Established Investigator Award Anti-Inflammatory Exposures in Cancer Prevention

Summary

Principal Investigator: Emily White
Abstract: DESCRIPTION (provided by applicant): In the 25 years of cancer prevention research, few interventions have been identified that have effects on more than one type of cancer. Chronic inflammation contributes to carcinogenesis in multiple organs, thus anti-inflammatory agents have the potential to reduce the risk of cancer at several sites. In 1999, Dr. Emily White was awarded funding for the VITamins And Lifestyle (VITAL) study, a prospective cohort study of dietary supplement use and cancer risk. 77,738 men and women in western Washington State, age 50-76, entered the cohort, by completing a detailed questionnaire on use of 38 supplements over the past 10 years, diet, and lifestyle factors. Over 54,000 participants also provided buccal cell specimens for DNA. The strongest and most consistent findings to date are that only the anti-inflammatory supplements (in particular glucosamine, chondroitin and fish oil/n-3 fatty acids) appear to reduce the risk of several cancers. This proposed Established Investigator Award (K05) for Dr. White would provide protected time for mentoring and research in the area of anti-inflammatory exposures and cancer risk, and other topics of interest to her trainees. The applicant has an extensive history of mentoring and directing training programs, is currently mentoring 1 pre-doctoral, 4 post-doctoral and 7 junior faculty members from a range of fields, and has a strong commitment to continue mentoring in the future. The availability of the data and specimens from the large VITAL cohort, the increasing numbers of cancers as the study matures (over 10,300 cancers expected by 2011), and the range of cancers that can be studied (prostate, breast, lung, colorectal, melanoma, bladder, blood/lymph) attract young investigators to work with her. In addition to providing ideas, guidance and the research platform for publishing research papers to her trainees, the applicant endeavors to provide guidance in developing their independent research as well. This award would provide additional time for Dr. White to expand her and her trainees'research to other anti-inflammatory supplements (e.g., grapeseed, MSM) which have not been ascertained by other cohorts, to anti-inflammatory drugs, and to pro- and anti-inflammatory dietary factors (e.g., n-6 and n-3 polyunsaturated fatty acids) in relation to incidence of multiple types of cancer, total cancer incidence and cancer mortality. In addition, the award would provide pilot data to allow her and her trainees to branch out into short-term randomized trials of the effects of potential chemopreventive agents on biomarkers of inflammation, and to studies of the anti-inflammatory exposures of interest and survival from cancer. Dr. White is also author of the book "Principles of Exposure Measurement in Epidemiology", and this award would provide dedicated time for her to pursue additional methodologic research in this area. To accomplish this, the applicant will reduce her large administrative responsibilities, including stepping down from her role as Associate Dean for Research in the University of Washington School of Public Health.
Funding Period: 2011-07-01 - 2016-06-30
more information: NIH RePORT

Top Publications

  1. ncbi Diet, the gut microbiome, and epigenetics
    Meredith A J Hullar
    From the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA
    Cancer J 20:170-5. 2014
  2. pmc SBERIA: set-based gene-environment interaction test for rare and common variants in complex diseases
    Shuo Jiao
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genet Epidemiol 37:452-64. 2013
  3. pmc Height as an explanatory factor for sex differences in human cancer
    Roland B Walter
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Natl Cancer Inst 105:860-8. 2013
  4. pmc Recent physical activity in relation to DNA damage and repair using the comet assay
    Stephanie Whisnant Cash
    Dept of Epidemiology, University of Washington, Seattle, WA
    J Phys Act Health 11:770-6. 2014
  5. pmc Use of glucosamine and chondroitin supplements and risk of colorectal cancer
    E D Kantor
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Mailbox M4 B402, Seattle, WA 98109, USA
    Cancer Causes Control 24:1137-46. 2013
  6. pmc Persistence of urothelial carcinoma of the bladder risk among former smokers: results from a contemporary, prospective cohort study
    Christopher J Welty
    Department of Urology, University of Washington, Seattle, WA Electronic address
    Urol Oncol 32:25.e21-5. 2014
  7. pmc Genome-wide search for gene-gene interactions in colorectal cancer
    Shuo Jiao
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 7:e52535. 2012
  8. pmc Antioxidant intake and pancreatic cancer risk: the Vitamins and Lifestyle (VITAL) Study
    Xuesong Han
    Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Cancer 119:1314-20. 2013
  9. pmc Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
    Ulrike Peters
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gastroenterology 144:799-807.e24. 2013
  10. pmc Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer
    Wei Hua Jia
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Nat Genet 45:191-6. 2013

