Rapid Trichomonas tests: a teen STI prevention strategy

Summary

Principal Investigator: Jill Huppert
Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA
Abstract: Jill Huppert, M.D., M.P.H., is an Ob/Gyn who served as a staff physician in the Indian Health Service and was assistant director of an Ob/Gyn residency program before she embarked on a research career. She obtained an M.P.H. from Johns Hopkins School of Public Health and completed a NRSA general research fellowship at Cincinnati Children's Hospital Medical Center. She joined the CCHMC faculty in Pediatric and Adolescent Gynecology in order to pursue a career in the prevention of sexually transmitted infections (STIs) in adolescents. David Bernstein, M.D., the project Sponsor, is an established NIH investigator with nationally recognized expertise in viral STIs and a successful mentor. Dr. Huppert has assembled an outstanding multidisciplinary research team to guide her career. She has outlined a training and research plan that utilizes the available research environment, builds on the work of her sponsor and others within the institution, and establishes links with outside resources. Dr. Huppert's overall career goal is to become an independent clinical investigator in adolescent STIs that will translate into prevention practice and improve public health. Her premise is that the accurate and rapid detection of trichomonas vaginalis (TV) in adolescents will result in changes in patient behavior, will improve the detection of other STIs, and ultimately improve STI-related health outcomes. The objective of this research plan is to explore rapid, point-of-care testing for TV and acceptability for self-testing in order to understand how these strategies may enhance a conceptual model for improved STI screening among adolescent females. Aim 1: To examine the performance of the new rapid TV test and it's associations with clinical outcomes among high risk adolescent females, in order to design and evaluate clinical guidelines for TV screening. This will be explored with a study of sexually active adolescent females with genitourinary symptoms. Aim 2: To explore the test characteristics of self- versus clinician-obtained tests for TV in adolescent females, in order to determine the best screening strategy for TV in adolescent females. Aim 3: To explore the acceptability of self- versus clinician-obtained rapid tests for TV in adolescent females, in order to expand the use of self testing as a strategy for STI detection in adolescent females. Aims 2 and 3 will be explored with a prospective study of asymptomatic adolescent females. Aim 4: To evaluate the impact of rapid TV testing on adolescent females on TV detection and treatment and subsequent sexual behavior, including condom use and abstinence. This will be piloted as a prospective longitudinal study of adolescent females.
Funding Period: 2005-07-01 - 2010-05-31
more information: NIH RePORT

Top Publications

  1. ncbi Rapid antigen testing compares favorably with transcription-mediated amplification assay for the detection of Trichomonas vaginalis in young women
    Jill S Huppert
    Division of Adoeslecent Medicine, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Clin Infect Dis 45:194-8. 2007
  2. pmc VirD: a virion display array for profiling functional membrane proteins
    Shaohui Hu
    Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Anal Chem 85:8046-54. 2013
  3. pmc Clinical evidence for the role of Trichomonas vaginalis in regulation of secretory leukocyte protease inhibitor in the female genital tract
    Jill S Huppert
    Division of Gynecology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    J Infect Dis 207:1462-70. 2013
  4. pmc Abnormal vaginal pH and Mycoplasma genitalium infection
    Jill S Huppert
    Division of Pediatric and Adolescent Gynecology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Pediatr Adolesc Gynecol 26:36-9. 2013
  5. pmc Accuracy and trust of self-testing for bacterial vaginosis
    Jill S Huppert
    Division of Pediatric and Adolescent Gynecology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Adolesc Health 51:400-5. 2012
  6. pmc Improving notification of sexually transmitted infections: a quality improvement project and planned experiment
    Jill S Huppert
    Division of Pediatric and Adolescent Gynecology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC Cincinnati, OH 45229 3039, USA
    Pediatrics 130:e415-22. 2012
  7. pmc Adolescent women can perform a point-of-care test for trichomoniasis as accurately as clinicians
    Jill S Huppert
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 4000, Cincinnati, OH 45229 3039, USA
    Sex Transm Infect 86:514-9. 2010
  8. pmc Acceptability of self-testing for trichomoniasis increases with experience
    Jill S Huppert
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Sex Transm Infect 87:494-500. 2011
  9. pmc Point-of-care testing for sexually transmitted infections increases awareness and short-term abstinence in adolescent women
    Jennifer L Reed
    Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Adolesc Health 46:270-7. 2010
  10. pmc Stepwise diagnosis of Trichomonas vaginalis infection in adolescent women
    Lucia Pattullo
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, ML 4000, Cincinnati, OH 45229 3039, USA
    J Clin Microbiol 47:59-63. 2009

Scientific Experts

  • Jennifer L Reed
  • P J Desai
  • Jill Huppert
  • Shaohui Hu
  • Lucia Pattullo
  • Amina I Malik
  • Min Li
  • Xiaofang Huang
  • Heng Zhu
  • Brandon Henson
  • Bochu Wang
  • Yingzhu Feng
  • Joel Mortensen
  • Jessica Kahn
  • Sarah Griffeth
  • Lili Ding

