Gene Symbol: xgb
Description: x globin
Alias: x globin, GbX1
Roesner A, Hankeln T, Burmester T. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). J Exp Biol. 2006;209:2129-37 pubmed
..There was little change in the expression of the two cytoglobin genes. Globin X mRNA significantly decreased under hypoxia, pointing to a functional linkage to oxygen-dependent metabolism. ..
Roesner A, Fuchs C, Hankeln T, Burmester T. A globin gene of ancient evolutionary origin in lower vertebrates: evidence for two distinct globin families in animals. Mol Biol Evol. 2005;22:12-20 pubmed publisher
..Phylogenetic analyses confirm an ancient evolutionary relationship of globin X with neuroglobin and suggest the existence of two distinct globin types in the last common ancestor of Protostomia and Deuterostomia...
Roesner A, Mitz S, Hankeln T, Burmester T. Globins and hypoxia adaptation in the goldfish, Carassius auratus. FEBS J. 2008;275:3633-43 pubmed publisher
Blank M, Burmester T. Widespread occurrence of N-terminal acylation in animal globins and possible origin of respiratory globins from a membrane-bound ancestor. Mol Biol Evol. 2012;29:3553-61 pubmed publisher
Tiedke J, Gerlach F, Mitz S, Hankeln T, Burmester T. Ontogeny of globin expression in zebrafish (Danio rerio). J Comp Physiol B. 2011;181:1011-21 pubmed publisher
..Globin X mRNA level was highest in oocytes, but low in later stages. Together, these data suggest a specific role for each globin, which are also associated with certain events in fish development. ..
Blank M, Wollberg J, Gerlach F, Reimann K, Roesner A, Hankeln T, et al
. A membrane-bound vertebrate globin. PLoS ONE. 2011;6:e25292 pubmed publisher
..A respiratory function of globin X is unlikely, but analogous to some prokaryotic membrane-globins it may either protect the lipids in cell membrane from oxidation or may act as a redox-sensing or signaling protein. ..
Corti P, Xue J, Tejero J, Wajih N, Sun M, Stolz D, et al
. Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells. Proc Natl Acad Sci U S A. 2016;113:8538-43 pubmed publisher
..The description of a novel, six-coordinate globin in RBCs with dominant electron transfer and nitrite reduction functionality provides new insights into the evolved signaling properties of ancestral heme-globins. ..
Amdahl M, Sparacino Watkins C, Corti P, Gladwin M, Tejero J. Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System. Biochemistry. 2017;56:3993-4004 pubmed publisher
..These data suggest that the cytochrome b5/cytochrome b5 reductase system is a viable reductant for cytoglobin in vivo, allowing for catalytic oxidoreductase activity. ..