Gene Symbol: xiap
Description: X-linked inhibitor of apoptosis
Alias: birc4, fb73d01, wu:fb73d01, zgc:91873, E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing 4
Inohara N, Nunez G. Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell Death Differ. 2000;7:509-10 pubmed
Santoro M, Samuel T, Mitchell T, Reed J, Stainier D. Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nat Genet. 2007;39:1397-402 pubmed
Oberoi T, Dogan T, Hocking J, Scholz R, Mooz J, Anderson C, et al
. IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J. 2012;31:14-28 pubmed publisher
..Here, we demonstrate X-linked IAP (XIAP) and cellular IAP1 (c-IAP1) directly bind to Rac1 in a nucleotide-independent manner to promote its ..
Pradhan A, Khalaf H, Ochsner S, Sreenivasan R, Koskinen J, Karlsson M, et al
. Activation of NF-?B protein prevents the transition from juvenile ovary to testis and promotes ovarian development in zebrafish. J Biol Chem. 2012;287:37926-38 pubmed publisher
Jung I, Leem G, Jung D, Kim M, Kim E, Kim S, et al
. Glioma is formed by active Akt1 alone and promoted by active Rac1 in transgenic zebrafish. Neuro Oncol. 2013;15:290-304 pubmed publisher
..The zebrafish model reinforces the pivotal role of Akt signaling in gliomagenesis and suggests Rac1 as an important protein involved in progression. ..
Hu J, Sun S, Jiang Q, Sun S, Wang W, Gui Y, et al
. Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio). Int J Biol Sci. 2013;9:267-78 pubmed publisher
..In conclusion, our results revealed that zebrafish yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis. ..
Fukui H, Terai K, Nakajima H, Chiba A, Fukuhara S, Mochizuki N. S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. Dev Cell. 2014;31:128-36 pubmed publisher
..Consistently, ctgfa morphants showed defects of the endodermal sheet and cardia bifida. Collectively, we show that S1pr2/Yap1-regulated ctgfa expression is essential for the proper endoderm formation required for CPC migration. ..