Fatty Acids and Cardiovascular Health

Summary

Principal Investigator: D Mozaffarian
Abstract: [unreadable] DESCRIPTION (provided by applicant): [unreadable] [unreadable] The broad, long-term objectives of this 5-year career development program are (1) to define more clearly relationships of dietary fatty acids with cardiovascular health; and (2) to gain the further training, knowledge, and funding necessary for success as an independent research investigator. The research objectives will be achieved via investigation using prospectively collected data from the Health Professionals Follow-up Study (HPFS), the Nurses Health Study (NHS), the Nurses Health Study 2 (NHS2), the Cardiovascular Health Study (CHS), the Estrogen Replacement and Atherosclerosis (ERA) trial, and the Heart Failure Study (HFS). The training objectives will be achieved via formal coursework in nutritional and cardiovascular epidemiology in the doctorate (DrPH) program in epidemiology; participation in conferences, seminars, and national meetings; and mentoring by recognized leaders in the fields of nutritional and cardiovascular epidemiology. An outstanding team of mentors and collaborators will facilitate and guide the candidate's research and career development. The primary mentor for the candidate's scientific development is Dr. Eric Rimm, a leader in the field of nutritional cardiovascular epidemiology. To further enhance the training, the career development program has enlisted the expertise of Dr. David Siscovick, a leader in research on fatty acids and cardiovascular disease; Dr. David Herrington, a leader in research on cardiovascular risk with expertise in assessment of angiographic progression; and Dr. Wayne Levy, a cardiologist with extensive research experience in heart failure and a particular interest in immune and inflammatory activation. The specific aims of this proposal are (1) to investigate whether polyunsaturated fat, monounsaturated fat, carbohydrate, or protein is the most effective replacement for saturated fat with regards to progression of coronary atherosclerosis and risk of coronary heart disease (CHD) events; (2) to investigate the separate and combined effects of n-6, n-3, and trans-fatty acids on progression of coronary atherosclerosis, risk of CHD events, and markers of immune and inflammatory activation related to cardiovascular disease; and (3) to begin preliminary investigation of relationships of n-3 fatty acids with atrial fibrillation and heart failure, about which very little is known. The Channing Laboratory in the Department of Medicine at Harvard Medical School and the Harvard School of Public Health provide an ideal environment for training this candidate for a career in independent research investigation, combining leading researchers in nutritional and cardiovascular epidemiology, an exceptional fund of high-quality data being generated in several large, long-running cohort studies, and advanced training in nutritional, biostatistical, and epidemiologic methodology. (End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]
Funding Period: 2004-09-15 - 2008-07-31
more information: NIH RePORT

Top Publications

  1. pmc Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 111:157-64. 2005
  2. ncbi Fish, n-3 fatty acids, and cardiovascular haemodynamics
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Cardiovasc Med (Hagerstown) 8:S23-6. 2007
  3. ncbi Commentary: Ruminant trans fatty acids and coronary heart disease--cause for concern?
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Int J Epidemiol 37:182-4. 2008
  4. ncbi Dietary fish and omega-3 fatty acid consumption and heart rate variability in US adults
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 117:1130-7. 2008
  5. ncbi The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences
    Sarah de Ferranti
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Clin Chem 54:945-55. 2008
  6. pmc Postmenopausal hormone therapy and stroke: role of time since menopause and age at initiation of hormone therapy
    Francine Grodstein
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, Massachusetts 02115, USA
    Arch Intern Med 168:861-6. 2008
  7. ncbi Metabolic syndrome and mortality in older adults: the Cardiovascular Health Study
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Arch Intern Med 168:969-78. 2008
  8. doi Beyond established and novel risk factors: lifestyle risk factors for cardiovascular disease
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 117:3031-8. 2008
  9. ncbi Nationwide product reformulations to reduce trans fatty acids in Canada: when trans fat goes out, what goes in?
    W M N Ratnayake
    Bureau of Nutritional Sciences, Food Directorate, Health Canada, Toronto, Ontario, Canada
    Eur J Clin Nutr 63:808-11. 2009
  10. pmc Physical activity and incidence of atrial fibrillation in older adults: the cardiovascular health study
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 118:800-7. 2008

