Shedding of HIV In Semen Despite Antiretroviral Therapy
Principal Investigator: Lee H Harrison
Affiliation: University of Pittsburgh
Abstract: This is an application for a Midcareer Award for Patient-Oriented Research (K24) for Lee H. Harrison, M.D., Associate Professor of Medicine, Epidemiology, and Infectious Diseases and Microbiology at the University of Pittsburgh School of Medicine and Graduate School of Public Health. The goal of this application is to allow the candidate to substantially change the direction of his career, with an increased emphasis on mentoring junior faculty, doctoral students, and infectious diseases fellows interested in pursuing careers in patient-oriented research. Specifically, this K24 award will allow Dr. Harrison to: 1) provide mentoring in patient-oriented research to infectious diseases fellows and junior faculty in the School of Medicine, doctoral students in the Graduate School of Public Health, and junior investigators from Brazil, 2) in collaboration with a junior faculty member mentored by the candidate, conduct a study to identify factors for persistent shedding of HIV RNA in semen among HIV-infected persons taking highly-active antiretroviral therapy, 3) build the research of the Infectious Diseases Epidemiology Research Unit, which the candidate recently established at the University of Pittsburgh. The focus of the unit is the epidemiology and prevention of HIV infection in Brazil and the epidemiology, molecular epidemiology, and prevention of vaccine-preventable and drug-resistant invasive bacterial infections. The candidate has a successful track record of publication and mentoring in both of these areas of research. This award will allow Dr. Harrison to substantially change his day-to-day role on a variety of research projects he directs. The increase in protected time will lead to an increase in research productivity particularly because it will provide protected time for mentoring the next generation of patient-oriented investigators at the University of Pittsburgh.
Funding Period: 2002-09-01 - 2007-11-30
more information: NIH RePORT
- A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone useCarlene A Muto
Division of Hospital Epidemiology and Infection Control, University of Pittsburgh Medical Center, Presbyterian Campus, Pittsburgh, Pennsylvania 15213, USA
Infect Control Hosp Epidemiol 26:273-80. 2005..difficile infections; of these, 26 resulted in colectomy and 18 resulted in death. We conducted an investigation of a large C. difficile outbreak in our hospital to identify risk factors and characterize the outbreak...
- Temporal changes in causes of death among HIV-infected patients in the HAART era in Rio de Janeiro, BrazilAntonio G Pacheco
Department of Epidemiology and Quantitative Methods in Health, National School of Public Health, FIOCRUZ, Brazil
J Acquir Immune Defic Syndr 51:624-30. 2009..The widespread use of highly active antiretroviral therapy (HAART) has led to marked decreases in death rates in Brazil in HIV-infected individuals. Nonetheless, there are scarce data on specific causes of death...
- Effect of pneumococcal conjugate vaccine on pneumococcal meningitisHeather E Hsu
University of Pittsburgh, Pittsburgh, PA 15261, USA
N Engl J Med 360:244-56. 2009..Invasive pneumococcal disease declined among children and adults after the introduction of the pediatric heptavalent pneumococcal conjugate vaccine (PCV7) in 2000, but its effect on pneumococcal meningitis is unclear...
- High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospitalScott R Curry
Department of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Clin Infect Dis 48:425-9. 2009..difficile-associated disease. Rifampin resistance in C. difficile strains has been reported to be uncommon...
- Emergence and disappearance of a virulent clone of Haemophilus influenzae biogroup aegyptius, cause of Brazilian purpuric feverLee H Harrison
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School ofMedicine, Pittsburgh, Pennsylvania 15261, USA
Clin Microbiol Rev 21:594-605. 2008..After a series of outbreaks and sporadic cases through 1993, no additional cases of BPF have been reported...
- Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in PennsylvaniaJennifer M Adams-Haduch
Division of Infectious Diseases, University of Pittsburgh Medical Center, S829 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261
Antimicrob Agents Chemother 52:3837-43. 2008..Fifty-nine percent of the MDR isolates belonged to a single clonal group over the course of the study period, as demonstrated by pulsed-field gel electrophoresis...
