Clinical and Research Training Program for Academic Vascular Medicine Specialists

Summary

Principal Investigator: Mark Creager
Affiliation: Massachusetts General Hospital
Country: USA
Abstract: Vascular diseases constitute some of the most common causes of disability and death in Western society. Yet, few physicians have chosen vascular disease as an area of clinical specialization. Academically oriented vascular medicine training programs are required to develop vascular medicine specialists with the leadership skills and academic credentials to educate future generations of vascular specialists. Accordingly, we propose to establish a comprehensive Vascular Medicine training program that includes: 1) a core clinical curriculum taught by a multidisciplinary faculty of vascular medicine physicians, vascular surgeons and vascular radiologists; 2) an extended didactic clinical research curriculum; and 3) a mentored clinical research experience. The proposed program will admit seven trainees, each for three years. The first year of the program will include clinical training and expose the trainee to all aspects of vascular medicine including peripheral arterial disease, renal and mesenteric vascular disease, cerebrovascular disease, venous thromboembolism, venous insufficiency, lymphedema, vasculitis, vasospasm, and less common vascular disorders. Clinical time will be devoted to inpatient and outpatient vascular consultations, the noninvasive vascular laboratory, computed tomographic and magnetic resonance angiography, peripheral angiography, endovascular interventions and vascular surgery. The second and third years of training will emphasize clinical research. This will include an extended didactic clinical research curriculum emphasizing epidemiology, statistics, clinical trials design, and include principles of pharmacology, genetics in clinical investigation, bioethics and responsible research conduct and additional coursework leading to a Masters degree in Medical Science or Public Health, as appropriate given training and career goals. Coursework will be supplemented by research seminars and journal clubs. Trainees will work closely with mentors who will supervise their research activity and guide the trainees' career development. The mentored clinical research experience will include a vascular research project and teach skills in protocol development, experimental technique, methods, analysis, oral presentation, manuscript writing and grant preparation. Research activities will leverage the many clinical research programs and facilities that are available at Brigham and Women's Hospital, Harvard Medical School and the Harvard School of Public Health. These resources will provide significant opportunities for the trainee to acquire clinical research skills and facilitate a successful transition towards independence as a clinical investigator. As a consequence of the intensive clinical and research training integrated in this program, we are confident that we will successfully prepare future academic leaders in the field of Vascular Medicine.
Funding Period: 2006-06-01 - 2011-05-31
more information: NIH RePORT

Top Publications

  1. ncbi Diagnostic performance of copeptin in patients with acute nontraumatic chest pain: BWH-TIMI ED chest pain study
    Devraj Sukul
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, Massachusetts
    Clin Cardiol 37:227-32. 2014
  2. pmc Venous thromboembolism in patients with chronic obstructive pulmonary disease
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Med 125:1010-8. 2012
  3. pmc Prevalence, distribution, and risk factor correlates of high thoracic periaortic fat in the Framingham Heart Study
    Kathryn A Britton
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Am Heart Assoc 1:e004200. 2012
  4. pmc Venous thromboembolic events in hospitalised medical patients
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Thromb Haemost 102:505-10. 2009
  5. doi Hospital costs of acute pulmonary embolism
    John Fanikos
    Department of Pharmacy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Med 126:127-32. 2013
  6. doi Randomized trial of physician alerts for thromboprophylaxis after discharge
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Med 126:435-42. 2013
  7. ncbi Effect of dabigatran on referrals to and switching from warfarin in two academic anticoagulation management services
    Julie K Atay
    Department of Pharmacy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Cardiol 112:387-9. 2013
  8. pmc Thoracic periaortic and visceral adipose tissue and their cross-sectional associations with measures of vascular function
    Kathryn A Britton
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Obesity (Silver Spring) 21:1496-503. 2013
  9. pmc Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality
    Kathryn A Britton
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Am Coll Cardiol 62:921-5. 2013
  10. pmc Evaluation of the diagnostic performance of current and next-generation assays for cardiac troponin I in the BWH-TIMI ED Chest Pain Study
    Marc P Bonaca
    Harvard Medical School, Boston, MA, USA
    Eur Heart J Acute Cardiovasc Care 2:195-202. 2013

Scientific Experts

  • Gregory Piazza
  • Reena L Pande
  • Kathryn A Britton
  • Mark Creager
  • Todd Perlstein
  • John Fanikos
  • Samuel Z Goldhaber
  • Julie K Atay
  • Marc P Bonaca
  • Devraj Sukul
  • Petr Jarolim
  • David A Morrow
  • Christian T Ruff
  • Sabina A Murphy
  • Marc S Sabatine
  • Joshua Kosowsky
  • Andrew C Seger
  • Steven Baroletti
  • Amanda Rao
  • Yoji Andrew Minamishima
  • Heather L Gornik
  • Michael Conrad
  • John Coatney
  • Michael J Conrad
  • James B Froehlich
  • Michael Ehle
  • Geoffrey D Barnes
  • Danielle Carter
  • Karen Fiumara
  • Shelley Hurwitz
  • Nicole A S Conti
  • Xiaohua Chen
  • Elaine Catapane
  • Nabeel Bardeesy
  • Darragh Cullen
  • Javid Moslehi
  • Roderick T Bronson
  • William G Kaelin

