Shedding of HIV In Semen Despite Antiretroviral Therapy

Summary

Principal Investigator: Lee H Harrison
Affiliation: University of Pittsburgh
Country: USA
Abstract: [unreadable] DESCRIPTION (provided by applicant): This is an application for a Midcareer Award for Patient-Oriented Research (K24) for Lee H. Harrison, M.D., Associate Professor of Medicine, Epidemiology, and Infectious Diseases and Microbiology at the University of Pittsburgh School of Medicine and Graduate School of Public Health. The goal of this application is to allow the candidate to substantially change the direction of his career, with an increased emphasis on mentoring junior faculty, doctoral students, and infectious diseases fellows interested in pursuing careers in patient-oriented research. Specifically, this K24 award will allow Dr. Harrison to: 1) provide mentoring in patient-oriented research to infectious diseases fellows and junior faculty in the School of Medicine, doctoral students in the Graduate School of Public Health, and junior investigators from Brazil, 2) in collaboration with a junior faculty member mentored by the candidate, conduct a study to identify factors for persistent shedding of HIV RNA in semen among HIV-infected persons taking highly-active antiretroviral therapy, 3) build the research of the Infectious Diseases Epidemiology Research Unit, which the candidate recently established at the University of Pittsburgh. The focus of the unit is the epidemiology and prevention of HIV infection in Brazil and the epidemiology, molecular epidemiology, and prevention of vaccine-preventable and drug-resistant invasive bacterial infections. The candidate has a successful track record of publication and mentoring in both of these areas of research. This award will allow Dr. Harrison to substantially change his day-to-day role on a variety of research projects he directs. The increase in protected time will lead to an increase in research productivity particularly because it will provide protected time for mentoring the next generation of patient-oriented investigators at the University of Pittsburgh.
Funding Period: 2002-09-01 - 2007-11-30
more information: NIH RePORT

Top Publications

  1. ncbi Internet death notices as a novel source of mortality surveillance data
    Marshall B Boak
    University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 21666, USA
    Am J Epidemiol 167:532-9. 2008
  2. doi Patient-associated risk factors for acquisition of methicillin-resistant Staphylococcus aureus in a tertiary care hospital
    Jo anne M Salangsang
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Infect Control Hosp Epidemiol 31:1139-47. 2010
  3. pmc Use of multilocus variable number of tandem repeats analysis genotyping to determine the role of asymptomatic carriers in Clostridium difficile transmission
    Scott R Curry
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine
    Clin Infect Dis 57:1094-102. 2013
  4. ncbi Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approach
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 45:1266-73. 2007
  5. pmc Validation of a hierarchical deterministic record-linkage algorithm using data from 2 different cohorts of human immunodeficiency virus-infected persons and mortality databases in Brazil
    Antonio G Pacheco
    Programa de Computacao Cientifica, Fundacao Oswaldo Cruz, Avenida Brasil 4365, Manguinhos, 21045 360 Rio de Janeiro, Brazil
    Am J Epidemiol 168:1326-32. 2008
  6. pmc Should vascular surgery patients be screened preoperatively for methicillin-resistant Staphylococcus aureus?