Research Grants

  1. Comparative Mechanisms of Cancer Chemoprevention
    Roderick H Dashwood; Fiscal Year: 2013

Detail Information

Publications58

  1. ncbi Diet, the gut microbiome, and epigenetics
    Meredith A J Hullar
    From the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, and Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA
    Cancer J 20:170-5. 2014
    ..In this review, we discuss the role of the gut microbiome in dietary metabolism and how microbial metabolites may influence gene expression linked to colon cancer risk. ..
  2. pmc SBERIA: set-based gene-environment interaction test for rare and common variants in complex diseases
    Shuo Jiao
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genet Epidemiol 37:452-64. 2013
    ....
  3. pmc Height as an explanatory factor for sex differences in human cancer
    Roland B Walter
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Natl Cancer Inst 105:860-8. 2013
    ..Numerous explanations for this excess risk have been proposed, yet no study has quantified the degree to which height explains the sex difference even though greater height has been associated with increased risk for many cancers...
  4. pmc Recent physical activity in relation to DNA damage and repair using the comet assay
    Stephanie Whisnant Cash
    Dept of Epidemiology, University of Washington, Seattle, WA
    J Phys Act Health 11:770-6. 2014
    ..Limited evidence suggests that very high-intensity exercise is positively associated with DNA damage but moderate exercise may be associated with DNA repair...
  5. pmc Use of glucosamine and chondroitin supplements and risk of colorectal cancer
    E D Kantor
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Mailbox M4 B402, Seattle, WA 98109, USA
    Cancer Causes Control 24:1137-46. 2013
    ..An exploratory analysis conducted within the VITamins And Lifestyle (VITAL) study observed any use of glucosamine and chondroitin to be associated with reduced risk of colorectal cancer (CRC) after 5 years of follow-up...
  6. pmc Persistence of urothelial carcinoma of the bladder risk among former smokers: results from a contemporary, prospective cohort study
    Christopher J Welty
    Department of Urology, University of Washington, Seattle, WA Electronic address
    Urol Oncol 32:25.e21-5. 2014
    ..However, the persistence of an increased risk for UC following smoking cessation is not well established. We assessed the risk of UC among former smokers using a recent, prospective cohort with a high proportion of former smokers...
  7. pmc Genome-wide search for gene-gene interactions in colorectal cancer
    Shuo Jiao
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 7:e52535. 2012
    ..1) (nominal combined p = 2.51×10(-6); Bonferroni adjusted p = 0.03). Our study represents the first comprehensive search for GxG in CRC, and our results may provide new insight into the genetic etiology of CRC...
  8. pmc Antioxidant intake and pancreatic cancer risk: the Vitamins and Lifestyle (VITAL) Study
    Xuesong Han
    Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Cancer 119:1314-20. 2013
    ..In this study, the authors examined the intake of antioxidants from diet and supplements in relation to pancreatic cancer risk among participants of the Vitamins and Lifestyle (VITAL) Study...
  9. pmc Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
    Ulrike Peters
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gastroenterology 144:799-807.e24. 2013
    ..Heritable factors contribute to the development of colorectal cancer. Identifying the genetic loci associated with colorectal tumor formation could elucidate the mechanisms of pathogenesis...
  10. pmc Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer
    Wei Hua Jia
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Nat Genet 45:191-6. 2013
    ..This study identified three new CRC susceptibility loci and provides additional insight into the genetics and biology of CRC...
  11. pmc Regular recreational physical activity and risk of hematologic malignancies: results from the prospective VITamins And lifestyle (VITAL) study
    R B Walter
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Ann Oncol 24:1370-7. 2013
    ..Conflicting evidence exists on the relationship between physical activity (PA) and incident hematologic malignancies. Herein, we used a large cohort study to examine this association...
  12. pmc Body mass index, tumor characteristics, and prognosis following diagnosis of early-stage breast cancer in a mammographically screened population
    Aruna Kamineni
    Group Health Research Institute, Seattle, WA 98101, USA
    Cancer Causes Control 24:305-12. 2013
    ....
  13. pmc Types of fish consumed and fish preparation methods in relation to pancreatic cancer incidence: the VITAL Cohort Study
