Research Training in Gene-Environment Interaction in China


Principal Investigator: Jiang He
Abstract: DESCRIPTION (provided by applicant): This is a joint application of the Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA, the Cardiovascular Institute and Fu Wai Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College, and the National Center for Cardiovascular Diseases of China to provide research training in gene-environment interaction in chronic diseases across the lifespan in China in response to Program Announcement: Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) (D43). Most chronic, non-communicable diseases and disorders are likely determined by genetic predisposition, environmental exposure and their interactions. This multidisciplinary training program is built on the long- standing collaboration in chronic disease research between the US and Chinese participating institutes and aims to strengthen capacity for gene-environment interaction research in chronic diseases in China. The specific aims are: (1) to establish a unique, interdisciplinary program for graduate students pursuing doctoral degrees at the Peking Union Medical College (PUMC), with a strong emphasis on multidisciplinary research training designed to study genetic variation, environmental exposure, and their interactions in chronic diseases in China. After the first year of course work at PUMC in China, the trainees will take advanced courses in genetics, statistics, epidemiology and clinical research methods, as well as gain experience in population or laboratory research, during their second year at Tulane University in the US. The trainees will conduct their dissertation research in China under co-mentorship from faculty at PUMC and Tulane. They will receive their doctoral degrees from PUMC;(2) To provide multidisciplinary postdoctoral research training in gene- environment interaction for junior researchers and clinicians in order to expand their research directions in chronic diseases. We will recruit geneticists and train them with the knowledge and skills for epidemiologic and clinical research and recruit epidemiologists and clinical researchers and train them with the knowledge and skills for genomic research at Tulane University for 6 months;(3) to initiate a Summer Institute in Gene- Environment Interaction in China and offer short courses in Biostatistics, Epidemiological Methods, Clinical Research Methods, Human Molecular Genetics, Statistical Genetics, Genetic Epidemiology, and Chronic Disease Epidemiology. We will widely publicize this summer institute and make the course materials available online to a wide audience in China;and 4) To organize a special session in Gene-Environment Interaction at the China Heart Congress to promote research in gene-environment interaction. This program takes the "train the trainer" approach, and graduates from this program will play a leadership role in building research and training capacity in gene-environment interaction in chronic diseases in China.
Funding Period: 2012-07-16 - 2017-02-28
more information: NIH RePORT

Detail Information

Research Grants30

  1. Exposure to antibiotics during infancy and subsequent risk of Crohn's disease: a
    Michael D Kappelman; Fiscal Year: 2013
    ..The goal of this and subsequent research is to identify potentially modifiable risk factors in susceptible individuals. This could lead to strategies for disease prevention. ..
  2. Emory Alzheimer's Disease Center
    Allan I Levey; Fiscal Year: 2013
    ..abstract_text> ..
  3. Elucidating Risks: From Exposure and Mechanism to Outcome
    James A Swenberg; Fiscal Year: 2013
    ..This Program is highly relevant to Superfund by addressing high-priority chemicals and by focusing on mechanisms underlying health effects, exposure assessment, and remediation to mitigate exposure and toxicity. ..
  4. Lifespan/Tufts/Brown Center for AIDS Research (CFAR)
    CHARLES CJ CARPENTER; Fiscal Year: 2013
    ..abstract_text> ..
  5. Baylor-UT Houston Center for AIDS Research
    Janet S Butel; Fiscal Year: 2013
    ..The unique environment of the Texas Medical Center creates many opportunities for scientific, clinical, and educational collaborations, of which the CFAR takes full advantage. ..
    JEFFREY NEIL KATZ; Fiscal Year: 2013
    ..abstract_text> ..
  7. Innovative Multidisciplinary Education: The Statistical Genetics of Addiction
    Sanjay Shete; Fiscal Year: 2013
    ..abstract_text> ..
  8. Eliminating Health Disparities Through Multi-Trans-Disciplinary Approaches
    MARINELLE PAYTON; Fiscal Year: 2013
    ..Most significantly, the Center will enhance the quality and quantity of research on minority health and health disparities, provide high quality research career development training, and strengthen community ties. ..
  9. Semi-volatile PCBs: Sources, Exposures, Toxicities
    Larry W Robertson; Fiscal Year: 2013
    ..These data and dietary studies in the last Aim will provide a scientific basis for risk assessment and advice for stakeholders with the ultimate goal to protect highly-exposed individuals and populations. ..
  10. Puerto Rico Testsite for Exploring Contamination Threats (PRoTECT)
    Akram N Alshawabkeh; Fiscal Year: 2013
    ..The cross-disciplinary approach will employ the data-rich centralized data repository and integrated modeling/analysis capabilities to better understand complex interrelationships between multiple risk factors. ..