Attention in Children with the 22q11 Deletion Syndrome

Summary

Principal Investigator: CHRISTINA A SOBIN
Abstract: DESCRIPTION: (Adapted from the applicant's Description) This project proposes to assess attention in children whose genetic differences may underlie both attention deficits and neurotransmitter dysregulation. Children with the 22q11 deletion syndrome lack genes that encode two neuromodulators that specifically impact dopamine / glutamate / GABA pathways, catechol-O-methytransferase and proline dehydrogenase. Eighty to 100 percent of 22q11 deletion syndrome children are estimated to have learning disabilities and attention deficit. Segregated networks of attention have been localized in the human brain via imaging methods, and the neurochemical substrates of these networks have been suggested. This research aims to compare 22q11 deletion syndrome children and matched normal controls with regard to: 1) efficiency of three attention networks; 2) pre-pulse inhibition; 3) neuropsychological functioning, temperament and behavior. Findings will be used to further consider the neuroanatomical models of attention, to relate sensory motor gating to these models, and to characterize the association between attention deficits and neuropsychological performance, temperament, and disordered behavior.
Funding Period: 2001-06-01 - 2006-05-31
more information: NIH RePORT

Top Publications

  1. pmc Associations between prepulse inhibition and executive visual attention in children with the 22q11 deletion syndrome
    C Sobin
    The Rockefeller University, New York, NY 10021, USA
    Mol Psychiatry 10:553-62. 2005
  2. pmc Neuropsychological characteristics of children with the 22q11 Deletion Syndrome: a descriptive analysis
    Christina Sobin
    Laboratory of Human Neurogenetics, The Rockefeller University, New York, New York 10021, USA
    Child Neuropsychol 11:39-53. 2005
  3. pmc Lower prepulse inhibition in children with the 22q11 deletion syndrome
    Christina Sobin
    Laboratory of Human Neurogenetics, Rockefeller University, New York, NY 10021, USA
    Am J Psychiatry 162:1090-9. 2005
  4. pmc Olfactory disorder in children with 22q11 deletion syndrome
    Christina Sobin
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York, USA
    Pediatrics 118:e697-703. 2006
  5. pmc Neuromotor deficits in children with the 22q11 deletion syndrome
    Christina Sobin
    Rockefeller University, New York, New York, USA
    Mov Disord 21:2082-9. 2006
  6. pmc Social skills and executive function deficits in children with the 22q11 Deletion Syndrome
    Karen Kiley-Brabeck
    Children s Evaluation Center, Newton, MA 02464, USA
    Appl Neuropsychol 13:258-68. 2006
  7. pmc Sex differences in the behavior of children with the 22q11 deletion syndrome
    Christina Sobin
    The Rockefeller University, New York, NY, United States
    Psychiatry Res 166:24-34. 2009

Scientific Experts

Detail Information

Publications7

  1. pmc Associations between prepulse inhibition and executive visual attention in children with the 22q11 deletion syndrome
    C Sobin
    The Rockefeller University, New York, NY 10021, USA
    Mol Psychiatry 10:553-62. 2005
    ..These results suggest that children with 22q11DS have early functional abnormality in pathways linking the prefrontal cortex and basal ganglia...
  2. pmc Neuropsychological characteristics of children with the 22q11 Deletion Syndrome: a descriptive analysis
    Christina Sobin
    Laboratory of Human Neurogenetics, The Rockefeller University, New York, New York 10021, USA
    Child Neuropsychol 11:39-53. 2005
    ..Implications of these findings are considered with regard to past results...
  3. pmc Lower prepulse inhibition in children with the 22q11 deletion syndrome
    Christina Sobin
    Laboratory of Human Neurogenetics, Rockefeller University, New York, NY 10021, USA
    Am J Psychiatry 162:1090-9. 2005
    ..This study was conducted to determine whether preattentive processing ("sensorimotor gating") deficits are present in this population...
  4. pmc Olfactory disorder in children with 22q11 deletion syndrome
    Christina Sobin
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York, USA
    Pediatrics 118:e697-703. 2006
    ..Despite its potential consequences, pediatric studies of impaired olfaction are rare, and odor detection in children with 22q11 deletion syndrome has not yet been examined...
  5. pmc Neuromotor deficits in children with the 22q11 deletion syndrome
    Christina Sobin
    Rockefeller University, New York, New York, USA
    Mov Disord 21:2082-9. 2006
    ..Further studies examining the specificity of motor impairment to 22q11DS are needed...
  6. pmc Social skills and executive function deficits in children with the 22q11 Deletion Syndrome
    Karen Kiley-Brabeck
    Children s Evaluation Center, Newton, MA 02464, USA
    Appl Neuropsychol 13:258-68. 2006
    ..Initiation and Monitoring significantly predicted Social Skill. Children with 22q11DS have marked differences in social skill development which are associated with executive dysfunction...
  7. pmc Sex differences in the behavior of children with the 22q11 deletion syndrome
    Christina Sobin
    The Rockefeller University, New York, NY, United States
    Psychiatry Res 166:24-34. 2009
    ..Categorical diagnoses do not reflect behavioral differences between male and female children with 22q11DS, and may miss significant behavior problems in 20% of affected males...