Wits Non-communicable Disease Research Leadership Program

Summary

Principal Investigator: Karen Sliwa
Abstract: The need for an integrated Research Training Program in non-communicable diseases in developing countries has arisen out of the need to understand the nature, extent and pace of the transition to the emerging diseases of lifestyle. The emphasis in training will be on cardiovascular and metabolic diseases (obesity and type 2 diabetes). The specific aim is to develop a Training Program and a group of well trained researchers at the Masters, PhD and post-doctoral levels that cut across disciplines and provide capacity to tackle the big questions. What is the prevalence of these diseases in southern Africa? How can we monitor and understand the underlying causes? What effective intervention programs could we develop? This Research Training Program will be embedded in a regional, national and international research framework. It is aligned with the Fogatry Goals of mobilizing the scientific community to address the shifting burden of disease and disability specifically in non-communicable diseases;it will develop human capacity to meet the challenges by providing sustainable training for health scientists;and it will foster a sustainable research environment in a developing country. It will be an integrated Program that will ensure knowledge generation and dissemination from the basic and clinical sciences to inform public health issues, including social and cultural considerstions. It is aimed at a translational approach that will feed back into population health policy. This training will be enabled through the integration and collaboration across several established research programs at the University of the Witwatersrand, including the Soweto Heart Study, the Agincourt Rural Facility and the Birth to Twenty Study, with the aim of understanding the epidemiology, the genetic risk factors, the mechanisms and opportunities for community intervention. Trainees recruited from developing countries will obtain a global insight into the causes and impact of non-communicable diseases on health. RELEVANCE (See instructions): Economic and cultural transition in developing nations is causing a shift to the increasing burden of non communicable diseases. A thorough understanding of the epidemiology and the social, genetic and environmental causes will lead to innovative and affordable interventions and treatments in developing countries.
Funding Period: 2010-07-01 - 2015-06-30
more information: NIH RePORT

Top Publications

  1. ncbi The impact of dietary habits and nutritional deficiencies in urban African patients living with heart failure in Soweto, South Africa--a review
    Sandra Pretorius
    Soweto Cardiovascular Research Unit, University of the Witwatersrand, Johannesburg, Republic of South Africa
    Endocr Metab Immune Disord Drug Targets 13:118-24. 2013

Research Grants

Detail Information

Publications1

  1. ncbi The impact of dietary habits and nutritional deficiencies in urban African patients living with heart failure in Soweto, South Africa--a review
    Sandra Pretorius
    Soweto Cardiovascular Research Unit, University of the Witwatersrand, Johannesburg, Republic of South Africa
    Endocr Metab Immune Disord Drug Targets 13:118-24. 2013
    ..Nutritional recommendations and intervention programs for the prevention and management of CHF focusing on food that is culturally sensitive and affordable should be implemented. ..

Research Grants30

  1. Boston Puerto Rican Health Study - CVD Risk Factors
    Katherine L Tucker; Fiscal Year: 2013
    ..abstract_text> ..
  2. Vermont Center on Behavior and Health
    Stephen T Higgins; Fiscal Year: 2013
    ..S. public health. ..
  3. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
    ..abstract_text> ..
  4. STUDIES OF JOINT AGING AND OSTEOARTHRITIS
    Martin K Lotz; Fiscal Year: 2013
    ..Sah) will analyze biomechanical mechanisms of early and advanced cartilage degeneration and determine consequences for chondrocyte function and survival. ..
  5. The Johns Hopkins Center for AIDS Research (JHU CFAR)
    Richard E Chaisson; Fiscal Year: 2013
    ..This new CFAR represents a major commitment of investigators and institutional leadership to promote excellence, productivity and growth of HIV research and control efforts at JHU, in Baltimore and globally. ..
  6. Center for Substance Use and HIV/AIDS Research on Latinos in the United States
    MARIO R DE LA ROSA; Fiscal Year: 2013
    ....
  7. UNIVERSITY OF WASHINGTON CENTER FOR AIDS RESEARCH
    King K Holmes; Fiscal Year: 2013
    ..The CFAR will support and provide added value for future local, national and international HIV/AIDS research priorities. ..