Comparison of kidney function measurement methods in the community

Summary

Principal Investigator: Andrew D Rule
Affiliation: Mayo Clinic
Country: USA
Abstract: Project Summary: The candidate is a nephrologist starting a staff position at the Mayo Clinic on July 1st, 2006. During the past 4 years as a nephrology trainee, the candidate obtained a Master's degree in Clinical Research, first-authored 10 peer-reviewed articles, and received institutional (T32) and individual (F32) National Research Awards. His expertise in the epidemiology of chronic kidney disease and in kidney function methods has gained national attention. He was a grant reviewer for the Centers for Disease Control and Prevention and will moderate a symposium at the American Society of Nephrology Renal Week (2006). The environment will consist of Mayo Clinic - Rochester, where he will have a joint appointment in Nephrology and Epidemiology. His sponsor, Stephen Turner, M.D., Professor of Medicine, will provide him with access to data and train him to be an independent investigator. His mentorship team will also include two Professors of Epidemiology, an Associate Professor of Biostatistics, and the Co-director of the Renal Function Laboratory where 5500 'gold-standard' kidney function measurements are performed annually. The project will compare kidney function measurements between a gold standard method (iothalamate clearance) and more convenient, but potentially less accurate methods, used in clinical practice and in most studies (serum creatinine, cystatin C, estimating equations, and creatinine clearance). The unique feature of this project will be to compare these kidney function methods in community-based samples (mentor's cohort and candidate's cohort). The effect of the kidney function measurement method on coronary artery calcification and risk factor associations with chronic kidney disease will be determined. Relevence: In the United States, 8 million adults have moderate-to-severe reductions in kidney function and are at risk for costly morbid interventions (dialysis or transplantation) and cardiovascular disease. Validation of kidney function methods is needed to identify chronic kidney disease at an earlier stage, characterize its risk factors, and develop new treatment strategies.
Funding Period: 2007-09-01 - 2012-08-31
more information: NIH RePORT

Top Publications

  1. pmc Kidney stones and the risk for chronic kidney disease
    Andrew D Rule
    Departments of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905
    Clin J Am Soc Nephrol 4:804-11. 2009
  2. pmc Estimating the glomerular filtration rate from serum creatinine is better than from cystatin C for evaluating risk factors associated with chronic kidney disease
    Andrew D Rule
    Division of Nephrology and Hypertension, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 83:1169-76. 2013
  3. doi The association of serum uric acid levels with outcomes following percutaneous coronary intervention
    Daniel B Spoon
    Division of Cardiovascular Disease and Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Interv Cardiol 23:277-83. 2010
  4. pmc Temporal trends in incidence of kidney stones among children: a 25-year population based study
    Moira E Dwyer
    Department of Urology, Mayo Clinic, Rochester, Minnesota, USA
    J Urol 188:247-52. 2012
  5. pmc Urolithiasis and the risk of ESRD
    Ziad M El-Zoghby
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin J Am Soc Nephrol 7:1409-15. 2012
  6. pmc Kidney stones associate with increased risk for myocardial infarction
    Andrew D Rule
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Am Soc Nephrol 21:1641-4. 2010
  7. pmc Kidney function and risk triage in adults: threshold values and hierarchical importance
    Robert N Foley
    United States Renal System, Minneapolis, Minnesota 55404, USA
    Kidney Int 79:99-111. 2011
  8. pmc Shock wave lithotripsy is not predictive of hypertension among community stone formers at long-term followup
    Amy E Krambeck
    Department of Urology, Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA
    J Urol 185:164-9. 2011
  9. pmc Association between SLC2A9 transporter gene variants and uric acid phenotypes in African American and white families
    Andrew D Rule
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Rheumatology (Oxford) 50:871-8. 2011
  10. pmc Clinical characteristics of potential kidney donors with asymptomatic kidney stones
    Elizabeth C Lorenz
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 26:2695-700. 2011

Scientific Experts

  • Andrew D Rule
  • EMILIO DANIEL POGGIO
  • Robert N Foley
  • R J Glassock
  • Amy E Krambeck
  • Lesley A Stevens
  • John C Lieske
  • Eric J Bergstralh
  • Xujian Li
  • Elizabeth C Lorenz
  • L Joseph Melton
  • Stephen T Turner
  • Ziad M El-Zoghby
  • Moira E Dwyer
  • Kazunori Murata
  • Terri J Vrtiska
  • Nathan A Saucier
  • Daniel B Spoon
  • Tibor Fulop
  • Andrea E Cassidy-Bushrow
  • James T McCarthy
  • Iftikhar J Kullo
  • Thomas H Mosley
  • Allison A Ellington
  • Dawn S Milliner
  • Amy K Saenger
  • Timothy S Larson
  • Nikola A Baumann
  • Kelly V Liang
  • John J Dillon
  • Mukesh K Sinha
  • Charanjit S Rihal
  • Ryan J Lennon
  • Amir Lerman
  • Abhiram Prasad
  • Amy L Weaver
  • Mark D Stegall
  • David R Holmes
  • Heather J Wiste
  • Patricia A Peyser
  • Eric Boerwinkle
  • Darren W Schmidt
  • Lawrence F Bielak
  • Kent R Bailey
  • Vesna D Garovic
  • Patrick F Sheedy
  • Gary L Schwartz
  • Sara J Achenbach
  • Sundeep Khosla
  • George G Klee
  • A Rauoof Malik

