Gene Symbol: xirp2a
Description: xin actin binding repeat containing 2a
Alias: sb:cb1045, wu:fc12g12, xirp2, xin actin-binding repeat-containing protein 2, Xin beta6, epithelial protein lost in neoplasm, xin actin-binding repeat containing 2
Species: zebrafish

Top Publications

  1. Otten C, van der Ven P, Lewrenz I, Paul S, Steinhagen A, Busch Nentwich E, et al. Xirp proteins mark injured skeletal muscle in zebrafish. PLoS ONE. 2012;7:e31041 pubmed publisher
    ..By combining laser-induced micro-injury with proliferation analyses, we found that Xirp1 and Xirp2a localize to nascent myofibrils within wounded skeletal muscle cells and that the repair of injuries does not ..
  2. Riedel Kruse I, Müller C, Oates A. Synchrony dynamics during initiation, failure, and rescue of the segmentation clock. Science. 2007;317:1911-5 pubmed
  3. Deniziak M, Thisse C, Rederstorff M, Hindelang C, Thisse B, Lescure A. Loss of selenoprotein N function causes disruption of muscle architecture in the zebrafish embryo. Exp Cell Res. 2007;313:156-67 pubmed
    ..Moreover, alteration of myofibrils architecture and tendon-like structure in embryo deficient for SelN function provide new insights into the pathological mechanism of SelN-related myopathy. ..
  4. Grosskurth S, Bhattacharya D, Wang Q, Lin J. Emergence of Xin demarcates a key innovation in heart evolution. PLoS ONE. 2008;3:e2857 pubmed publisher
    ..We postulate that the emergence of the Xin paralogs and their functional differentiation may have played a key role in the evolutionary development of the heart. ..
  5. Schroter C, Oates A. Segment number and axial identity in a segmentation clock period mutant. Curr Biol. 2010;20:1254-8 pubmed publisher
  6. Soza Ried C, zt rk E, Ish Horowicz D, Lewis J. Pulses of Notch activation synchronise oscillating somite cells and entrain the zebrafish segmentation clock. Development. 2014;141:1780-8 pubmed publisher
    ..Thus, entrainment of intracellular clocks by periodic activation of the Notch pathway is indeed the mechanism maintaining cell synchrony during somitogenesis...
  7. Richter S, Schulze U, Tomancak P, Oates A. Small molecule screen in embryonic zebrafish using modular variations to target segmentation. Nat Commun. 2017;8:1901 pubmed publisher
    ..This modular screening strategy is applicable to other developmental questions and disease models, highlighting the power of relatively small chemical libraries to accelerate gene discovery and disease study. ..
  8. Soroldoni D, Jörg D, Morelli L, Richmond D, Schindelin J, Jülicher F, et al. Genetic oscillations. A Doppler effect in embryonic pattern formation. Science. 2014;345:222-5 pubmed publisher
    ..We conclude that the rhythm of segmentation is an emergent property controlled by the time scale of genetic oscillations, the change of oscillation profile, and tissue shortening. ..
  9. Walters K, Dodd M, Mathias J, Gallagher A, Bennin D, Rhodes J, et al. Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24. Dev Dyn. 2009;238:86-99 pubmed publisher

More Information


  1. Hanisch A, Holder M, Choorapoikayil S, Gajewski M, Ozbudak E, Lewis J. The elongation rate of RNA polymerase II in zebrafish and its significance in the somite segmentation clock. Development. 2013;140:444-53 pubmed publisher
  2. Chen J, Galloway J. The development of zebrafish tendon and ligament progenitors. Development. 2014;141:2035-45 pubmed publisher
    ..scleraxis (scx), collagen 1a2 (col1a2) and tenomodulin (tnmd), or in the tendon-like myosepta of the zebrafish (xirp2a)...
  3. Fior R, Maxwell A, Ma T, Vezzaro A, Moens C, Amacher S, et al. The differentiation and movement of presomitic mesoderm progenitor cells are controlled by Mesogenin 1. Development. 2012;139:4656-65 pubmed publisher
    ..Through its combined effects on gene expression and cell movement, Msgn1 (with Spt) plays a key role both in genesis of the paraxial mesoderm and in maintenance of the progenitor population from which it derives...
  4. Herrgen L, Ares S, Morelli L, Schroter C, Jülicher F, Oates A. Intercellular coupling regulates the period of the segmentation clock. Curr Biol. 2010;20:1244-53 pubmed publisher
    ..Here we ask whether Delta-Notch coupling additionally influences the collective period of the segmentation clock...
  5. Lee H, Tseng W, Lo F, Liu T, Tsai H. FoxD5 mediates anterior-posterior polarity through upstream modulator Fgf signaling during zebrafish somitogenesis. Dev Biol. 2009;336:232-45 pubmed publisher
    ..An Fgf-FoxD5-Mesps signaling network is therefore proposed. ..
  6. Mikami S, Nakaura M, Kawahara A, Mizoguchi T, Itoh M. Mindbomb 2 is dispensable for embryonic development and Notch signalling in zebrafish. Biol Open. 2015;4:1576-82 pubmed publisher
    ..These observations suggest that Mib2 is dispensable for embryonic development and does not have redundant functions with Mib1 in Notch signalling at least during early development stages in zebrafish. ..
  7. Schroter C, Ares S, Morelli L, Isakova A, Hens K, Soroldoni D, et al. Topology and dynamics of the zebrafish segmentation clock core circuit. PLoS Biol. 2012;10:e1001364 pubmed publisher
    ..The control of the circuit's dynamics by a population of dimers with and without DNA binding activity is a new principle for the segmentation clock and may be relevant to other biological clocks and transcriptional regulatory networks. ..
  8. Hayes M, Gao X, Yu L, Paria N, Henkelman R, Wise C, et al. ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease. Nat Commun. 2014;5:4777 pubmed publisher
    ..Our data suggest novel molecular origins of, and genetic links between, congenital and idiopathic forms of disease. ..
  9. Liao B, Jörg D, Oates A. Faster embryonic segmentation through elevated Delta-Notch signalling. Nat Commun. 2016;7:11861 pubmed publisher
  10. Rost F, Eugster C, Schröter C, Oates A, Brusch L. Chevron formation of the zebrafish muscle segments. J Exp Biol. 2014;217:3870-82 pubmed publisher
    ..Altogether, our results support the notion that a simple physical mechanism suffices to self-organize the observed spatiotemporal pattern in chevron formation. ..
  11. Morrow Z, Maxwell A, Hoshijima K, Talbot J, Grunwald D, Amacher S. tbx6l and tbx16 are redundantly required for posterior paraxial mesoderm formation during zebrafish embryogenesis. Dev Dyn. 2017;246:759-769 pubmed publisher
    ..Developmental Dynamics 246:759-769, 2017. © 2017 Wiley Periodicals, Inc. ..