Vascular and Inflammatory Predictors of MCI Risk and Progression

Summary

Principal Investigator: ROSEBUD ROBERTS
Abstract: [unreadable] DESCRIPTION (provided by applicant): Mild cognitive impairment (MCI) is an important condition; 10-15% of MCI subjects convert to Alzheimer's disease (AD) per year, compared to 1-2% in the general population. The long-term goal of this candidate is to develop an independent program dedicated to the prevention of AD through the investigation of risk factors for MCI. To achieve this, the candidate needs expertise and knowledge in neurodegenerative diseases, and longitudinal population-based research in MCI and AD. The candidate is applying for this K01 Mentored Research Scientist Development Award to facilitate a transition from the study of prostatic diseases to the study of neurodegenerative diseases. The K01 award will meet the long-term goal of the candidate through two short term goals: 1) To develop understanding and expertise in neurodegenerative disorders, with an emphasis on MCI, an intermediate stage between normal aging and AD; and 2) To develop expertise in identification of vascular and infammatory risk factors for MCI in a population based longitudinal cohort. These short-term goals will be accomplished through mentored activities, course work, and research. The primary mentor of this candidate, Dr. Ronald Petersen, the Principal Investigator (PI) of the population-based prospective study of MCI, and PI on a recently concluded multi-center clinical trial for MCI, will meet regularly with the candidate to discuss issues regarding characterization of MCI subjects, progress of the study, and novel research regarding MCI. In addition, the candidate will meet with secondary [unreadable] mentors in cardiovascular disease Dr Veronique Roger, an eminent cardiologist and epidemiologist with [unreadable] special interests in association of dementia and myocardial infarction; and Dr Robert Ivnik, a [unreadable] neuropsychologist with extensive experience in the development of population-based age- and educationadjusted neuropsychometric normative data for Olmsted County residents. The candidate's research plan will focus on vascular risk factors and inflammatory markers for MCI. The candidate's research plan is innovative because of the focus on non-cognitive, modifiable risk factors. While genetic risk factors may be important predictors of early onset AD, vascular risk factors may account for a larger proportion of AD. Since they are modifiable, they are more amenable to interventions that may prevent or reduce the risk of MCI and consequently, of AD. In this award, the candidate proposes to investigate hypotheses that vascular risk factors (e.g diabetes, hypertension), coronary heart disease, and inflammatory markers of vascular risk (e.g. C reactive protein) increase risk of MCI and MCI progression among participants in a longitudinal populationbased cohort. The study will be conducted at the Mayo Clinic Abigail van Buren Alzheimer's Disease Research Clinic. The K01 award will culminate in an R01 application that will pave the way for the candidate to become an independent investigator in MCI and AD research. [unreadable] [unreadable] [unreadable]
Funding Period: 2006-09-30 - 2010-06-30
more information: NIH RePORT

Top Publications

  1. pmc Association of duration and severity of diabetes mellitus with mild cognitive impairment
    Rosebud O Roberts
    Department of Health Sciences Research, Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 65:1066-73. 2008
  2. pmc Comparison of imaging biomarkers in the Alzheimer Disease Neuroimaging Initiative and the Mayo Clinic Study of Aging
    Jennifer L Whitwell
    Department of Radiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 69:614-22. 2012
  3. pmc Probable rapid eye movement sleep behavior disorder increases risk for mild cognitive impairment and Parkinson disease: a population-based study
    Brendon P Boot
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 71:49-56. 2012
  4. pmc Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia
    Rosebud O Roberts
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    J Alzheimers Dis 32:329-39. 2012
  5. pmc Cardiac disease associated with increased risk of nonamnestic cognitive impairment: stronger effect on women
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    JAMA Neurol 70:374-82. 2013
  6. pmc Assessing the temporal relationship between cognition and gait: slow gait predicts cognitive decline in the Mayo Clinic Study of Aging
    Michelle M Mielke
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, 200 First Street S W, Rochester, MN 55905, USA
    J Gerontol A Biol Sci Med Sci 68:929-37. 2013
  7. pmc Association of diabetes with amnestic and nonamnestic mild cognitive impairment
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Department of Neurology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:18-26. 2014
  8. pmc Caloric intake, aging, and mild cognitive impairment: a population-based study
    Yonas E Geda
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    J Alzheimers Dis 34:501-7. 2013
  9. pmc Chronic obstructive pulmonary disease and association with mild cognitive impairment: the Mayo Clinic Study of Aging
    Balwinder Singh
    Department of Neurology, Mayo Clinic, Rochester, MN Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Fargo, ND Electronic address
    Mayo Clin Proc 88:1222-30. 2013
  10. pmc Classification and epidemiology of MCI
    ROSEBUD ROBERTS
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA Department of Neurology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA Electronic address
    Clin Geriatr Med 29:753-72. 2013

