbi Selective inhibition of cyclooxygenase-2 exacerbates methamphetamine-induced dopamine depletion in the striatum in rats
    X Zhang
    Division of Pharmaceutical Sciences, Graduate Neuroscience Program and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071 3375, USA
    Neuroscience 150:950-8. 2007
    ..The COX-2 induction appears during the recovery period, and NFkappa B activation may be an important mechanism...
  5. pmc The missing piece in the 'use it or lose it' puzzle: is inhibition regulated by activity or does it act on its own accord?
    Qian Quan Sun
    Laboratory of Neural Development and Learning, Department of Zoology and Physiology and Neuroscience Program, University of Wyoming, Laramie, WY, USA
    Rev Neurosci 18:295-310. 2007
    ..and cellular mechanisms that underlie the activity-dependent maturation of inhibitory networks? 5) What are the functional advantages of experience-dependent plasticity of inhibitory networks to network processing in sensory cortices?..
  6. ncbi Myelinated skin sensory neurons project extensively throughout adult mouse substantia gelatinosa
    M Danilo Boada
    Department of Zoology and Physiology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Neurosci 28:2006-14. 2008
    ..Arguments are presented that the SG likely plays a predominant role in tactile processing under normal conditions, but that this role switches rapidly to nociceptive-only during environmental exigencies imposed by temperature extremes...
  7. pmc Cleavage of Mcd1 by caspase-like protease Esp1 promotes apoptosis in budding yeast
    Hui Yang
    Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA
    Mol Biol Cell 19:2127-34. 2008
    ..When apoptosis is induced, Esp1 is released from the anaphase inhibitor Pds1. The activated Esp1 acts as caspase-like protease for the cleavage of Mcd1, which enhances the cell death via its translocation from nucleus to mitochondria...
  8. ncbi Tachykinin neurokinin 3 receptor signaling in cholecystokinin-elicited release of oxytocin and vasopressin
    Gwendolen E Haley
    Neuroscience Program, University of Wyoming, Laramie, WY 82071, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1760-7. 2008
    ..Therefore, central NK3R signaling is required for OT and VP release in response to CCK administration...
  9. pmc Immunoreactive GnRH type I receptors in the mouse and sheep brain
    Asher J Albertson
    Department of Zoology and Physiology and Neurobiology Program, University of Wyoming, Dept 3166, 1000 E University Avenue, Laramie, WY 82071, USA
    J Chem Neuroanat 35:326-33. 2008
    ..Although GnRH may act at some of these sites to regulate reproductive processes, evidence is accumulating to support an extra-reproductive role for this hypothalamic decapeptide...
  10. ncbi Musca domestica inspired machine vision sensor with hyperacuity
    D T Riley
    Sensors and Platform Branch, Naval Air Warfare Center, China Lake, CA, USA
    Bioinspir Biomim 3:026003. 2008
    ..The sensor's ability to locate a line stimulus in a two-dimensional space is demonstrated. Discussion is provided to extend this work in scale, cartridge dimension, information and array processing...
  11. pmc Gonadotropin-releasing hormone in third ventricular cerebrospinal fluid: endogenous distribution and exogenous uptake
    Alain Caraty
    Unité Mixte de Recherche 6175, Physiologie de la Reproduction et des Comportements Institut National de la Recherche Agronomique Centre National de la Recherche Scientifique Université Tours Haras Nationaux, 37380, Nouzilly, France
    Endocrinology 149:5227-34. 2008
    ..Thus, CSF-GnRH may affect sites that are closer in proximity to the infundibular recess region than previously thought...
  12. pmc Trafficking of tachykinin neurokinin 3 receptor to nuclei of neurons in the paraventricular nucleus of the hypothalamus following osmotic challenge
    D Jensen
    Graduate Neuroscience Program, University of Wyoming, Department 3166, Laramie, WY 82071, USA
    Neuroscience 155:308-16. 2008
    ..NK3R antibody specificity was confirmed by small interfering (SI) RNA technology. This study establishes that the NK3R is trafficked to the nucleus of PVN neurons following a peripheral osmotic challenge...
