Prevention of Hip Dysplasia with Thermal Energy

Summary

Principal Investigator: Mandi J Lopez
Affiliation: Louisiana State University
Country: USA
Abstract: The fundamental goals of this research proposal are to test the hypotheses that: 1) application of thermal energy at 65 degrees C using radio-frequency energy to the coxofemoral joint capsule of puppies with radiographic evidence of joint laxity will result in normal hip congruity, 2) will prevent the development of the lameness and the cartilagenous and bony changes characteristic of CHD, and 3) will not have detrimental effects on the biomechanical or viscoelastic properties of the joint capsular tissue. These investigations will yield insights into the fundamental mechanisms of thermal modification of musculoskeletal soft tissue. This research program is designed to determine whether thermal modification of coxocofemoral joint capsule of 16-week-old puppies with excessive joint: laxity will prevent CHD. Ultimately, this model will serve to evaluate the potential of thermal energy to reduce excessively lax coxofemoral joints in neonatal children and thereby help prevent DDH. The candidate of this application graduated magna cum laude from Humboldt State University with a B.S. in cellular-molecular biology and a minor in chemistry. She worked as a molecular biologist at Amgen, Thousand Oaks, CA, before undertaking and; completing her D.V.M. at the University of California-Davis. Dr. Lopez was awarded 5 scholarships and 2 research grants while a D.V.M. student. She completed an internship at Kansas State University and a large animal surgery residency/Master's degree at they University of Wisconsin- Madison. She is a board certified large animal surgeon. Dr. Lopez's Master's thesis was entitled "Effects of Radio-frequency Energy on Ovine Stifle Joint Capsule", and she performed much of the early radio- frequency work in the Comparative Orthopaedic Research Laboratory. She was awarded an NRSA in 1998 and has performed the background research and preliminary, studies that form the basis for this proposal. She passed her preliminary examinations "With Honors" in November, 1999, and is scheduled to complete her PhD in June 2001. Her ultimate goal is to join the faculty of an academic institution as a well-trained scientist and productive researcher specializing in integrative, translational research. The training environment will be guided toward mentoring the candidate while teaching valuable research techniques necessary to begin an independent research career. The majority of supervision will be provided by Mark D. Markel, an internationally known and respected investigator in the area of thermal tissue modification, Professor of Surgery, and Professor and Chairman of Medical Sciences. The advisory committee will consist of well-respected and highly experienced individuals within the University. The Comparative Orthopaedic Research Laboratory is a well established laboratory that houses multi- disciplinary research programs. The University of Wisconsin provides an exceptional environment for interaction with experts in a variety of fields, and it is well known for its exceptional research programs, especially in the medical sciences.
Funding Period: 2001-09-01 - 2007-07-31
more information: NIH RePORT

Top Publications

  1. pmc Evaluation of gait kinetics in puppies with coxofemoral joint laxity
    Mandi J Lopez
    Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
    Am J Vet Res 67:236-41. 2006
  2. pmc Associations between canine juvenile weight gain and coxofemoral joint laxity at 16 weeks of age
    Mandi J Lopez
    Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
    Vet Surg 35:214-8. 2006
  3. pmc Monopolar radiofrequency energy application to the dorsal extensor tendon apparatus in a canine model of tendon injury
    Mandi J Lopez
    Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, 70803, USA
    J Hand Surg Am 31:1296-302. 2006
  4. pmc In vivo evaluation of intra-articular protection in a novel model of canine cranial cruciate ligament mid-substance elongation injury
    Mandi J Lopez
    Laboratory for Equine and Comparative Orthopedic Research, Veterinary Clinical Sciences Department, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
    Vet Surg 35:711-20. 2006
  5. pmc Biomechanical characteristics of an implant used to secure semitendinosus-gracilis tendon grafts in a canine model of extra-articular anterior cruciate ligament reconstruction
    Mandi J Lopez
    Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, and the Department of Biological and Agricultural Engineering, Louisiana State University and AgCenter, Baton Rouge, LA 70803 8410, USA
    Vet Surg 36:599-604. 2007
  6. doi Characterization of normal canine anterior cruciate ligament-associated synoviocytes
    Sunil C Vasanjee
    Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Skip Bertman Drive, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    J Orthop Res 26:809-15. 2008
  7. pmc Interobserver repeatability of measurements on computed tomography images of lax canine hip joints from youth to maturity
    Mandi J Lopez
    Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
    Vet Surg 38:920-6. 2009

Detail Information

Publications7

  1. pmc Evaluation of gait kinetics in puppies with coxofemoral joint laxity
    Mandi J Lopez
    Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
    Am J Vet Res 67:236-41. 2006
    ..To characterize ground reaction forces (GRFs) and determine whether there were correlations between forces and passive coxofemoral joint laxity in puppies...
  2. pmc Associations between canine juvenile weight gain and coxofemoral joint laxity at 16 weeks of age
    Mandi J Lopez
    Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
    Vet Surg 35:214-8. 2006
    ..Evaluation of the relationship between canine weight gain from 6 to 15 weeks of age and passive coxofemoral joint (CFJ) laxity at 16 weeks of age...
  3. pmc Monopolar radiofrequency energy application to the dorsal extensor tendon apparatus in a canine model of tendon injury
    Mandi J Lopez
    Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, 70803, USA
    J Hand Surg Am 31:1296-302. 2006
    ..To evaluate the use of monopolar radiofrequency energy (MRFE) to shorten stretched dorsal extensor tendon apparatus (DETA) tissues in a canine model...
  4. pmc In vivo evaluation of intra-articular protection in a novel model of canine cranial cruciate ligament mid-substance elongation injury
    Mandi J Lopez
    Laboratory for Equine and Comparative Orthopedic Research, Veterinary Clinical Sciences Department, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
    Vet Surg 35:711-20. 2006
    ..To evaluate the effects of intra-articular protection (IAP) on the canine cranial cruciate ligament (CrCL) and stifle in a CrCL midsubstance elongation injury model...
  5. pmc Biomechanical characteristics of an implant used to secure semitendinosus-gracilis tendon grafts in a canine model of extra-articular anterior cruciate ligament reconstruction
    Mandi J Lopez
    Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, and the Department of Biological and Agricultural Engineering, Louisiana State University and AgCenter, Baton Rouge, LA 70803 8410, USA
    Vet Surg 36:599-604. 2007
    ..To compare initial femoral fixation properties of a new implant, Graftgrab (GG), with 2 established methods of extra-articular femoral graft fixation, spiked washers (SW) and bone staples (ST)...
  6. doi Characterization of normal canine anterior cruciate ligament-associated synoviocytes
    Sunil C Vasanjee
    Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Skip Bertman Drive, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    J Orthop Res 26:809-15. 2008
    ..Identification and quantification of ACL synoviocytes may serve as the foundation for future studies involving ACL disease or reconstruction...
  7. pmc Interobserver repeatability of measurements on computed tomography images of lax canine hip joints from youth to maturity
    Mandi J Lopez
    Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
    Vet Surg 38:920-6. 2009
    ..To determine interobserver repeatability of measurements on computed tomography (CT) images of lax canine hip joints at different ages and in the presence of degenerative joint disease at maturity...