Detail Information

Publications39

  1. ncbi Diagnostic performance of copeptin in patients with acute nontraumatic chest pain: BWH-TIMI ED chest pain study
    Devraj Sukul
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, Massachusetts
    Clin Cardiol 37:227-32. 2014
    ..Copeptin is the C-terminal fragment of vasopressin precursor hormone that is more easily measured than AVP. Studies assessing the utility of copeptin in the diagnosis of myocardial infarction (MI) have demonstrated mixed results...
  2. pmc Venous thromboembolism in patients with chronic obstructive pulmonary disease
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Med 125:1010-8. 2012
    ..Our aim was to compare the clinical characteristics, prophylaxis, treatment, and outcomes of venous thromboembolism in patients with and without previously diagnosed chronic obstructive pulmonary disease...
  3. pmc Prevalence, distribution, and risk factor correlates of high thoracic periaortic fat in the Framingham Heart Study
    Kathryn A Britton
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Am Heart Assoc 1:e004200. 2012
    ..We sought to determine the prevalence, distribution, and risk factor correlates of high TAT...
  4. pmc Venous thromboembolic events in hospitalised medical patients
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Thromb Haemost 102:505-10. 2009
    ..The number of VTE-related events would be halved with universal thromboprophylaxis. Further efforts focused on improving VTE prevention strategies in hospitalised medical patients are warranted...
  5. doi Hospital costs of acute pulmonary embolism
    John Fanikos
    Department of Pharmacy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Med 126:127-32. 2013
    ..We evaluated hospitalized patients with the primary diagnosis of pulmonary embolism. Our goal was to determine the total and component costs associated with their hospital care...
  6. doi Randomized trial of physician alerts for thromboprophylaxis after discharge
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Med 126:435-42. 2013
    ....
  7. ncbi Effect of dabigatran on referrals to and switching from warfarin in two academic anticoagulation management services
    Julie K Atay
    Department of Pharmacy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Cardiol 112:387-9. 2013
    ..The frequency of initial prescription of dabigatran for stroke prevention in AF and the frequency of transition from warfarin to dabigatran have been less than expected...
  8. pmc Thoracic periaortic and visceral adipose tissue and their cross-sectional associations with measures of vascular function
    Kathryn A Britton
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Obesity (Silver Spring) 21:1496-503. 2013
    ..Perivascular fat may have a local adverse effect on the vasculature. We evaluated whether thoracic periaortic adipose tissue (TAT), a type of perivascular fat, and visceral adipose tissue (VAT) were associated with vascular function...
  9. pmc Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality
    Kathryn A Britton
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Am Coll Cardiol 62:921-5. 2013
    ..The aim of this study was to determine whether ectopic fat depots are prospectively associated with cardiovascular disease, cancer, and all-cause mortality...
  10. pmc Evaluation of the diagnostic performance of current and next-generation assays for cardiac troponin I in the BWH-TIMI ED Chest Pain Study
    Marc P Bonaca
    Harvard Medical School, Boston, MA, USA
    Eur Heart J Acute Cardiovasc Care 2:195-202. 2013
    ..We examined the performance of an investigational troponin I (TnI) assay with 10-100-times greater sensitivity than current commercial assays...
  11. doi Hospital budget implications of substituting dabigatran for warfarin in an anticoagulation service
    Julie K Atay
    Department of Pharmacy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Appl Thromb Hemost 18:181-4. 2012
    ..This was comprised of $856,842 for labor, $473,658 for INR testing, and $54,994 for the drug cost of warfarin. Substitution will result in increased expense due to drug cost...
  12. doi Venous thromboembolism in patients with symptomatic atherosclerosis
    Gregory Piazza
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Thromb Haemost 106:1095-102. 2011
    ..Despite a high frequency of comorbid conditions contributing to the risk of VTE, we observed a low rate of thromboprophylaxis in patients with symptomatic atherosclerosis...
  13. doi Thrombosis in suspected heparin-induced thrombocytopenia occurs more often with high antibody levels
    Steven Baroletti
    Department of Pharmacy, MetroWest Medical Center, Framingham, MA, USA
    Am J Med 125:44-9. 2012
    ..An enzyme-linked immunosorbent assay detects anti-PF4/heparin antibodies to support a suspected clinical diagnosis of heparin-induced thrombocytopenia. The utility of quantitative enzyme-linked immunosorbent assay results is uncertain...
  14. pmc Anticoagulation-associated adverse drug events
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Med 124:1136-42. 2011
    ..We performed a 5-year retrospective study at Brigham and Women's Hospital to determine clinical characteristics, types, root causes, and outcomes of anticoagulant-associated ADEs...
  15. doi Venous thromboembolism prophylaxis for medical service-mostly cancer-patients at hospital discharge
    John Fanikos
    Department of Pharmacy, Brigham and Women s Hospital, Boston, MA, USA
    Am J Med 124:1143-50. 2011
    ....