Detail Information

Publications35

  1. pmc Association of duration and severity of diabetes mellitus with mild cognitive impairment
    Rosebud O Roberts
    Department of Health Sciences Research, Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 65:1066-73. 2008
    ..It remains unknown whether diabetes mellitus (DM) is a risk factor for mild cognitive impairment (MCI)...
  2. pmc Comparison of imaging biomarkers in the Alzheimer Disease Neuroimaging Initiative and the Mayo Clinic Study of Aging
    Jennifer L Whitwell
    Department of Radiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 69:614-22. 2012
    ..To determine whether magnetic resonance imaging measurements observed in the Alzheimer Disease Neuroimaging Initiative (ADNI) convenience sample differ from those observed in the Mayo Clinic Study of Aging (MCSA) population-based sample...
  3. pmc Probable rapid eye movement sleep behavior disorder increases risk for mild cognitive impairment and Parkinson disease: a population-based study
    Brendon P Boot
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 71:49-56. 2012
    ..There are no data on such risks in a population-based sample...
  4. pmc Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia
    Rosebud O Roberts
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    J Alzheimers Dis 32:329-39. 2012
    ..52-1.20]; p for trend = 0.03) in the fully adjusted models. A dietary pattern with relatively high caloric intake from carbohydrates and low caloric intake from fat and proteins may increase the risk of MCI or dementia in elderly persons...
  5. pmc Cardiac disease associated with increased risk of nonamnestic cognitive impairment: stronger effect on women
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    JAMA Neurol 70:374-82. 2013
    ..Nonamnestic mild cognitive impairment, a putative precursor of vascular and other non-Alzheimer dementias, is hypothesized to have a vascular etiology...
  6. pmc Assessing the temporal relationship between cognition and gait: slow gait predicts cognitive decline in the Mayo Clinic Study of Aging
    Michelle M Mielke
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, 200 First Street S W, Rochester, MN 55905, USA
    J Gerontol A Biol Sci Med Sci 68:929-37. 2013
    ..The association between gait speed and cognition has been reported; however, there is limited knowledge about the temporal associations between gait slowing and cognitive decline among cognitively normal individuals...
  7. pmc Association of diabetes with amnestic and nonamnestic mild cognitive impairment
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA Department of Neurology, Mayo Clinic, Rochester, MN, USA Electronic address
    Alzheimers Dement 10:18-26. 2014
    ..We examined the association of type 2 diabetes with mild cognitive impairment (MCI) and MCI subtype (aMCI and naMCI) overall and by sex...
  8. pmc Caloric intake, aging, and mild cognitive impairment: a population-based study
    Yonas E Geda
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    J Alzheimers Dis 34:501-7. 2013
    ..96, 95% CI 1.26-3.06, p = 0.003) as compared to the reference group. Therefore, high caloric intake was associated with MCI but not moderate caloric intake. This association is not necessarily a cause-effect relationship...
  9. pmc Chronic obstructive pulmonary disease and association with mild cognitive impairment: the Mayo Clinic Study of Aging
    Balwinder Singh
    Department of Neurology, Mayo Clinic, Rochester, MN Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Fargo, ND Electronic address
    Mayo Clin Proc 88:1222-30. 2013
    ..To investigate the association of chronic obstructive pulmonary disease (COPD) with mild cognitive impairment (MCI) and MCI subtype: amnestic MCI and nonamnestic MCI, in a population-based study of elderly patients...
  10. pmc Classification and epidemiology of MCI
    ROSEBUD ROBERTS
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA Department of Neurology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA Electronic address
    Clin Geriatr Med 29:753-72. 2013
    ..In this review, we present an overview of the classification of MCI, estimates of the incidence and prevalence of MCI, risk factors for MCI, and the outcomes following an MCI diagnosis. ..
  11. pmc Association of type 2 diabetes with brain atrophy and cognitive impairment
    Rosebud O Roberts
    From the Division of Epidemiology, Department of Health Sciences Research R O R, M M M, Y E G, W A R, R C P, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research S A P, V S P, and Departments of Neurology R O R, D S K, B F B, W A R, R C P, Radiology K K, G M P, M L S, C R J, and Psychiatry and Psychology R J I, Mayo Clinic, Rochester, MN and Departments of Psychiatry and Psychology Y E G and Neurology Y E G, Mayo Clinic, Scottsdale, AZ
