Interdisciplinary research training: NCD epidemiology and prevention in India

Summary

Principal Investigator: KABAYAM M VENKAT NARAYAN
Abstract: DESCRIPTION (provided by applicant): There is an acute shortage of post-doctoral and junior faculty research capacity in India, with no postdoctoral programs in epidemiology and prevention of non-communicable diseases (NCDs). The proposed interdisciplinary training program will focus on the epidemiology and prevention of NCD across the life-course, in cross-connecting subject areas (child health;nutrition and lifestyle, environmental health, obesity and diabetes, stroke and other vascular diseases) and population science disciplines (epidemiology and biostatistics;clinical trials;translation research, social sciences, and economics). This effort will leverage an established network of research collaborations involving partners in India and the US (Ovations Center for Excellence in Chronic Diseases, New Delhi). The program will have two components: (1) Short-term training in year 1: Eight junior faculty researchers will receive four months of training at Emory to acquire specific and focused mentoring and research skills. (2) Long-term training in years 2-5: A total of ten post-doctoral fellows (one batch of five in years 2-3 and one batch in years 4-5) will receive 24 months of training (four months at Emory in the first year, six weeks at Emory in the second year, and the remaining 18.5 months in India). Training components include mentored research, coursework, professional development (ethics, grants-writing, communication skills), and an emphasis on context-specific innovation in health programs and research. Collaboration with Emory will compliment India-based mentoring and training, and permit transfer of skills and expertise in specific areas. The program will build a critical mass of NCD researchers and incorporate them within integrated NCD research programs in India. An important innovation of our program is the emphasis on retaining talented young scientists in India, enabling them to develop world-class research skills in an Indian-based training program, facilitating international collaborations, and providing end-of-training grants to promote in-country research projects. We expect the program to have a cascade effect, as each of the 18 trainees will serve as a resource upon completion of the program, disseminating knowledge and skills to other researchers at in- country institutions.
Funding Period: 2009-09-15 - 2014-06-30
more information: NIH RePORT

Top Publications

  1. pmc Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21
    Rubina Tabassum
    Genomics and Molecular Medicine Unit, Council for Scientific and Industrial Research Institute of Genomics and Integrative Biology, Delhi, India
    Diabetes 62:977-86. 2013
  2. ncbi Should your family history of coronary heart disease scare you?
    Dorairaj Prabhakaran
    Centre for Chronic Disease Control, New Delhi, India
    Mt Sinai J Med 79:721-32. 2012
  3. ncbi Fruit and vegetable purchasing patterns and preferences in South Delhi
    Lauren E Finzer
    Centre for Chronic Disease Control, New Delhi, India
    Ecol Food Nutr 52:1-20. 2013
  4. pmc Association between gender, process of care measures, and outcomes in ACS in India: results from the detection and management of coronary heart disease (DEMAT) registry
    Neha J Pagidipati
    Centre for Chronic Disease Control, New Delhi, India
    PLoS ONE 8:e62061. 2013
  5. pmc Optimal in-hospital and discharge medical therapy in acute coronary syndromes in Kerala: results from the Kerala acute coronary syndrome registry
    Mark D Huffman
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Circ Cardiovasc Qual Outcomes 6:436-43. 2013
  6. pmc Serum adiponectin helps to differentiate type 1 and type 2 diabetes among young Asian Indians
    Kuppan Gokulakrishnan
    Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialities Centre, WHO Collaborating Centre for Non communicable Diseases Prevention and Control, IDF Centre for Education, Gopalapuram, Chennai, India
    Diabetes Technol Ther 15:696-702. 2013
  7. pmc Association between maternal folate concentrations during pregnancy and insulin resistance in Indian children
    Ghattu V Krishnaveni
    Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, P O Box 38, Mandi Mohalla, Mysore, 570021, India
    Diabetologia 57:110-21. 2014
  8. ncbi Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population
    Om Prakash Dwivedi
    Genomics and Molecular Medicine Unit, CSIR Institute of Genomics and Integrative Biology, Delhi, India
    J Hum Genet 58:27-32. 2013
  9. pmc Stress and diabetes in socioeconomic context: a qualitative study of urban Indians
    Emily Mendenhall
    MRC Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
    Soc Sci Med 75:2522-9. 2012
  10. pmc Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children
    Om Prakash Dwivedi
    Genomics and Molecular Medicine Unit, CSIR Institute of Genomics and Integrative Biology, Delhi, India
    PLoS ONE 7:e47772. 2012