    Bruce Y Lee
    Section of Decision Sciences and Clinical Systems Modeling, Department of Biomedical Informatics, School of Medicine, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 30:1158-65. 2009
  7. pmc Pre- and postvaccination clonal compositions of invasive pneumococcal serotypes for isolates collected in the United States in 1999, 2001, and 2002
    Bernard Beall
    Repsiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mailstop C02, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:999-1017. 2006
  8. pmc Increase in non-AIDS related conditions as causes of death among HIV-infected individuals in the HAART era in Brazil
    Antonio G Pacheco
    Department of Epidemiology and Quantitative Methods in Health, National School of Public Health Scientific Computing Program, Oswaldo Cruz Foundation FIOCRUZ, Rio de Janeiro, Brazil
    PLoS ONE 3:e1531. 2008
  9. pmc Use of sodC versus ctrA for real-time polymerase chain reaction-based detection of Neisseria meningitidis in sterile body fluids
    Fábio Takenori Higa
    Centro de Imunologia, Instituto Adolfo Lutz, Sao Paulo, SP, Brasil
    Mem Inst Oswaldo Cruz 108:246-7. 2013
  10. pmc The economic effect of screening orthopedic surgery patients preoperatively for methicillin-resistant Staphylococcus aureus
    Bruce Y Lee
    Public Health Computational and Operations Research PHICOR Group, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 31:1130-8. 2010

Scientific Experts

  • Lee H Harrison
  • B Y Lee
  • Jane W Marsh
  • Antonio G Pacheco
  • Scott Curry
  • Maria Cecília O Gorla
  • D Rebecca Prevots
  • Yohei Doi
  • Carlene A Muto
  • MARY C MCELLISTREM
  • David E Barroso
  • Claudio T Sacchi
  • Kathleen A Shutt
  • Suely H Tuboi
  • Peter T Beernink
  • Mauro Schechter
  • Eduardo Sprinz
  • Fábio Takenori Higa
  • Ana Paula Silva de Lemos
  • Ivano de Filippis
  • Mary Krauland
  • Ana Paula S Lemos
  • Jo anne M Salangsang
  • Rolando Pajon
  • Suely Hiromi Tuboi
  • Heather E Hsu
  • Mary G Krauland
  • Francois Dabis
  • Martin W G Brinkhof
  • David L Paterson
  • Roslyn A Stone
  • Matthias Egger
  • Denis Nash
  • Paula Braitstein
  • Dan M Granoff
  • Jennifer M Adams-Haduch
  • Marshall B Boak
  • Cynthia G Whitney
  • Amanda D Castel
  • Bernard Beall
  • Anna C Noller
  • Maria Gisele Gonçalves
  • Claudio Tavares Sacchi
  • Carla Naufal da Silva
  • Lucila Okuyama Fukasawa
  • Maristela Marques Salgado
  • Priscilla Lima de Oliveira
  • Jessica B Hostetler
  • Kurt Wollenberg
  • Ana Paula S de Lemos
  • Julie C Dunning Hotopp
  • Margaret C Bash
  • Juang H Jyh
  • Rossini Modesto
  • M Cristina C Brandileone
  • Maria G Gonçalves
  • Elza L U Vicentine
  • Fabio Rossi
  • Célia E Guarnieri
  • A M Frigatto
  • Marcelo Maki
  • Sueli Rosenfeld
  • Marilia V Nogueira
  • Veronica M Sincok
  • Angela Cruciano
  • Simone A de Souza
  • Fabio Valdetaro
  • Sonia R T da Silva Ramos
  • Rosemeire Cobo Zanella
  • Carlos E Levy
  • Vera Malheiro
  • Maristela M Salgado
  • Rogério A Kuboyama
  • Maria J P Rujula
  • Elizabete A Russi
  • Walter B G Amorin
  • Maria Luiza L S Guerra
  • Eneida G L Marques
  • Conceição Martins da Costa Zanelato
  • Katsumi Osiro
  • Ricardo A Cocolisce
  • Brigina Kemp
  • Anna Vera Custódio
  • Regina M Loda
  • Ricardo K Albernaz
  • Marta Galhardo
  • Terezinha P Araújo
  • Lucila O Fukasawa
  • Eliseu A Waldman
  • Elaine Magalhães

Detail Information

Publications52

  1. ncbi Internet death notices as a novel source of mortality surveillance data
    Marshall B Boak
    University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 21666, USA
    Am J Epidemiol 167:532-9. 2008
    ..The Pittsburgh Post-Gazette Internet death notices provided accurate, timely mortality data for nearly three fourths of all Allegheny County deaths...
  2. doi Patient-associated risk factors for acquisition of methicillin-resistant Staphylococcus aureus in a tertiary care hospital
    Jo anne M Salangsang
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Infect Control Hosp Epidemiol 31:1139-47. 2010
    ..Determining risk factors for acquisition of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals is important for defining infection-control measures that may lead to fewer hospital-acquired infections...
  3. pmc Use of multilocus variable number of tandem repeats analysis genotyping to determine the role of asymptomatic carriers in Clostridium difficile transmission
    Scott R Curry
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine
    Clin Infect Dis 57:1094-102. 2013
    ..Multilocus variable number of tandem repeats analysis (MLVA) is a highly discriminatory molecular subtyping tool that helps to determine possible transmission sources...
  4. ncbi Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approach
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 45:1266-73. 2007
    ..Forty-seven (51%) of 92 HA CD isolates in 2001 were identified as the "epidemic BI strain." A comprehensive CD infection control "bundle" was implemented to control the outbreak of CD infection...