    Ka He
    Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Epidemiol 177:152-60. 2013
    ..LC-PUFAs, particularly docosahexaenoic acid, and nonfried fish, but not shellfish or fried fish, may be beneficial in the primary prevention of pancreatic cancer...
  14. pmc Adherence to WCRF/AICR cancer prevention recommendations and risk of postmenopausal breast cancer
    Theresa A Hastert
    Fred Hutchinson Cancer Research Center Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 22:1498-508. 2013
    ..However, limited information exists on the association between meeting these recommendations and risks of specific cancers, including breast cancer...
  15. pmc Innate immunity gene polymorphisms and the risk of colorectal neoplasia
    Cindy M Chang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA
    Carcinogenesis 34:2512-20. 2013
    ..Other notable findings were observed for SNPs in BPI/LBP and MYD88. Although the results need to be replicated, our findings suggest that genetic variation in inflammation-related genes may be related to the risk of colorectal neoplasia...
  16. pmc Lifestyle factors and inflammation: associations by body mass index
    Elizabeth D Kantor
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 8:e67833. 2013
    ..These results suggest that posited anti-inflammatory drugs and behaviors may be less strongly associated with inflammation among the obese than among lower weight persons. ..
  17. pmc Genome-wide diet-gene interaction analyses for risk of colorectal cancer
    Jane C Figueiredo
    Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 10:e1004228. 2014
    ..03). Our results identify a novel gene-diet interaction with processed meat for colorectal cancer, highlighting that diet may modify the effect of genetic variants on disease risk, which may have important implications for prevention...
  18. pmc Adherence to the WCRF/AICR cancer prevention recommendations and cancer-specific mortality: results from the Vitamins and Lifestyle (VITAL) Study
    Theresa A Hastert
    Department of Epidemiology, University of Washington, 1959 NE Pacific Street, Health Sciences Building F 262, Box 357236, Seattle, WA, 98195 7236, USA
    Cancer Causes Control 25:541-52. 2014
    ..The purpose of this paper is to estimate the association between meeting these recommendations and cancer-specific mortality...
  19. pmc Associations of long-chain ω-3 fatty acids and fish intake with endometrial cancer risk in the VITamins And Lifestyle cohort
    Theodore M Brasky
    Department of Internal Medicine, Division of Cancer Prevention and Control TMB and the Department of Obstetrics and Gynecology, Division of Gynecologic Oncology DEC, The Ohio State University College of Medicine, Columbus, OH, and the Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA MLN and EW
    Am J Clin Nutr 99:599-608. 2014
    ..Long-chain ω-3 (n-3) polyunsaturated fatty acids (PUFAs), derived from marine sources, are thought to be antiinflammatory; however, several studies of fish consumption suggest an increase in risk...
  20. pmc Eating frequency and risk of colorectal cancer
    Martine M Perrigue
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Mailbox M4 B402, Seattle, WA, 98109, USA
    Cancer Causes Control 24:2107-15. 2013
    ..We examined the association between eating frequency and CRC in a large, prospective cohort study, and explored whether this relationship was modified by sex, coffee consumption, or dietary glycemic load...
  21. pmc Long-chain omega-3 polyunsaturated fatty acid intake and risk of colorectal cancer
    Elizabeth D Kantor
    a Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA, Washington
    Nutr Cancer 66:716-27. 2014
    ..Results suggest that associations between LC-PUFA intake and CRC may vary by gender, subsite, and genetic risk, providing additional insight into the potential role of LC-PUFAs in cancer prevention. ..
  22. pmc Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer
    Linda T Hiraki
    Authors Affiliations Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Departments of Nutrition, and Biostatistics, Harvard School of Public Health Department of Medicine, and Channing Division of Network Medicine, Brigham and Women s Hospital Division of Gastroenterology, Massachusetts General Hospital Department of Medicine, Harvard Medical School Gastrointestinal Malignancy Program, and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts Public Health Sciences Division, Fred Hutchinson Cancer Research Center Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina Divisions of Cancer Epidemiology and Genetics, and Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda University of Maryland, School of Medicine, Baltimore, Maryland Service de Génétique Médicale, CHU Nantes, Nantes, France Divisions of Clinical Epidemiology and Aging Research and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany Division of Research, Kaiser Permanente Medical Care Program, Oakland Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California Translational Genomics Research Institute, Phoenix, Arizona Department of Surgery, Turkey