Detail Information

Publications38

  1. pmc Kidney stones and the risk for chronic kidney disease
    Andrew D Rule
    Departments of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota 55905
    Clin J Am Soc Nephrol 4:804-11. 2009
    ..Kidney stones lead to chronic kidney disease (CKD) in people with rare hereditary disorders (e.g., primary hyperoxaluria, cystinuria), but it is unknown whether kidney stones are an important risk factor for CKD in the general population...
  2. pmc Estimating the glomerular filtration rate from serum creatinine is better than from cystatin C for evaluating risk factors associated with chronic kidney disease
    Andrew D Rule
    Division of Nephrology and Hypertension, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 83:1169-76. 2013
    ..This is explained by the association of these risk factors with the non-GFR determinants of cystatin C...
  3. doi The association of serum uric acid levels with outcomes following percutaneous coronary intervention
    Daniel B Spoon
    Division of Cardiovascular Disease and Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Interv Cardiol 23:277-83. 2010
    ..Our goal was to assess the association of serum uric acid levels and the outcomes of patients who have undergone percutaneous coronary intervention (PCI)...
  4. pmc Temporal trends in incidence of kidney stones among children: a 25-year population based study
    Moira E Dwyer
    Department of Urology, Mayo Clinic, Rochester, Minnesota, USA
    J Urol 188:247-52. 2012
    ..We conducted a population based pediatric study to determine the incidence of symptomatic kidney stones during a 25-year period and to identify factors related to variation in stone incidence during this period...
  5. pmc Urolithiasis and the risk of ESRD
    Ziad M El-Zoghby
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin J Am Soc Nephrol 7:1409-15. 2012
    ..The contribution of urolithiasis, if any, to the development of ESRD is unclear...
  6. pmc Kidney stones associate with increased risk for myocardial infarction
    Andrew D Rule
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Am Soc Nephrol 21:1641-4. 2010
    ..In conclusion, kidney stone formers are at increased risk for MI, and this risk is independent of CKD and other risk factors...
  7. pmc Kidney function and risk triage in adults: threshold values and hierarchical importance
    Robert N Foley
    United States Renal System, Minneapolis, Minnesota 55404, USA
    Kidney Int 79:99-111. 2011
    ..Thus, the albumin-creatinine ratio and eGFR may be at least as efficient for survival-based clinical triage as most other classic risk factors...
  8. pmc Shock wave lithotripsy is not predictive of hypertension among community stone formers at long-term followup
    Amy E Krambeck
    Department of Urology, Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA
    J Urol 185:164-9. 2011
    ..Concern exists over the subsequent development of hypertension after shock wave lithotripsy for the treatment of symptomatic urolithiasis. Referral bias and lack of long-term followup have been limitations of prior studies...
  9. pmc Association between SLC2A9 transporter gene variants and uric acid phenotypes in African American and white families
    Andrew D Rule
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Rheumatology (Oxford) 50:871-8. 2011
    ....
  10. pmc Clinical characteristics of potential kidney donors with asymptomatic kidney stones
    Elizabeth C Lorenz
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 26:2695-700. 2011
    ..Whether these characteristics differ in patients with asymptomatic kidney stones is unknown...
  11. pmc Association of kidney function and metabolic risk factors with density of glomeruli on renal biopsy samples from living donors
    Andrew D Rule
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905
    Mayo Clin Proc 86:282-90. 2011
    ..To test the hypothesis that kidney function and metabolic risk factors are associated with glomerular density on renal biopsy samples from healthy adults...
  12. pmc Relative performance of the MDRD and CKD-EPI equations for estimating glomerular filtration rate among patients with varied clinical presentations
    Kazunori Murata
    Mayo Clinic Division of Nephrology and Hypertension, 200 First Street SW, Rochester, MN 55905, USA
    Clin J Am Soc Nephrol 6:1963-72. 2011
    ..The objective of our study was to compare the accuracy of the MDRD and CKD-EPI equations for estimating GFR in a large group of patients having GFR measurements for diverse clinical indications...
  13. pmc Chronic kidney disease in kidney stone formers
    Andrew D Rule
    Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Clin J Am Soc Nephrol 6:2069-75. 2011
    ..Further studies that better classify CKD, better characterize stone formers, more thoroughly address potential confounding by comorbidities, and have active instead of passive follow-up to avoid detection bias are needed...
  14. pmc Senile nephrosclerosis--does it explain the decline in glomerular filtration rate with aging?
    Andrew D Rule
    Division of Nephrology and Hypertension and Division of Epidemiology, Rochester, MN 55905, USA rule andrew mayo edu
    Nephron Physiol 119:p6-11. 2011
    ..However, the argument that the age-related decline in GFR can be fully explained by the development of nephrosclerosis in a subset of older adults is not supported by existing data...
  15. pmc Characteristics of renal cystic and solid lesions based on contrast-enhanced computed tomography of potential kidney donors
    Andrew D Rule
