Center for Integrative Neuroscience

Summary

Principal Investigator: Michael A Webster
Abstract: DESCRIPTION (provided by applicant): This proposal is to create a Center of Biomedical Research Excellence (COBRE) in Integrative Neuroscience at the University of Nevada, Reno (UNR). Research in the neurosciences is proceeding on many fronts and addressing fundamental questions in both basic and clinical science. The aim of this COBRE is to establish a research center that can promote interdisciplinary interactions and investigations of neural function, impairments, and repair, by bridging and cross-fertilizing several research units at UNR that have already developed teams of focused expertise in neuroscience, from molecular to behavioral and from understanding normal structure and function to neurological deficits and their treatment. The center will span 3 different colleges and the Medical School, and will support projects led by 5 highly accomplished junior faculty drawn from the departments of Psychology, Biology, Biomedical Engineering, and Physiology and Cell Biology. The research and professional development of these faculty will be mentored by a strong team of successful researchers who will also bring perspectives and expertise drawn from many disciplines. The center will also provide the infrastructure to support the projects as well as new research opportunities throughout the institution by establishing two new core facilities. One core will support training, use, and analysis of structural and functional magnetic resonance imaging (MRl). This core will provide - for the first time - access at UNR to the now standard research tools provided by MRl. The second core will support investigations directed at different patient populations by developing a database that will allow researchers to identify and recruit participants with well defined neurological lesions. Both the center and new core facilities will expand research strengths and translational neuroscience at UNR in entirely new directions, while providing infrastructure that has broad applications in both basic and clinical research and can thus support use and research synergisms across many disciplines and programs on campus and in the state.
Funding Period: 2012-09-05 - 2017-05-31
more information: NIH RePORT

Top Publications

  1. pmc Differential frontal involvement in shifts of internal and perceptual attention
    Ryan T Tanoue
    Department of Psychology, University of Nevada, 1664 N Virginia Street, Reno, NV 89557, USA
    Brain Stimul 6:675-82. 2013
  2. pmc Color synesthesia improves color but impairs motion perception
    J Daniel McCarthy
    Department of Psychology, University of Nevada Reno, Mailstop 296, Reno, NV 89577, USA
    Trends Cogn Sci 18:224-6. 2014
  3. pmc Orienting attention in visual working memory requires central capacity: decreased retro-cue effects under dual-task conditions
    Markus Janczyk
    Department of Psychology III, Julius Maximilians University of Wurzburg, Rontgenring 11, 97070, Wurzburg, Germany
    Atten Percept Psychophys 76:715-24. 2014
  4. pmc Two plus blue equals green: grapheme-color synesthesia allows cognitive access to numerical information via color
    J Daniel McCarthy
    Department of Psychology, University of Nevada, Mail stop 296, Reno, NV 89557, USA Electronic address
    Conscious Cogn 22:1384-92. 2013
  5. pmc Synesthetic grapheme-color percepts exist for newly encountered Hebrew, Devanagari, Armenian and Cyrillic graphemes
    Christopher David Blair
    Department of Psychology, Program in Cognitive and Brain Science, University of Nevada, Reno, NV 89557, United States Electronic address
    Conscious Cogn 22:944-54. 2013
  6. pmc The Gestalt principle of similarity benefits visual working memory
    Dwight J Peterson
    Department of Psychology 296, University of Nevada, Reno, 1664 N Virginia Street, Reno, NV, 89557, USA
    Psychon Bull Rev 20:1282-9. 2013
  7. pmc Molecular mechanisms of age-related sleep loss in the fruit fly - a mini-review
    Meagan Robertson
    Department of Biology, University of Nevada, Reno, NV 89557, USA
    Gerontology 59:334-9. 2013
  8. pmc Effects of attention on visual experience during monocular rivalry
    Eric A Reavis
    Department of Psychological and Brain Sciences, Dartmouth College, 6207 Moore Hall, Hanover, NH 03755, USA
    Vision Res 83:76-81. 2013
  9. pmc COMT and ANKK1-Taq-Ia genetic polymorphisms influence visual working memory
    Marian E Berryhill
    Memory and Brain Laboratory, Department of Psychology, University of Nevada, Reno, Nevada, United States of America
    PLoS ONE 8:e55862. 2013
  10. pmc Dynamic illusory size contrast: a relative-size illusion modulated by stimulus motion and eye movements
    Ryan E B Mruczek
    Department of Psychology, University of Nevada, Reno, Reno, NV, USA
    J Vis 14:2. 2014

