CAREER DEVELOPMENT IN WOMEN'S HEALTH RESEARCH AND GENDE*
Principal Investigator: Ellen Freeman
Abstract: [unreadable] DESCRIPTION (provided by applicant): Funds are requested to establish a BIRCWH program at the University of Pennsylvania to increase the number of independent investigators in women's health and gender biology utilizing multidisciplinary research paradigms. The proposed program will have a steady state of 5 IWHR Scholars. It will benefit from the pre-existing Center for Research on Reproduction and Women's Health and Center of Excellence in Women' s Health (CRRWH-COE), which provides umbrella support for research, training and educational activities relevant to women's health. Individuals holding the M.D., Ph.D. or equivalent degrees that have completed clinical fellowship or post-doctoral training will be nominated or recruited for IWHR Scholarships by academic units. Scholars will be selected by the BIRCWH Advisory Committee based on past academic and research accomplishments, commitment to women's health, and the relevance of their research interests to the field. Individualized career development plans will be formulated in collaboration with a designated research mentor. Scholars will be expected pursue a research program leading to independence, with space and additional funding for start-up costs being provided by the nominating academic unit during the transition to independence. Scholars will participate in required BIRCWH activities including bi-monthly "chalk talks" and a writing and grant preparation workshop as well as other academic enrichment activities offered in their chosen research discipline as well as the programs of the CRRWH-COE. CRRWH-COE core facilities and support functions as well as CRRWH-COE pilot grant support will be available to all Scholars. The BIRCWH Advisory Committee will monitor the progress of Scholars on a periodic basis with guidance from the research mentor. IWHR Scholars will relinquish support from the BIRCWH program when they receive an R01 or equivalent grant as principal investigator. The success of the BIRCWH program will be measured in the short term by the Scholars' progress in gaining research skills, their research productivity, the visibility of their work in their chosen fields, and the attainment of independent investigator status with extramural funding. The long-term impact of this program on women's health research can only be traced beyond the scope of the initial period of support. The BIRCWH program will track the career trajectories of Scholars and will continue to serve as a resource in terms of career counseling and research advice. [unreadable] [unreadable]
Funding Period: 2002-09-26 - 2008-07-31
more information: NIH RePORT
- Pregnancy, contraception and emergency contraception: the language of urban adolescent young womenC J Mollen
The Division of Emergency Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Adolesc Gynecol 25:238-40. 2012..We sought to characterize how a group of urban adolescent females understands the domains of pregnancy, contraception, and emergency contraception (EC)...
- Design, recruitment and start up of a primary care weight loss trial targeting African American and Hispanic adultsShiriki Kumanyika
Center for Clinical Epidemiology and Biostatistics, 8th Floor Blockley Hall, 423 Guardian Drive, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Contemp Clin Trials 32:215-24. 2011..The study will have particular relevance to African Americans and women...
- Adolescent input for designing an emergency department-based intervention about emergency contraception: results from an in-depth interview studyCynthia J Mollen
Division of Emergency Medicine, The Children s Hospital of Philadelphia 19104, USA
Pediatr Emerg Care 25:625-8. 2009..To explore the attitudes of urban, minority adolescent girls about an emergency department (ED)-based intervention to address emergency contraceptive pill (ECP) use...
- Direct medical cost of overweight and obesity in the USA: a quantitative systematic reviewA G Tsai
Division of General Internal Medicine and Center for Human Nutrition, University of Colorado Denver, Denver, CO, USA
Obes Rev 12:50-61. 2011..0% to 10% of US healthcare spending. Future studies should include nationally representative samples, evaluate adults of all ages, report all medical costs and use standard body mass index cut-offs...
- One-year results of the Think Health! study of weight management in primary care practicesShiriki K Kumanyika
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 20:1249-57. 2012..We conclude that the Basic Plus approach of moderate-intensity counseling by PCPs and their staff can facilitate modest weight loss, with clinically significant weight loss in high program attenders...
- Treatment of obesity in primary care practice in the United States: a systematic reviewAdam Gilden Tsai
Division of General Internal Medicine, Department of Medicine, University of Colorado Denver, Denver, CO, USA
J Gen Intern Med 24:1073-9. 2009..This review examines the results of randomized controlled trials in which behavioral weight loss interventions, used alone or with pharmacotherapy, were provided in primary care settings...
- A primary care intervention for weight loss: results of a randomized controlled pilot studyAdam G Tsai
Division of General Internal Medicine and Center for Human Nutrition, University of Colorado Denver, Denver, Colorado, USA
Obesity (Silver Spring) 18:1614-8. 2010..Brief Counseling by MAs induced significant weight loss during 6 months. Office-based obesity treatment should be tested in larger trials and should include weight loss maintenance counseling...
- A pilot study to assess candidacy for emergency contraception and interest in sexual health education in a pediatric emergency department populationLauren C Fine
University of Pennsylvania School of Medicine, PA, USA
Pediatr Emerg Care 26:413-6. 2010..The objective of the study was to assess potential candidacy for hormonal emergency contraception (EC) and desire for sexual health education among female adolescents presenting for care to a pediatric emergency department (ED)...
