Postpartum Depression: Omega-3 FA vs Placebo

Summary

Principal Investigator: M P Freeman
Abstract: [unreadable] DESCRIPTION (provided by applicant): Dr. Freeman is an Assistant Professor of Psychiatry at the University of Arizona and Director of the Women's Mental Health Program of the Department of Psychiatry. After receiving her M.D. from Northwestern University Medical School, she completed a psychiatry residency at the Harvard Longwood Psychiatry Residency Training Program and a Fellowship in Biological Psychiatry at the University of Cincinnati. Her immediate goals are: I) to obtain proficiency in clinical research methodology, with specific emphasis on gender-specific psychopharmacologic research, statistics, and ethical issues, and 2) to gain expertise in the research on mood disorders during pregnancy and the postpartum period. Long term goals are: 1) to become an independent investigator of mood disorders during pregnancy and postpartum, 2) to obtain an ROI award to support further study as an independent investigator, and 3) to serve as a mentor for junior investigators. The career development plan includes a structured didactic program designed to facilitate development to an independent investigator. Mentorship includes work with a primary mentor, Alan Gelenberg, M.D., and strong mentorship in the areas of women's psychiatry and omega-3 fatty acids. A multidisciplinary Advisory Committee will oversee the career development activities at the University of Arizona. The proposed research study is a double-blind, placebo-controlled 3-arm trial of omega-3 fatty acids (FA) in postpartum depression. Data suggest omega-3 fatty acids are efficacious in the treatment and prophylaxis of major depressive disorders. Omega-3 fatty acids may be especially relevant in the treatment of postpartum depression, due to the depletion of maternal omega-3 fatty acids that occurs during pregnancy. The purpose of this study is to determine the efficacy, as well as most effective dose, of omega-3 fatty acids for postpartum depression. Two omega-3 fatty acids in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Two different active arms are included in this protocol, one in which patients receive 2.8 g of EPA plus DHA (1.7 g EPA and 1.1 g DHA) and another in which patients receive I g EPA. The active arms were carefully chosen on the basis of pilot treatment data and epidemiological data; they should produce optimal tissue levels. These doses should provide an adequate test of the efficacy of omega-3 fatty acids while being safe for the mother and breastfeeding baby.
Funding Period: 2002-09-01 - 2007-06-30
more information: NIH RePORT

Top Publications

  1. ncbi Omega-3 fatty acids and supportive psychotherapy for perinatal depression: a randomized placebo-controlled study
    Marlene P Freeman
    Women s Mental Health Center, University of Texas Southwestern Medical Center, Dallas TX, USA
    J Affect Disord 110:142-8. 2008
  2. ncbi Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression
    M P Freeman
    Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ 85724 5002, USA
    Acta Psychiatr Scand 113:31-5. 2006
  3. ncbi Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry
    Marlene P Freeman
    Women s Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson 85724 5002, USA
    J Clin Psychiatry 67:1954-67. 2006
  4. ncbi Tolerability of omega-3 fatty acid supplements in perinatal women
    Marlene P Freeman
    Women s Mental Health Center, Department of Psychiatry, Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, 6363 Forest Park, Suite 800, Dallas, TX 75235 9086, USA
    Prostaglandins Leukot Essent Fatty Acids 77:203-8. 2007
  5. ncbi Pharmacokinetics of sertraline across pregnancy and postpartum
    Marlene P Freeman
    Department of Psychiatry, Women s Mental Health Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Clin Psychopharmacol 28:646-53. 2008
  6. ncbi Supportive psychotherapy for perinatal depression: preliminary data for adherence and response
    Marlene P Freeman
    Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital, Boston, Massachusetts, USA
    Depress Anxiety 27:39-45. 2010

Scientific Experts

Detail Information

Publications6

  1. ncbi Omega-3 fatty acids and supportive psychotherapy for perinatal depression: a randomized placebo-controlled study
    Marlene P Freeman
    Women s Mental Health Center, University of Texas Southwestern Medical Center, Dallas TX, USA
    J Affect Disord 110:142-8. 2008
    ..This study was designed to investigate the feasibility, safety, and efficacy of omega-3 fatty acids for perinatal depression in addition to supportive psychotherapy...
  2. ncbi Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression
    M P Freeman
    Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ 85724 5002, USA
    Acta Psychiatr Scand 113:31-5. 2006
    ..Postpartum depression (PPD) affects 10-15% of mothers. Omega-3 fatty acids are an intriguing potential treatment for PPD...
  3. ncbi Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry
    Marlene P Freeman
    Women s Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson 85724 5002, USA
    J Clin Psychiatry 67:1954-67. 2006
    ..To determine if the available data support the use of omega-3 essential fatty acids (EFA) for clinical use in the prevention and/or treatment of psychiatric disorders...
  4. ncbi Tolerability of omega-3 fatty acid supplements in perinatal women
    Marlene P Freeman
    Women s Mental Health Center, Department of Psychiatry, Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, 6363 Forest Park, Suite 800, Dallas, TX 75235 9086, USA
    Prostaglandins Leukot Essent Fatty Acids 77:203-8. 2007
    ..Benefits of omega-3 fatty acids in perinatal women are well documented, although fish intake has declined among perinatal women...
  5. ncbi Pharmacokinetics of sertraline across pregnancy and postpartum
    Marlene P Freeman
    Department of Psychiatry, Women s Mental Health Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Clin Psychopharmacol 28:646-53. 2008
    ..Despite nonsignificant mean pharmacokinetic changes, the range of pharmacokinetic changes across pregnancy warrants careful monitoring of depressive symptoms in women with MDD in late pregnancy and further study...
  6. ncbi Supportive psychotherapy for perinatal depression: preliminary data for adherence and response
    Marlene P Freeman
    Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital, Boston, Massachusetts, USA
    Depress Anxiety 27:39-45. 2010
    ..We sought to determine patient factors associated with adherence and response to a manualized supportive psychotherapy designed for pregnant and postpartum women with major depressive disorder (MDD)...