Mentoring of Clinical Investigators in Patient Oriented Research

Summary

Principal Investigator: ERIC STRAIN
Abstract: This is an application for a K24 Mid-career Investigator Award in Patient Oriented Research (POR). The applicant is Eric Strain, a physician-researcher in the Department of Psychiatry at Johns Hopkins University School of Medicine. Dr. Strain has devoted his career to POR, and specifically to issues related to research on drug abuse and to treatment of substance abusing patients. His areas of focus have included the development of medications for the treatment of opioid and cocaine dependence, the testing of medications combined with behavioral treatment interventions, the role of psychiatric symptoms and comorbidity in substance use disorders, the testing of abuse liability of medications, and the special treatment needs of women and men with substance abuse. This application describes the candidate's three immediate career goals (to recruit young physicians/clinical investigators to conduct research fellowships in clinical addictions research, to integrate these clinical investigators into ongoing and new studies of POR conducted at the BPRU by providing direct experience in all aspects of clinical investigation, and to assist and mentor these clinical investigators in the transition from fellow to junior faculty member, encouraging each to continue in a career path of addictions-related research). In addition, three long-term career goals are also described (to develop a group of junior, mid-level, and senior clinician investigators with expertise in conducting addictions-related research to serve as a next generation of investigators in substance abuse research at Johns Hopkins, to maintain current investigative strengths of the BPRU while building new complementary areas of clinical research through collaborative efforts within the research community, and to utilize this investigative team in advancing scientific understanding of addictive disorders and their treatment through coordinated efforts). These goals will be accomplished through currently funded research efforts, and a clinical pharmacology study is succinctly presented to illustrate work currently funded by the candidate. In addition, funds from the present application will be used for pilot studies to be conducted with young clinicians, and the research plan for a study comparing tramadol to buprenorphine for the treatment of opioid withdrawal is presented. This work is highly relevant to the mission of NIH and NIDA. Recruiting and training young clinical investigators in the area of addictions are needed to advance understanding and treatment of these disorders. The applicant is well positioned to recruit young clinical investigators, has experience in successfully mentoring young researchers, and is in a strong research environment with excellent resources for mentoring and providing high quality clinical research experiences.
Funding Period: 2007-06-01 - 2012-05-31
more information: NIH RePORT

Top Publications

  1. ncbi Methadone safety: a clinical practice guideline from the American Pain Society and College on Problems of Drug Dependence, in collaboration with the Heart Rhythm Society
    Roger Chou
    Departments of Medicine and Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, and Pacific Northwest Evidence based Practice Center, Portland, Oregon Electronic address
    J Pain 15:321-37. 2014
  2. pmc An fMRI investigation of cerebellar function during verbal working memory in methadone maintenance patients
    Cherie L Marvel
    Department of Neurology, Division of Cognitive Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cerebellum 11:300-10. 2012
  3. pmc Comparison of cognitive performance in methadone maintenance patients with and without current cocaine dependence
    Porche K Henry
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, United States
    Drug Alcohol Depend 124:167-71. 2012
  4. pmc A double-blind, placebo-controlled trial assessing the efficacy of levetiracetam extended-release in very heavy drinking alcohol-dependent patients
    Joanne B Fertig
    Division of Treatment and Recovery Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Alcohol Clin Exp Res 36:1421-30. 2012
  5. pmc Opioid abusers' ability to differentiate an opioid from placebo in laboratory challenge testing
    Denis G Antoine
    Johns Hopkins University School of Medicine, Bayview Campus, Behavioral Pharmacology Research Unit, 5510 Nathan Shock Drive, Baltimore, MD 21224, United States
    Drug Alcohol Depend 132:369-72. 2013
  6. pmc The effect of repeated intramuscular alfentanil injections on experimental pain and abuse liability indices in healthy males
    David Andrew Tompkins
    Departments of Psychiatry and Behavioral Sciences, Behavioral Pharmacology Research Unit Psychiatry and Behavioral Sciences, Behavioral Sleep Medicine Program, Johns Hopkins University School of Medicine Intramural Research Program, National Institute on Aging, Baltimore, MD
    Clin J Pain 30:36-45. 2014
  7. pmc Human abuse liability assessment of oxycodone combined with ultra-low-dose naltrexone
    David Andrew Tompkins
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 210:471-80. 2010
  8. pmc Pretreatment alcohol drinking goals are associated with treatment outcomes
    Kelly E Dunn
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Alcohol Clin Exp Res 37:1745-52. 2013
  9. pmc A double blind, within subject comparison of spontaneous opioid withdrawal from buprenorphine versus morphine
    D Andrew Tompkins
    Behavioral Pharmacology Research Unit D A T, E C S, M Z M and Behavioral Sleep Medicine Program M T S, Department of Psychiatry and Behavioral Sciences C M C, Johns Hopkins University School of Medicine, Baltimore, Maryland
    J Pharmacol Exp Ther 348:217-26. 2014
  10. pmc Cognitive performance in methadone maintenance patients: effects of time relative to dosing and maintenance dose level
    Olga Rass
    Department of Psychiatry and Behavioral Sciences
    Exp Clin Psychopharmacol 22:248-56. 2014