  5. pmc Validation of a hierarchical deterministic record-linkage algorithm using data from 2 different cohorts of human immunodeficiency virus-infected persons and mortality databases in Brazil
    Antonio G Pacheco
    Programa de Computacao Cientifica, Fundacao Oswaldo Cruz, Avenida Brasil 4365, Manguinhos, 21045 360 Rio de Janeiro, Brazil
    Am J Epidemiol 168:1326-32. 2008
    ..These results indicate that the algorithm is accurate enough to recover vital status information on patients lost to follow-up in cohort studies...
  6. pmc Should vascular surgery patients be screened preoperatively for methicillin-resistant Staphylococcus aureus?
    Bruce Y Lee
    Section of Decision Sciences and Clinical Systems Modeling, Department of Biomedical Informatics, School of Medicine, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 30:1158-65. 2009
    ..Testing all vascular surgery patients preoperatively for MRSA and attempting to decolonize those who have positive results may be a strategy to prevent MRSA infection. The economic value of such a strategy has not yet been determined...
  7. pmc Pre- and postvaccination clonal compositions of invasive pneumococcal serotypes for isolates collected in the United States in 1999, 2001, and 2002
    Bernard Beall
    Repsiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mailstop C02, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:999-1017. 2006
    ..Continued genotypic surveillance is warranted, since certain clones not targeted by PCV7 are expanding, and their emergence as significant pathogens could occur with maintained vaccine pressure...
  8. pmc Increase in non-AIDS related conditions as causes of death among HIV-infected individuals in the HAART era in Brazil
    Antonio G Pacheco
    Department of Epidemiology and Quantitative Methods in Health, National School of Public Health Scientific Computing Program, Oswaldo Cruz Foundation FIOCRUZ, Rio de Janeiro, Brazil
    PLoS ONE 3:e1531. 2008
    ....
  9. pmc Use of sodC versus ctrA for real-time polymerase chain reaction-based detection of Neisseria meningitidis in sterile body fluids
    Fábio Takenori Higa
    Centro de Imunologia, Instituto Adolfo Lutz, Sao Paulo, SP, Brasil
    Mem Inst Oswaldo Cruz 108:246-7. 2013
    ..5% less sensitive than ctrA. Given the public health impact of possible false-negative results due to the use of the sodC target gene alone, sodC-based RT-PCR for the diagnosis of meningococcal meningitis should be used with caution...
  10. pmc The economic effect of screening orthopedic surgery patients preoperatively for methicillin-resistant Staphylococcus aureus
    Bruce Y Lee
    Public Health Computational and Operations Research PHICOR Group, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 31:1130-8. 2010
    ..We sought to estimate the economic value of routine preoperative MRSA screening and decolonization of orthopedic surgery patients...
  11. pmc Estimating the extent of underreporting of mortality among HIV-infected individuals in Rio de Janeiro, Brazil
    Antonio G Pacheco
    FIOCRUZ, Rio de Janeiro, Brazil
    AIDS Res Hum Retroviruses 27:25-8. 2011
    ....
  12. pmc Universal methicillin-resistant Staphylococcus aureus (MRSA) surveillance for adults at hospital admission: an economic model and analysis
    Bruce Y Lee
    Section of Decision Sciences and Clinical Systems Modeling, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania, USA
    Infect Control Hosp Epidemiol 31:598-606. 2010
    ..Although some have recommended universal surveillance for MRSA at hospital admission to identify and to isolate MRSA-colonized patients, there is a need for formal economic studies to determine the cost-effectiveness of such a strategy...
  13. pmc Epidemiological profile of meningococcal disease in the United States
    Lee H Harrison
    University of Pittsburgh Graduate School of Public Health and School of Medicine, Pennsylvania, USA
    Clin Infect Dis 50:S37-44. 2010
    ..Broadly protective vaccines for endemic serogroup B disease are also needed...
  14. doi Phenotypic and molecular characterization of invasive serogroup W135 Neisseria meningitidis strains from 1990 to 2005 in Brazil
    Ana Paula S Lemos
    Bacteriology Department, Adolfo Lutz Institute, Sao Paulo, Brazil
    J Infect 60:209-17. 2010
    ..meningitidis serogroup W135 clone has been causing disease in Brazil, the present study characterized invasive N. meningitidis serogroup W135 isolates recovered in Brazil from 1990 to 2005...
