NIH Director's Pioneer Award

Summary

Principal Investigator: Junying Yuan
Abstract: No Abstract provided
Funding Period: 2005-09-30 - 2010-07-31
more information: NIH RePORT

Top Publications

  1. ncbi Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 23:1-12. 2006
  2. pmc Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival
    Caroline H Yi
    Department of Cell Biology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Cell 146:607-20. 2011
  3. pmc A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions
    Marta M Lipinski
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 18:1041-52. 2010
  4. pmc Necroptosis as an alternative form of programmed cell death
    Dana E Christofferson
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, United States
    Curr Opin Cell Biol 22:263-8. 2010
  5. pmc A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses
    Bénédicte F Py
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Autophagy 5:393-6. 2009
  6. pmc The Jekyll and Hyde functions of caspases
    Caroline H Yi
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 16:21-34. 2009
  7. pmc Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Apoptosis 14:469-77. 2009
  8. pmc Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
    Junichi Hitomi
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 135:1311-23. 2008
  9. pmc Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity
    Bénédicte F Py
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 38:1063-72. 2013

Detail Information

Publications10

  1. ncbi Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 23:1-12. 2006
    ..Such evidence suggests that evolution has led to an extensive integration of mammalian apoptosis machinery with multiple cellular physiological processes...
  2. pmc Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival
    Caroline H Yi
    Department of Cell Biology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Cell 146:607-20. 2011
    ..We propose that acetyl-CoA serves as a signaling molecule that couples apoptotic sensitivity to metabolism by regulating protein N-alpha-acetylation...
  3. pmc A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions
    Marta M Lipinski
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 18:1041-52. 2010
    ....
  4. pmc Necroptosis as an alternative form of programmed cell death
    Dana E Christofferson
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, United States
    Curr Opin Cell Biol 22:263-8. 2010
    ..Necroptosis and necrostatins provide an exciting new opportunity for developing new treatments for multiple human diseases involving necrosis and inflammation...
  5. pmc A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses
    Bénédicte F Py
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Autophagy 5:393-6. 2009
    ....
  6. pmc The Jekyll and Hyde functions of caspases
    Caroline H Yi
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 16:21-34. 2009
    ..Exciting recent developments have focused on uncovering nonapoptotic roles of caspases ranging from immune regulation to spermatogenesis, in highly specialized cellular frameworks...
  7. pmc Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke
    Junying Yuan
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Apoptosis 14:469-77. 2009
    ....
  8. pmc Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
    Junichi Hitomi
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 135:1311-23. 2008
    ..Our study defines a cellular signaling network that regulates necroptosis and the molecular bifurcation that controls apoptosis and necroptosis...
  9. pmc Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity
    Bénédicte F Py
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 38:1063-72. 2013
    ..By producing cochlin, FDCs thus contribute to the innate immune response in defense against bacteria...