Research Grants

Detail Information

Publications25

  1. pmc Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21
    Rubina Tabassum
    Genomics and Molecular Medicine Unit, Council for Scientific and Industrial Research Institute of Genomics and Integrative Biology, Delhi, India
    Diabetes 62:977-86. 2013
    ..Our study suggests that common susceptibility variants for T2D are largely the same across populations, but also reveals a population-specific locus and provides further insights into genetic architecture and etiology of T2D...
  2. ncbi Should your family history of coronary heart disease scare you?
    Dorairaj Prabhakaran
    Centre for Chronic Disease Control, New Delhi, India
    Mt Sinai J Med 79:721-32. 2012
    ..More studies are warranted to assess the benefits and risks of intensive interventions, both targeted individually and at the family level, among individuals with a valid family history and borderline elevated risk factors...
  3. ncbi Fruit and vegetable purchasing patterns and preferences in South Delhi
    Lauren E Finzer
    Centre for Chronic Disease Control, New Delhi, India
    Ecol Food Nutr 52:1-20. 2013
    ....
  4. pmc Association between gender, process of care measures, and outcomes in ACS in India: results from the detection and management of coronary heart disease (DEMAT) registry
    Neha J Pagidipati
    Centre for Chronic Disease Control, New Delhi, India
    PLoS ONE 8:e62061. 2013
    ..Data on gender differences in ACS presentation, management, and outcomes are sparse in India...
  5. pmc Optimal in-hospital and discharge medical therapy in acute coronary syndromes in Kerala: results from the Kerala acute coronary syndrome registry
    Mark D Huffman
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Circ Cardiovasc Qual Outcomes 6:436-43. 2013
    ..Our objective was to define the prevalence, associations, and impact of optimal in-hospital and discharge medical therapy in the Kerala ACS Registry of 25,718 admissions...
  6. pmc Serum adiponectin helps to differentiate type 1 and type 2 diabetes among young Asian Indians
    Kuppan Gokulakrishnan
    Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialities Centre, WHO Collaborating Centre for Non communicable Diseases Prevention and Control, IDF Centre for Education, Gopalapuram, Chennai, India
    Diabetes Technol Ther 15:696-702. 2013
    ..This study assessed whether serum adiponectin could be used as a biochemical marker to differentiate type 1 diabetes mellitus (T1DM) from type 2 diabetes mellitus (T2DM) among young Asian Indians...
  7. pmc Association between maternal folate concentrations during pregnancy and insulin resistance in Indian children
    Ghattu V Krishnaveni
    Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, P O Box 38, Mandi Mohalla, Mysore, 570021, India
    Diabetologia 57:110-21. 2014
    ..Disordered one-carbon metabolism during early development may increase later metabolic risk. We explored these associations in another birth cohort in India at three age points...
  8. ncbi Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population
    Om Prakash Dwivedi
    Genomics and Molecular Medicine Unit, CSIR Institute of Genomics and Integrative Biology, Delhi, India
    J Hum Genet 58:27-32. 2013
    ..In conclusion, the study demonstrates association of variants near MC4R with obesity and related traits in Indian children and adults, with higher impact during childhood...
  9. pmc Stress and diabetes in socioeconomic context: a qualitative study of urban Indians
    Emily Mendenhall
    MRC Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
    Soc Sci Med 75:2522-9. 2012
    ..This research has many implications for public health care in India as diabetes prevalence shifts to affect lower income groups who concurrently experience higher rates of depression and poorer access to medical care...
  10. pmc Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children
    Om Prakash Dwivedi
    Genomics and Molecular Medicine Unit, CSIR Institute of Genomics and Integrative Biology, Delhi, India
    PLoS ONE 7:e47772. 2012
    ..Although studies have shown association of FTO variants with adiposity in adult Indian, its association in Indian children is yet to be confirmed...
  11. ncbi The effect of growth hormone deficiency on size-corrected bone mineral measures in pre-pubertal children
    M Gahlot
    Department of Dietetics and Nutrition, All India Institute of Medical Sciences, New Delhi, India
    Osteoporos Int 23:2211-7. 2012
    ..We studied size-corrected bone mineral measures in 30 pre-pubertal GHD children and 75 healthy controls. Our study shows that size-corrected whole-body bone mineral content of GHD children were comparable with controls...
  12. pmc Common variants of IL6, LEPR, and PBEF1 are associated with obesity in Indian children
    Rubina Tabassum
    Genomics and Molecular Medicine Unit, Council of Scientific and Industrial Research, Institute of Genomics and Integrative Biology, Delhi, India
    Diabetes 61:626-31. 2012
    ..2 × 10(-7)). In conclusion, our results demonstrate the association of the common variants of IL6, LEPR, and PBEF1 with obesity in Indian children...
  13. ncbi Elevated level of C-reactive protein is associated with risk of prediabetes in Indians
    Alok Jaiswal
    Genomics and Molecular Medicine Unit, CSIR Institute of Genomics and Integrative Biology, Delhi, India
    Atherosclerosis 222:495-501. 2012
    ....
  14. pmc Genetic variant of AMD1 is associated with obesity in urban Indian children
    Rubina Tabassum
    Genomics and Molecular Medicine Unit, CSIR Institute of Genomics and Integrative Biology, Delhi, India
    PLoS ONE 7:e33162. 2012
    ..Thus here we investigated association of common variants from homocysteine metabolism pathway genes with obesity in 3,168 urban Indian children...
  15. pmc Status of epidemiology in the WHO South-East Asia region: burden of disease, determinants of health and epidemiological research, workforce and training capacity
    Preet K Dhillon
    South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India
    Int J Epidemiol 41:847-60. 2012
    ..In this article, we describe the disease burden and status of epidemiological research and capacity in the SEAR to understand, analyse and develop capacity in response to the diverse burdens of diseases in the region...
  16. pmc Tobacco use and nicotine dependency in a cross-sectional representative sample of 18,018 individuals in Andaman and Nicobar Islands, India
    Sathya Prakash Manimunda
    Regional Medical Research Centre ICMR, Port Blair 744101, Andaman and Nicobar Islands, India
    BMC Public Health 12:515. 2012
    ..The aim of the study was to estimate the prevalence and determinants of tobacco use and nicotine dependency...
  17. pmc Presentation, management, and outcomes of 25 748 acute coronary syndrome admissions in Kerala, India: results from the Kerala ACS Registry
    Padinhare Purayil Mohanan
    Department of Cardiology, Westfort Hi Tech Hospital, Ltd, P B No 930, Punkunnam, Thrissur 680 002, Kerala, India
    Eur Heart J 34:121-9. 2013
    ..We aimed to develop a prospective registry to address treatment and health systems gaps in the management of ACSs in Kerala, India...
  18. ncbi Does uric acid qualify as an independent risk factor for cardiovascular mortality?
    Panniyammakal Jeemon
    Centre for Chronic Disease Control, New Delhi, India
    Clin Sci (Lond) 124:255-7. 2013
    ..However, long-term follow-up studies are required with serial UA measurement to establish the time-dependent association of UA with mortality outcomes...
  19. ncbi Evidence for interventions to prevent and control obesity among children and adolescents: its applicability to India
    Meghana Sreevatsava
    Department of Epidemiology, Rollins School of Public Health and Laney Graduate School, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA
    Indian J Pediatr 80:S115-22. 2013
    ..Existing gaps in knowledge about obesity should be addressed by conducting research in India and carrying out interventions to determine what strategies will be successful and sustainable locally...
  20. pmc Association between being employed in a smoke-free workplace and living in a smoke-free home: evidence from 15 low and middle income countries
    Gaurang P Nazar
    Public Health Foundation of India PHFI, New Delhi, India London School of Hygiene and Tropical Medicine LSHTM, UK Electronic address
    Prev Med 59:47-53. 2014
    ..To assess whether being employed in a smoke-free workplace is associated with living in a smoke-free home in 15 low and middle income countries (LMICs)...