Scientific Experts

  • Margaret S Chisolm
  • E C Strain
  • Kelly E Dunn
  • Ryan K Lanier
  • MIRIAM MINTZER
  • David Andrew Tompkins
  • R G Vandrey
  • Matthew W Johnson
  • ERIN L WINSTANLEY
  • MICHELLE RENEE LOFWALL
  • George E Bigelow
  • Angela N Duke
  • Lian Yu Chen
  • Roger Chou
  • Olga Rass
  • Denis G Antoine
  • Bethea A Kleykamp
  • Joanne B Fertig
  • Porche K Henry
  • Cherie L Marvel
  • CHAD J REISSIG
  • Steven M Marcus
  • Shirley Otis-Green
  • Pierre K├ębreau Alexandre
  • Marc L Copersino
  • John T Farrar
  • Ramin Mojtabai
  • Sharon Walsh
  • Maxine L Stitzer
  • John R Knight
  • Silvia S Martins
  • Marjorie C Meyer
  • Davendra Mehta
  • Russell Portenoy
  • Ricardo A Cruciani
  • Lonnie Zeltzer
  • Seddon Savage
  • Jeannie Marie Leoutsakos
  • David A Fiellin
  • Charles Inturrisi
  • Mark C Haigney
  • G Caleb Alexander
  • Peggy Compton
  • Alan I Green
  • Monica L Faulkner
  • John E Desmond
  • Margaret E Mattson
  • Bankole Johnson
  • David A Tompkins
  • Kyle Kampman
  • Annie Umbricht
  • Domenic Ciraulo
  • Robert Stout
  • Raye Z Litten
  • Mary F Brunette
  • Nassima A Tiouririne
  • Megan L Ryan
  • JANET RANSOM
  • Eric Devine
  • Helen Pettinati
  • Charles Scott
  • Daniel E Falk
  • William J Rickman
  • Christopher J Correia
  • Sharon L Walsh
  • Roland R Griffiths