    Cancer Epidemiol Biomarkers Prev 22:2037-46. 2013
    ..The identified single-nucleotide polymorphisms (SNPs) from four gene regions collectively explain approximately 5% of the variance in circulating 25(OH)D...
  23. pmc Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia
    Iona Cheng
    Cancer Prevention Institute of California, Fremont, California, USA
    Gut 63:800-7. 2014
    ..In a large-scale study, we examined 171 SNPs previously associated with 18 different cancers for their associations with colorectal cancer...
  24. pmc Associations between allergies and risk of hematologic malignancies: results from the VITamins and lifestyle cohort study
    Mazyar Shadman
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington Department of Medicine, Division of Hematology, University of Washington, Seattle, Washington
    Am J Hematol 88:1050-4. 2013
    ..82-1.29], P = 0.782; and HR = 0.99 [0.77-1.27], P = 0.960). Together, our study indicates a moderately increased risk of HMs in women but not men with a history of allergies to airborne allergens, especially to plant, grass, or trees...
  25. pmc Specialty supplement use and biologic measures of oxidative stress and DNA damage
    Elizabeth D Kantor
    Authors Affiliations Public Health Sciences Division, Clinical Research Division, Fred Hutchinson Cancer Research Center Departments of Epidemiology, Pharmacy, and Pharmaceutics, University of Washington, Seattle, Washington Division of Preventive Oncology, National Center for Tumor Diseases Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 22:2312-22. 2013
    ..Identifying factors associated with reduced oxidative stress and resulting damage may guide future disease-prevention strategies...
  26. pmc No association between germline variation in catechol-O-methyltransferase and colorectal cancer survival in postmenopausal women
    Michael N Passarelli
    From the 1Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 2Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 3Division of General Medical Disciplines, Stanford University School of Medicine, Stanford, CA 4SRI International, Menlo Park, CA 5Department of Biostatistics, University of Washington School of Public Health, Seattle, WA 6Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ 7Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA and 8Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Menopause 21:415-20. 2014
    ..Because catechol-O-methyltransferase (COMT; 22q11.21) activity is an important component of estrogen-mediated carcinogenesis, we hypothesized that germline variation in COMT may be associated with CRC survival...
  27. pmc Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women
    Michael N Passarelli
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Res 73:767-75. 2013
    ..79; CI, 0.64-0.98 in replication]. No associations were noted for SNPs of AR, ESR1, or PGR. SNPs in the promoter of ESR2 may be important to pathways related to the association between ERβ and tumor progression and metastasis...
  28. pmc Association between use of specialty dietary supplements and C-reactive protein concentrations
    Elizabeth D Kantor
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Am J Epidemiol 176:1002-13. 2012
    ....
  29. pmc Non-steroidal anti-inflammatory drugs and cancer incidence by sex in the VITamins And Lifestyle (VITAL) cohort
    Theodore M Brasky
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Unit, Seattle, WA 98109 1024, USA
    Cancer Causes Control 23:431-44. 2012
    ..A recent meta-analysis of randomized trials of aspirin reported a reduction in cancer mortality; however, few studies have investigated whether aspirin or other NSAIDs reduce overall cancer risk...
  30. pmc Cancer risk associated with long-term use of acetaminophen in the prospective VITamins and lifestyle (VITAL) study
    Roland B Walter
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 20:2637-41. 2011
    ....
  31. pmc Vitamin, mineral, and specialty supplements and risk of hematologic malignancies in the prospective VITamins And Lifestyle (VITAL) study
    Roland B Walter
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 20:2298-308. 2011
    ..Increasing evidence suggests that nutrients from fruits and vegetables have chemoprotective effects on various cancers including hematologic malignancies, but the effects of nutritional supplements are poorly examined...