Research Grants30

  1. Jules Stein Eye Institute Core Grant for Vision Research
    Wayne L Hubbell; Fiscal Year: 2013
    ..Support in the form of the Core grant is requested to maintain these Modules through instrument service contracts, and to provide necessary personnel support to assist and train users and provide routine maintenance. ..
  2. Semi-volatile PCBs: Sources, Exposures, Toxicities
    Larry W Robertson; Fiscal Year: 2013
    ..These data and dietary studies in the last Aim will provide a scientific basis for risk assessment and advice for stakeholders with the ultimate goal to protect highly-exposed individuals and populations. ..
  3. Hopkins Center for Eliminate Cardiovascular Health Disparities
    Lisa A Cooper; Fiscal Year: 2013
    ..abstract_text> ..
  4. Rush Center for Urban Health Equity
    Lynda H Powell; Fiscal Year: 2013
    ..Funding is now sought to bring these resources together to establish a unique center of excellence in health disparities interventions. ..
  5. STUDIES OF JOINT AGING AND OSTEOARTHRITIS
    Martin K Lotz; Fiscal Year: 2013
    ..Sah) will analyze biomechanical mechanisms of early and advanced cartilage degeneration and determine consequences for chondrocyte function and survival. ..
  6. Eliminating Health Disparities Through Multi-Trans-Disciplinary Approaches
    MARINELLE PAYTON; Fiscal Year: 2013
    ..Most significantly, the Center will enhance the quality and quantity of research on minority health and health disparities, provide high quality research career development training, and strengthen community ties. ..