  13. ncbi The gonadotropin-releasing hormone type I receptor is expressed in the mouse cerebellum
    Asher J Albertson
    Department of Zoology and Physiology and Neurobiology Program, University of Wyoming, Dept 3166, 1000 E University Avenue, Laramie, WY 82071, USA
    Cerebellum 7:379-84. 2008
    ..Dysfunction of this link occurs in the rare genetic ataxia disorders--Gordon Holmes syndrome and Boucher-Neuhauser syndrome...
  14. pmc Dietary sodium manipulation during critical periods in development sensitize adult offspring to amphetamines
    Shawna M McBride
    Graduate Neuroscience Program, Dept of Zoology and Physiology, Univ of Wyoming, Laramie, WY 82071, USA
    Am J Physiol Regul Integr Comp Physiol 295:R899-905. 2008
    ..These results indicate that early life experience with low- and high-sodium diets, during the prenatal or early postnatal period, is a stress that produces long-term changes in responsiveness to amphetamines and to subsequent stressors...
  15. pmc Blockade of NK3R signaling in the PVN decreases vasopressin and oxytocin release and c-Fos expression in the magnocellular neurons in response to hypotension
    Gwendolen E Haley
    Graduate Neuroscience Program, University of Wyoming, Laramie, Wyoming 82071, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1158-67. 2008
    ..Therefore, NK3R signaling in magnocellular neurons has a critical role for the release of VP and OT in response to hypotension...
  16. pmc Hierarchical regulation of photosynthesis gene expression by the oxygen-responsive PrrBA and AppA-PpsR systems of Rhodobacter sphaeroides
    Larissa Gomelsky
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
    J Bacteriol 190:8106-14. 2008
    ....
  17. ncbi Centrally administered vasopressin cross-sensitizes rats to amphetamine and drinking hypertonic NaCl
    Shawna M McBride
    Graduate Neuroscience Program, Department of Zoology and Physiology, University of Wyoming, 1000 E University Ave, Laramie, WY 82071, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1452-8. 2007
    ..This pattern of cross-sensitization links central VP signaling, amphetamine, and sodium deficiency, and therefore it may play a role in the cross-sensitization between sodium appetite and amphetamines...
  18. ncbi Physiological properties of mouse skin sensory neurons recorded intracellularly in vivo: temperature effects on somal membrane properties
    M Danilo Boada
    Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA
    J Neurophysiol 98:668-80. 2007
    ..This novel in vivo preparation therefore holds considerable promise for future analyses of nociceptor function and plasticity in normal and transgenic models of pain mechanisms...
  19. ncbi Agonist and hypertonic saline-induced trafficking of the NK3-receptors on vasopressin neurons within the paraventricular nucleus of the hypothalamus
    Gwendolen E Haley
    Dept of Zoology and Physiology, Univ of Wyoming, Laramie, WY 82071, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1242-50. 2006
    ..These results show that hyperosmolarity stimulates the local release of an endogenous ligand in the PVN to bind to and activate NK3R on vasopressinergic neurons...
  20. ncbi Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling
    Shi Yan Li
    Center for Cardiovascular Research and Alterative Medicine, Division of Pharmaceutical Sciences, University of Wyoming, Laramie, WY 82071, USA
    J Mol Cell Cardiol 40:283-94. 2006
    ..Our data are consistent with the notion of acetaldehyde as a contributor to alcoholic cardiomyopathy and implicate the therapeutic potential of ALDH2 enzyme in alcoholic complications...
  21. ncbi Prenatal and early postnatal dietary sodium restriction sensitizes the adult rat to amphetamines
    Shawna M McBride
    Graduate Neuroscience Program, Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1192-9. 2006
    ..These results show that early life experience with low-sodium diets produce long-term changes in adult rats' behavioral responses to amphetamine...
  22. ncbi Hypotensive hypovolemia and hypoglycemia activate different hindbrain catecholamine neurons with projections to the hypothalamus
    Thu T Dinh
    Programs in Neuroscience, Washington State University, Pullman, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 291:R870-9. 2006
    ..Lack of an AVP response to insulin-induced hypoglycemia in intact rats therefore indicates that responses to hypovolemia and hypoglycemia are mediated by different catecholamine neurons under distinct sensory controls...