Detail Information

Publications15

  1. ncbi Rapid antigen testing compares favorably with transcription-mediated amplification assay for the detection of Trichomonas vaginalis in young women
    Jill S Huppert
    Division of Adoeslecent Medicine, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Clin Infect Dis 45:194-8. 2007
    ..We assessed the sensitivity and specificity of 4 tests for the identification of TV using 3 statistical approaches...
  2. pmc VirD: a virion display array for profiling functional membrane proteins
    Shaohui Hu
    Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Anal Chem 85:8046-54. 2013
    ..This method can be readily scaled or tailored for different modalities including a high-content, high-throughput platform for screening ligands and drugs of human membrane proteins. ..
  3. pmc Clinical evidence for the role of Trichomonas vaginalis in regulation of secretory leukocyte protease inhibitor in the female genital tract
    Jill S Huppert
    Division of Gynecology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    J Infect Dis 207:1462-70. 2013
    ..Depressed cervicovaginal SLPI levels have been correlated with both Trichomonas vaginalis infection and poor reproductive health outcomes...
  4. pmc Abnormal vaginal pH and Mycoplasma genitalium infection
    Jill S Huppert
    Division of Pediatric and Adolescent Gynecology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Pediatr Adolesc Gynecol 26:36-9. 2013
    ..Mycoplasma genitalium (MG) is a sexually transmitted pathogen linked to female morbidity, but testing for MG is not standardized. We aimed to determine which point-of-care (POC) vaginal tests could predict MG infection...
  5. pmc Accuracy and trust of self-testing for bacterial vaginosis
    Jill S Huppert
    Division of Pediatric and Adolescent Gynecology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Adolesc Health 51:400-5. 2012
    ....
  6. pmc Improving notification of sexually transmitted infections: a quality improvement project and planned experiment
    Jill S Huppert
    Division of Pediatric and Adolescent Gynecology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC Cincinnati, OH 45229 3039, USA
    Pediatrics 130:e415-22. 2012
    ..The goal of this study was to improve our ability to contact adolescent women with positive STI test results after an emergency department visit...
  7. pmc Adolescent women can perform a point-of-care test for trichomoniasis as accurately as clinicians
    Jill S Huppert
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 4000, Cincinnati, OH 45229 3039, USA
    Sex Transm Infect 86:514-9. 2010
    ..To compare the accuracy (ie, correlation, sensitivity, specificity) of self-performed point-of-care (POC) tests with clinician-performed tests for trichomoniasis in adolescent women...
  8. pmc Acceptability of self-testing for trichomoniasis increases with experience
    Jill S Huppert
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Sex Transm Infect 87:494-500. 2011
    ....
  9. pmc Point-of-care testing for sexually transmitted infections increases awareness and short-term abstinence in adolescent women
    Jennifer L Reed
    Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Adolesc Health 46:270-7. 2010
    ..To evaluate the effect of point-of-care (POC) testing for sexually transmitted infections (STIs) on reported awareness of test results and STI risk-reduction behaviors in adolescents...
  10. pmc Stepwise diagnosis of Trichomonas vaginalis infection in adolescent women
    Lucia Pattullo
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, ML 4000, Cincinnati, OH 45229 3039, USA
    J Clin Microbiol 47:59-63. 2009
    ..Until a NAAT for T. vaginalis is commercially available, a stepwise approach using an additional rapid test for wet-mount-negative women is recommended for adolescent women regardless of clinical factors...
  11. pmc Localization of herpes simplex virus type 1 UL37 in the Golgi complex requires UL36 but not capsid structures
    Prashant Desai
    Johns Hopkins University, Viral Oncology Program, 353 CRB1, 1650 Orleans St, Baltimore, MD 21117, USA
    J Virol 82:11354-61. 2008
    ..This is the first demonstration of a functional role for UL36:UL37 interaction in HSV-1-infected cells...
  12. pmc Predictors of adolescent participation in sexually transmitted infection research: brief report
    Jennifer L Reed
    Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Adolesc Health 43:195-7. 2008
    ..94%, p = .01). Of the adolescents, 100% requested confidential test results. We conclude that requiring parental consent decreases participation in STI research...
  13. pmc Mycoplasma genitalium detected by transcription-mediated amplification is associated with Chlamydia trachomatis in adolescent women
    Jill S Huppert
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center Cincinnati, Ohio 45229 3039, USA
    Sex Transm Dis 35:250-4. 2008
    ....
  14. pmc Interval to treatment of sexually transmitted infections in adolescent females
    Amina I Malik
    University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Pediatr Adolesc Gynecol 20:275-9. 2007
    ....