Function of the Urethra in Continent Women

Summary

Principal Investigator: Kimberly Kenton
Abstract: [unreadable] DESCRIPTION (provided by applicant): This application requests funds for two purposes: [unreadable] [unreadable] 1) Career Development: The applicant plans to obtain a Master of Science degree in Clinical Research Design and Statistical Analysis from the University of Michigan. The career goals include short and long-term goals. Short-term goals include the obtaining the Master Degree and beginning an innovative well-designed patient-oriented research project under the mentorship of a highly productive clinical researcher. The long-term goals include developing into an independent patient-oriented researcher with expertise in electrodiagnosis and urethral function, enhancing research abilities with a better understanding of methodology and design, designing follow-up studies to prevent and treat neuromuscular injuries to the urethral sphincter, submission of an R01 to fund such studies, and developing research mentoring skills to begin training the next generation of patient-oriented clinical researchers. [unreadable] [unreadable] 2) Research Project: The specific aims of the research plan are: 1. To acquire high-quality neuromuscular signals from the urethra using concentric needle electromyography (EMG; with quantitative motor unit analysis) and current perception threshold testing to test the null hypothesis that there are no differences in urethral neuromuscular function in: i) Caucasian and African American women; ii) Continent and stress incontinent women; and iii) Continent nulliparous and parous women. 2. To establish quantitative parameters of urethral sphincter function in women of various races. Normative ranges will be calculated for EMG, current perception thresholds, and urethral pressures for Caucasian and African American women. These data can then be used by other centers as reference data. [unreadable] [unreadable]
Funding Period: 2004-09-30 - 2010-09-29
more information: NIH RePORT

Top Publications

  1. ncbi Validation of a real-time urodynamic measure of urinary sensation
    Lior Lowenstein
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Loyola Medical Center, Chicago, IL 60153, USA
    Am J Obstet Gynecol 198:661.e1-4; discussion 661.e4-5. 2008
  2. ncbi Observations relating to urinary sensation during detrusor overactivity
    Lior Lowenstein
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics Gynecology and Urology, Loyola Medical Center, Chicago, Illinois, USA
    Neurourol Urodyn 28:497-500. 2009
  3. pmc Continent women have better urethral neuromuscular function than those with stress incontinence
    Kimberly Kenton
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Loyola University Stritch School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA
    Int Urogynecol J 22:1479-84. 2011
  4. pmc Neuromuscular characterization of the urethra in continent women
    Kimberly Kenton
    From the Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, and Department of Urology, Loyola University Stritch School of Medicine, Maywood, IL
    Female Pelvic Med Reconstr Surg 17:226-30. 2011
  5. ncbi Complex repetitive discharges--a feature of the urethral continence mechanism or a pathological finding?
    Olga Ramm
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Urol 187:2140-3. 2012
  6. pmc Effect of material properties on predicted vesical pressure during a cough in a simplified computational model of the bladder and urethra
    Thomas Spirka
    Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland Clinic Main Campus, Mail Code ND20, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Ann Biomed Eng 41:185-94. 2013

Detail Information

Publications6

  1. ncbi Validation of a real-time urodynamic measure of urinary sensation
    Lior Lowenstein
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Loyola Medical Center, Chicago, IL 60153, USA
    Am J Obstet Gynecol 198:661.e1-4; discussion 661.e4-5. 2008
    ..The purpose of this study was to test the feasibility and validity of a continuous measurement of urinary sensation during cystometry...
  2. ncbi Observations relating to urinary sensation during detrusor overactivity
    Lior Lowenstein
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics Gynecology and Urology, Loyola Medical Center, Chicago, Illinois, USA
    Neurourol Urodyn 28:497-500. 2009
    ..To describe the temporal relationship between increases in lower urinary tract (LUT) sensation and changes in detrusor and/or urethral pressures measured in real time...
  3. pmc Continent women have better urethral neuromuscular function than those with stress incontinence
    Kimberly Kenton
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Loyola University Stritch School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA
    Int Urogynecol J 22:1479-84. 2011
    ..The objective of this study is to describe urethral neuromuscular function using concentric needle electromyography (EMG) in stress incontinent (SUI) and asymptomatic women...
  4. pmc Neuromuscular characterization of the urethra in continent women
    Kimberly Kenton
    From the Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, and Department of Urology, Loyola University Stritch School of Medicine, Maywood, IL
    Female Pelvic Med Reconstr Surg 17:226-30. 2011
    ..The study's objective was to describe quantitative urethral function parameters in a racially diverse group of continent women...
  5. ncbi Complex repetitive discharges--a feature of the urethral continence mechanism or a pathological finding?
    Olga Ramm
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Urol 187:2140-3. 2012
    ..We compared the proportion of women with complex repetitive discharges on urethral sphincter electromyography during filling cystometry among women with and without urinary disorders...
  6. pmc Effect of material properties on predicted vesical pressure during a cough in a simplified computational model of the bladder and urethra
    Thomas Spirka
    Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland Clinic Main Campus, Mail Code ND20, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Ann Biomed Eng 41:185-94. 2013
    ..However, the insensitivity of vesical pressure predictions to material properties ensures that the outcome of our models is not highly sensitive to tissue material properties, which are not well characterized...