Research Grants

  1. CENTER FOR GASTROINTESTINAL BIOLOGY AND DISEASE
    Robert S Sandler; Fiscal Year: 2013
  2. CENTER FOR BIOMEDICAL RESEARCH
    Timothy Turner; Fiscal Year: 2013
  3. Molecular Mechanisms of Fate Choice in Neural Stem Cells (P01)
    Charles D Stiles; Fiscal Year: 2013
  4. Regulation of CNS viral persistence
    Cornelia Bergmann; Fiscal Year: 2013
  5. COBRE for Skeletal Health and Repair
    Qian Chen; Fiscal Year: 2013
  6. Synaptic Function: Effects of the Nerve Injury, Repair, and Altered Activity
    Timothy C Cope; Fiscal Year: 2013
  7. Endogenous Cannabinoids and Brain Function
    Aron H Lichtman; Fiscal Year: 2013
  8. Vermont Center on Behavior and Health
    Stephen T Higgins; Fiscal Year: 2013
  9. Molecular and Cellular Therapies for Muscular Dystrophy
    Stanley C Froehner; Fiscal Year: 2013
  10. Semi-volatile PCBs: Sources, Exposures, Toxicities
    Larry W Robertson; Fiscal Year: 2013

Detail Information

Publications14

  1. pmc Differential frontal involvement in shifts of internal and perceptual attention
    Ryan T Tanoue
    Department of Psychology, University of Nevada, 1664 N Virginia Street, Reno, NV 89557, USA
    Brain Stimul 6:675-82. 2013
    ..Yet reports of behavioral and neuroimaging differences suggest that pre- and retro-cueing differentially recruit frontal and parietal cortices (Lepsien and Nobre, 2006)...
  2. pmc Color synesthesia improves color but impairs motion perception
    J Daniel McCarthy
    Department of Psychology, University of Nevada Reno, Mailstop 296, Reno, NV 89577, USA
    Trends Cogn Sci 18:224-6. 2014
    ..The results suggest that synesthesia broadly impacts perception with greater neural implications than previously considered. ..
  3. pmc Orienting attention in visual working memory requires central capacity: decreased retro-cue effects under dual-task conditions
    Markus Janczyk
    Department of Psychology III, Julius Maximilians University of Wurzburg, Rontgenring 11, 97070, Wurzburg, Germany
    Atten Percept Psychophys 76:715-24. 2014
    ..Our results apparently contradict these findings and point to a critical time period around cue onset and briefly thereafter during which attention is required. ..
  4. pmc Two plus blue equals green: grapheme-color synesthesia allows cognitive access to numerical information via color
    J Daniel McCarthy
    Department of Psychology, University of Nevada, Mail stop 296, Reno, NV 89557, USA Electronic address
    Conscious Cogn 22:1384-92. 2013
    ..We discuss these results in the context of possible cognitive strategies used to access the information...
  5. pmc Synesthetic grapheme-color percepts exist for newly encountered Hebrew, Devanagari, Armenian and Cyrillic graphemes
    Christopher David Blair
    Department of Psychology, Program in Cognitive and Brain Science, University of Nevada, Reno, NV 89557, United States Electronic address
    Conscious Cogn 22:944-54. 2013
    ..Thus, synesthetes can form and consolidate percepts to novel graphemes as adults. These percepts may depend on pre-existing grapheme-color relationships but they can flexibly shift with familiarity. ..
  6. pmc The Gestalt principle of similarity benefits visual working memory
    Dwight J Peterson
    Department of Psychology 296, University of Nevada, Reno, 1664 N Virginia Street, Reno, NV, 89557, USA
    Psychon Bull Rev 20:1282-9. 2013
    ..Thus, the Gestalt principle of similarity benefits visual perception, but it can provide benefits to VWM as well. ..
  7. pmc Molecular mechanisms of age-related sleep loss in the fruit fly - a mini-review
    Meagan Robertson
    Department of Biology, University of Nevada, Reno, NV 89557, USA
    Gerontology 59:334-9. 2013
    ..The fruit fly, Drosophila melanogaster, provides a genetically amenable system for dissecting the molecular basis of these processes. In this review, we examine the role of metabolism and circadian rhythms in age-dependent sleep loss...
  8. pmc Effects of attention on visual experience during monocular rivalry
    Eric A Reavis
    Department of Psychological and Brain Sciences, Dartmouth College, 6207 Moore Hall, Hanover, NH 03755, USA
    Vision Res 83:76-81. 2013
    ..The results of these experiments show that volitional attention can dramatically influence the contents of visual experience...
  9. pmc COMT and ANKK1-Taq-Ia genetic polymorphisms influence visual working memory
    Marian E Berryhill
    Memory and Brain Laboratory, Department of Psychology, University of Nevada, Reno, Nevada, United States of America
    PLoS ONE 8:e55862. 2013
    ..These findings link WM performance with slower dopaminergic metabolism in the prefrontal cortex as well as a greater density of dopamine receptors in the striatum...
  10. pmc Dynamic illusory size contrast: a relative-size illusion modulated by stimulus motion and eye movements
    Ryan E B Mruczek
    Department of Psychology, University of Nevada, Reno, Reno, NV, USA
    J Vis 14:2. 2014
    ..Given the compelling nature of the DISC effect and the inherently dynamic nature of our environment, these factors are likely to play an important role in everyday size judgments. ..

