zic1

Summary

Gene Symbol: zic1
Description: zic family member 1 (odd-paired homolog, Drosophila)
Alias: opl, wu:fj51c06, zgc:136736, zinc finger protein ZIC 1, zinc finger protein of the cerebellum 1
Species: zebrafish

Top Publications

  1. England S, Blanchard G, Mahadevan L, Adams R. A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia. Development. 2006;133:4613-7 pubmed
    ..We postulate a new model for forebrain neurulation and demonstrate how mutations affecting two signalling pathways can generate cyclopic phenotypes by disrupting normal cell movements or introducing new erroneous behaviours. ..
  2. Ramel M, Lekven A. Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox. Development. 2004;131:3991-4000 pubmed
    ..Thus, whereas both Wnt8 and zygotic BMP are ventralizing agents that regulate common target genes, their temporally different modes of action are necessary to pattern the embryo harmoniously along its DV axis. ..
  3. Waxman J, Yelon D. Zebrafish retinoic acid receptors function as context-dependent transcriptional activators. Dev Biol. 2011;352:128-40 pubmed publisher
    ..Taking into account studies of RA signaling in tunicates and tetrapods, we propose a parsimonious model of the evolution of RAR function during chordate anterior-posterior patterning. ..
  4. Elsen G, Choi L, Millen K, Grinblat Y, Prince V. Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis. Dev Biol. 2008;314:376-92 pubmed publisher
    ..zebrafish is dependent upon the pleiotropic functions of the genes implicated in human Dandy Walker Malformation, Zic1 and Zic4...
  5. Köster R, Fraser S. FGF signaling mediates regeneration of the differentiating cerebellum through repatterning of the anterior hindbrain and reinitiation of neuronal migration. J Neurosci. 2006;26:7293-304 pubmed
    ..Moreover, the regenerating system offers a means to uncouple cerebellar differentiation from complex morphogenetic tissue rearrangements. ..
  6. Thorpe C, Weidinger G, Moon R. Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development. 2005;132:1763-72 pubmed
    ..These data place sp5l downstream of wnt3a and wnt8 in a Wnt/beta-catenin signaling pathway that controls tail development in zebrafish. ..
  7. Kim S, Shin J, Park H, Yeo S, Hong S, Han S, et al. Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish. Development. 2002;129:4443-55 pubmed
    ..In conclusion, we suggest that a gradient of Fz8a-mediated Wnt8b signalling may play crucial role in patterning the posterior diencephalon and midbrain regions in the late gastrula. ..
  8. Maurus D, Harris W. Zic-associated holoprosencephaly: zebrafish Zic1 controls midline formation and forebrain patterning by regulating Nodal, Hedgehog, and retinoic acid signaling. Genes Dev. 2009;23:1461-73 pubmed publisher
    ..Danio rerio as a model system to study Zic knockdown during midline formation by looking at the close homolog Zic1, which is expressed in an overlapping fashion with Zic2...
  9. Brockschmidt A, Filippi A, Charbel Issa P, Nelles M, Urbach H, Eter N, et al. Neurologic and ocular phenotype in Pitt-Hopkins syndrome and a zebrafish model. Hum Genet. 2011;130:645-55 pubmed publisher
    ..and the morphant phenotype was characterized for expression of neural differentiation genes neurog1, ascl1b, pax6a, zic1, atoh1a, atoh2b. Data from PTHS-patient and zebrafish morphants were compared...