  23. ncbi Phytoestrogen alpha-zearalanol antagonizes homocysteine-induced imbalance of nitric oxide/endothelin-1 and apoptosis in human umbilical vein endothelial cells
    Jinhong Duan
    University of North Dakota School of Medicine, Grand Forks, ND Chinese Academy of Medical Sciences, Beijing, P R China
    Cell Biochem Biophys 45:137-45. 2006
    ..In summary, these results suggested that alpha-ZAL may effectively preserve Hcy-induced decrease in NO, increase in ET-1/NO ratio and apoptosis, which contributes to protective effects of phytoestrogens on endothelial function...
  24. ncbi Earliest changes in the left ventricular transcriptome postmyocardial infarction
    Mark H Harpster
    Department of Molecular Biology, University of Wyoming, Laramie, 82071, USA
    Mamm Genome 17:701-15. 2006
    ..ARG1: was the single-most highly induced transcript in the database (121-fold in IF region) and its induction in heart has not been previously reported...
  25. ncbi Major effects of sensory experiences on the neocortical inhibitory circuits
    Yuanyuan Jiao
    Department of Zoology and Physiology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Neurosci 26:8691-701. 2006
    ..Together, these results suggest that the properties of local intracortical inhibitory networks are modified by sensory experiences. Perisomatic inhibition mediated by PV-positive basket cells is pruned by sensory deprivation...
  26. ncbi Novel interneuronal network in the mouse posterior piriform cortex
    ChunZhao Zhang
    Department of Zoology and Physiology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Comp Neurol 499:1000-15. 2006
    ..We conclude that the GAD65-GFP neurons may play distinct roles in regulating information flow and olfactory-related oscillation within the PPC in vivo...
  27. pmc Major defects in neocortical GABAergic inhibitory circuits in mice lacking the fragile X mental retardation protein
    Leah Selby
    Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, United States
    Neurosci Lett 412:227-32. 2007
    ..Uncovering the changes in specific GABAergic inhibitory circuits could help understand mechanisms underlying the behavior deficits of fragile X syndrome and autism...
  28. ncbi Intraventricular injections of tachykinin NK3 receptor agonists suppress the intake of "salty" tastes by sodium deficient rats
    Francis W Flynn
    Department of Zoology and Physiology, Graduate Neuroscience Program, University of Wyoming, Laramie, WY 82071, USA
    Behav Brain Res 166:1-8. 2006
    ....
  29. ncbi Tachykinin NK3 receptor contribution to systemic release of vasopressin and oxytocin in response to osmotic and hypotensive challenge
    Gwendolen E Haley
    Graduate Neuroscience Program, University of Wyoming, Laramie, WY 82071, USA
    Am J Physiol Regul Integr Comp Physiol 293:R931-7. 2007
    ..HDZ-induced VP and OT release was eliminated by pretreatment with 500 pmol SB-222200. Therefore, NK3R activation contributes significantly to the systemic release of both VP and OT in response to osmotic and hypotensive challenges...
  30. ncbi Biomimetic motion detection based on overlapping Gaussian profiles
    Travis M Anderson
    University of Wyoming, Laramie, Wyoming, USA
    Biomed Sci Instrum 43:372-7. 2007
    ..The advantages of this approach will also be explained by comparing motion detection using overlapping Gaussian profiles to the traditional elementary motion detector proposed by Reichardt...
  31. ncbi A quantitative comparison between manual segmentation and threshold-based segmentation of CLSM recorded images
    Jeffrey R Anderson
    Electrical and Computer Engineering, University of Wyoming, Laramie, WY 82071, USA
    Biomed Sci Instrum 43:290-5. 2007
    ..The image sample used in this report is a portion of the brain of the common housefly, Musca domestica. The very small size of the object makes it impractical to compare the computer segmentation results to the actual object...
  32. ncbi Line width determination using a biomimetic fly eye vision system
    John B Benson
    Electrical and Computer Engineering Department, University of Wyoming, Laramie, WY, USA
    Biomed Sci Instrum 43:224-9. 2007
    ..This is an important first step for determining the width of any arbitrary object, with unknown velocity...
  33. ncbi Electrooculogram wheelchair control
    Gavin R Philips
    University of Wyoming, Laramie, Wyoming, USA
    Biomed Sci Instrum 43:164-9. 2007
    ..Finally, an ultra-sonic rangefinder was added to provide an extra measure of safety, alerting the user to sudden changes in grade. This is part of an ongoing project to allow greater independence for those with special needs...