    Neurology 82:1132-41. 2014
    ..We investigated the associations of diabetes and hypertension with imaging biomarkers (markers of neuronal injury and ischemic damage) and with cognition in a population-based cohort without dementia...
  12. pmc Association of mediterranean diet with mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis
    Balwinder Singh
    Department of Neurology, Mayo Clinic, Rochester, MN, USA Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA
    J Alzheimers Dis 39:271-82. 2014
    ..To conduct a systematic review of all studies to determine whether there is an association between the Mediterranean diet (MeDi) and cognitive impairment...
  13. pmc Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study
    Michelle M Mielke
    From the Divisions of Epidemiology M M Mielke, R O R, R C P, Y E G and Biomedical Statistics and Informatics H J W, S D W, Department of Health Sciences Research Departments of Neurology R S, D S K, R O R, R C P, Psychiatry and Psychology M M Machulda, and Radiology P V, V J L, C R J, Mayo Clinic, Rochester, MN and Departments of Psychiatry, Psychology, and Neurology Y E G, Mayo Clinic, Scottsdale, AZ
    Neurology 82:70-6. 2014
    ..We determined whether head trauma was associated with amyloid deposition and neurodegeneration among individuals who were cognitively normal (CN) or had mild cognitive impairment (MCI)...
  14. pmc Hypothyroidism and risk of mild cognitive impairment in elderly persons: a population-based study
    Ajay K Parsaik
    Department of Psychiatry and Behavior Sciences, The University of Texas Medical School, Houston2Mayo Alzheimer s Disease Research Center, Mayo Clinic, Rochester, Minnesota3Department of Neurology, Mayo Clinic, Rochester, Minnesota
    JAMA Neurol 71:201-7. 2014
    ..An association of clinical and subclinical hypothyroidism with mild cognitive impairment (MCI) has not been established...
  15. pmc Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal
    Rosebud O Roberts
    From the Divisions of Epidemiology R O R, M M M, Y E G, W A R, R C P and Biomedical Statistics and Informatics R H C V S P, T J H C, Department of Health Sciences Research Department of Neurology R O R, D S K, B F B, R C P Department of Psychiatry and Psychology R J I and Division of Primary Care Internal Medicine, Department of Internal Medicine E G T, Mayo Clinic, Rochester, MN and Departments of Psychiatry and Psychology and Neurology Y E G, Mayo Clinic, Scottsdale, AZ
    Neurology 82:317-25. 2014
    ..To estimate rates of progression from mild cognitive impairment (MCI) to dementia and of reversion from MCI to being cognitively normal (CN) in a population-based cohort...
  16. pmc Viral hepatitis among Somali immigrants in Minnesota: association of hepatitis C with hepatocellular carcinoma
    Abdirashid M Shire
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 87:17-24. 2012
    ..To study the frequencies of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, and their associations with hepatocellular carcinoma (HCC) in immigrant Somalis seen at Mayo Clinic in Rochester, Minnesota...
  17. pmc Computer activities, physical exercise, aging, and mild cognitive impairment: a population-based study
    Yonas E Geda
    Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Mayo Clin Proc 87:437-42. 2012
    ..To examine the association between computer use, physical exercise, aging, and mild cognitive impairment (MCI)...
  18. pmc The incidence of MCI differs by subtype and is higher in men: the Mayo Clinic Study of Aging
    R O Roberts
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Neurology 78:342-51. 2012
    ..We estimated the incidence of amnestic MCI (aMCI) and nonamnestic MCI (naMCI) in men and women separately...
  19. pmc Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: population-based study
    Yonas E Geda
    Department of Psychiatry and Psychology, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Gen Psychiatry 65:1193-8. 2008
    ..Little is known about the population-based prevalence of neuropsychiatric symptoms in mild cognitive impairment (MCI)...
  20. pmc The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics
    Rosebud O Roberts
    Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neuroepidemiology 30:58-69. 2008
    ..The objective of this study was to establish a prospective population-based cohort to investigate the prevalence, incidence and risk factors for mild cognitive impairment (MCI) and dementia...
  21. pmc Association of prior stroke with cognitive function and cognitive impairment: a population-based study
    David S Knopman
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 66:614-9. 2009
    ..Defining the nature of the contribution of stroke to cognitive impairment remains challenging...