  32. pmc Use of glucosamine and chondroitin and lung cancer risk in the VITamins And Lifestyle (VITAL) cohort
    Theodore M Brasky
    Cancer Prevention Unit, The Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Causes Control 22:1333-42. 2011
    ..After an additional year of follow-up, we further examined the association including frequency/duration of use, interaction with factors associated with inflammation, and lung cancer histology...
  33. pmc Supplement use and risk of cutaneous squamous cell carcinoma
    Maryam M Asgari
    Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA
    J Am Acad Dermatol 65:1145-51. 2011
    ..Laboratory and epidemiologic studies suggest that certain dietary supplements may alter risk of cutaneous squamous cell carcinoma (SCC)...
  34. pmc Specialty supplements and prostate cancer risk in the VITamins and Lifestyle (VITAL) cohort
    Theodore M Brasky
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Nutr Cancer 63:573-82. 2011
    ..Grapeseed may be a potential chemopreventive agent; however, as current evidence is limited, it should not yet be promoted for prevention of prostate cancer...
  35. pmc Long-term use of acetaminophen, aspirin, and other nonsteroidal anti-inflammatory drugs and risk of hematologic malignancies: results from the prospective Vitamins and Lifestyle (VITAL) study
    Roland B Walter
    Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    J Clin Oncol 29:2424-31. 2011
    ..Herein, we used a large prospective cohort study to examine these associations...
  36. pmc Serum phospholipid fatty acids and prostate cancer risk: results from the prostate cancer prevention trial
    Theodore M Brasky
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Am J Epidemiol 173:1429-39. 2011
    ..48, 95% CI: 0.27, 0.84). The study findings are contrary to those expected from the pro- and antiinflammatory effects of these fatty acids and suggest a greater complexity of effects of these nutrients with regard to prostate cancer risk...
  37. pmc Non-steroidal anti-inflammatory drugs (NSAIDs) and breast cancer risk: differences by molecular subtype
    Theodore M Brasky
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA
    Cancer Causes Control 22:965-75. 2011
    ..28, 95% CI: 1.04-1.57), as well as luminal A or B breast cancers. These findings support the hypothesis of heterogeneous etiologies of breast cancer subtypes and that aspirin and ibuprofen vary in their effects...
  38. pmc Circulating 25-hydroxyvitamin-D and risk of colorectal adenomas and hyperplastic polyps
    Scott V Adams
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Nutr Cancer 63:319-26. 2011
    ..17 (0.55-2.51)] or among those without prior polyps [adjusted OR (95%CI): 1.42 (0.55-3.65)]. Our study suggests that the established inverse association between circulating 25(OH)D and adenoma may not apply to hyperplastic polyps...
  39. pmc Long-term use of supplemental vitamins and minerals does not reduce the risk of urothelial cell carcinoma of the bladder in the VITamins And Lifestyle study
    James M Hotaling
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98103, USA
    J Urol 185:1210-5. 2011
    ....
  40. pmc Nonsteroidal anti-inflammatory drugs and prostate cancer risk in the VITamins And Lifestyle (VITAL) cohort
    Theodore M Brasky
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 19:3185-8. 2010
    ..Several epidemiologic studies have reported inverse associations between nonsteroidal anti-inflammatory drugs (NSAIDs) and prostate cancer risk, although many studies are limited by assessment of short-term use only...
  41. pmc Characterization of gene-environment interactions for colorectal cancer susceptibility loci
    Carolyn M Hutter
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Res 72:2036-44. 2012
    ....
  42. pmc Association of vitamin A and carotenoid intake with melanoma risk in a large prospective cohort
    Maryam M Asgari
    Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA
    J Invest Dermatol 132:1573-82. 2012
    ..There was no association of melanoma risk with dietary or total intake of vitamin A or carotenoids. Retinol supplementation may have a preventative role in melanoma among women...
  43. pmc Dietary intake of specific fatty acids and breast cancer risk among postmenopausal women in the VITAL cohort
    Anna K Sczaniecka
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, Washington 98109 1024, USA
    Nutr Cancer 64:1131-42. 2012
    ..Our findings show that fatty acids are heterogeneous in their association with postmenopausal breast cancer risk...
  44. pmc Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival
    Xabier Garcia-Albeniz
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 34:292-8. 2013