  34. pmc Regulation of hydrogen peroxide-dependent gene expression in Rhodobacter sphaeroides: regulatory functions of OxyR
    Tanja Zeller
    Institut fur Mikrobiologie und Molekularbiologie, University of Giessen, Giessen, Germany
    J Bacteriol 189:3784-92. 2007
    ..The role of reduced OxyR as an activator is shown for the first time. Our data reveal that the OxyR-mediated response is fast and transient. In addition, we found that additional regulatory pathways are involved in the H(2)O(2) response...
  35. pmc Early postnatal loss of heat sensitivity among cutaneous myelinated nociceptors in Swiss-Webster mice
    Yi Ye
    Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA
    J Neurophysiol 103:1385-96. 2010
    ..Potential mechanisms underlying these postnatal changes in AMH number are discussed...
  36. pmc The PpaA/AerR regulators of photosynthesis gene expression from anoxygenic phototrophic proteobacteria contain heme-binding SCHIC domains
    Oleg V Moskvin
    Department of Molecular Biology, University of Wyoming, Dept 3944, 1000 E University Ave, Laramie, WY 82071, USA
    J Bacteriol 192:5253-6. 2010
    ..Here we show that the predicted SCHIC domain PpaA/AerR regulators also bind heme and respond to oxygen in vitro, despite their low sequence identity with AppA...
  37. pmc Expression of the nuclear transport protein importin ß-1 and its association with the neurokinin 3 receptor in the rat hypothalamus following acute hyperosmotic challenge
    D D Jensen
    Neuroscience Program and Department of Zoology and Physiology, University of Wyoming, 1000 E University Avenue, Laramie, WY 82071, USA
    Neuroscience 170:1020-7. 2010
    ..This is the first in vivo study linking importin ß-1 and the nuclear transport of a G protein coupled receptor, the NK3R, in brain...
  38. ncbi The heart: a novel gonadotrophin-releasing hormone target
    F Dong
    College of Health Sciences, University of Wyoming, Laramie, WY 82071, USA
    J Neuroendocrinol 23:456-63. 2011
    ..If present in the human heart, dysfunction of such a system may play an important role in cardiac pathology observed in men treated with GnRH agonists for prostate cancer...
  39. pmc Intra-pituitary administration revisited: development of a novel in vivo approach to investigate the ovine hypophysis
    W Andrew Taylor
    Neurobiology Program and Department of Zoology and Physiology, University of Wyoming, 1000 E Univ Ave, Dept 3166, Laramie, WY 82071, USA
    J Neurosci Methods 199:175-82. 2011
    ..Using this technique, infusion of TRH (17 ng/1 μl/min for up to 6h) induced a sustained rise in systemic prolactin levels that lasted for the duration of the infusion...
  40. pmc Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein
    Jonathan H Fox
    Department of Veterinary Science and Neuroscience Graduate Program, University of Wyoming, Laramie, Wyoming 82070, USA
    J Biol Chem 286:18320-30. 2011
    ..These findings show that inhibiting formation of oxidation-dependent huntingtin oligomers, or promoting their dissolution, may have protective effects in HD by decreasing the burden of soluble mutant huntingtin...
  41. pmc Characterization of nuclear neurokinin 3 receptor expression in rat brain
    C D Sladek
    Department of Physiology and Biophysics, University of Colorado School of Medicine, 12800 E 19th Avenue, Aurora, CO 80045, USA
    Neuroscience 196:35-48. 2011
    ..Since NK3-R is widely distributed in the CNS, the presence of NK3-R in nuclei from multiple brain regions suggests that it may broadly influence CNS gene expression in a ligand-dependent manner...
  42. pmc Neurokinin 3 receptor forms a complex with acetylated histone H3 and H4 in hypothalamic neurons following hyperosmotic challenge
    Francis W Flynn
    Graduate Neuroscience Program, Department of Zoology and Physiology, University of Wyoming, Laramie, Wyoming, USA
    Am J Physiol Regul Integr Comp Physiol 301:R822-31. 2011
    ..In response to hyperosmolarity, NK3R is transported to the nucleus of PVN neurons and associates with transcriptionally active chromatin, where it may influence the transcription of genes...