  22. pmc Association of C-reactive protein with mild cognitive impairment
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Alzheimers Dement 5:398-405. 2009
    ..This study examined the association of inflammatory markers in serum or plasma with prevalent MCI and MCI subtypes in a population-based sample...
  23. pmc Vegetables, unsaturated fats, moderate alcohol intake, and mild cognitive impairment
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA roberts rosebud mayo edu
    Dement Geriatr Cogn Disord 29:413-23. 2010
    ..To investigate associations of the Mediterranean diet (MeDi) components and the MeDi score with mild cognitive impairment (MCI)...
  24. pmc Coronary heart disease is associated with non-amnestic mild cognitive impairment
    Rosebud O Roberts
    Mayo Clinic, Department of Health Sciences Research, Division of Epidemiology, 200 First Street SW, Rochester, MN 55905, United States
    Neurobiol Aging 31:1894-902. 2010
    ..75; 95% CI=1.28-2.41), but not with na-MCI (OR=1.17; 95% CI=0.69-2.00). The association of CHD with prevalent na-MCI but not with a-MCI suggests that CHD and na-MCI may have similar underlying etiologies...
  25. pmc Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging
    R C Petersen
    Department of Neurology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 75:889-97. 2010
    ..We investigated the prevalence of mild cognitive impairment (MCI) in Olmsted County, MN, using in-person evaluations and published criteria...
  26. pmc Validation of the telephone interview for cognitive status-modified in subjects with normal cognition, mild cognitive impairment, or dementia
    David S Knopman
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neuroepidemiology 34:34-42. 2010
    ..The telephone assessment of cognitive functions may reduce the cost and burden of epidemiological studies...
  27. pmc Polyunsaturated fatty acids and reduced odds of MCI: the Mayo Clinic Study of Aging
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    J Alzheimers Dis 21:853-65. 2010
    ..In this study, higher intake of PUFA and MUFA was associated with a reduced likelihood of MCI among elderly persons in the population-based setting...
  28. pmc Vascular risk factors: imaging and neuropathologic correlates
    David S Knopman
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    J Alzheimers Dis 20:699-709. 2010
    ..The role of vascular risk factors in midlife should be the focus of public health efforts to reduce the burden of late-life cognitive impairment...
  29. pmc Metabolic syndrome, inflammation, and nonamnestic mild cognitive impairment in older persons: a population-based study
    Rosebud O Roberts
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    Alzheimer Dis Assoc Disord 24:11-8. 2010
    ..31; 95% CI=1.07, 5.00), but not with a-MCI (OR=0.96; 95% CI=0.59, 1.54). The combined presence of MetS and high levels of inflammation is associated with na-MCI in this elderly cohort, and suggests etiologic differences in MCI subtypes...
  30. pmc Physical exercise, aging, and mild cognitive impairment: a population-based study
    Yonas E Geda
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905
    Arch Neurol 67:80-6. 2010
    ..Physical exercise is associated with decreased risk of dementia and Alzheimer disease...
  31. pmc Passive case-finding for Alzheimer's disease and dementia in two U.S. communities
    David S Knopman
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Alzheimers Dement 7:53-60. 2011
    ..In this article, the advantages and disadvantages of passive case-finding were discussed, and the following conclusion was drawn: the purpose of the study being conducted should determine the case-finding approach that is to be used...
  32. pmc Induction of IL-10-producing CD4+ T-cells in chronic periodontitis
    R Kobayashi
    Department of Pediatric Dentistry, Immunobiology Vaccine Center, Institute of Oral Health Research, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Dent Res 90:653-8. 2011
    ..These results suggest that there are potential roles for Treg cells during the chronic stage of periodontitis in the regulation of gingival inflammation and alveolar bone loss...
  33. pmc Untreated type 2 diabetes and its complications are associated with subcortical infarctions
    Rosebud O Roberts
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes Care 34:184-6. 2011
    ..To investigate the association of type 2 diabetes with subcortical infarctions...
  34. pmc Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation
    Rosebud O Roberts
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota
    J Nucl Med 55:759-64. 2014
    ..We investigated the associations of type 2 diabetes with amyloid accumulation measured using (11)C-Pittsburgh compound B ((11)C-PiB) and brain hypometabolism measured using (18)F-FDG PET...