Gene Symbol: wt1a
Description: wilms tumor 1a
Alias: wt1, zwt1, wilms tumor 1a
Species: zebrafish
Products:     wt1a

Top Publications

  1. Majumdar A, Drummond I. Podocyte differentiation in the absence of endothelial cells as revealed in the zebrafish avascular mutant, cloche. Dev Genet. 1999;24:220-9 pubmed
    ..In clo mutants, glomerular epithelial cells expressing the podocyte specific marker wt1 display well-formed foot processes and are able to form a GBM, suggesting podocytes are able to morphologically ..
  2. Bollig F, Mehringer R, Perner B, Hartung C, Schafer M, Schartl M, et al. Identification and comparative expression analysis of a second wt1 gene in zebrafish. Dev Dyn. 2006;235:554-61 pubmed
    ..we report the existence of a second wt1 gene in zebrafish, which we have named wt1b (we named the initial gene wt1a)...
  3. Majumdar A, Lun K, Brand M, Drummond I. Zebrafish no isthmus reveals a role for pax2.1 in tubule differentiation and patterning events in the pronephric primordia. Development. 2000;127:2089-98 pubmed
    ..in the lateral cells of the pronephric primordium is required to restrict the domains of Wilms' tumor suppressor (wt1) and vascular endothelial growth factor (VEGF) gene expression to medial podocyte progenitors...
  4. Klüver N, Herpin A, Braasch I, Driessle J, Schartl M. Regulatory back-up circuit of medaka Wt1 co-orthologs ensures PGC maintenance. Dev Biol. 2009;325:179-88 pubmed publisher
    ..In teleost fish, however, two wt1 genes have been identified. In medaka wt1a is expressed in the lateral plate mesoderm during early embryogenesis...
  5. Bisgrove B, Snarr B, Emrazian A, Yost H. Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Dev Biol. 2005;287:274-88 pubmed
    ..Our data suggest that the functions of polaris and pkd2 in LR patterning are conserved between zebrafish and mice and that Kupffer's vesicle functions as a ciliated organ of asymmetry. ..
  6. Ebarasi L, He L, Hultenby K, Takemoto M, Betsholtz C, Tryggvason K, et al. A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier. Dev Biol. 2009;334:1-9 pubmed publisher
    ..This report is the first to show a role for crb function in podocyte differentiation. Furthermore, these results suggest a novel link between epithelial polarization and the maintenance of a functional filtration barrier. ..
  7. Bollig F, Perner B, Besenbeck B, Köthe S, Ebert C, Taudien S, et al. A highly conserved retinoic acid responsive element controls wt1a expression in the zebrafish pronephros. Development. 2009;136:2883-92 pubmed publisher
    ..Here, we have used transgenesis in zebrafish harboring two wt1 genes, wt1a and wt1b, in order to define regulatory elements that drive wt1 expression in the kidney...
  8. de Groh E, Swanhart L, Cosentino C, Jackson R, Dai W, Kitchens C, et al. Inhibition of histone deacetylase expands the renal progenitor cell population. J Am Soc Nephrol. 2010;21:794-802 pubmed publisher
    ..In summary, these results support a mechanistic link among renal progenitor cells, HDAC, and the retinoid pathway. Whether PTBA holds promise as a therapeutic agent to promote renal regeneration requires further study. ..
  9. O Brien L, Grimaldi M, Kostun Z, Wingert R, Selleck R, Davidson A. Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish. Dev Biol. 2011;358:318-30 pubmed publisher
    ..Here, we use the zebrafish to demonstrate that embryos treated with morpholinos against wt1a, foxc1a, or the Notch transcriptional mediator rbpj develop fewer podocytes, as determined by wt1b, hey1 and ..

More Information


  1. Liu Y, Guo L. Endothelium is required for the promotion of interrenal morphogenetic movement during early zebrafish development. Dev Biol. 2006;297:44-58 pubmed
    ..We thus conclude that endothelial signaling is involved in the morphogenetic movement of early interrenal tissue. ..
  2. Anzenberger U, Bit Avragim N, Rohr S, Rudolph F, Dehmel B, Willnow T, et al. Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros. J Cell Sci. 2006;119:2127-37 pubmed
    ..Using this model system, we provide first genetic evidence that renal tubular endocytosis and formation of endosomes is a ligand-induced process that crucially depends on megalin/LRP2 activity. ..
  3. Horsfield J, Ramachandran A, Reuter K, LaVallie E, Collins Racie L, Crosier K, et al. Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development. Mech Dev. 2002;115:15-26 pubmed
    ..This finding contrasts with the role of mammalian CDH17, which does not appear to be involved in nephric development. ..
  4. Serluca F, Xu B, Okabe N, Baker K, Lin S, Sullivan Brown J, et al. Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning. Development. 2009;136:1621-31 pubmed publisher
    ..Combined with recently published results, our alleles suggest that the function of seahorse in cilia motility is separable from its function in other cilia-related phenotypes. ..