  43. pmc Brainstem reticulospinal neurons are targets for corticotropin-releasing factor-Induced locomotion in roughskin newts
    Catherine S Hubbard
    Neuroscience Program, University of Wyoming, Laramie, WY 82071 3166, USA
    Horm Behav 57:237-46. 2010
    ....
  44. ncbi A bio-inspired apposition compound eye machine vision sensor system
    J D Davis
    Applied Research Laboratories, University of Texas, 10000 Burnet Rd, Austin, TX 78757, USA
    Bioinspir Biomim 4:046002. 2009
    ..The robot exhibits the ability to follow a pre-defined target and avoid specified obstacles using a simple control algorithm...
  45. pmc Substance P-immunoreactive cells in the ovine pars tuberalis
    Donal C Skinner
    Department of Zoology and Physiology, and Neurobiology Program, University of Wyoming, Laramie, Wyo 82071, USA
    Neuroendocrinology 89:3-8. 2009
    ..RT-PCR confirmed the presence of preprotachykinin A mRNA in the PT. We hypothesize that SP, and possibly other preprotachykinin A-derived tachykinins, may play a role in the seasonal regulation of prolactin secretion in sheep...
  46. pmc Rethinking the stalk effect: a new hypothesis explaining suprasellar tumor-induced hyperprolactinemia
    Donal C Skinner
    Department of Zoology, Physiology and Neurobiology Program, University of Wyoming, Dept 3166, 1000 E University Avenue, Laramie, WY 82071, USA
    Med Hypotheses 72:309-10. 2009
    ..Hypothesized candidates are the preprotachykinin A derived tachykinins, substance P and/or neurokinin A...
  47. pmc Effects of gonadotrophin-releasing hormone outside the hypothalamic-pituitary-reproductive axis
    D C Skinner
    Neurobiology Program and Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA
    J Neuroendocrinol 21:282-92. 2009
    ....
  48. pmc Differential metabotropic glutamate receptor expression and modulation in two neocortical inhibitory networks
    Qian Quan Sun
    Dept of Zoology, University of Wyoming, Laramie, WY 82071, USA
    J Neurophysiol 101:2679-92. 2009
    ..The results reported here help to increase our understanding of the roles of mGluRs in endogenous glutamatergic-induced plasticity of interneuronal networks...
  49. ncbi Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice
    X Zhang
    Division of Pharmaceutical Sciences and Graduate Neuroscience Program, University of Wyoming, College of Health Sciences, Department 3375, 1000 East University Avenue, Laramie, WY 82071 3375, USA
    Neuroscience 161:53-8. 2009
    ..Our findings suggest that NF-kappaB can mediate induction of COX-2, TNFalpha and astrogliosis in APPswe/PS1dE9 mice. Additionally, these results support the idea that neuroinflammation contributes to the clearance of Abeta...
  50. pmc GABAergic inhibitory interneurons in the posterior piriform cortex of the GAD67-GFP mouse
    Andrew Young
    Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA
    Cereb Cortex 19:3011-29. 2009
    ..These data aid in the identification of PPC interneurons and allow us to make well-supported postulations about their functional properties...
  51. pmc Identification of brain target neurons using a fluorescent conjugate of corticotropin-releasing factor
    Catherine S Hubbard
    Neuroscience Program, University of Wyoming, Laramie, WY 82071 3166, United States
    J Chem Neuroanat 37:245-53. 2009
    ....
  52. pmc A novel animal model to study hot flashes: no effect of gonadotropin-releasing hormone
    Asher J Albertson
    Department of Zoology and Physiology and Neurobiology Program, University of Wyoming, Laramie, WY 82071, USA
    Menopause 16:1030-6. 2009
    ..The physiological mechanisms underlying hot flashes remain poorly understood, and the absence of an animal model to investigate hot flashes hinders investigations in this field...
  53. ncbi Predominant suppression of follicle-stimulating hormone β-immunoreactivity after long-term treatment of intact and castrate adult male rats with the gonadotrophin-releasing hormone agonist deslorelin
    A W Smith
    Neurobiology Program and Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA
    J Neuroendocrinol 24:737-47. 2012
    ..We hypothesise that the FSH dominant suppression may be central to the long-term contraceptive efficacy of deslorelin in the male...