Drug Dependence Through the Lifespan: US-Thai Training Program


Principal Investigator: Robert T Malison
Abstract: Abstract Drug Dependence Through the Lifespan: Thai-Yale Training Program Drug dependence is a set of chronic, non-communicable diseases that constitute a global public health problem of enormous economic, social, and medical cost to the international community. Developing countries, in particular, are disproportionately affected, due to both the economic incentives associated with the production of illicit drugs, and the less well-established institutional infrastructures (facilities, personnel, and research) dedicated to the understanding, treatment and prevention of drug dependence disorders - problems that are often specific to world regions. In this application, we propose a collaborative research training program in drug dependence between Faculty of Medicine, Chulalongkorn University in Bangkok, Thailand (a leading medical research center in Thailand) and the Yale University School of Medicine in the U.S. Three major training mechanisms are proposed for Thai trainees, including long-term (1-2-yr) predoctoral and postdoctoral fellowships, and short and intermediate-term (1-6 months) mini-fellowships. Over the course of the five year program, training responsibility increases at Chulalongkorn (as experience builds) and decreases at Yale, such that in the final two years the Thai site is responsible for two postdoctoral FTEs. This program builds on an extensive research program in drug dependence at Yale University School of Medicine, and on existing training and research collaborations between investigators at Yale and investigators at Chulalongkorn in the study of the genetics of drug dependence in Thai populations. The program will contribute to the capacity of investigators at Chulalongkorn and more generally in Thailand to conduct state-of-the-art research in substance dependence through a range of training experiences (genetics, epidemiology, molecular biology, clinical, developmental, and translational neuroscience, psychopharmacology and clinical trials, and health services and evaluation research). The explicit long-term goal of the program will be to build a critical mass of scientists, health professionals, and academics with expertise and a sustainable research environment at the collaborating lower-middle income country to understand better, treat, and prevent the chronic non- communicable disease of drug dependence. The training program is also specifically designed to serve a major public health purpose by enhancing Thailand's capacity to confront an epidemic of drug dependence that is unprecedented in its history.
Funding Period: 2011-08-08 - 2016-07-31
more information: NIH RePORT

Top Publications

  1. pmc Clinical features of methamphetamine-induced paranoia and preliminary genetic association with DBH-1021C→T in a Thai treatment cohort
    Rasmon Kalayasiri
    Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Addiction 109:965-76. 2014

Detail Information


  1. pmc Clinical features of methamphetamine-induced paranoia and preliminary genetic association with DBH-1021C→T in a Thai treatment cohort
    Rasmon Kalayasiri
    Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Addiction 109:965-76. 2014
    ..To explore the clinical features of methamphetamine-induced paranoia (MIP) and associations between MIP and a genetic polymorphism in dopamine β-hydroxylase (DBH-1021C→T)...

Research Grants30

  1. HIV and addictions among criminal justice-involved populations.
    Josiah D Rich; Fiscal Year: 2013
    ..This award will protect time for mentorship and research that would otherwise be diverted to administrative and clinical duties. ..
    Jerome A Zack; Fiscal Year: 2013
    ..Inclusion of this resource will be highly beneficial to clinical, behavioral and basic science studies. ..
  3. University of Rochester Center for AIDS Research
    Stephen Dewhurst; Fiscal Year: 2013
    ..Finally, Aim 5 will stimulate communication and engagement with the full range of communities that the UR CFAR serves. ..
    Linda J Waite; Fiscal Year: 2013
  5. Optimization of HIV vaccines for the induction of cross-reactive antibodies
    Shan Lu; Fiscal Year: 2013
    ..RELEVANCE: To optimize the next generation polyvalent Env HIV vaccine formulations using the multi-gene, polyvalent DNA prime - protein boost technology platform. ..
  6. Plan for Cardiovascular Research Training in Advanced Biostatistics, Aging, and H
    Dorairaj Prabhakaran; Fiscal Year: 2013
    ..As such, this proposal aims to strengthen the collaboration between CCDC, Northwestern, and AIIMS by creating an effective research training plan for a future D43 application in Year 2 to address these needs. ..
  7. Center for Novel Therapeutics for HIV-Associated Cognitive Disorders
    Justin C McArthur; Fiscal Year: 2013
    ..5. To identify and validate surrogate biomarkers based on proteomics and lipomics. ..
  8. Novel molecular and cellular approaches for alcoholism medication development
    Robert A Harris; Fiscal Year: 2013
    ..The PPG has both internal and external advisory board members, providing expert guidance from scientists with a wide range of expertise in drug development and therapeutics. ..
  9. China Health and Retirement Longitudinal Study
    YAOHUI ZHAO; Fiscal Year: 2013
    ..We will track households and individuals who have moved, to attain low attrition rates. ..
  10. Pacific NorthWest Regional Center of Excellence (PNWRCE)
    Jay A Nelson; Fiscal Year: 2013
    ..pseudomallei host pathogen response during both the septicemic as well as the intracellular phases of the disease. ..
  11. A Chiang Mai University - HMRI MRI/MRS Project: A Neurobiology Study of Methamphe
    Napapon Sailasuta; Fiscal Year: 2013
    ..These data will serve as preliminary data to develop hypothesis in the dysfunction of CNS for subsequence R01 grant application. ..
  12. Southeast Regional Centers of Excellence for Biodefense &Emerging Infectious Di
    Philip Frederick Sparling; Fiscal Year: 2013
    ..SERCEB brings new investigators to the biodefense effort through a combination of educational programs, support of innovative new projects, and the synergistic interactions among its world-class investigators. ..
  13. Center for Public Genomics 2.0
    Robert Mullan Cook-Deegan; Fiscal Year: 2013
    ..abstract_text> ..
  14. UMB Center for Pain Studies
    Susan G Dorsey; Fiscal Year: 2013
    ..abstract_text> ..
  15. Four-Arm RCT of Brief MI vs. Couples-Based HIV/STI Prevention in South Africa
    William W Latimer; Fiscal Year: 2013
    ..abstract_text> ..
  16. Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)
    Sten H Vermund; Fiscal Year: 2013
    ..abstract_text> ..
  17. Rush Center for Urban Health Equity
    Lynda H Powell; Fiscal Year: 2013
    ..Funding is now sought to bring these resources together to establish a unique center of excellence in health disparities interventions. ..
    Martin K Lotz; Fiscal Year: 2013
    ..Sah) will analyze biomechanical mechanisms of early and advanced cartilage degeneration and determine consequences for chondrocyte function and survival. ..
  19. The Miami Center for AIDS Research
    Savita Pahwa; Fiscal Year: 2013
    ..The Miami CFAR will play to the research strengths contained within the institution and accelerate the pace of research at UM, so that we can truly make a mark towards elimination of the HIV/AIDS epidemic. ..