Effects of Androgens and Cannabinoids on Learning
Principal Investigator: Stuart T Leonard
Abstract: There is growing evidence to indicate an interaction between the biologically active constituent of marijuana, delta-9-tetrahydrocannabinol (THC), and testosterone (T) in the central nervous system. However, little information is currently available regarding the functional consequences of this interaction on behavior. The proposed study will test the following hypotheses: 1)T replacement will attenuate the disruptive effects of systemically administered THC on overall response rate and percent errors in castrated male rats responding under a multiple schedule of repeated acquisition and performance of behavioral chains, 2) T replacement will differentially affect levels and function of cannabinoid receptor binding, as measured by quantitative receptor autoradiography, in brain areas implicated in learning and memory and will potentiate decreases in cannabinoid receptor binding induced by chronic administration of THC, 3) T replacement will attenuate the disruptive effects of intrahippocampally-administered THC on overall response rate and percent errors in ovariectomized rats responding under a multiple schedule. These results will provide, for the first time, information regarding the interactive effects of testosterone and THC on cognitive behavior.
Funding Period: 2005-02-18 - 2006-02-17
more information: NIH RePORT
- Effects of gamma-hydroxybutyric acid and flunitrazepam on ethanol intake in male ratsStuart T Leonard
Department of Pharmacology and Experimental Therapeutics at Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112, USA
Pharmacol Biochem Behav 85:780-6. 2006..These data suggest that there are perceptible or qualitative differences between GHB, flunitrazepam, and ethanol in terms of their capacity for modulating oral ethanol intake in outbred rats...
- Testosterone potentiates scopolamine-induced disruptions of nonspatial learning in gonadectomized male ratsStuart T Leonard
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Exp Clin Psychopharmacol 15:48-57. 2007..Furthermore, the present findings suggest that testosterone may decrease the activity of the cholinergic system during nonspatial tasks and thereby work in concert with the antagonism produced by scopolamine...