Scientific Experts

Detail Information

Publications30

  1. pmc Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 111:157-64. 2005
    ..Additionally, seafood-based, long-chain n-3 PUFAs may modify the effects of plant-based, intermediate-chain n-3 PUFAs. However, the interactions of these PUFAs in relation to CHD risk are not well established...
  2. ncbi Fish, n-3 fatty acids, and cardiovascular haemodynamics
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Cardiovasc Med (Hagerstown) 8:S23-6. 2007
    ..These haemodynamic effects could in part account for clinical benefits of fish or fish oil intake, including lower risk of cardiac death and possibly ischaemic stroke, heart failure, cognitive decline, and nonfatal coronary events...
  3. ncbi Commentary: Ruminant trans fatty acids and coronary heart disease--cause for concern?
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Int J Epidemiol 37:182-4. 2008
  4. ncbi Dietary fish and omega-3 fatty acid consumption and heart rate variability in US adults
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 117:1130-7. 2008
    ..We hypothesized that habitual consumption of fish and marine omega-3 fatty acids would be associated with more favorable HRV, elucidating electrophysiological influences and supporting effects on clinical risk...
  5. ncbi The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences
    Sarah de Ferranti
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Clin Chem 54:945-55. 2008
    ....
  6. pmc Postmenopausal hormone therapy and stroke: role of time since menopause and age at initiation of hormone therapy
    Francine Grodstein
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, Massachusetts 02115, USA
    Arch Intern Med 168:861-6. 2008
    ..We evaluated stroke risk associated with hormone therapy (HT) in younger women, in recently menopausal women, and in older women...
  7. ncbi Metabolic syndrome and mortality in older adults: the Cardiovascular Health Study
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Arch Intern Med 168:969-78. 2008
    ..In addition, few studies have compared the predictive utility of MetS to that of its individual risk factors...
  8. doi Beyond established and novel risk factors: lifestyle risk factors for cardiovascular disease
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 117:3031-8. 2008
  9. ncbi Nationwide product reformulations to reduce trans fatty acids in Canada: when trans fat goes out, what goes in?
    W M N Ratnayake
    Bureau of Nutritional Sciences, Food Directorate, Health Canada, Toronto, Ontario, Canada
    Eur J Clin Nutr 63:808-11. 2009
    ..The findings suggest that manufacturers/restaurants generally take advantage of costs and efforts of reformulation to not only reduce TFA but also increase the content of cis unsaturated fats...
  10. pmc Physical activity and incidence of atrial fibrillation in older adults: the cardiovascular health study
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 118:800-7. 2008
    ..Vigorous exertion and endurance training have been reported to increase atrial fibrillation (AF). Associations of habitual light or moderate activity with AF incidence have not been evaluated...
  11. pmc Lifestyle risk factors and new-onset diabetes mellitus in older adults: the cardiovascular health study
    Dariush Mozaffarian
    Divisions of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard School of Public Health, 665 Huntington Ave, Bldg 2 319, Boston, MA 02115, USA
    Arch Intern Med 169:798-807. 2009
    ..The objective of this study was to determine how lifestyle factors, assessed in combination, relate to new-onset diabetes in a broad and relatively unselected population of older adults...
  12. ncbi Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils
    D Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Clin Nutr 63:S22-33. 2009
    ..We performed quantitative estimates of CHD effects if a person's PHVO consumption were to be replaced with alternative fats and oils based on (1) randomized dietary trials and (2) prospective observational studies...
  13. ncbi Health effects of trans-fatty acids: experimental and observational evidence
    D Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Clin Nutr 63:S5-21. 2009
    ..As part of the World Health Organization (WHO) Scientific Update on TFA, we reviewed the evidence for effects of TFA consumption on coronary heart disease (CHD)...
  14. pmc Fish, mercury, selenium and cardiovascular risk: current evidence and unanswered questions
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Int J Environ Res Public Health 6:1894-916. 2009