- Race/ethnic differences in adult mortality: the role of perceived stress and health behaviorsPatrick M Krueger
University Colorado Denver and Health Sciences Center, Denver, CO, USA
Soc Sci Med 73:1312-22. 2011....
- Circadian rhythm profiles in women with night eating syndromeNamni Goel
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Biol Rhythms 24:85-94. 2009..Indeed, bright light therapy has shown efficacy in reducing night eating in case studies and should be evaluated in controlled clinical trials...
- The changing relationship of obesity and disability, 1988-2004Dawn E Alley
Robert Wood Johnson Health and Society Scholars Program, University of Pennsylvania, Philadelphia, PA 19104 6218, USA
JAMA 298:2020-7. 2007..However, whether these improvements have conferred decreased risk for disability is unknown. The obese population may be living longer with better-controlled risk factors but paradoxically experiencing more disability...
- Psychopathology and treatment of night eating syndrome: a reviewP Vinai
Studi Cognitivi Research Group, Milan, Italy
Eat Weight Disord 13:54-63. 2008..Most of the literature focuses on pharmacological treatment, with fewer psychotherapeutic approaches reported at this time. Larger, multi-site treatment studies would serve to confirm the findings of this first wave of clinical trials...
- Use of immuno-LCM to identify the in situ expression profile of cellular constituents of the tumor microenvironmentRonald J Buckanovich
Center for Research on Reproduction and Women s Health, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 5:635-42. 2006..We propose that immuno-LCM coupled with transcriptional profiling is a convenient tool for dissecting molecular and cellular events in complex biological systems such as the tumor microenvironment...
- Fundamental cause theory, technological innovation, and health disparities: the case of cholesterol in the era of statinsVirginia W Chang
Department of Medecine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Health Soc Behav 50:245-60. 2009..We find that the influence of technologies on socioeconomic disparities is subject to two important modifiers: (1) the nature of the technological change and (2) the extent of its diffusion and adoption...
- Weight status and restaurant availability a multilevel analysisNeil K Mehta
Graduate Group in Demography, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Prev Med 34:127-33. 2008..An important change to this environment is the increasing availability of away-from-home eating establishments such as restaurants...
- Racial residential segregation and weight status among US adultsVirginia W Chang
Center for Health Equity Research and Promotion, Philadelphia VAMC, USA
Soc Sci Med 63:1289-303. 2006..These findings suggest that in addition to differences among people, differences among places and, in particular, differences in the spatial organization of persons may be relevant to health policy and promotion efforts...
- Modeling circadian rhythms of food intake by means of parametric deconvolution: results from studies of the night eating syndromeRaymond C Boston
New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
Am J Clin Nutr 87:1672-7. 2008..Disordered temporal eating patterns are a feature of a number of eating disorders. There is currently no standard mathematical model to quantify temporal eating patterns...
- High self-reported rates of neglect and emotional abuse, by persons with binge eating disorder and night eating syndromeKelly C Allison
Department of Psychiatry, Weight and Eating Disorders Program, University of Pennsylvania School of Medicine, 3535 Market Street, Suite 3021, Philadelphia, PA 19104 3309, USA
Behav Res Ther 45:2874-83. 2007....
- Metabolic syndrome and health-related quality of life in obese individuals seeking weight reductionAdam Gilden Tsai
Center for Weight and Eating Disorders, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 16:59-63. 2008..We hypothesized that MetSyn would be associated with lower HRQoL on measures of physical and mental health...
- Exploring emergency contraception knowledge, prescription practices, and barriers to prescription for adolescents in the emergency departmentMonika Goyal
Children s Hospital of Philadelphia, Division of Emergency Medicine, 3400 Civic Center Blvd, Philadelphia PA 19104, USA
Pediatrics 123:765-70. 2009....
- The relationship between measured performance and satisfaction with care among clinically complex patientsRachel M Werner
Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
J Gen Intern Med 23:1729-35. 2008....
- Sex ratio skewing of offspring in families with hereditary susceptibility to breast cancerS M Domchek
J Med Genet 42:511-3. 2005
- Income disparities in body mass index and obesity in the United States, 1971-2002Virginia W Chang
Center for Health Equity Research and Promotion, Philadelphia VAMC, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
Arch Intern Med 165:2122-8. 2005..Although obesity is frequently associated with poverty, recent increases in obesity may not occur disproportionately among the poor. Furthermore, the relationship between income and weight status may be changing with time...
- Disparities by ethnicity and socioeconomic status in the use of weight loss treatmentsAdam Gilden Tsai
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Natl Med Assoc 101:62-70. 2009..Prior research suggests that ethnic minorities and individuals of low socioeconomic status (SES) may be more likely to attempt weight loss using unproven methods...
