Training in Environmental Health to Reduce Chronic Disease in Latin America

Summary

Principal Investigator: Philip J Landrigan
Abstract: DESCRIPTION (provided by applicant): Environmental exposures early in life contribute significantly to some of the most common, chronic non-communicable diseases in children and can have an effect throughout the lifespan. Examples are: 1) asthma, the most common chronic disease in children is caused or aggravated by environmental factors including indoor allergens, air pollution and tobacco smoke;2) obesity and diabetes are epidemic in developed countries and are increasing alarmingly in the developing world. Exposures in the built environment related to increasing urbanization contribute to both conditions. 3) exposure to lead and other heavy metals and neurotoxins such as pesticides continue in the developing world and contribute to neurobehavioral effects later in life. Despite the contribution of childhood environmental exposures to the burden of chronic disease, few pediatricians or other health care providers are trained to study, diagnose, treat or prevent disease of environmental origin. The goal of the Division of International Health of the Department of Community and Preventive Medicine at Mount Sinai School of Medicine is to train health professionals in Latin America to implement research and service programs that identify, treat and prevent chronic disease of environmental origin. Specific Aims are: 1) Train medical professionals to implement clinical and research practices that aim to ameliorate chronic disease by identifying environmental exposures in children. 2) To create an online reference tool and distance learning program to reach a large number of health professionals in Latin America. 3) To train and support key leaders in pediatric environmental health. By leveraging resources from existing international training programs at Mount Sinai, it will be possible to offer mentored research opportunities to Latin American researchers who are trained through the offerings described above. Recipients of the training will initially be selected through partnerships with institutions in Costa Rica, Mexico, Colombia and Uruguay, to be expanded in later years to other Latin American nations. It is expected that this program will result in the opening of at least three new PEHSUs in Latin America with the potential to implement research programs in those countries, thus ensuring continuity beyond the scope of this proposal. PUBLIC HEALTH RELEVANCE: A significant proportion of chronic non-communicable diseases have an origin in environmental exposures during childhood including asthma, some neurological disorders, obesity and diabetes. In the developing, these diseases are on the rise and are taking a significant toll on health of the growing populations. This program will provide training in the identification, prevention, research, and treatment pediatric environmental health for Latin American health care providers and scientists.
Funding Period: 2009-09-01 - 2014-08-31
more information: NIH RePORT

Top Publications

  1. pmc Case control study of periconceptional folic acid intake and nervous system tumors in children
    Juan Antonio Ortega-Garcia
    Paediatric Environmental Health Speciality Unit, Translational Cancer Research Center, University Hospital Virgen of Arrixaca, 30120, Murcia, Spain
    Childs Nerv Syst 26:1727-33. 2010
  2. pmc Asthma mortality in Puerto Rico: 1980-2007
    Jose Antonio Bartolomei-Díaz
    Puerto Rico Asthma Project, Puerto Rico Department of Health, San Juan, Puerto Rico
    J Asthma 48:202-9. 2011
  3. pmc Smoking prevention and cessation programme in cystic fibrosis: integrating an environmental health approach
    Juan Antonio Ortega-Garcia
    Paediatric Environmental Health Speciality Unit, University Hospital Virgen of Arrixaca, Murcia, Spain
    J Cyst Fibros 11:34-9. 2012
  4. pmc Socioeconomic determinants associated with willingness to participate in medical research among a diverse population
    Katherine Svensson
    Department of Preventive Medicine, Division of International Health, Mount Sinai School of Medicine, New York, NY 10029, USA
    Contemp Clin Trials 33:1197-205. 2012
  5. ncbi [The association of adherence to a Mediterranean diet during early pregnancy and the risk of gastroschisis in the offspring]
    A Cánovas-Conesa
    Unidad de Salud Medioambiental Pediátrica, Hospital Universitario Virgen de la Arrixaca, Madrid Cartagena, El Palmar
    Cir Pediatr 26:37-43. 2013
  6. pmc Violence against women and gastroschisis: a case-control study
    Juan Antonio Ortega-Garcia
    Paediatric Environmental Health Speciality Unit, Department of Paediatrics, Hospital Clinic University Virgen of Arrixaca, Murcia, 30120, Spain
    Int J Environ Res Public Health 10:5178-90. 2013
  7. pmc Blood and hair manganese concentrations in pregnant women from the infants' environmental health study (ISA) in Costa Rica
    Ana M Mora
    Central American Institute for Studies on Toxic Substances IRET, Universidad Nacional, P O Box 86 3000 Heredia, Costa Rica
    Environ Sci Technol 48:3467-76. 2014