More Information

Publications50

  1. Keller M, Chitnis A. Insights into the evolutionary history of the vertebrate zic3 locus from a teleost-specific zic6 gene in the zebrafish, Danio rerio. Dev Genes Evol. 2007;217:541-7 pubmed
    The Zic gene family of zinc-finger transcription factors includes five orthologues, zic1-5, that are common to the Euteleostian vertebrates (fish, frogs, birds, and mammals)...
  2. Ding Y, Xi Y, Chen T, Wang J, Tao D, Wu Z, et al. Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J Cell Biol. 2008;182:865-72 pubmed publisher
    ..Therefore, Caprin-2 promotes activation of the canonical Wnt signaling pathway by regulating LRP5/6 phosphorylation. ..
  3. Chaplin N, Tendeng C, Wingate R. Absence of an external germinal layer in zebrafish and shark reveals a distinct, anamniote ground plan of cerebellum development. J Neurosci. 2010;30:3048-57 pubmed publisher
    ..We show that these anamniotes share a common ground plan of granule cell production that does not include an external germinal layer. ..
  4. SAGERSTROM C, Gammill L, Veale R, Sive H. Specification of the enveloping layer and lack of autoneuralization in zebrafish embryonic explants. Dev Dyn. 2005;232:85-97 pubmed
    ..Zebrafish early gastrula ectodermal explants are specified to express the neural markers opl (zic1) and otx2, and this expression is prevented by BMP4...
  5. Kim H, Lee M, Jeong Y, Ro H, Kim D, Shin Y, et al. Ottogi Inhibits Wnt/?-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8. Sci Rep. 2017;7:13278 pubmed publisher
    ..Taken together, our data indicate that OTG functions as a novel negative regulator of Wnt signaling during development by the modulation of cell surface expression of Fz receptor. ..
  6. Kim J, Chun H, Kim S, Kim H, Kim Y, Kim M, et al. Normal forebrain development may require continual Wnt antagonism until mid-somitogenesis in zebrafish. Biochem Biophys Res Commun. 2009;381:717-21 pubmed publisher
    ..These results suggest that normal forebrain development requires continual Wnt antagonism from the early gastrula to the mid-somitogenesis stage. ..
  7. Sassa T, Aizawa H, Okamoto H. Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems. Dev Dyn. 2007;236:706-18 pubmed
    ..sequences) system in combination with the promoter/enhancer regions of gad2 for the Gad1/2(+) neurons and zic1 for the zn-5(+)Lhx2/9(+) neurons...
  8. Varga Z, Wegner J, Westerfield M. Anterior movement of ventral diencephalic precursors separates the primordial eye field in the neural plate and requires cyclops. Development. 1999;126:5533-46 pubmed
    ..Our results indicate that movement of a median subpopulation of diencephalic precursors separates retinal precursors into left and right eyes. Wild-type cyclops gene function is required for these morphogenetic movements. ..
  9. Coyle R, Latimer A, Jessen J. Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signaling. Exp Cell Res. 2008;314:2150-62 pubmed publisher
    ..Together, our results support the notion that pathways regulating pericellular proteolysis and cell polarity converge to promote efficient cell migration. ..
  10. Pei W, Noushmehr H, Costa J, Ouspenskaia M, Elkahloun A, Feldman B. An early requirement for maternal FoxH1 during zebrafish gastrulation. Dev Biol. 2007;310:10-22 pubmed
    ..Our studies thus point to an essential role for maternal FoxH1 and downstream keratins during gastrulation that is epistatic to Nodal signaling. ..
  11. Hu C, Tseng C, Chien C, Huang H, Ku W, Lee S, et al. Quantitative proteomics reveals diverse roles of miR-148a from gastric cancer progression to neurological development. J Proteome Res. 2013;12:3993-4004 pubmed publisher
    ..These results provided important insight into the regulation of neurological development elicited by miR-148a. ..
  12. Ohtsuka M, Kikuchi N, Ozato K, Inoko H, Kimura M. Comparative analysis of a 229-kb medaka genomic region, containing the zic1 and zic4 genes, with Fugu, human, and mouse. Genomics. 2004;83:1063-71 pubmed
    ..Sequence comparisons of developmental genes zic1 and zic4, identified within this region, revealed that zic1, but not zic4, is highly conserved among vertebrates...
  13. Ramel M, Buckles G, Lekven A. Conservation of structure and functional divergence of duplicated Wnt8s in pufferfish. Dev Dyn. 2004;231:441-8 pubmed publisher
    ..This finding suggests that zebrafish (and possibly teleost in general) Wnt8 receptors are able to discriminate between highly related ligands...
  14. Meng F, Braasch I, Phillips J, Lin X, Titus T, Zhang C, et al. Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish. Mol Biol Evol. 2013;30:1527-43 pubmed publisher