Detail Information

Publications30

  1. ncbi Methadone safety: a clinical practice guideline from the American Pain Society and College on Problems of Drug Dependence, in collaboration with the Heart Rhythm Society
    Roger Chou
    Departments of Medicine and Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, and Pacific Northwest Evidence based Practice Center, Portland, Oregon Electronic address
    J Pain 15:321-37. 2014
    ..Although these guidelines are based on a systematic review, the panel identified numerous research gaps, most recommendations were based on low-quality evidence, and no recommendations were based on high-quality evidence...
  2. pmc An fMRI investigation of cerebellar function during verbal working memory in methadone maintenance patients
    Cherie L Marvel
    Department of Neurology, Division of Cognitive Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cerebellum 11:300-10. 2012
    ..These results indicate that verbal working memory in opioid-dependent individuals involves a disrupted cerebro-cerebellar circuit and shed light on the neuroanatomical basis of working memory impairments in this population...
  3. pmc Comparison of cognitive performance in methadone maintenance patients with and without current cocaine dependence
    Porche K Henry
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, United States
    Drug Alcohol Depend 124:167-71. 2012
    ..It is unknown whether MMP with concurrent cocaine dependence perform worse on tests of cognitive function than MMP without cocaine dependence...
  4. pmc A double-blind, placebo-controlled trial assessing the efficacy of levetiracetam extended-release in very heavy drinking alcohol-dependent patients
    Joanne B Fertig
    Division of Treatment and Recovery Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Alcohol Clin Exp Res 36:1421-30. 2012
    ..Previous research suggests that the anticonvulsant levetiracetam may be beneficial in an alcohol-dependent population of very heavy drinkers...
  5. pmc Opioid abusers' ability to differentiate an opioid from placebo in laboratory challenge testing
    Denis G Antoine
    Johns Hopkins University School of Medicine, Bayview Campus, Behavioral Pharmacology Research Unit, 5510 Nathan Shock Drive, Baltimore, MD 21224, United States
    Drug Alcohol Depend 132:369-72. 2013
    ..The present analyses assessed differences between qualification phase qualifiers and non-qualifiers...
  6. pmc The effect of repeated intramuscular alfentanil injections on experimental pain and abuse liability indices in healthy males
    David Andrew Tompkins
    Departments of Psychiatry and Behavioral Sciences, Behavioral Pharmacology Research Unit Psychiatry and Behavioral Sciences, Behavioral Sleep Medicine Program, Johns Hopkins University School of Medicine Intramural Research Program, National Institute on Aging, Baltimore, MD
    Clin J Pain 30:36-45. 2014
    ..However, there is no accepted, prospective model of OIH after repeated opioid exposures currently available in humans. This study assessed a potential prospective OIH model...
  7. pmc Human abuse liability assessment of oxycodone combined with ultra-low-dose naltrexone
    David Andrew Tompkins
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 210:471-80. 2010
    ..Prescription opioid abuse has risen dramatically in the United States as clinicians have increased opioid prescribing for alleviation of both acute and chronic pain. Opioid analgesics with decreased risk for abuse are needed...
  8. pmc Pretreatment alcohol drinking goals are associated with treatment outcomes
    Kelly E Dunn
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Alcohol Clin Exp Res 37:1745-52. 2013
    ..g., reduction in drinking) rather than abstinence, and this pretreatment goal choice may be associated with drinking outcomes and alcohol-related problems...
  9. pmc A double blind, within subject comparison of spontaneous opioid withdrawal from buprenorphine versus morphine
    D Andrew Tompkins
    Behavioral Pharmacology Research Unit D A T, E C S, M Z M and Behavioral Sleep Medicine Program M T S, Department of Psychiatry and Behavioral Sciences C M C, Johns Hopkins University School of Medicine, Baltimore, Maryland
    J Pharmacol Exp Ther 348:217-26. 2014
    ..In conclusion, spontaneous withdrawal from high-dose buprenorphine appears subjectively and objectively milder compared with that of morphine for at least 18 days after drug cessation. ..
  10. pmc Cognitive performance in methadone maintenance patients: effects of time relative to dosing and maintenance dose level
    Olga Rass
    Department of Psychiatry and Behavioral Sciences
    Exp Clin Psychopharmacol 22:248-56. 2014
    ..For patients on stable methadone maintenance doses, maintenance at higher doses may not significantly increase the risk of performance impairment...
  11. pmc Correlates of nonmedical use of stimulants and methamphetamine use in a national sample
    Lian Yu Chen
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, 7th Floor, Baltimore, MD 21205, United States Center for Drug Safety and Effectiveness, Johns Hopkins University, 615 N Wolfe Street W6035, Baltimore, MD 21205, United States Electronic address
    Addict Behav 39:829-36. 2014
    ..Despite chemical similarities, ADHD stimulants and methamphetamine have distinct use patterns in the community. This study compared the characteristics of nonmedical ADHD stimulants users and methamphetamine users in a household sample...
  12. pmc The association between outpatient buprenorphine detoxification duration and clinical treatment outcomes: a review
    Kelly E Dunn
    Johns Hopkins University, Baltimore, MD 21224, USA