Detail Information

Publications7

  1. pmc Case control study of periconceptional folic acid intake and nervous system tumors in children
    Juan Antonio Ortega-Garcia
    Paediatric Environmental Health Speciality Unit, Translational Cancer Research Center, University Hospital Virgen of Arrixaca, 30120, Murcia, Spain
    Childs Nerv Syst 26:1727-33. 2010
    ..It has been speculated that both NTD and nervous system tumors (NST) may share common mechanisms of altered development. It examines the association between folic acid supplementation and the risk for childhood NST...
  2. pmc Asthma mortality in Puerto Rico: 1980-2007
    Jose Antonio Bartolomei-Díaz
    Puerto Rico Asthma Project, Puerto Rico Department of Health, San Juan, Puerto Rico
    J Asthma 48:202-9. 2011
    ..Asthma is a highly prevalent chronic disease. Prevalence and mortality are particularly high in Puerto Ricans living in the United States as compared with other populations...
  3. pmc Smoking prevention and cessation programme in cystic fibrosis: integrating an environmental health approach
    Juan Antonio Ortega-Garcia
    Paediatric Environmental Health Speciality Unit, University Hospital Virgen of Arrixaca, Murcia, Spain
    J Cyst Fibros 11:34-9. 2012
    ..Our objective is to present one tobacco prevention and cessation programme targeting patients with CF in the Mediterranean region of Murcia (Spain)...
  4. pmc Socioeconomic determinants associated with willingness to participate in medical research among a diverse population
    Katherine Svensson
    Department of Preventive Medicine, Division of International Health, Mount Sinai School of Medicine, New York, NY 10029, USA
    Contemp Clin Trials 33:1197-205. 2012
    ..The purpose of this study was to assess attitudes and beliefs toward medical research among a racially and socioeconomically diverse population of parents of school children...
  5. ncbi [The association of adherence to a Mediterranean diet during early pregnancy and the risk of gastroschisis in the offspring]
    A Cánovas-Conesa
    Unidad de Salud Medioambiental Pediátrica, Hospital Universitario Virgen de la Arrixaca, Madrid Cartagena, El Palmar
    Cir Pediatr 26:37-43. 2013
    ..The aim of this study was to study the association of adherence to the Mediterranean diet in early pregnancy maternal and the offspring's risk of gastroschisis...
  6. pmc Violence against women and gastroschisis: a case-control study
    Juan Antonio Ortega-Garcia
    Paediatric Environmental Health Speciality Unit, Department of Paediatrics, Hospital Clinic University Virgen of Arrixaca, Murcia, 30120, Spain
    Int J Environ Res Public Health 10:5178-90. 2013
    ..Forty concurrent controls were recruited at gestation weeks 20-24 or post-partum. All mothers of cases and controls completed a comprehensive, in-person, 'green sheet' questionnaire on environmental exposures...
  7. pmc Blood and hair manganese concentrations in pregnant women from the infants' environmental health study (ISA) in Costa Rica
    Ana M Mora
    Central American Institute for Studies on Toxic Substances IRET, Universidad Nacional, P O Box 86 3000 Heredia, Costa Rica
    Environ Sci Technol 48:3467-76. 2014
    ..2 to 76.9) and Mn concentrations in drinking water (% change = 17.5; 95% CI: 12.2 to 22.8). Our findings suggest that pregnant women living near banana plantations aerially sprayed with mancozeb may be environmentally exposed to Mn. ..