    ..These results show that the independent evolution of retinal degeneration in cavefish can occur by different developmental genetic mechanisms. ..
  15. Stanton S, McReynolds L, Evans T, Schreiber Agus N. Yaf2 inhibits caspase 8-mediated apoptosis and regulates cell survival during zebrafish embryogenesis. J Biol Chem. 2006;281:28782-93 pubmed
    ..Our findings implicate Yaf2 as a survival factor during early zebrafish development and organogenesis. This may suggest that Yaf2 and Rybp can encode opposing functions in the regulation of apoptosis. ..
  16. Xie X, Liu J, Hu B, Xiao W. Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis. PLoS ONE. 2011;6:e24469 pubmed publisher
    ..Our studies provide an in vivo model for illustrating function of FOXO transcription factors in embryogenesis. ..
  17. Jessen J, Topczewski J, Bingham S, Sepich D, Marlow F, Chandrasekhar A, et al. Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements. Nat Cell Biol. 2002;4:610-5 pubmed
    ..We propose Trilobite/Stbm mediates cellular interactions that confer directionality on distinct movements during vertebrate embryogenesis. ..
  18. Hu Z, Zhang J, Zhang Q. Expression pattern and functions of autophagy-related gene atg5 in zebrafish organogenesis. Autophagy. 2011;7:1514-27 pubmed
    ..2, pink1, ?-synuclein, xb51 and zic1. We further demonstrated that ATG5 protein is involved in autophagy by LC3-II/LC3I ratio and rapamycin-induction ..
  19. Formstone C, Mason I. Combinatorial activity of Flamingo proteins directs convergence and extension within the early zebrafish embryo via the planar cell polarity pathway. Dev Biol. 2005;282:320-35 pubmed
    ..However, while we show that control over axial extension is autonomous, we find that Fmi1a is not required within lateral cells undergoing dorsal convergence. ..
  20. Delvaeye M, De Vriese A, Zwerts F, Betz I, Moons M, Autiero M, et al. Role of the 2 zebrafish survivin genes in vasculo-angiogenesis, neurogenesis, cardiogenesis and hematopoiesis. BMC Dev Biol. 2009;9:25 pubmed publisher
  21. Thorpe C, Moon R. nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development. Development. 2004;131:2899-909 pubmed
    ..Additionally, nlk strongly enhances convergent/extension phenotypes associated with wnt11/silberblick, suggesting a role in modulating cell movements as well as cell fate. ..
  22. Toyama R, Gomez D, Mana M, Dawid I. Sequence relationships and expression patterns of zebrafish zic2 and zic5 genes. Gene Expr Patterns. 2004;4:345-50 pubmed
    ..A zic2.2 ortholog has not been identified in other vertebrate species, suggesting that the zic2.1/zic2.2 pair resulted from a genome duplication event during the evolution of the zebrafish lineage. ..
  23. Rohrschneider M, Elsen G, Prince V. Zebrafish Hoxb1a regulates multiple downstream genes including prickle1b. Dev Biol. 2007;309:358-72 pubmed
    ..Using morpholino knock-down and cell transplantation, we demonstrate that the Hoxb1a target Prickle1b functions cell-autonomously to control facial neuron migration, a single aspect of r4 identity. ..
  24. Londin E, Niemiec J, Sirotkin H. Chordin, FGF signaling, and mesodermal factors cooperate in zebrafish neural induction. Dev Biol. 2005;279:1-19 pubmed
    ..Our results support a model in which specification of anterior neural tissue requires early FGF-mediated repression of BMP transcript levels and later activities of Chordin and mesodermal factors. ..
  25. Kawakami A, Nojima Y, Toyoda A, Takahoko M, Satoh M, Tanaka H, et al. The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling. Curr Biol. 2005;15:480-8 pubmed
    ..We further show that Bmp activity can be attenuated by the coexpression of Scube2. Our data support the idea that Scube2 can modulate the long-range action of Bmp-dependent signaling in the neural tube and somites. ..
  26. Li Z, Nie F, Wang S, Li L. Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation. Proc Natl Acad Sci U S A. 2011;108:3116-23 pubmed publisher
    ..Our findings also indicate that H4K20me-1 is a marker for gene transcription activation, at least in canonical Wnt signaling. ..
  27. Hauptmann G, Söll I, Gerster T. The early embryonic zebrafish forebrain is subdivided into molecularly distinct transverse and longitudinal domains. Brain Res Bull. 2002;57:371-5 pubmed
    ..Furthermore, we identified a series of eight transverse diencephalic domains which may indicate a prosomeric organization of the rostral zebrafish brain. ..