  15. pmc Frequency of factor H-binding protein modular groups and susceptibility to cross-reactive bactericidal activity in invasive meningococcal isolates
    Rolando Pajon
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Vaccine 28:2122-9. 2010
    ..The results confirmed the modular architecture of fHbp and underscored its importance for the design of broadly protective group B vaccines in different regions...
  16. pmc Screening for Acinetobacter baumannii colonization by use of sponges
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Scaife Hall S829, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 49:154-8. 2011
    ..003). The combined sensitivity for the upper arm and leg with a sponge was 89.1%. The novel screening method using sterile sponges was easy to perform and achieved excellent sensitivity for the detection of A. baumannii colonization...
  17. doi Economic value of Acinetobacter baumannii screening in the intensive care unit
    B Y Lee
    Public Health Computational and Operations Research, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Microbiol Infect 17:1691-7. 2011
    ..Sponge screening tended to be more cost-saving than swab screening (additional savings ranged from $1 to $421). Routine A. baumannii screening of ICU patients may save costs for hospitals...
  18. pmc Prevalence of Clostridium difficile in uncooked ground meat products from Pittsburgh, Pennsylvania
    Scott R Curry
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Appl Environ Microbiol 78:4183-6. 2012
    ..The prevalence of C. difficile in retail meat may not be as high as previously reported in North America. When contamination occurs, it may be related to events at processing facilities...
  19. pmc Molecular epidemiology of Neisseria meningitidis serogroup B in Brazil
    Ivano de Filippis
    National Quality Control Institute INCQS, Oswaldo Cruz Foundation FIOCRUZ, Rio de Janeiro, Brazil
    PLoS ONE 7:e33016. 2012
    ....
  20. pmc Perirectal swab surveillance for Clostridium difficile by use of selective broth preamplification and real-time PCR detection of tcdB
    Scott R Curry
    Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Clin Microbiol 49:3788-93. 2011
    ..6%), and 422/422 (100.0%), respectively. These data demonstrate that selective broth preamplification and real-time PCR of perirectal swab specimens constitute a practical approach to the detection of asymptomatic C. difficile carriage...
  21. doi β-Lactam resistance, serotype distribution, and genotypes of meningitis-causing Streptococcus pneumoniae, Rio de Janeiro, Brazil
    David E Barroso
    Laboratory of Biochemical Systematics, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
    Pediatr Infect Dis J 31:30-6. 2012
    ..Here, we report a laboratory-based study of Streptococcus pneumoniae recovered from patients with meningitis in Rio de Janeiro State, Brazil...
  22. pmc Incorporation of real-time PCR into routine public health surveillance of culture negative bacterial meningitis in São Paulo, Brazil
    Claudio T Sacchi
    Division of Medical Biology, Department of Immunology, Instituto Adolfo Lutz, Sao Paulo, Brazil
    PLoS ONE 6:e20675. 2011
    ..2, 95% CI 5.9-25.0). RT-PCR using CSF was highly sensitive and specific and substantially added to measures of meningitis disease burden when incorporated into routine public health surveillance in Brazil...
  23. doi Diversity of factor H-binding protein in Neisseria meningitidis carriage isolates
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, PA, United States
    Vaccine 29:6049-58. 2011
    ..The FHbp genetic repertoire observed in carriage isolate populations will be useful in understanding the potential impact of FHbp-containing vaccines on meningococcal carriage...
  24. doi Multi-locus variable number tandem repeat analysis for investigation of the genetic association of Clostridium difficile isolates from food, food animals and humans
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine, Graduate School of Public Health, PA, USA
    Anaerobe 17:156-60. 2011
    ..Rigorous epidemiologic and laboratory investigations that employ highly discriminatory genotyping methods are necessary to compare C. difficile isolates from food and food animals to those from humans...
  25. doi The economic value of screening haemodialysis patients for methicillin-resistant Staphylococcus aureus in the USA
    B Y Lee
    Public Health Computational and Operations Research PHICOR, VA Pittsburgh Health Care System, Pittsburgh, PA, USA
    Clin Microbiol Infect 17:1717-26. 2011
    ..Routine periodic testing and decolonization of haemodialysis patients for MRSA may be a cost-effective strategy over a wide range of MRSA prevalences, decolonization success rates, and testing intervals...