Research Grants62

  1. Emory Alzheimer's Disease Center
    Allan I Levey; Fiscal Year: 2013
    ..abstract_text> ..
  2. Elucidating Risks: From Exposure and Mechanism to Outcome
    James A Swenberg; Fiscal Year: 2013
    ..This Program is highly relevant to Superfund by addressing high-priority chemicals and by focusing on mechanisms underlying health effects, exposure assessment, and remediation to mitigate exposure and toxicity. ..
  3. Southern California Children's Enviromental Health Center (SC-CEHC)
    Rob S McConnell; Fiscal Year: 2013
    ....
  4. Semi-volatile PCBs: Sources, Exposures, Toxicities
    Larry W Robertson; Fiscal Year: 2013
    ..These data and dietary studies in the last Aim will provide a scientific basis for risk assessment and advice for stakeholders with the ultimate goal to protect highly-exposed individuals and populations. ..
  5. Duke Center on the Demography of Aging
    James W Vaupel; Fiscal Year: 2013
    ..It will foster innovative networks, pilot project research, and education for new researchers, new professorships, and the establishment of a Duke demographic data service with deep expertise in data analysis methodology. ..
  6. NCMHD Health Disparities Research Center of Excellence at Meharry
    Paul D Juarez; Fiscal Year: 2013
    ..5: To develop an administrative infrastructure that supports inter-institutional community participation in health disparities research across the three institutions. ..
  7. Lifecourse Exposures &Diet: Epigenetics, Maturation &Metabolic Syndrome
    KAREN EILEEN PETERSON; Fiscal Year: 2013
    ..Career development and training activities will draw upon extensive institutional resources and will be fully integrated with the Center's Research Projects and Cores. ..
  8. The effect of peptide therapy and allergen provocation on Fel d1-specific T Cells
    Mark Larché; Fiscal Year: 2013
    ..Additionally this Aim will assess the effects of peptide immunotherapy in the murine allergen challenge model ..
  9. Environmental Determinants of Airway Disease in Children
    DAVID ALBERT SCHWARTZ; Fiscal Year: 2013
    ..Our PPG proposal includes three interactive projects (1 clinical and 2 basic), a Community Outreach and Translational Core, an Inhalation Toxicology Core, and an Administrative Core. ..
  10. Molecular Regulation of Mammalian Meiosis
    Kenneth Paigen; Fiscal Year: 2013
    ..Results of the program project will significantly increase the understanding of the mechanisms that regulate meiosis as well as their involvement in other important biological processes. ..
  11. Penn TREC Survivor Center
    Kathryn H Schmitz; Fiscal Year: 2013
    ..abstract_text> ..
  12. Enhancing Research Informatics Capacity for Health Information in Colombia (ENRIC
    Juan Carlos Puyana; Fiscal Year: 2013
    ..These individuals will play a major role in improving the quality, safety and efficiency of health car in Colombia and Latin America..
  13. BIOMARKERS OF EXPOSURE TO HAZARDOUS SUBSTANCES
    Bruce D Hammock; Fiscal Year: 2013
    ..abstract_text> ..
  14. Beryllium: Exposure Immune and Genetic Mechanisms
    Lee S Newman; Fiscal Year: 2013
    ..The productivity and continuance demonstrate quality, commitment and ability to work together. PROGRAM AS INTERGRATED EFFORT ..
  15. Center for Novel Therapeutics for HIV-Associated Cognitive Disorders
    Justin C McArthur; Fiscal Year: 2013
    ..5. To identify and validate surrogate biomarkers based on proteomics and lipomics. ..
  16. CENTER FOR CHILD ENVIRONMENTAL HEALTH RISKS RESEARCH
    Elaine M Faustman; Fiscal Year: 2013
    ..The Center also includes junior investigators, new scientists since the 2003 Center renewal, and a Faculty Development Investigator. The Internal Steering Committee in comprised of a number of Center investigators and directors. ..
  17. Novel Methods to Assess the Effects of Chemicals on Child Development
    Susan L Schantz; Fiscal Year: 2013
    ..This Center's research will fill an important gap in our knowledge by investigating the effects of these chemicals, both alone and combination with a high fat diet on reproductive and neural development. ..
  18. The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center
    Tracey J Woodruff; Fiscal Year: 2013
    ..Finally, the Administrative Core will work closely with a program evaluator, to monitor the progress of the PEEC Children's Center and ensure the achievement of its goals. ..
  19. Puerto Rico Testsite for Exploring Contamination Threats (PRoTECT)
    Akram N Alshawabkeh; Fiscal Year: 2013
    ..The cross-disciplinary approach will employ the data-rich centralized data repository and integrated modeling/analysis capabilities to better understand complex interrelationships between multiple risk factors. ..