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 59:611-8. 2012
    ..The objective of this study was to detail renal cystic and solid lesions and identify any association with clinical characteristics...
  16. pmc The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli
    Richard J Glassock
    Geffen School of Medicine at UCLA, Los Angeles, California 92677, USA
    Kidney Int 82:270-7. 2012
    ..This review describes important shortcomings and deficiencies with our current approach and understanding of CKD in the older and elderly adult...
  17. pmc The association between age and nephrosclerosis on renal biopsy among healthy adults
    Andrew D Rule
    Mayo Clinic, Rochester, Minnesota, USA
    Ann Intern Med 152:561-7. 2010
    ..Chronic kidney disease is common with older age and is characterized on renal biopsy by global glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis...
  18. pmc C-reactive Protein among Community-Dwelling Hypertensives on Single-agent Antihypertensive Treatment
    Tibor Fulop
    Internal Medicine, University of Mississippi Medical Center, Jackson, MS, United States
    J Am Soc Hypertens 3:260-6. 2009
    ..C-reactive protein is a predictor of adverse cardiovascular outcomes. The effect of antihypertensive therapy on C-reactive protein levels is largely unknown...
  19. pmc Demographic and clinical characteristics associated with glomerular filtration rates in living kidney donors
    Emilio D Poggio
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland, Ohio 44195, USA
    Kidney Int 75:1079-87. 2009
    ..49+/-0.61 ml/min per 1.73 m(2) per decade of testing. Our study shows that age and gender are important factors determining normal GFR in living kidney donors...
  20. pmc Development and validation of GFR-estimating equations using diabetes, transplant and weight
    Lesley A Stevens
    Tufts Medical Center, Boston, MA, USA
    Nephrol Dial Transplant 25:449-57. 2010
    ..Here, we describe the development and validation of this equation as well as other equations that incorporate diabetes, transplant and weight as additional predictor variables...
  21. pmc Prevalence of renal artery and kidney abnormalities by computed tomography among healthy adults
    Elizabeth C Lorenz
    Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Clin J Am Soc Nephrol 5:431-8. 2010
    ..Therefore, the prevalence and management of these abnormalities were determined among a large cohort of potential kidney donors undergoing protocol evaluations...
  22. ncbi Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults
    Allison A Ellington
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St Southwest, Rochester, MN 55905, USA
    Hypertension 50:708-14. 2007
    ..This association was independent of coronary heart disease risk factors and markers of insulin resistance and inflammation...
  23. pmc Use of renal function measurements for assessing fracture risk in postmenopausal women
    James T McCarthy
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 83:1231-9. 2008
    ....
  24. pmc Do we need another equation to estimate GFR from serum creatinine in renal allograft recipients?
    Andrew D Rule
    Nephrol Dial Transplant 23:2427-8; author reply 2428. 2008
  25. pmc For estimating creatinine clearance measuring muscle mass gives better results than those based on demographics
    Andrew D Rule
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 75:1071-8. 2009
    ..Our study shows that the likelihood of chronic kidney disease in the elderly and in women and the risk of adverse outcomes may be inflated by equations that use patient demographics to estimate creatinine generation...
  26. pmc Genome-wide linkage analysis for uric acid in families enriched for hypertension
    Andrew D Rule
    Division of Nephrology and Hypertension, Division of Biostatistics, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 24:2414-20. 2009
    ..Uric acid is heritable and associated with hypertension and insulin resistance. We sought to identify genomic regions influencing serum uric acid in families in which two or more siblings had hypertension...
  27. pmc Three-dimensional ultrasound bladder characteristics and their association with prostate size and lower urinary tract dysfunction among men in the community
    Andrew D Rule
    Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA
    Urology 74:908-13. 2009
    ..To characterize ultrasound bladder measures, and to determine whether these measures were associated with measures of lower urinary tract dysfunction...
  28. pmc Hypertension during pregnancy is associated with coronary artery calcium independent of renal function
    Andrea E Cassidy-Bushrow
    Department of Biostatistics, Henry Ford Hospital, Detroit, Michigan, USA
    J Womens Health (Larchmt) 18:1709-16. 2009
    ..Reduced renal function is both a complication of HDP and a risk factor for CHD...
  29. pmc Risk factors for CKD in persons with kidney stones: a case-control study in Olmsted County, Minnesota
    Nathan A Saucier
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 55:61-8. 2010
    ..Kidney stones are associated with increased risk of chronic kidney disease (CKD); however, risk factors in the general community are poorly defined...
  30. ncbi Can we do better than a single estimated GFR threshold when screening for chronic kidney disease?
    E D Poggio
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Kidney Int 72:534-6. 2007
    ..However, data derived from healthy individuals challenge this approach and suggest that age- and gender-specific reference values may be more useful in the screening setting...