    ..These findings suggest that individuals with this SMAD7 variant that develop CRC are more probably to have tumors with greater invasiveness and methylation of RUNX3, which potentially contributes to their poorer observed survival...
  45. pmc Non-steroidal anti-inflammatory drugs and endometrial cancer risk in the VITamins And Lifestyle (VITAL) cohort
    Theodore M Brasky
    The Ohio State University College of Medicine, Department of Internal Medicine, Division of Cancer Prevention and Control, Columbus, OH, USA
    Gynecol Oncol 128:113-9. 2013
    ..Chronic inflammation may be an important factor in the initiation and promotion of endometrial cancer. Use of non-steroidal anti-inflammatory drugs (NSAIDs), however, has been inconsistently associated with endometrial cancer risk...
  46. pmc A pooled analysis of smoking and colorectal cancer: timing of exposure and interactions with environmental factors
    Jian Gong
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 21:1974-85. 2012
    ..What is unclear, however, is the impact of quitting smoking on risk attenuation and whether other risk factors for CRC modify this association...
  47. pmc Prediagnostic nonsteroidal anti-inflammatory drug use and lung cancer survival in the VITAL study
    Theodore M Brasky
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA, USA
    J Thorac Oncol 7:1503-12. 2012
    ..Inflammation is important for lung oncogenesis. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to improve colorectal cancer survival. However, few studies have examined the association in lung cancer patients...
  48. pmc Association between adult height, genetic susceptibility and risk of glioma
    Cari M Kitahara
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Int J Epidemiol 41:1075-85. 2012
    ..In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease...
  49. pmc Use of glucosamine and chondroitin in relation to mortality
    Griffith A Bell
    Cancer Prevention Program, The Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Eur J Epidemiol 27:593-603. 2012
    ..Although bias cannot be ruled out, these results suggest that glucosamine may provide some mortality benefit...
  50. pmc Long-term NSAID use and incident urothelial cell carcinoma in the VITamins and Lifestyle (VITAL) study
    Cheryl Shih
    Department of Urology, University of Washington School of Medicine, Seattle, WA 98195, USA Electronic address
    Urol Oncol 31:1689-95. 2013
    ..We examine the association between NSAID use and UC risk...
  51. pmc Non-steroidal anti-inflammatory drugs and small cell lung cancer risk in the VITAL study
    Theodore M Brasky
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA, USA
    Lung Cancer 77:260-4. 2012
    ..Large, prospective studies with comprehensive assessments of NSAID use and smoking history and data on both men and women, are needed in order to better understand the association between use of aspirin and SCLC...
  52. pmc Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer
    Amanda I Phipps
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Gastroenterology 143:51-4.e4. 2012
    ..05-1.30; P = .005). Other SNPs were not associated significantly with survival. Common germline variations might be prognostic factors for patients with CRC. A variant in SMAD7 could affect progression of CRC...
  53. pmc Reliability of serum biomarkers of inflammation from repeated measures in healthy individuals
    Sandi L Navarro
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 21:1167-70. 2012
    ..Biomarkers of low-grade systemic inflammation are used to study the associations of inflammation with chronic diseases, including cancer. However, relatively little is known about the intraindividual variability of most of these measures...
  54. pmc Dietary cadmium and risk of invasive postmenopausal breast cancer in the VITAL cohort
    Scott V Adams
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Cancer Causes Control 23:845-54. 2012
    ..The aim of the study was to estimate the association between dietary intake of cadmium, a carcinogenic heavy metal, and risk of invasive postmenopausal breast cancer...
  55. pmc Genetic variants in COX-2, non-steroidal anti-inflammatory drugs, and breast cancer risk: the Western New York Exposures and Breast Cancer (WEB) Study
    Theodore M Brasky
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA
    Breast Cancer Res Treat 126:157-65. 2011
    ..Better understanding of the role of COX-2 genetic variation and interaction with NSAID use in breast carcinogenesis has potential to inform prevention strategies...

Research Grants30

  1. Comparative Mechanisms of Cancer Chemoprevention
    Roderick H Dashwood; Fiscal Year: 2013
    ..This application is innovative and timely in bridging basic mechanisms, preclinical models, and human studies of epigenetics and diet. ..