  28. Li S, Liu W, Li Z, Li W, Wang Y, Zhou L, et al. greb1 regulates convergent extension movement and pituitary development in zebrafish. Gene. 2017;627:176-187 pubmed publisher
    ..Therefore, our present study indicates that greb1 is a novel regulator for CE movement and pituitary development in zebrafish. ..
  29. Grinblat Y, Gamse J, Patel M, Sive H. Determination of the zebrafish forebrain: induction and patterning. Development. 1998;125:4403-16 pubmed
    ..In order to study these events, we isolated zebrafish homologs of two neural markers, odd-paired-like (opl), which encodes a zinc finger protein, and fkh5, which encodes a forkhead domain protein...
  30. Dodou E, Barald K, Postlethwait J. Ventralized zebrafish embryo rescue by overexpression of Zic2a. Zebrafish. 2004;1:239-56 pubmed publisher
  31. Grinblat Y, Sive H. zic Gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula. Dev Dyn. 2001;222:688-93 pubmed
    ..These data show an early subdivision of the A/P axis in the presumptive neurectoderm. ..
  32. Clements W, Kimelman D. LZIC regulates neuronal survival during zebrafish development. Dev Biol. 2005;283:322-34 pubmed publisher
    ..Surprisingly, despite this high similarity, LZIC does not interact with beta-catenin in vitro or in vivo. Our results reveal that LZIC, a protein conserved in vertebrates, is required for neuronal survival in zebrafish...
  33. Lu F, Sun Y, Wei C, Thisse C, Thisse B. Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nat Commun. 2014;5:5368 pubmed publisher
    ..These findings reveal a novel level of regulation of the canonical Wnt/β-catenin signalling pathway occurring in the nucleus and involving tissue-specific derepression of TCF by Lbx2. ..
  34. Liu J, Zhang D, Xie X, Ouyang G, Liu X, Sun Y, et al. Eaf1 and Eaf2 negatively regulate canonical Wnt/?-catenin signaling. Development. 2013;140:1067-78 pubmed publisher
    ..In summary, our evidence points to a novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt/?-catenin signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity. ..
  35. Williams B, Cantrell V, Mundell N, Bennett A, Quick R, Jessen J. VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration. J Cell Sci. 2012;125:2141-7 pubmed publisher
    ..Our findings implicate matrix metalloproteinases as downstream effectors of PCP and suggest a broadly applicable mechanism whereby VANGL2 affects diverse morphogenetic processes. ..
  36. Drummond D, Cheng C, Selland L, Hocking J, Prichard L, Waskiewicz A. The role of Zic transcription factors in regulating hindbrain retinoic acid signaling. BMC Dev Biol. 2013;13:31 pubmed publisher
    ..Zic transcription factors function in patterning hindbrain motor neurons through their regulation of embryonic retinoic acid signaling. ..
  37. Ghiselli G, Farber S. D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish. BMC Dev Biol. 2005;5:19 pubmed
    ..In particular Glce acts during gastrulation by affecting Bmp-mediated cell specification. The results obtained further corroborate the concept that HS encodes information that affect morphogenesis during early vertebrate development. ..
  38. McCollum C, Amin S, Pauerstein P, Lane M. A zebrafish LMO4 ortholog limits the size of the forebrain and eyes through negative regulation of six3b and rx3. Dev Biol. 2007;309:373-85 pubmed
    ..We propose that lmo4b has an essential role in forebrain development as a modulator of six3 and rx3 expression, and thus indirectly influences neural cell fate commitment, cell proliferation and tissue growth in the anterior CNS. ..
  39. Kaslin J, Ganz J, Geffarth M, Grandel H, Hans S, Brand M. Stem cells in the adult zebrafish cerebellum: initiation and maintenance of a novel stem cell niche. J Neurosci. 2009;29:6142-53 pubmed publisher
    ..Nevertheless, retained epithelial properties such as distinct polarization and ventricular contact are critical common determinants to maintain neural stem cell activity in vertebrates. ..
  40. Dutta S, Dietrich J, Aspöck G, Burdine R, Schier A, Westerfield M, et al. pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development. 2005;132:1579-90 pubmed
    ..During mid-somitogenesis, Hedgehog then acts on the established median placode as a necessary and sufficient signal to specify pituitary cell types. ..
  41. Paulus J, Halloran M. Zebrafish bashful/laminin-alpha 1 mutants exhibit multiple axon guidance defects. Dev Dyn. 2006;235:213-24 pubmed
    ..In contrast to CNS axons, most peripheral axons appear normal in bal mutants. Our results, thus, reveal important and diverse functions for laminin-alpha1 in guiding developing axons in vivo. ..