  26. pmc Mortality associated with discordant responses to antiretroviral therapy in resource-constrained settings
    Suely Hiromi Tuboi
    Departamento de Epidemiologia e Bioestatística, Universidade Federal Fluminense, Niteroi, Brazil
    J Acquir Immune Defic Syndr 53:70-7. 2010
    ..We assessed mortality associated with immunologic and virologic patterns of response at 6 months of highly active antiretroviral therapy (HAART) in HIV-infected individuals from resource-limited countries in Africa and South America...
  27. pmc Multilocus variable-number tandem-repeat analysis and multilocus sequence typing reveal genetic relationships among Clostridium difficile isolates genotyped by restriction endonuclease analysis
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Clin Microbiol 48:412-8. 2010
    ..difficile disease pathogenesis. This study demonstrates that a combination of MLST and MLVA may prove useful for the investigation and surveillance of emergent C. difficile clones of global public health concern...
  28. pmc Novel integron gene cassette arrays identified in a global collection of multi-drug resistant non-typhoidal Salmonella enterica
    Mary Krauland
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, Pittsburgh, USA
    Curr Microbiol 60:217-23. 2010
    ..enterica integrons described in the present study represent novel collections of resistance genes which confer multi-drug resistance and have the potential to be widely disseminated among S. enterica as well as other bacterial species...
  29. pmc Integron-mediated multidrug resistance in a global collection of nontyphoidal Salmonella enterica isolates
    Mary G Krauland
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Emerg Infect Dis 15:388-96. 2009
    ..This study demonstrates that clonal expansion and horizontal gene transfer contribute to the global dissemination of antimicrobial drug resistance in S. enterica...
  30. doi Phenotypic and molecular characterization of serogroup C Neisseria meningitidis associated with an outbreak in Bahia, Brazil
    Maria Cecília O Gorla
    Division of Medical Biology, Bacteriology Department, Adolfo Lutz Institute, Brazil
    Enferm Infecc Microbiol Clin 30:56-9. 2012
    ..All cases, with the exception of a 39-year-old male, attended a dance party with approximately 1000 youngsters in a rural site...
  31. pmc Population structure and capsular switching of invasive Neisseria meningitidis isolates in the pre-meningococcal conjugate vaccine era--United States, 2000-2005
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Infect Dis 201:1208-24. 2010
    ..Neisseria meningitidis changes its capsular phenotype through capsular switching, which has implications for vaccines that do not protect against all serogroups...
  32. ncbi Vaccine prevention of meningococcal disease: making slow progress
    Lee H Harrison
    Clin Infect Dis 43:1395-7. 2006
  33. pmc tcdC genotypes associated with severe TcdC truncation in an epidemic clone and other strains of Clostridium difficile
    Scott R Curry
    Department of Medicine, University of Pittsburgh, School of Medicine, PA 15261, USA
    J Clin Microbiol 45:215-21. 2007
    ..Further investigations are required to determine the effect of this and other tcdC genotypes on toxin production and clinical disease...
  34. pmc Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Medical Center, Division of Hospital Epidemiology and Infection Control, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 44:2558-66. 2006
    ..Thus, MLVA is an objective, portable genotyping method that permits reliable detection of C. difficile outbreaks and can aid epidemiologic investigations of nosocomial transmission...
  35. ncbi Antigenic shift and increased incidence of meningococcal disease
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Infect Dis 193:1266-74. 2006
    ..The cyclical nature of endemic meningococcal disease remains unexplained. The purpose of this study was to investigate the mechanisms associated with the increase in the incidence of meningococcal disease...
  36. pmc Locus-specific mutational events in a multilocus variable-number tandem repeat analysis of Escherichia coli O157:H7
    Anna C Noller
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, 521 Parran Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
    J Clin Microbiol 44:374-7. 2006
    ..The remaining four loci had no slippage events detected. The mutation rates were locus specific and may impact the interpretation of MLVA data for epidemiologic investigations...
  37. ncbi Predictors of virologic failure in HIV-1-infected patients starting highly active antiretroviral therapy in Porto Alegre, Brazil
    Suely H Tuboi
    Infectious Diseases Epidemiology Research Unit, Graduate School of Public Health and School of Medicine, University of Pittsburgh, PA, USA
    J Acquir Immune Defic Syndr 40:324-8. 2005
    ..To assess predictors of virologic response 6 months after initiation of highly active antiretroviral therapy (HAART) in a cohort of HIV-infected patients in Brazil...
  38. pmc Erythromycin-nonsusceptible Streptococcus pneumoniae in children, 1999-2001
    M Catherine McEllistrem
    University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15213 2582, USA
    Emerg Infect Dis 11:969-72. 2005
    ..The decline in infection rates was likely due to the pneumococcal 7-valent conjugate vaccine...