Research Grants30

  1. CENTER FOR GASTROINTESTINAL BIOLOGY AND DISEASE
    Robert S Sandler; Fiscal Year: 2013
    ..Through all of its activities, the Center improves communication, promotes collaboration, develops careers and generally enriches the intellectual climate for digestive disease research. ..
  2. CENTER FOR BIOMEDICAL RESEARCH
    Timothy Turner; Fiscal Year: 2013
    ..abstract_text> ..
  3. Molecular Mechanisms of Fate Choice in Neural Stem Cells (P01)
    Charles D Stiles; Fiscal Year: 2013
    ..abstract_text> ..
  4. Regulation of CNS viral persistence
    Cornelia Bergmann; Fiscal Year: 2013
    ..Importantly, it will provide valuable information on the interactions of specific CNS cells involved in viral persistence and demyelination and the cellular and soluble mediators of the host immune response...
  5. COBRE for Skeletal Health and Repair
    Qian Chen; Fiscal Year: 2013
    ..This multidisciplinary approach is absolutely necessary to develop translational strategies for prevention and treatment of skeletal joint diseases. ..
  6. Synaptic Function: Effects of the Nerve Injury, Repair, and Altered Activity
    Timothy C Cope; Fiscal Year: 2013
    ..The Resume and Summary of Discussion above summarizes the final outcome of the group discussion. OVERALL PROGRAM EVALUATION ..
  7. Endogenous Cannabinoids and Brain Function
    Aron H Lichtman; Fiscal Year: 2013
    ..Ultimately, the knowledge gained from this basic research will yield novel therapeutic targets that can be exploited with the pharmacological agents developed here. PROGRAM CHARACTERISTICS ..
  8. Vermont Center on Behavior and Health
    Stephen T Higgins; Fiscal Year: 2013
    ..S. public health. ..
  9. Molecular and Cellular Therapies for Muscular Dystrophy
    Stanley C Froehner; Fiscal Year: 2013
    ..The mechanism of NPC1 phenotype amelioration and its applicability to LGMDs will be studied. Two core facilities will serve the participating laboratories. ..
  10. Semi-volatile PCBs: Sources, Exposures, Toxicities
    Larry W Robertson; Fiscal Year: 2013
    ..These data and dietary studies in the last Aim will provide a scientific basis for risk assessment and advice for stakeholders with the ultimate goal to protect highly-exposed individuals and populations. ..
  11. Regional, Synpatic, Cellular Modulation of Abeta Metabolism
    David M Holtzman; Fiscal Year: 2013
    ..abstract_text> ..
  12. UNMC EPPLEY CANCER CENTER SUPPORT GRANT
    Kenneth H Cowan; Fiscal Year: 2013
    ....