Genomes and Genes
Gene Symbol: you
Description: signal peptide, CUB domain, EGF-like 2
Alias: wu:fc27f08, you, signal peptide, CUB and EGF-like domain-containing protein 2, U shaped somites, protein You, u-shaped somites
- Tsai M, Cheng C, Lin Y, Chen C, Wu A, Wu M, et al. Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans. Biochem J. 2009;422:119-28 pubmed publisher..Thus human SCUBE2 could play important roles in HH-related biology and pathology, such as during organ development and tumour progression. ..
- Creanga A, Glenn T, Mann R, Saunders A, Talbot W, Beachy P. Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev. 2012;26:1312-25 pubmed publisher..Yet Hh proteins are also capable of mobilizing to and eliciting direct responses from distant cells. The zebrafish you gene, identified genetically >15 years ago, was more recently shown to encode a secreted glycoprotein that acts ..
- Tsao K, Tu C, Lee S, Yang R. Zebrafish scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1) is involved in primitive hematopoiesis. J Biol Chem. 2013;288:5017-26 pubmed publisher..Our results suggest that scube1 is critical for and functions at the top of the regulatory hierarchy of primitive hematopoiesis by modulating BMP activity during zebrafish embryogenesis. ..
- Corallo D, Schiavinato A, Trapani V, Moro E, Argenton F, Bonaldo P. Emilin3 is required for notochord sheath integrity and interacts with Scube2 to regulate notochord-derived Hedgehog signals. Development. 2013;140:4594-601 pubmed publisher..Overall, this study reveals a new role for an EMILIN protein and reinforces the concept that structure and function of the notochord are strictly linked. ..