Neuroimaging Studies of Frontal Lobe Pathology in OCD

Summary

Principal Investigator: P R Szeszko
Affiliation: Long Island Jewish Medical Center
Country: USA
Abstract: DESCRIPTION (Provided by applicant): This revised application for a Mentored Research Scientist Development Award (KOl) is from a licensed clinical psychologist and Assistant Professor of Psychiatry. He is proposing a research career development plan that will enable him to learn how to use diffusion tensor imaging and functional magnetic resonance imaging techniques to better elucidate the neurobiology and neuropsychology of obsessive-compulsive disorder (OCD). Compared to other major psychiatric disorders such as schizophrenia and depression there have been fewer neuroimaging studies in OCD, and the majority of studies conducted thus far have utilized either PET or SPECT. Moreover, the neural mechanisms underlying cognitive dysfunction in OCD have been poorly elaborated. The applicant has preliminary data (Szeszko et al 1999) implicating orbital frontal lobe structural abnormalities in OCD using morphometric methods and wants to learn how to conduct additional studies investigating the frontal lobes of these patients. The training plan would increase the applicant's knowledge in three broad domains: (1) neurobiology, phenomenology and pharmacology of OCD; (2) diffusion tensor imaging and (3) neuropsychology of OCD and cognitive neuroscience applications of fMRI in OCD. The training goals will be accomplished through the completion of the research plan, which will examine the relative contributions of dorsal and ventral frontal regions to the pathophysiology of OCD using brain morphometry, diffusion tensor imaging, functional magnetic resonance imaging and comprehensive neuropsychological assessment. In collaboration with the applicant's mentors and consultants various statistical and image processing techniques will be used to analyze and interpret the neuroimaging data and the functional correlates of structural brain pathology will be identified. Completion of the training goals and research studies are expected to provide the applicant with the knowledge and experience to develop into an independent investigator capable of conducting high quality neuroimaging studies in OCD and to apply for an ROl.
Funding Period: 2001-05-01 - 2006-04-30
more information: NIH RePORT

Top Publications

  1. ncbi Effects of age on prefrontal subregions and hippocampal volumes in young and middle-aged healthy humans
    Robin L Wellington
    Department of Psychology, St John s University, Jamaica, NY, USA
    Hum Brain Mapp 34:2129-40. 2013
  2. pmc Gray matter volume deficits are associated with motor and attentional impairments in adolescents with schizophrenia
    Sanjiv Kumra
    University of Minnesota, Department of Psychiatry, Minneapolis, MN 55454, USA
    Prog Neuropsychopharmacol Biol Psychiatry 35:939-43. 2011
  3. pmc Diffusion tensor imaging reliably differentiates patients with schizophrenia from healthy volunteers
    Babak A Ardekani
    Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Hum Brain Mapp 32:1-9. 2011
  4. doi Gray matter structural alterations in psychotropic drug-naive pediatric obsessive-compulsive disorder: an optimized voxel-based morphometry study
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 165:1299-307. 2008
  5. pmc Patterns of stress in schizophrenia
    Julia D Betensky
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Psychiatry Res 160:38-46. 2008
  6. doi Volumetric and shape analysis of the thalamus in first-episode schizophrenia
    Denise M Coscia
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
    Hum Brain Mapp 30:1236-45. 2009
  7. doi Neurocognitive profile analysis in obsessive-compulsive disorder
    Katherine E Burdick
    Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    J Int Neuropsychol Soc 14:640-5. 2008
  8. pmc Greater regional cortical gray matter thickness in obsessive-compulsive disorder
    Veena M Narayan
    Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Neuroreport 19:1551-5. 2008
  9. pmc Gray matter structural alterations in obsessive-compulsive disorder: relationship to neuropsychological functions
    Christopher J Christian
    Zucker Hillside Hospital, Psychiatry Research, Glen Oaks, NY, United States
    Psychiatry Res 164:123-31. 2008
  10. pmc Lower orbital frontal white matter integrity in adolescents with bipolar I disorder
    Vivian Kafantaris
    Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System
    J Am Acad Child Adolesc Psychiatry 48:79-86. 2009

