Gene Symbol: zeb2b
Description: zinc finger E-box binding homeobox 2b
Alias: sip1b, zfhx1b, zinc finger E-box-binding homeobox 2, Smad-interacting protein-1b, transcription factor SIP1b
Londin E, Mentzer L, Sirotkin H. Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling. BMC Dev Biol. 2007;7:120 pubmed
..These findings reveal a dynamic role for chch in regulating cell movement and fate during early development. ..
Taibi A, Mandavawala K, Noel J, Okoye E, Milano C, Martin B, et al
. Zebrafish churchill regulates developmental gene expression and cell migration. Dev Dyn. 2013;242:614-21 pubmed publisher
..Together, these results suggest that chch is not essential for survival, but functions to modulate early mesendodermal gene expression and limit cell migration. ..
Ghoumid J, Drévillon L, Alavi Naini S, Bondurand N, Rio M, Briand Suleau A, et al
. ZEB2 zinc-finger missense mutations lead to hypomorphic alleles and a mild Mowat-Wilson syndrome. Hum Mol Genet. 2013;22:2652-61 pubmed publisher
..Finally, these findings broaden the clinical spectrum of ZEB2 mutations, indicating that MWS ought to be considered in patients with lesser degrees of ID and a suggestive facial gestalt, even in the absence of congenital malformation. ..
Delalande J, Guyote M, Smith C, Shepherd I. Zebrafish sip1a and sip1b are essential for normal axial and neural patterning. Dev Dyn. 2008;237:1060-9 pubmed publisher
..This results in a subsequent absence of neural crest precursors in the posterior pharyngeal arches and a loss of enteric precursors in the intestine. ..
Kok F, Shepherd I, Sirotkin H. Churchill and Sip1a repress fibroblast growth factor signaling during zebrafish somitogenesis. Dev Dyn. 2010;239:548-58 pubmed publisher
..Finally, we found that blocking FGF8 restores somite morphology in ChCh and Sip1a compromised embryos. These results demonstrate a novel role for ChCh and Sip1a in repression of FGF activity. ..
Cui S, Erlichman J, Russo P, Haber B, Matthews R. Intrahepatic biliary anomalies in a patient with Mowat-Wilson syndrome uncover a role for the zinc finger homeobox gene zfhx1b in vertebrate biliary development. J Pediatr Gastroenterol Nutr. 2011;52:339-44 pubmed publisher
..We used the zebrafish model system to determine whether zfhx1b has a role in vertebrate biliary development...