  20. Center of Excellence for Health Disparties in the Nation's Capital
    PHYLLIS R MAGRAB; Fiscal Year: 2013
    ..The important cross-cutting objectives of Cultural Competence intersect with each of these areas. ..
  21. Bridging Research, Innovation, Training &Education Solutions for Minority Health
    Vickie M Mays; Fiscal Year: 2013
    ..abstract_text> ..
  22. Air pollution, stress and urban child development
    Rosalind J Wright; Fiscal Year: 2013
    ..Such knowledge may inform efforts to design programs that improve neurodevelopmental trajectories in high-risk urban populations disproportionately exposed to adverse physical and social environments. ..
  23. SCHS, mitochondria, healthy aging and longevity
    Gino A Cortopassi; Fiscal Year: 2013
    ..abstract_text> ..
  24. Neurodevelopmental Effects of Early Life Arsenic Exposure
    Maitreyi Mazumdar; Fiscal Year: 2013
    ..Mazumdar in meeting the objectives of her career development and research plans. ..
  25. Environmental and respiratory health across the lifespan in Mongolia
    David Warburton; Fiscal Year: 2013
    ..abstract_text> ..
  26. The role of cyclooxygenase in the adaptive immune response and tolerance
    Ray Stokes Peebles; Fiscal Year: 2013
    ....
  27. Network of Excellence in Neuroscience Clinical Trial (NEXT)
    Susan T Iannaccone; Fiscal Year: 2013
    ..Referral volumes are high and benefit from the fact that the Dallas-Fort Worth metropolitan area is the largest in the United States with a single allopathic medical school. ..
  28. Cellular Senescence and Aging
    James L Kirkland; Fiscal Year: 2013
    ..Our approach will provide timely, innovative, and clinically relevant interventional results based on addressing the fundamental question of the role of cellular senescence that has remained unanswered for many years. ..
  29. Minority Health and Health Disparties International Research Training Program
    Robert S Pozos; Fiscal Year: 2013
    ..abstract_text> ..
  30. The impact of natural experiments on child obesity: A systems science approach
    May C Wang; Fiscal Year: 2013
    ....
  31. The Role of H6PDH and 11beta-HSD1 in Type 2 Diabetes and Obesity
    Yanjun Liu; Fiscal Year: 2013
    ..Blocking the effects of H6PDH on 112-HSD1 may represent a new strategy in the effective treatment of type 2 diabetes and obesity through reduction of tissue GC availability mediating insulin sensitivity and glucose homeostasis. ..
  32. Interdisciplinary research training: NCD epidemiology and prevention in India
    KABAYAM M VENKAT NARAYAN; Fiscal Year: 2013
    ..We expect the program to have a cascade effect, as each of the 18 trainees will serve as a resource upon completion of the program, disseminating knowledge and skills to other researchers at in- country institutions. ..
  33. Hazardous Material Worker Health and Safety Training (U45), Cooperative Agreement
    JOHN J LECONCHE; Fiscal Year: 2013
    ..Training helps participants identify and address potential hazards on the job, at home and in their communities. Hazardous Waste Worker Training Program (HWWTP) ..
  34. PAHs: New Technologies and Emerging Health Risks
    David E Williams; Fiscal Year: 2013
    ..Accomplishing these goals will provide significant scientific advancement and improve the quality of life for impacted communities. ..
  35. Delivering Geospatial Intelligence to Health Care Professionals
    Gilbert C Liu; Fiscal Year: 2013
    ..We also hypothesize that CHICA-GIS will allow pediatricians to better screen children for environmental hazards such as lead exposure. ..
  36. Successful Cogn. Aging and Cardiovascular Risk Factors in the Central Valley CR
    Jeremy M Silverman; Fiscal Year: 2013
    ..A major study of the genetic and epigenetic basis of SCA will be designed based on these results, to identify mechanisms underlying SCA, leading to interventions to promote it. ..
  37. Promoting Capacity Building in Chronic Diseases Research in South America
    Adolfo Luis Rubinstein; Fiscal Year: 2013
    ..One of the most innovative components of this Program will be the implementation of a new Faculty development program that will include faculty visits from IECS to HSPH and from HSPH to IECS along the 5-year training period. ..
  38. EARLY LIFE VITAMIN D, RACIAL DISPARITIES, AND WHEEZING
    GANESA REBECCA WEGIENKA; Fiscal Year: 2013
    ..Vitamin D needs to be evaluated rigorously as it is modifiable and can potentially provide a low cost public health intervention that could help prevent clinical allergy and asthma and reduce racial disparities. ..
  39. NIMHD RESEARCH CENTER ON LATINO IMMIGRANT/REFUGEE HEALTH DISPARITIES
    Mark Edberg; Fiscal Year: 2013
    ..5) Disseminate the results of the research to the participating communities and to the field, via the Center website and multiple channels. ..