- Toward improving the diagnosis and the treatment of adolescent pelvic inflammatory disease in emergency departments: results of a brief, educational interventionFran Balamuth
Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pediatr Emerg Care 26:85-92. 2010..To assess the utility of an abbreviated teaching tool (ATT) in improving emergency medicine pediatricians' knowledge of the diagnosis and the treatment of pelvic inflammatory disease (PID)...
- Assessing attitudes about emergency contraception among urban, minority adolescent girls: an in-depth interview studyCynthia J Mollen
Division of Emergency Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Pediatrics 122:e395-401. 2008..The purpose of this work was to explore the knowledge, attitudes, and beliefs of urban, minority adolescent girls about intention to use emergency contraception pills and to identify barriers to emergency contraception pill use...
- Being poor and coping with stress: health behaviors and the risk of deathPatrick M Krueger
Division of Management, Policy, and Community Health, University of Texas School of Public Health, 1200 Herman Pressler, RAS E 907, Houston, TX 77030, USA
Am J Public Health 98:889-96. 2008..We examined whether smoking, alcohol use, and physical inactivity moderate the relationship between perceived stress and the risk of death in the US population as a whole and across socioeconomic strata...
- Trends in the association of poverty with overweight among US adolescents, 1971-2004Richard A Miech
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
JAMA 295:2385-93. 2006..Whether socioeconomic disparities in adolescent overweight increased, decreased, or remained constant during this period is not known...
- Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapyRonald J Buckanovich
Center for Research on Ovarian Cancer Early Detection and Cure, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Med 14:28-36. 2008..These findings highlight a molecular mechanism with the potential to be pharmacologically manipulated to enhance the efficacy of tumor immunotherapy in humans...
- Income inequality and weight status in US metropolitan areasVirginia W Chang
Center for Health Equity Research and Promotion, Philadelphia VAMC, USA
Soc Sci Med 61:83-96. 2005..Although our findings are suggestive of a contextual effect of metropolitan area income inequality, we do not find an increased risk for unhealthy weight outcomes, adding to recent debates surrounding this topic...
- A little bit pregnant: modeling how the accurate detection of pregnancy can improve HIV prevention trialsCourtney A Schreiber
Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Epidemiol 169:515-21. 2009..Pregnancy prevention and precise pregnancy diagnosis are critical to the statistical power and integrity of HIV prevention trials...
- A descriptive study of non-obese persons with night eating syndrome and a weight-matched comparison groupJennifer D Lundgren
University of Pennsylvania School of Medicine, 3535 Market Street, Philadelphia, PA 19104, USA
Eat Behav 9:343-51. 2008....
- Weight change, initial BMI, and mortality among middle- and older-aged adultsMikko Myrskylä
Max Planck Institute for Demographic Research, Rostock, Germany
Epidemiology 20:840-8. 2009..It is not known how the relationship between weight change and mortality is influenced by initial body mass index (BMI) or the magnitude of weight change...
- Metabolic syndrome and weight gain in adulthoodDawn E Alley
Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, 660 W Redwood Street No 221B, Baltimore, MD 21201, USA
J Gerontol A Biol Sci Med Sci 65:111-7. 2010..The influence of long-term adult weight history on metabolic risk independent of attained body mass index (BMI) is unknown...
- Prevalence and trends in obesity among aged and disabled U.S. Medicare beneficiaries, 1997-2002Jalpa A Doshi
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Health Aff (Millwood) 26:1111-7. 2007..4 percent and 32.5 percent, respectively, in 1997. Using 2002 data, we estimate that three million beneficiaries would be eligible for bariatric surgery coverage under current Medicare policy...
- Mortality attributable to obesity among middle-aged adults in the United StatesNeil K Mehta
University of Michigan, School of Public Health, 3628 SPH Tower, 1415 Washington Heights, Ann Arbor, MI 48109, USA
Demography 46:851-72. 2009..These findings challenge the viewpoint that obesity will stem the long-term secular decline in U.S. mortality...
- Correlation of telomere length and telomerase activity with occult ovarian insufficiencySamantha Butts
Division of Infertility and Reproductive Endocrinology, University of Pennsylvania Medical School, 3701 Market Street, Suite 800, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 94:4835-43. 2009..Abnormalities in telomere length and telomerase activity in human granulosa cells may serve as molecular markers for this condition...
- Tumor vascular proteins as biomarkers in ovarian cancerRonald J Buckanovich
Center for Research on Reproduction and Women s Health, Abramson Family Cancer Research Institute, Department of Medicine Division of Hematology Oncology, Philadelphia, PA, USA
J Clin Oncol 25:852-61. 2007..This study aimed to identify novel ovarian cancer biomarkers and potential therapeutic targets through molecular analysis of tumor vascular cells...
- Endothelin B receptor, a new target in cancer immune therapyLana E Kandalaft
Ovarian Cancer Research Center University of Pennsylvania, Philadelphia, Pennsylvania, USA
Clin Cancer Res 15:4521-8. 2009..We also review our recent findings on the effects of ET(B)R-specific blockade in increasing T-cell homing to tumors and enhancing the efficacy of otherwise ineffective immunotherapy...