  39. pmc Deletion of fetA gene sequences in serogroup B and C Neisseria meningitidis isolates
    Jane W Marsh
    University of Pittsburgh School of Medicine, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 45:1333-5. 2007
    ..In this report, we describe the characterization of three meningococcal isolates that have deleted fetA sequences through genetic recombination at repetitive elements...
  40. pmc Prevalence of factor H-binding protein variants and NadA among meningococcal group B isolates from the United States: implications for the development of a multicomponent group B vaccine
    Peter T Beernink
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Infect Dis 195:1472-9. 2007
    ..Antibodies against fHBP are bactericidal against strains within a variant group. There are limited data on the prevalence of strains expressing different fHBP variants in the United States...
  41. ncbi Discordant responses to potent antiretroviral treatment in previously naive HIV-1-infected adults initiating treatment in resource-constrained countries: the antiretroviral therapy in low-income countries (ART-LINC) collaboration
    Suely H Tuboi
    Infectious Diseases Epidemiology Research Unit, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Acquir Immune Defic Syndr 45:52-9. 2007
    ..To assess the frequency of and risk factors for discordant responses at 6 months on highly active antiretroviral therapy (HAART) in previously treatment-naive HIV patients from resource-limited countries...
  42. doi Global epidemiology of meningococcal disease
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, 521 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, United States
    Vaccine 27:B51-63. 2009
    ....
  43. pmc Temporal changes in causes of death among HIV-infected patients in the HAART era in Rio de Janeiro, Brazil
    Antonio G Pacheco
    Department of Epidemiology and Quantitative Methods in Health, National School of Public Health, FIOCRUZ, Brazil
    J Acquir Immune Defic Syndr 51:624-30. 2009
    ..The widespread use of highly active antiretroviral therapy (HAART) has led to marked decreases in death rates in Brazil in HIV-infected individuals. Nonetheless, there are scarce data on specific causes of death...
  44. pmc High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital
    Scott R Curry
    Department of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 48:425-9. 2009
    ..difficile-associated disease. Rifampin resistance in C. difficile strains has been reported to be uncommon...
  45. doi Effect of pneumococcal conjugate vaccine on pneumococcal meningitis
    Heather E Hsu
    University of Pittsburgh, Pittsburgh, PA 15261, USA
    N Engl J Med 360:244-56. 2009
    ..Invasive pneumococcal disease declined among children and adults after the introduction of the pediatric heptavalent pneumococcal conjugate vaccine (PCV7) in 2000, but its effect on pneumococcal meningitis is unclear...
  46. pmc Emergence and disappearance of a virulent clone of Haemophilus influenzae biogroup aegyptius, cause of Brazilian purpuric fever
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School ofMedicine, Pittsburgh, Pennsylvania 15261, USA
    Clin Microbiol Rev 21:594-605. 2008
    ..After a series of outbreaks and sporadic cases through 1993, no additional cases of BPF have been reported...
  47. pmc Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania
    Jennifer M Adams-Haduch
    Division of Infectious Diseases, University of Pittsburgh Medical Center, S829 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261
    Antimicrob Agents Chemother 52:3837-43. 2008
    ..Fifty-nine percent of the MDR isolates belonged to a single clonal group over the course of the study period, as demonstrated by pulsed-field gel electrophoresis...
  48. doi Risk factors for meningococcal disease in students in grades 9-12
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Pediatr Infect Dis J 27:193-9. 2008
    ..Universal immunization of adolescents with meningococcal conjugate vaccine was recently recommended. We studied risk factors for meningococcal disease in students in grades 9-12...
  49. ncbi College and university compliance with a required meningococcal vaccination law
    Amanda D Castel
    The Department of Epidemiology and Biostatistics, George Washington University s School of Public Health and Health Services, Washington, DC 20037, USA
    J Am Coll Health 56:119-27. 2007
    ..The authors sought to identify how Maryland colleges addressed the law and determine whether schools were in full compliance...
  50. ncbi A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, University of Pittsburgh Medical Center, Presbyterian Campus, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 26:273-80. 2005
    ..difficile infections; of these, 26 resulted in colectomy and 18 resulted in death. We conducted an investigation of a large C. difficile outbreak in our hospital to identify risk factors and characterize the outbreak...