Attention in Children with the 22q11 Deletion Syndrome
Principal Investigator: CHRISTINA A SOBIN
Abstract: DESCRIPTION: (Adapted from the applicant's Description) This project proposes to assess attention in children whose genetic differences may underlie both attention deficits and neurotransmitter dysregulation. Children with the 22q11 deletion syndrome lack genes that encode two neuromodulators that specifically impact dopamine / glutamate / GABA pathways, catechol-O-methytransferase and proline dehydrogenase. Eighty to 100 percent of 22q11 deletion syndrome children are estimated to have learning disabilities and attention deficit. Segregated networks of attention have been localized in the human brain via imaging methods, and the neurochemical substrates of these networks have been suggested. This research aims to compare 22q11 deletion syndrome children and matched normal controls with regard to: 1) efficiency of three attention networks; 2) pre-pulse inhibition; 3) neuropsychological functioning, temperament and behavior. Findings will be used to further consider the neuroanatomical models of attention, to relate sensory motor gating to these models, and to characterize the association between attention deficits and neuropsychological performance, temperament, and disordered behavior.
Funding Period: 2001-06-01 - 2006-05-31
more information: NIH RePORT
- Associations between prepulse inhibition and executive visual attention in children with the 22q11 deletion syndromeC Sobin
The Rockefeller University, New York, NY 10021, USA
Mol Psychiatry 10:553-62. 2005..These results suggest that children with 22q11DS have early functional abnormality in pathways linking the prefrontal cortex and basal ganglia...
- Neuropsychological characteristics of children with the 22q11 Deletion Syndrome: a descriptive analysisChristina Sobin
Laboratory of Human Neurogenetics, The Rockefeller University, New York, New York 10021, USA
Child Neuropsychol 11:39-53. 2005..Implications of these findings are considered with regard to past results...
- Lower prepulse inhibition in children with the 22q11 deletion syndromeChristina Sobin
Laboratory of Human Neurogenetics, Rockefeller University, New York, NY 10021, USA
Am J Psychiatry 162:1090-9. 2005..This study was conducted to determine whether preattentive processing ("sensorimotor gating") deficits are present in this population...
- Olfactory disorder in children with 22q11 deletion syndromeChristina Sobin
Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York, USA
Pediatrics 118:e697-703. 2006..Despite its potential consequences, pediatric studies of impaired olfaction are rare, and odor detection in children with 22q11 deletion syndrome has not yet been examined...
- Neuromotor deficits in children with the 22q11 deletion syndromeChristina Sobin
Rockefeller University, New York, New York, USA
Mov Disord 21:2082-9. 2006..Further studies examining the specificity of motor impairment to 22q11DS are needed...
- Social skills and executive function deficits in children with the 22q11 Deletion SyndromeKaren Kiley-Brabeck
Children s Evaluation Center, Newton, MA 02464, USA
Appl Neuropsychol 13:258-68. 2006..Initiation and Monitoring significantly predicted Social Skill. Children with 22q11DS have marked differences in social skill development which are associated with executive dysfunction...
- Sex differences in the behavior of children with the 22q11 deletion syndromeChristina Sobin
The Rockefeller University, New York, NY, United States
Psychiatry Res 166:24-34. 2009..Categorical diagnoses do not reflect behavioral differences between male and female children with 22q11DS, and may miss significant behavior problems in 20% of affected males...