    ..The relevant current unanswered questions and directions of further research are summarized...
  15. ncbi Incidence of new-onset diabetes and impaired fasting glucose in patients with recent myocardial infarction and the effect of clinical and lifestyle risk factors
    Dariush Mozaffarian
    Department of Medicine, Harvard Medical School and Harvard School of Public Health, Boston, MA 02115, USA
    Lancet 370:667-75. 2007
    ..We set out to estimate this incidence and investigate whether lifestyle factors such as dietary habits might alter this risk...
  16. ncbi Consumption of trans fats and estimated effects on coronary heart disease in Iran
    D Mozaffarian
    The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Eur J Clin Nutr 61:1004-10. 2007
    ..To investigate the consumption of industrial trans-fatty acids (TFAs) in Iranian homes and the proportion of coronary heart disease (CHD) events in Iran attributable to such intake...
  17. pmc Fish consumption and stroke risk in elderly individuals: the cardiovascular health study
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, MA, USA
    Arch Intern Med 165:200-6. 2005
    ..Additionally, such relationships have not been specifically evaluated in the elderly, in whom disease burden may be high and diet less influential...
  18. ncbi Does alpha-linolenic acid intake reduce the risk of coronary heart disease? A review of the evidence
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    Altern Ther Health Med 11:24-30; quiz 31, 79. 2005
    ..Presently, the weight of the evidence favors recommendations for modest dietary consumption of ALA (2 to 3 g per day) for the primary and secondary prevention of CHD...
  19. ncbi Fish intake and risk of incident heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Am Coll Cardiol 45:2015-21. 2005
    ..Our aim was to investigate the relation between fish consumption and incidence of congestive heart failure (CHF)...
  20. ncbi Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:1945-52. 2005
    ..The effect of fish oil on heart rate (HR), a major risk factor for sudden death, is not well established. We calculated this effect in a meta-analysis of randomized, double-blind, placebo-controlled trials in humans...
  21. ncbi Effects of dietary fats versus carbohydrates on coronary heart disease: a review of the evidence
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Atheroscler Rep 7:435-45. 2005
    ....
  22. ncbi Electron-beam computed tomography for coronary calcium: a useful test to screen for coronary heart disease?
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    JAMA 294:2897-901. 2005
  23. ncbi The effects of atorvastatin (10 mg) on systemic inflammation in heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:1699-704. 2005
    ..In conclusion, short-term atorvastatin therapy reduced the levels of several important inflammatory markers in patients with HF...
  24. ncbi Intake of tuna or other broiled or baked fish versus fried fish and cardiac structure, function, and hemodynamics
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 97:216-22. 2006
    ..These findings suggest potential specific physiologic mechanisms that may, in part, account for the effects of fish intake on cardiovascular health...
  25. ncbi Optimal dietary habits for the prevention of stroke
    Eric L Ding
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Semin Neurol 26:11-23. 2006
    ..Further research is needed regarding the possible effects of other major dietary factors on stroke risk...
  26. ncbi Trans fatty acids and cardiovascular disease
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 354:1601-13. 2006
  27. ncbi Trans fatty acids - effects on systemic inflammation and endothelial function
    Dariush Mozaffarian
    The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Atheroscler Suppl 7:29-32. 2006
    ..Further study is indicated to define these effects of TFA and the implications of such effects for cardiovascular health...
  28. ncbi Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 48:478-84. 2006
    ..We evaluated the association between dietary fish intake and several cardiac electrocardiographic parameters in humans relevant to arrhythmic risk...
  29. ncbi Fish intake, contaminants, and human health: evaluating the risks and the benefits
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 296:1885-99. 2006
    ..Fish (finfish or shellfish) may have health benefits and also contain contaminants, resulting in confusion over the role of fish consumption in a healthy diet...