  16. pmc The Creating an Optimal Warfarin Nomogram (CROWN) Study
    Todd S Perlstein
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Thromb Haemost 107:59-68. 2012
    ..07), and the time to achieve stable therapeutic anticoagulation (p < 0.001). In conclusion, warfarin pharmacogenetic dosing can be optimised in real time utilising observed PK/PD information in an adaptive fashion...
  17. doi Patient education program for venous thromboembolism prevention in hospitalized patients
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Med 125:258-64. 2012
    ..We conducted a prospective cohort study to determine whether a patient education program would improve medication adherence to clinician-ordered injectable prophylactic anticoagulation...
  18. pmc Insulin resistance and incident peripheral artery disease in the Cardiovascular Health Study
    Kathryn A Britton
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Vasc Med 17:85-93. 2012
    ..15-4.58). As expected, further adjustment for potential mediators led to some attenuation of effect estimates. In conclusion, insulin resistance is associated with a higher risk of PAD in older adults...
  19. doi Effect of angiotensin receptor blockade on insulin sensitivity and endothelial function in abdominally obese hypertensive patients with impaired fasting glucose
    Todd S Perlstein
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, U S A
    Clin Sci (Lond) 122:193-202. 2012
    ....
  20. pmc Secondary prevention and mortality in peripheral artery disease: National Health and Nutrition Examination Study, 1999 to 2004
    Reena L Pande
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 124:17-23. 2011
    ..We aimed to determine the number of US adults with PAD who are not receiving preventive therapies and whether treatment is associated with reduced mortality in PAD subjects without known cardiovascular disease...
  21. pmc Physician alerts to prevent symptomatic venous thromboembolism in hospitalized patients
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 119:2196-201. 2009
    ....
  22. pmc A pooled analysis of the durability and predictors of treatment response of cilostazol in patients with intermittent claudication
    Reena L Pande
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Vasc Med 15:181-8. 2010
    ..Cilostazol demonstrated no increased risk of all-cause mortality...
  23. doi Fibrinolysis for acute pulmonary embolism
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Vasc Med 15:419-28. 2010
    ....
  24. ncbi Impaired skeletal muscle glucose uptake by [18F]fluorodeoxyglucose-positron emission tomography in patients with peripheral artery disease and intermittent claudication
    Reena L Pande
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 31:190-6. 2011
    ..We aimed to determine whether skeletal muscle glucose uptake, assessed by [(18)F]fluorodeoxyglucose positron emission tomography, is reduced in patients with claudication...
  25. doi Venous thromboembolism in heart failure: preventable deaths during and after hospitalization
    Gregory Piazza
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Am J Med 124:252-9. 2011
    ..Our aim was to compare the clinical characteristics, prophylaxis, treatment, and outcomes of patients with venous thromboembolism with and without heart failure...
  26. pmc Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
    Yoji Andrew Minamishima
    Department of Medical Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Blood 111:3236-44. 2008
    ..The latter is likely the result of hyperviscosity syndrome and volume overload, although a direct effect of chronic, high-level HIF stimulation on cardiac myocytes cannot be excluded...
  27. doi A randomized trial of iloprost in patients with intermittent claudication
    Mark A Creager
    Department of Medicine, Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Vasc Med 13:5-13. 2008
    ..039). Neither iloprost nor pentoxifylline enhanced quality of life. These results indicate that oral iloprost is not effective in improving exercise performance or quality of life in patients with PAD who have intermittent claudication...
  28. pmc Aortitis
    Heather L Gornik
    Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Circulation 117:3039-51. 2008
  29. pmc Association of insulin resistance and inflammation with peripheral arterial disease: the National Health and Nutrition Examination Survey, 1999 to 2004
    Reena L Pande
    Brigham and Women s Hospital, Cardiovascular Division, 75 Francis St, A Bldg, 3rd Floor, Boston, MA 02115, USA
    Circulation 118:33-41. 2008
    ..We hypothesized that IR is associated with PAD and that the presence of IR would influence the association between C-reactive protein (CRP) and PAD, an association established predominantly in healthy individuals...
  30. pmc Serum total bilirubin level, prevalent stroke, and stroke outcomes: NHANES 1999-2004
    Todd S Perlstein
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Med 121:781-788.e1. 2008
    ..Clinical data addressing the association of bilirubin with stroke are not available. We hypothesized that higher bilirubin levels would be associated with reduced stroke prevalence and improved stroke outcomes...
  31. ncbi Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004
    Todd S Perlstein
    Brigham and Women s Hospital, Cardiovascular Division, Harvard Medical School, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 28:166-72. 2008
    ..We hypothesized that higher levels of bilirubin would reduce susceptibility to peripheral arterial disease (PAD)...