Scientific Experts

  • P R Szeszko
  • Sanjiv Kumra
  • Babak A Ardekani
  • David Roofeh
  • Vivian Kafantaris
  • Manzar Ashtari
  • Katherine E Burdick
  • Robert M Bilder
  • Delbert G Robinson
  • Anil K Malhotra
  • Julia D Betensky
  • Robin L Wellington
  • Denise M Coscia
  • Katie Mahon
  • Handan Gunduz-Bruce
  • Joanne McCormack
  • Serge Sevy
  • Katherine L Narr
  • Frank P MacMaster
  • Todd Lencz
  • Veena M Narayan
  • Christopher J Christian
  • Harvey N Kranzler
  • Barbara Napolitano
  • Liberty S Hamilton
  • Pamela DeRosse
  • Jinghui Wu
  • Yousha Mirza
  • Michelle Lynch
  • Arthur W Toga
  • John M Kane
  • Rachel Miller
  • Phillip C Easter
  • Lauren E Kmiecik
  • Michelle Rose
  • David R Rosenberg
  • S Preeya Taormina
  • Owen R Phillips
  • Gregory J Moore
  • Paul M Thompson
  • Joseph Youngerman
  • Guy Beauzile
  • Inika N Henderson
  • Ginny Gerbino-Rosen
  • Keith Ditkowsky
  • Hana M Kester

