HIPPOCAMPAL FUNCTION DURING CORTICOSTEROID THERAPY
Principal Investigator: EDSON S BROWN
Affiliation: University of Texas Southwestern Medical Center
Abstract: DESCRIPTION: (Adapted from applicant's abstract) This Mentored Clinical Scientist Development Award (MCSDA) application defines a training program to facilitate the development of the Pl as an independent researcher in the area of mood disorders. The educational activities outlined will enable the Pl to explore the biological basis of corticosteroid effects on brain function. During the course of this award, Dr. A. John Rush will serve as the PI's mentor. Additional experts providing instruction and training include: Drs. Frederick Petty (clinical trials), Bruce S. McEwen (glucocorticoids and the hippocampus), and Alan Frol and C. Munro Cullum (cognitive neuroscience). Measurement of hippocampal volumes from MRI scans will be performed by Dr. John Csernansky's group at Washington University. The training entails increasing the PI's knowledge of neuropsychological testing and clinical research methodology. The Pl plans to use cognitive testing to develop a paradigm in humans for exploring pharmacologic interventions which may prevent or reverse hippocampal changes associated with corticosteroids. In order to achieve the stated training goals, the Pl has developed a program that includes didactic courses, tutorials, and a research project. The proposed project will afford a hands-on experience, reinforcing the information and techniques learned through mentoring and classroom environments. The Pl will first examine memory, mood, and hippocampal volume in asthma and rheumatoid arthritis patients receiving chronic oral prescription corticosteroid therapy, a population the Pl has actively researched for over three years. In animals, agents which inhibit the release of glutamate appear to prevent and reverse hippocampal damage secondary to corticosteroids. Thus, the first experiment in the training plan will be followed by a clinical trial of the glutamate release inhibitor, lamotrigine, to determine if neurocognitive changes associated with corticosteroids can be reversed in humans. Through this award, the Pl will extend his previous research experience by adding new skills and knowledge which will be used for investigations at the interface of neuroscience and clinical research.
Funding Period: 2000-09-01 - 2006-08-31
more information: NIH RePORT
- Effects of chronic prednisone therapy on mood and memoryE Sherwood Brown
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 75390 8849, United States
J Affect Disord 99:279-83. 2007..We previously reported greater depressive symptom severity, poorer memory and smaller hippocampal volumes in patients with asthma or rheumatic diseases receiving long-term prednisone therapy than in controls...
- Tactile perception in adults with autism: a multidimensional psychophysical studyCarissa Cascio
Center for Neurodevelopmental Disorders Research, University of North Carolina, Chapel Hill, NC 27599, USA
J Autism Dev Disord 38:127-37. 2008..These findings suggest normal perception along with certain areas of enhanced perception in autism, consistent with previous studies...
- Amygdala volume in patients receiving chronic corticosteroid therapyE Sherwood Brown
Psychoneuroendocrine Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8849, USA
Biol Psychiatry 63:705-9. 2008..We assessed amygdala volume in patients receiving chronic prescription corticosteroid therapy and control subjects with similar medical histories not receiving corticosteroids...
- Attenuation of the effects of corticosteroids on declarative memory with lamotrigineE Sherwood Brown
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8849, USA
Neuropsychopharmacology 33:2376-83. 2008..Results suggest that lamotrigine may improve declarative memory in patients taking prescription corticosteroids although differential dropout rate in the two groups is a concern...
- Attenuation of amygdala atrophy with lamotrigine in patients receiving corticosteroid therapyShuchi Desai
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8849, USA
J Clin Psychopharmacol 29:284-7. 2009..To our knowledge, no data are available on preventing or reversing the impact of corticosteroids on the amygdala...