Gene Symbol: yap1
Description: Yes-associated protein 1
Alias: YAP65, cb194, sb:cb194, si:ch211-181p1.5, si:dkey-3b8.3, wu:fc18c04, zYAP, zgc:158380, transcriptional coactivator YAP1, protein yorkie homolog, yap, yes-associated protein YAP65 homolog, yorkie homolog
Species: zebrafish
Products:     yap1

Top Publications

  1. Skouloudaki K, Puetz M, Simons M, Courbard J, Boehlke C, Hartleben B, et al. Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc Natl Acad Sci U S A. 2009;106:8579-84 pubmed publisher
    ..Depletion of Yes-associated protein 1 (YAP1), a transcriptional co-activator inhibited by Hippo signaling, ameliorated the cyst formation in Fat1-deficient ..
  2. Gee S, Milgram S, Kramer K, Conlon F, Moody S. Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone. PLoS ONE. 2011;6:e20309 pubmed publisher
    Yes-associated protein 65 (YAP) contains multiple protein-protein interaction domains and functions as both a transcriptional co-activator and as a scaffolding protein. Mouse embryos lacking YAP did not survive past embryonic day 8...
  3. Hu J, Sun S, Jiang Q, Sun S, Wang W, Gui Y, et al. Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). Int J Biol Sci. 2013;9:267-78 pubmed publisher
    ..The kinase cascade ultimately antagonizes the transcriptional co-activator Yki/YAP, which is a key regulator of cell proliferation and apoptosis...
  4. Jiang Q, Liu D, Gong Y, Wang Y, Sun S, Gui Y, et al. yap is required for the development of brain, eyes, and neural crest in zebrafish. Biochem Biophys Res Commun. 2009;384:114-9 pubmed publisher
    The Yes-associated protein (YAP) is a small protein that binds to many transcription factors and modulates their activity...
  5. Cebola I, Rodríguez Seguí S, Cho C, Bessa J, Rovira M, Luengo M, et al. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Nat Cell Biol. 2015;17:615-626 pubmed publisher
    ..TEAD and its coactivator YAP activate key pancreatic signalling mediators and transcription factors, and regulate the expansion of pancreatic ..
  6. Loh S, Teh C, Müller J, Guccione E, Hong W, Korzh V. Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line. Sci Rep. 2014;4:4289 pubmed publisher
    ..signaling pathway controls organ size by regulating cell proliferation and apoptosis and this process involves Yap1. The zebrafish Yap1 acts during neural differentiation, but its function is not fully understood...
  7. Fukui H, Terai K, Nakajima H, Chiba A, Fukuhara S, Mochizuki N. S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. Dev Cell. 2014;31:128-36 pubmed publisher
    ..Here we show that S1P signaling regulates CPC migration through Yes-associated protein 1 (Yap1)-dependent endoderm survival...
  8. Nagasawa Masuda A, Terai K. Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization. PLoS ONE. 2017;12:e0174633 pubmed publisher
    ..of the caudal vein plexus (dCVP) in Zebrafish to investigate the mechanism of regression and discover a new role of Yap/Taz in vascular regression. During regression, Yap/Taz is activated by blood circulation in the endothelial cells...
  9. He L, Xu W, Jing Y, Wu M, Song S, Cao Y, et al. Yes-associated protein (Yap) is necessary for ciliogenesis and morphogenesis during pronephros development in zebrafish (Danio Rerio). Int J Biol Sci. 2015;11:935-47 pubmed publisher
    The Hippo signaling pathway and its transcriptional co-activator Yap are known as essential regulators for cell proliferation and organ size. However, little is known about their roles in kidney development and ciliogenesis...

More Information


  1. Miesfeld J, Gestri G, Clark B, Flinn M, Poole R, Bader J, et al. Yap and Taz regulate retinal pigment epithelial cell fate. Development. 2015;142:3021-32 pubmed publisher
    ..yap (yap1) mutants lack a subset of RPE cells and/or exhibit coloboma...
  2. Asaoka Y, Hata S, Namae M, Furutani Seiki M, Nishina H. The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish. PLoS ONE. 2014;9:e97365 pubmed publisher
    ..Mst1/2 kinases activate the Lats1/2 kinases, which in turn phosphorylate and inhibit the transcriptional cofactor Yap. During mouse retinogenesis, overexpression of Yap prolongs progenitor cell proliferation, whereas inhibition of ..
  3. Agarwala S, Duquesne S, Liu K, Boehm A, Grimm L, Link S, et al. Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish. elife. 2015;4:e08201 pubmed publisher
    ..Amotl2a function in the LLP is mediated together by the Hippo pathway effector Yap1 and the Wnt/β-catenin effector Lef1...
  4. Cox A, Hwang K, Brown K, Evason K, Beltz S, Tsomides A, et al. Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat Cell Biol. 2016;18:886-896 pubmed publisher
    ..Here, we demonstrate that transgenic zebrafish expressing an activated form of the Hippo pathway effector Yap1 (also known as YAP) develop enlarged livers and are prone to liver tumour formation...
  5. Pappalardo A, Porreca I, Caputi L, De Felice E, Schulte Merker S, Zannini M, et al. Thyroid development in zebrafish lacking Taz. Mech Dev. 2015;138 Pt 3:268-78 pubmed publisher
    ..These findings indicate that the zebrafish Taz protein is needed for the normal differentiation of the thyroid and are the first to suggest that Taz confers growth advantage to the endocrine gland. ..
  6. Nakajima H, Yamamoto K, Agarwala S, Terai K, Fukui H, Fukuhara S, et al. Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Dev Cell. 2017;40:523-536.e6 pubmed publisher
    ..We indirectly monitored transcriptional activity of Yap1 (zebrafish YAP) and its spatiotemporal localization in living zebrafish and found that Yap1 entered the nucleus and ..
  7. Miesfeld J, Link B. Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway. Mech Dev. 2014;133:177-88 pubmed publisher
    ..development transgenic zebrafish lines were generated and validated to dynamically monitor and manipulate Yap/Taz-Tead activity...
  8. Mateus R, Lourenço R, Fang Y, Brito G, Farinho A, Valério F, et al. Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration. Development. 2015;142:2752-63 pubmed publisher
    ..However, how this is established and regulated is not well understood. Here, we report that Yap, the Hippo pathway effector, is a chief player in this process: functionally manipulating Yap during regeneration ..