Comparison of kidney function measurement methods in the community

Summary

Principal Investigator: Andrew D Rule
Affiliation: Mayo Clinic
Country: USA
Abstract: Project Summary: The candidate is a nephrologist starting a staff position at the Mayo Clinic on July 1st, 2006. During the past 4 years as a nephrology trainee, the candidate obtained a Master's degree in Clinical Research, first-authored 10 peer-reviewed articles, and received institutional (T32) and individual (F32) National Research Awards. His expertise in the epidemiology of chronic kidney disease and in kidney function methods has gained national attention. He was a grant reviewer for the Centers for Disease Control and Prevention and will moderate a symposium at the American Society of Nephrology Renal Week (2006). The environment will consist of Mayo Clinic - Rochester, where he will have a joint appointment in Nephrology and Epidemiology. His sponsor, Stephen Turner, M.D., Professor of Medicine, will provide him with access to data and train him to be an independent investigator. His mentorship team will also include two Professors of Epidemiology, an Associate Professor of Biostatistics, and the Co-director of the Renal Function Laboratory where 5500 'gold-standard' kidney function measurements are performed annually. The project will compare kidney function measurements between a gold standard method (iothalamate clearance) and more convenient, but potentially less accurate methods, used in clinical practice and in most studies (serum creatinine, cystatin C, estimating equations, and creatinine clearance). The unique feature of this project will be to compare these kidney function methods in community-based samples (mentor's cohort and candidate's cohort). The effect of the kidney function measurement method on coronary artery calcification and risk factor associations with chronic kidney disease will be determined. Relevence: In the United States, 8 million adults have moderate-to-severe reductions in kidney function and are at risk for costly morbid interventions (dialysis or transplantation) and cardiovascular disease. Validation of kidney function methods is needed to identify chronic kidney disease at an earlier stage, characterize its risk factors, and develop new treatment strategies.
Funding Period: 2007-09-01 - 2012-08-31
more information: NIH RePORT

Top Publications

  1. pmc Kidney stones and the risk for chronic kidney disease
    Andrew D Rule
    Departments of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905
    Clin J Am Soc Nephrol 4:804-11. 2009
  2. ncbi Can we do better than a single estimated GFR threshold when screening for chronic kidney disease?
    E D Poggio
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Kidney Int 72:534-6. 2007
  3. pmc Hypertension during pregnancy is associated with coronary artery calcium independent of renal function
    Andrea E Cassidy-Bushrow
    Department of Biostatistics, Henry Ford Hospital, Detroit, Michigan, USA
    J Womens Health (Larchmt) 18:1709-16. 2009
  4. pmc Three-dimensional ultrasound bladder characteristics and their association with prostate size and lower urinary tract dysfunction among men in the community
    Andrew D Rule
    Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA
    Urology 74:908-13. 2009
  5. pmc Genome-wide linkage analysis for uric acid in families enriched for hypertension
    Andrew D Rule
    Division of Nephrology and Hypertension, Division of Biostatistics, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 24:2414-20. 2009
  6. pmc For estimating creatinine clearance measuring muscle mass gives better results than those based on demographics
    Andrew D Rule
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 75:1071-8. 2009
  7. pmc Use of renal function measurements for assessing fracture risk in postmenopausal women
    James T McCarthy
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 83:1231-9. 2008
  8. pmc Do we need another equation to estimate GFR from serum creatinine in renal allograft recipients?
    Andrew D Rule
    Nephrol Dial Transplant 23:2427-8; author reply 2428. 2008
  9. ncbi Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults
    Allison A Ellington
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St Southwest, Rochester, MN 55905, USA
    Hypertension 50:708-14. 2007
  10. pmc Risk factors for CKD in persons with kidney stones: a case-control study in Olmsted County, Minnesota
    Nathan A Saucier
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 55:61-8. 2010

Scientific Experts

  • Andrew D Rule
  • EMILIO DANIEL POGGIO
  • Nathan A Saucier
  • Andrea E Cassidy-Bushrow
  • Eric J Bergstralh
  • James T McCarthy
  • Stephen T Turner
  • Allison A Ellington
  • Kelly V Liang
  • Mukesh K Sinha
  • Xujian Li
  • John C Lieske
  • Amy L Weaver
  • Amy E Krambeck
  • Lawrence F Bielak
  • Patricia A Peyser
  • Vesna D Garovic
  • Patrick F Sheedy
  • Sara J Achenbach
  • Sundeep Khosla
  • L Joseph Melton
  • Thomas H Mosley
  • George G Klee
  • Iftikhar J Kullo
  • A Rauoof Malik

Detail Information

Publications12

  1. pmc Kidney stones and the risk for chronic kidney disease
    Andrew D Rule
    Departments of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905
    Clin J Am Soc Nephrol 4:804-11. 2009
    ..Kidney stones lead to chronic kidney disease (CKD) in people with rare hereditary disorders (e.g., primary hyperoxaluria, cystinuria), but it is unknown whether kidney stones are an important risk factor for CKD in the general population...
  2. ncbi Can we do better than a single estimated GFR threshold when screening for chronic kidney disease?
    E D Poggio
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Kidney Int 72:534-6. 2007
    ..However, data derived from healthy individuals challenge this approach and suggest that age- and gender-specific reference values may be more useful in the screening setting...
  3. pmc Hypertension during pregnancy is associated with coronary artery calcium independent of renal function
    Andrea E Cassidy-Bushrow
    Department of Biostatistics, Henry Ford Hospital, Detroit, Michigan, USA
    J Womens Health (Larchmt) 18:1709-16. 2009
    ..Reduced renal function is both a complication of HDP and a risk factor for CHD...
  4. pmc Three-dimensional ultrasound bladder characteristics and their association with prostate size and lower urinary tract dysfunction among men in the community
    Andrew D Rule
    Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA
    Urology 74:908-13. 2009
    ..To characterize ultrasound bladder measures, and to determine whether these measures were associated with measures of lower urinary tract dysfunction...
  5. pmc Genome-wide linkage analysis for uric acid in families enriched for hypertension
    Andrew D Rule
    Division of Nephrology and Hypertension, Division of Biostatistics, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 24:2414-20. 2009
    ..Uric acid is heritable and associated with hypertension and insulin resistance. We sought to identify genomic regions influencing serum uric acid in families in which two or more siblings had hypertension...
  6. pmc For estimating creatinine clearance measuring muscle mass gives better results than those based on demographics
    Andrew D Rule
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 75:1071-8. 2009
    ..Our study shows that the likelihood of chronic kidney disease in the elderly and in women and the risk of adverse outcomes may be inflated by equations that use patient demographics to estimate creatinine generation...
  7. pmc Use of renal function measurements for assessing fracture risk in postmenopausal women
    James T McCarthy
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 83:1231-9. 2008
    ....
  8. pmc Do we need another equation to estimate GFR from serum creatinine in renal allograft recipients?
    Andrew D Rule
    Nephrol Dial Transplant 23:2427-8; author reply 2428. 2008
  9. ncbi Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults
    Allison A Ellington
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St Southwest, Rochester, MN 55905, USA
    Hypertension 50:708-14. 2007
    ..This association was independent of coronary heart disease risk factors and markers of insulin resistance and inflammation...
  10. pmc Risk factors for CKD in persons with kidney stones: a case-control study in Olmsted County, Minnesota
    Nathan A Saucier
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 55:61-8. 2010
    ..Kidney stones are associated with increased risk of chronic kidney disease (CKD); however, risk factors in the general community are poorly defined...