Detail Information

Publications24

  1. ncbi Effects of age on prefrontal subregions and hippocampal volumes in young and middle-aged healthy humans
    Robin L Wellington
    Department of Psychology, St John s University, Jamaica, NY, USA
    Hum Brain Mapp 34:2129-40. 2013
    ....
  2. pmc Gray matter volume deficits are associated with motor and attentional impairments in adolescents with schizophrenia
    Sanjiv Kumra
    University of Minnesota, Department of Psychiatry, Minneapolis, MN 55454, USA
    Prog Neuropsychopharmacol Biol Psychiatry 35:939-43. 2011
    ..Our findings point to widespread, perhaps multifocal, pathology as contributing to cognitive dysfunction in adolescents with schizophrenia...
  3. pmc Diffusion tensor imaging reliably differentiates patients with schizophrenia from healthy volunteers
    Babak A Ardekani
    Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Hum Brain Mapp 32:1-9. 2011
    ..Patterns of water self-diffusion in the brain as estimated by DTI can be used in conjunction with automated pattern recognition algorithms to reliably distinguish between patients with schizophrenia and normal control subjects...
  4. doi Gray matter structural alterations in psychotropic drug-naive pediatric obsessive-compulsive disorder: an optimized voxel-based morphometry study
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 165:1299-307. 2008
    ....
  5. pmc Patterns of stress in schizophrenia
    Julia D Betensky
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Psychiatry Res 160:38-46. 2008
    ....
  6. doi Volumetric and shape analysis of the thalamus in first-episode schizophrenia
    Denise M Coscia
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York, USA
    Hum Brain Mapp 30:1236-45. 2009
    ..Our findings suggest that thalamic abnormalities are evident at the onset of a first episode of schizophrenia prior to extensive pharmacologic intervention and that these abnormalities have neuropsychological correlates...
  7. doi Neurocognitive profile analysis in obsessive-compulsive disorder
    Katherine E Burdick
    Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    J Int Neuropsychol Soc 14:640-5. 2008
    ..Findings of specific abnormalities on tasks of motor and processing speed are consistent with a hypothesized role of thalamocortical and basal ganglia regions in the pathogenesis of OCD...
  8. pmc Greater regional cortical gray matter thickness in obsessive-compulsive disorder
    Veena M Narayan
    Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Neuroreport 19:1551-5. 2008
    ....
  9. pmc Gray matter structural alterations in obsessive-compulsive disorder: relationship to neuropsychological functions
    Christopher J Christian
    Zucker Hillside Hospital, Psychiatry Research, Glen Oaks, NY, United States
    Psychiatry Res 164:123-31. 2008
    ..Moreover, our data suggest that gray matter structural alterations in OCD have neuropsychological correlates, which may be useful in further characterizing structure-function relations in this disorder...
  10. pmc Lower orbital frontal white matter integrity in adolescents with bipolar I disorder
    Vivian Kafantaris
    Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System
    J Am Acad Child Adolesc Psychiatry 48:79-86. 2009
    ..To examine white matter microstructure, as assessed via diffusion tensor imaging (DTI), in adolescents with bipolar I disorder compared with control volunteers...
  11. pmc A voxel-based diffusion tensor imaging study of white matter in bipolar disorder
    Katie Mahon
    Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 34:1590-600. 2009
    ..Our findings are consistent with models of bipolar disorder that implicate dysregulation of cortico-subcortical and cerebellar regions in the disorder and may have relevance for phenomenology...
  12. pmc DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia
    Philip R Szeszko
    Feinstein Institute for Medical Research, Manhasset, NY, USA
    Biol Psychol 79:103-10. 2008
    ..Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology...
  13. pmc Amygdala and hippocampal volumes in familial early onset major depressive disorder
    Frank P MacMaster
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Biol Psychiatry 63:385-90. 2008
    ..To our knowledge, no prior study has examined amygdala-hippocampus anatomy in pediatric patients with familial MDD (at least one first degree relative with MDD)...
  14. ncbi White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study
    Philip R Szeszko
    The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 162:602-5. 2005
    ..The goal of this study was to investigate brain white matter abnormalities by using diffusion tensor imaging in patients with schizophrenia or schizoaffective disorder close to illness onset...
  15. ncbi Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation
    P R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Mol Psychiatry 10:631-6. 2005
    ..These findings implicate genetic involvement of BDNF in variation of human hippocampal volume and suggest that this effect may be greater among patients compared to healthy volunteers...
  16. ncbi White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 62:782-90. 2005
    ....
  17. ncbi White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study
    Sanjiv Kumra
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    J Am Acad Child Adolesc Psychiatry 44:934-41. 2005
    ..To investigate abnormalities in the structural integrity of brain white matter as suggested by diffusion tensor imaging in adolescents with early-onset schizophrenia (onset of psychosis by age 18)...
  18. ncbi Treatment-refractory schizophrenia in children and adolescents: an update on clozapine and other pharmacologic interventions
    Harvey N Kranzler
    Department of Psychiatry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Child Adolesc Psychiatr Clin N Am 15:135-59. 2006
    ....
  19. ncbi Deficits in memory strategy use are related to verbal memory impairments in adolescents with schizophrenia-spectrum disorders
    David Roofeh
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Schizophr Res 85:201-12. 2006
    ..To assess the nature of learning and verbal memory deficits in adolescents with schizophrenia-spectrum disorders (SzS) (i.e., schizophrenia, schizoaffective disorder, and schizophreniform disorder)...
  20. ncbi Ethical and practical considerations in the management of incidental findings in pediatric MRI studies
    Sanjiv Kumra
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA
    J Am Acad Child Adolesc Psychiatry 45:1000-6. 2006
    ..The authors examined the ethical and practical management issues resulting from the detection of incidental abnormal findings on magnetic resonance imaging (MRI) research studies in healthy pediatric volunteers...
  21. ncbi Increased stress and smaller anterior hippocampal volume
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Neuroreport 17:1825-8. 2006
    ..Our results may also have implications for neuropsychiatric disorders that have implicated stress and hippocampal abnormalities in their pathogenesis...
  22. ncbi Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophrenia
    Philip R Szeszko
    Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Br J Psychiatry 190:230-6. 2007
    ..Despite the high prevalence of cannabis use in schizophrenia, few studies have examined the potential relationship between cannabis exposure and brain structural abnormalities in schizophrenia...
  23. ncbi Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 33:976-84. 2008
    ..These abnormalities have clinical and neuropsychological correlates, which may be useful in further characterizing structure-function relations in schizophrenia and constraining neurobiological models of the disorder...
  24. ncbi Attention-deficit/hyperactivity disorder: a preliminary diffusion tensor imaging study
    Manzar Ashtari
    Departments of Radiology, North Shore Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Biol Psychiatry 57:448-55. 2005
    ..Based upon the literature, we predicted decreased fractional anisotropy (FA) findings in the frontal and cerebellar regions...