- Risk factors for meningococcal disease in students in grades 9-12Lee H Harrison
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Pediatr Infect Dis J 27:193-9. 2008..Universal immunization of adolescents with meningococcal conjugate vaccine was recently recommended. We studied risk factors for meningococcal disease in students in grades 9-12...
- College and university compliance with a required meningococcal vaccination lawAmanda D Castel
The Department of Epidemiology and Biostatistics, George Washington University s School of Public Health and Health Services, Washington, DC 20037, USA
J Am Coll Health 56:119-27. 2007..The authors sought to identify how Maryland colleges addressed the law and determine whether schools were in full compliance...
- Discordant responses to potent antiretroviral treatment in previously naive HIV-1-infected adults initiating treatment in resource-constrained countries: the antiretroviral therapy in low-income countries (ART-LINC) collaborationSuely H Tuboi
Infectious Diseases Epidemiology Research Unit, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
J Acquir Immune Defic Syndr 45:52-9. 2007..To assess the frequency of and risk factors for discordant responses at 6 months on highly active antiretroviral therapy (HAART) in previously treatment-naive HIV patients from resource-limited countries...
- Prevalence of factor H-binding protein variants and NadA among meningococcal group B isolates from the United States: implications for the development of a multicomponent group B vaccinePeter T Beernink
Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
J Infect Dis 195:1472-9. 2007..Antibodies against fHBP are bactericidal against strains within a variant group. There are limited data on the prevalence of strains expressing different fHBP variants in the United States...
- Deletion of fetA gene sequences in serogroup B and C Neisseria meningitidis isolatesJane W Marsh
University of Pittsburgh School of Medicine, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
J Clin Microbiol 45:1333-5. 2007..In this report, we describe the characterization of three meningococcal isolates that have deleted fetA sequences through genetic recombination at repetitive elements...
- Vaccine prevention of meningococcal disease: making slow progressLee H Harrison
Clin Infect Dis 43:1395-7. 2006
- tcdC genotypes associated with severe TcdC truncation in an epidemic clone and other strains of Clostridium difficileScott R Curry
Department of Medicine, University of Pittsburgh, School of Medicine, PA 15261, USA
J Clin Microbiol 45:215-21. 2007..Further investigations are required to determine the effect of this and other tcdC genotypes on toxin production and clinical disease...
- Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in HospitalsJane W Marsh
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Medical Center, Division of Hospital Epidemiology and Infection Control, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
J Clin Microbiol 44:2558-66. 2006..Thus, MLVA is an objective, portable genotyping method that permits reliable detection of C. difficile outbreaks and can aid epidemiologic investigations of nosocomial transmission...
- Antigenic shift and increased incidence of meningococcal diseaseLee H Harrison
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
J Infect Dis 193:1266-74. 2006..The cyclical nature of endemic meningococcal disease remains unexplained. The purpose of this study was to investigate the mechanisms associated with the increase in the incidence of meningococcal disease...
- Locus-specific mutational events in a multilocus variable-number tandem repeat analysis of Escherichia coli O157:H7Anna C Noller
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, 521 Parran Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
J Clin Microbiol 44:374-7. 2006..The remaining four loci had no slippage events detected. The mutation rates were locus specific and may impact the interpretation of MLVA data for epidemiologic investigations...
- Predictors of virologic failure in HIV-1-infected patients starting highly active antiretroviral therapy in Porto Alegre, BrazilSuely H Tuboi
Infectious Diseases Epidemiology Research Unit, Graduate School of Public Health and School of Medicine, University of Pittsburgh, PA, USA
J Acquir Immune Defic Syndr 40:324-8. 2005..With currently available therapies, compliance and education were shown to be predictors of virologic response, particularly in more immunocompromised patients...
- Erythromycin-nonsusceptible Streptococcus pneumoniae in children, 1999-2001M Catherine McEllistrem
University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15213 2582, USA
Emerg Infect Dis 11:969-72. 2005..The decline in infection rates was likely due to the pneumococcal 7-valent conjugate vaccine...
- Global epidemiology of meningococcal diseaseLee H Harrison
Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, 521 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, United States
Vaccine 27:B51-63. 2009....