  5. Serluca F, Fishman M. Pre-pattern in the pronephric kidney field of zebrafish. Development. 2001;128:2233-41 pubmed
    ..mesoderm as candidates for the pronephric field by expression patterns of the Wilms' Tumor suppressor gene (wt1), single-minded 1 (sim1) and pax2.1...
  6. Perner B, Englert C, Bollig F. The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros. Dev Biol. 2007;309:87-96 pubmed
    ..In zebrafish, two paralogous wt1 genes exist, wt1a and wt1b. The wt1 genes are expressed in a similar and overlapping but not identical pattern...
  7. Chai C, Liu Y, Chan W. Ff1b is required for the development of steroidogenic component of the zebrafish interrenal organ. Dev Biol. 2003;260:226-44 pubmed
    ..Based on these data, we propose that ff1b is required for the development of the steroidogenic tissue of the interrenal organ...
  8. Von Hofsten J, Olsson P. Zebrafish sex determination and differentiation: involvement of FTZ-F1 genes. Reprod Biol Endocrinol. 2005;3:63 pubmed
    ..The role of FTZ-F1 and other candidates for zebrafish sex determination and differentiation is in focus of this review. ..
  9. Hsu H, Lin G, Chung B. Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b. Development. 2003;130:2107-16 pubmed
    ..These cells then migrate toward the axial midline and fuse together. The pronephric primordia are wt1-expressing cells located next to the interrenal...
  10. Hill A, Bello S, Prasch A, Peterson R, Heideman W. Water permeability and TCDD-induced edema in zebrafish early-life stages. Toxicol Sci. 2004;78:78-87 pubmed
    ..In conclusion, TCDD exposure may inhibit the function of a permeability barrier to water, which is critical for maintaining osmotic balance in early development. ..
  11. Mudumana S, Hentschel D, Liu Y, Vasilyev A, Drummond I. odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate. Development. 2008;135:3355-67 pubmed publisher
  12. Wu T, Yang J, Yu F, Liu B. Evaluation of nephrotoxic effects of mycotoxins, citrinin and patulin, on zebrafish (Danio rerio) embryos. Food Chem Toxicol. 2012;50:4398-404 pubmed publisher
    ..of proinflammation genes, including COX2a, TNF-? and IL-1?, but failed to modify the levels and distribution of wt1a transcript and Na(+)/K(+)-ATPase protein...
  13. Navratilova P, Fredman D, Hawkins T, Turner K, Lenhard B, Becker T. Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes. Dev Biol. 2009;327:526-40 pubmed publisher
    ..human HCNEs. HCNEs from the same area often drive overlapping patterns, suggesting that multiple regulatory inputs are required to achieve robust and precise complex expression patterns exhibited by developmental genes. ..
  14. Hall G, Gbadegesin R, Lavin P, Wu G, Liu Y, Oh E, et al. A novel missense mutation of Wilms' Tumor 1 causes autosomal dominant FSGS. J Am Soc Nephrol. 2015;26:831-43 pubmed publisher
    ..We depleted wt1a in zebrafish embryos and observed glomerular injury and filtration defects, both of which were rescued with wild-..
  15. Kur E, Christa A, Veth K, Gajera C, Andrade Navarro M, Zhang J, et al. Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development. Dev Dyn. 2011;240:1567-77 pubmed publisher
  16. Chou C, Chiu C, Liu Y. Fibronectin mediates correct positioning of the interrenal organ in zebrafish. Dev Dyn. 2013;242:432-43 pubmed publisher
    ..However, how Fn is involved in organ formation of the adrenal gland remains unclear...
  17. Paredes Zúñiga S, Morales R, Muñoz Sánchez S, Muñoz Montecinos C, Parada M, Tapia K, et al. CXCL12a/CXCR4b acts to retain neutrophils in caudal hematopoietic tissue and to antagonize recruitment to an injury site in the zebrafish larva. Immunogenetics. 2017;69:341-349 pubmed publisher
  18. Leerberg D, Sano K, Draper B. Fibroblast growth factor signaling is required for early somatic gonad development in zebrafish. PLoS Genet. 2017;13:e1006993 pubmed publisher
    ..Finally, we argue that the role of Fgf24 in zebrafish is functionally analogous to the role of tetrapod FGF9 in early gonad development. ..
  19. Kroeger P, Drummond B, Miceli R, McKernan M, Gerlach G, Marra A, et al. The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Dev Biol. 2017;428:148-163 pubmed publisher
  20. Hsu H, Lin G, Chung B. Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b. Endocr Res. 2004;30:803 pubmed
  21. Wang Y, Sun Z, Zhou L, Li Z, Gui J. Grouper tsh? promoter-driven transgenic zebrafish marks proximal kidney tubule development. PLoS ONE. 2014;9:e97806 pubmed publisher
    ..Therefore, this transgenic line provides a useful tool for genetic or chemical analysis of kidney tubule. ..