    Drug Alcohol Depend 119:1-9. 2011
    ..The association between buprenorphine taper duration and treatment outcomes is not well understood. This review evaluated whether duration of outpatient buprenorphine taper is significantly associated with treatment outcomes...
  13. pmc Discriminative stimulus effects of tramadol in humans
    Angela N Duke
    Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Pharmacol Exp Ther 338:255-62. 2011
    ....
  14. pmc Increased blood pressure after abrupt cessation of daily cannabis use
    Ryan Vandrey
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Addict Med 5:16-20. 2011
    ..The objective of this report is to describe unexpected changes in cardiovascular function during brief periods of supervised cannabis use and abstinence in daily cannabis users...
  15. doi Drug use and sport--a commentary on: Injury, pain and prescription opioid use among former National Football League football players by Cottler et al
    Eric C Strain
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 116:8-10. 2011
    ....
  16. pmc Concurrent validation of the Clinical Opiate Withdrawal Scale (COWS) and single-item indices against the Clinical Institute Narcotic Assessment (CINA) opioid withdrawal instrument
    D Andrew Tompkins
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Behavioral Pharmacology Research Unit, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 105:154-9. 2009
    ..Though commonly used in clinical practice, it has not been systematically validated. The present study validated the COWS in comparison to the validated Clinical Institute Narcotic Assessment (CINA) scale...
  17. pmc Effects of repeated tramadol and morphine administration on psychomotor and cognitive performance in opioid-dependent volunteers
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 111:265-8. 2010
    ..These findings suggest that tramadol is generally a safe medication with respect to cognitive and psychomotor measures and support tramadol's further evaluation as an opioid-dependence treatment...
  18. pmc Acute effects of intramuscular and sublingual buprenorphine and buprenorphine/naloxone in non-dependent opioid abusers
    Angela N Duke
    Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 211:303-12. 2010
    ..However, the addition of naloxone may not limit abuse potential of this medication when taken by individuals without opioid physical dependence...
  19. pmc Physical dependence potential of daily tramadol dosing in humans
    Ryan K Lanier
    Rock Creek Pharmaceuticals, Inc, 55 Blackburn Center, Gloucester, MA 01930, USA
    Psychopharmacology (Berl) 211:457-66. 2010
    ..Tramadol is an atypical, mixed-mechanism analgesic involving both opioid and catecholamine processes that appears to have low abuse potential and may be useful as a treatment for opioid dependence...
  20. pmc Cigarette smoking knowledge, attitudes, and practices of patients and staff at a perinatal substance abuse treatment center
    Margaret S Chisolm
    The Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Subst Abuse Treat 39:298-305. 2010
    ....
  21. pmc Effects of oral caffeine pretreatment on response to intravenous nicotine and cocaine
    Matthew W Johnson
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6823, USA
    Exp Clin Psychopharmacol 18:305-15. 2010
    ..In contrast to the previous research using chronic caffeine maintenance, these data suggest that infrequent acute caffeine administration may attenuate nicotine effects...
  22. pmc A randomized controlled trial of fluoxetine in the treatment of cocaine dependence among methadone-maintained patients
    ERIN L WINSTANLEY
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA
    J Subst Abuse Treat 40:255-64. 2011
    ..Cocaine abuse and dependence continue to be widespread. Currently, there are no pharmacotherapies shown to be effective in the treatment of cocaine dependence...
  23. pmc Induction of opioid-dependent individuals onto buprenorphine and buprenorphine/naloxone soluble-films
    E C Strain
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Clin Pharmacol Ther 89:443-9. 2011
    ..There was a significant decrease in COWS scores but no significant differences between the groups. The results support the use of B and B/N soluble films as safe and effective delivery methods for opioid induction...
  24. pmc The relationship between antidepressant use and smoking cessation in pregnant women in treatment for substance abuse
    Margaret S Chisolm
    The Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Drug Alcohol Abuse 36:46-51. 2010
    ..Bupropion's efficacy for smoking cessation in pregnant women is unknown...
  25. pmc Relationship between cigarette use and mood/anxiety disorders among pregnant methadone-maintained patients
    Margaret S Chisolm
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Addict 18:422-9. 2009
    ....
  26. pmc Changing profile of abused substances by older persons entering treatment
    Michelle R Lofwall
    Department of Psychiatry, University of Kentucky College of Medicine, Lexington, Kentucky 40509, USA
    J Nerv Ment Dis 196:898-905. 2008
    ..Efforts to determine best practices for prevention, identification, and treatment of illicit drug abuse in older persons are indicated...
  27. pmc Caffeinated energy drinks--a growing problem
    CHAD J REISSIG
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 99:1-10. 2009
    ..Several studies suggest that energy drinks may serve as a gateway to other forms of drug dependence. Regulatory implications concerning labeling and advertising, and the clinical implications for children and adolescents are discussed...