zic2b

Summary

Gene Symbol: zic2b
Description: zic family member 2 (odd-paired homolog, Drosophila) b
Alias: hm:zeh0655, id:ibd5017, zic2.2, zic2l, zic family member 2b, zinc finger cerebellum 2, like
Species: zebrafish

Top Publications

  1. Toyama R, Gomez D, Mana M, Dawid I. Sequence relationships and expression patterns of zebrafish zic2 and zic5 genes. Gene Expr Patterns. 2004;4:345-50 pubmed
    ..A zic2.2 ortholog has not been identified in other vertebrate species, suggesting that the zic2.1/zic2.2 pair resulted from a genome duplication event during the evolution of the zebrafish lineage. ..
  2. Kudoh T, Concha M, Houart C, Dawid I, Wilson S. Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains. Development. 2004;131:3581-92 pubmed
    ..We further show that Bmp signalling does occur within the vegetal prospective neural domain and that Bmp activity promotes the adoption of caudal fate by this tissue. ..
  3. Wu S, Zhang H, Cairns B. Genes for embryo development are packaged in blocks of multivalent chromatin in zebrafish sperm. Genome Res. 2011;21:578-89 pubmed publisher
    ..Taken together, gene sets with particular functions in the embryo are packaged by distinctive types of complex and often atypical chromatin in sperm. ..
  4. Drummond D, Cheng C, Selland L, Hocking J, Prichard L, Waskiewicz A. The role of Zic transcription factors in regulating hindbrain retinoic acid signaling. BMC Dev Biol. 2013;13:31 pubmed publisher
    ..Depletion of zebrafish Zic2a and Zic2b results in a strong downregulation of aldh1a2 expression and a concomitant reduction in activity of a retinoid-..
  5. Rhinn M, Lun K, Luz M, Werner M, Brand M. Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling. Development. 2005;132:1261-72 pubmed
    ..Our findings argue that graded Wnt8 activity mediates overall neuroectodermal posteriorization and thus determines the location of the MHB organizer. ..
  6. Keller M, Chitnis A. Insights into the evolutionary history of the vertebrate zic3 locus from a teleost-specific zic6 gene in the zebrafish, Danio rerio. Dev Genes Evol. 2007;217:541-7 pubmed
    ..We present evidence that zic6 is an ancestral locus arising by chromosomal duplication early in the Euteleostomi that was subsequently lost in the terrestrial vertebrates. ..
  7. Toyama R, Chen X, Jhawar N, Aamar E, Epstein J, Reany N, et al. Transcriptome analysis of the zebrafish pineal gland. Dev Dyn. 2009;238:1813-26 pubmed publisher
    ..Among the multiple candidate genes suggested by these data, we note the identification of a tissue-specific form of the unc119 gene with a possible role in pineal development. ..
  8. Teslaa J, Keller A, Nyholm M, Grinblat Y. Zebrafish Zic2a and Zic2b regulate neural crest and craniofacial development. Dev Biol. 2013;380:73-86 pubmed publisher
    ..Here, we demonstrate that ZIC2 orthologs zic2a and zic2b also regulate the forming zebrafish craniofacial skeleton, including the jaw and neurocranial cartilages, and use ..
  9. Stapel L, Zechner C, Vastenhouw N. Uniform gene expression in embryos is achieved by temporal averaging of transcription noise. Genes Dev. 2017;31:1635-1640 pubmed publisher
    ..Temporal averaging might provide a general context in which to understand how embryos deal with stochastic transcription. ..

More Information

Publications16

  1. Dee C, Gibson A, Rengifo A, Sun S, Patient R, Scotting P. A change in response to Bmp signalling precedes ectodermal fate choice. Int J Dev Biol. 2007;51:79-84 pubmed
    ..Hence, we have shown a dynamic change in the molecular machinery underlying the Bmp response in the ectoderm during gastrulation stages of development. ..
  2. Gribble S, Kim H, Bonner J, Wang X, Dorsky R. Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression. Development. 2009;136:781-9 pubmed publisher
    ..Both of these functions are mediated by Tcf3 independently of canonical Wnt signaling. Together, our data indicate a novel mechanism for the regulation of neurogenesis by Tcf3-mediated repression. ..
  3. Cheng Y, Chiang M, Shih H, Ma T, Yeh T, Huang Y, et al. The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis. Dev Biol. 2015;397:116-28 pubmed publisher
    ..Together, these two mechanisms ensure the proper development of the neural progenitor cell pool. ..
  4. Dodou E, Barald K, Postlethwait J. Ventralized zebrafish embryo rescue by overexpression of Zic2a. Zebrafish. 2004;1:239-56 pubmed publisher
  5. Stapel L, Lombardot B, Broaddus C, Kainmueller D, Jug F, Myers E, et al. Automated detection and quantification of single RNAs at cellular resolution in zebrafish embryos. Development. 2016;143:540-6 pubmed publisher
  6. Milash B, Gao J, Stevenson T, Son J, Dahl T, Bonkowsky J. Temporal Dysynchrony in brain connectivity gene expression following hypoxia. BMC Genomics. 2016;17:334 pubmed publisher
    ..The observed dysynchrony of gene expression could impair the development of normal CNS connectivity maps. ..
  7. Sedykh I, Yoon B, Roberson L, Moskvin O, Dewey C, Grinblat Y. Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis. Dev Biol. 2017;429:92-104 pubmed publisher
    ..We now report that zebrafish with genetic lesions in zebrafish zic2 orthologs, zic2a and zic2b, develop with retinal coloboma and craniofacial anomalies...