  22. Xiao A, Wang Z, Hu Y, Wu Y, Luo Z, Yang Z, et al. Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Nucleic Acids Res. 2013;41:e141 pubmed publisher
    ..To facilitate the analyses and application of existing ZFN, TALEN and CRISPR/Cas data, we have updated our EENdb database to provide a chromosomal view of all reported engineered endonucleases targeting human and zebrafish genomes. ..
  23. Bergeron S, Milla L, Villegas R, Shen M, Burgess S, Allende M, et al. Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos. Genomics. 2008;91:165-77 pubmed
    ..We thus provide a comprehensive survey of Hh/Gli-regulated genes during embryogenesis and we identify new Hh-regulated genes that may be targets of misregulation during tumorigenesis. ..
  24. Vasilyev A, Liu Y, Mudumana S, Mangos S, Lam P, Majumdar A, et al. Collective cell migration drives morphogenesis of the kidney nephron. PLoS Biol. 2009;7:e9 pubmed publisher
    ..Our results establish intimate links between nephron function, fluid flow, and morphogenesis. ..
  25. Choi S, Chacon Heszele M, Huang L, McKenna S, Wilson F, Zuo X, et al. Cdc42 deficiency causes ciliary abnormalities and cystic kidneys. J Am Soc Nephrol. 2013;24:1435-50 pubmed publisher
    ..Abnormalities in this pathway result in deranged ciliogenesis and polycystic kidney disease...
  26. Weber S, Taylor J, Winyard P, Baker K, Sullivan Brown J, Schild R, et al. SIX2 and BMP4 mutations associate with anomalous kidney development. J Am Soc Nephrol. 2008;19:891-903 pubmed publisher
    ..Defects in these proteins could affect kidney development at multiple stages, leading to the congenital anomalies observed in patients with RHD. ..
  27. Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman J, et al. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol. 2017;28:981-994 pubmed publisher
    ..This study expands the number of loci associated with kidney function and identifies novel genes with potential roles in kidney formation. ..
  28. Huang C, Wilson V, Pennings S, Macrae C, Mullins J. Sequential effects of spadetail, one-eyed pinhead and no tail on midline convergence of nephric primordia during zebrafish embryogenesis. Dev Biol. 2013;384:290-300 pubmed publisher
    ..To characterize the process of PGP midline convergence, we used Wilms' tumour 1a (wt1a) as a marker to label kidney primordia, and performed quantitative analyses of the migration of the bilateral PGP...
  29. Zennaro C, Mariotti M, Carraro M, Pasqualetti S, Corbelli A, Armelloni S, et al. Podocyte developmental defects caused by adriamycin in zebrafish embryos and larvae: a novel model of glomerular damage. PLoS ONE. 2014;9:e98131 pubmed publisher
    ..demonstrated by onset of pericardial edema and reduction of expression of the podocyte proteins nephrin and wt1. Podocyte damage is morphologically confirmed by electron microscopy and functionally supported by increased ..
  30. Liang P, Jones C, Bisgrove B, Song L, Glenn S, Yost H, et al. Genomic characterization and expression analysis of the first nonmammalian renin genes from zebrafish and pufferfish. Physiol Genomics. 2004;16:314-22 pubmed publisher
  31. Gering M, Yamada Y, Rabbitts T, Patient R. Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development. 2003;130:6187-99 pubmed
    ..These results suggest that, in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2-induced haemangioblasts differentiate into endothelial cells. ..
  32. Huang L, Xiao A, Choi S, Kan Q, Zhou W, Chacon Heszele M, et al. Wnt5a is necessary for normal kidney development in zebrafish and mice. Nephron Exp Nephrol. 2014;128:80-8 pubmed publisher
    ..Our data demonstrated the important role of Wnt5a in kidney development. Disrupted Wnt5a resulted in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice. ..
  33. Gerlach G, Wingert R. Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta. Dev Biol. 2014;396:183-200 pubmed publisher
    ..morphants displayed ectopic expression of the transcription factor pax2a and the podocyte-associated genes wt1a, wt1b, and podxl, suggesting that prkcι/ζ are needed to maintain renal epithelial identity...
  34. Chou C, Lin J, Jiang Y, Liu Y. Aberrant Global and Jagged-Mediated Notch Signaling Disrupts Segregation Between wt1-Expressing and Steroidogenic Tissues in Zebrafish. Endocrinology. 2017;158:4206-4217 pubmed publisher
    ..In the present study, we explored how the Wilms tumor 1 (WT1)-expressing cells are segregated from the SF-1-expressing steroidogenic cells in the zebrafish model...
  35. Cao J, Poss K. Explant culture of adult zebrafish hearts for epicardial regeneration studies. Nat Protoc. 2016;11:872-81 pubmed publisher
    ..Our protocols complement and extend in vivo studies of heart regeneration. ..
  36. White Y, Kyle J, Wood A. Targeted gene knockdown in zebrafish reveals distinct intraembryonic functions for insulin-like growth factor II signaling. Endocrinology. 2009;150:4366-75 pubmed publisher
  37. Xie J, Wang W, Liu T, Deng M, Ning G. Spatio-temporal expression of chromogranin A during zebrafish embryogenesis. J Endocrinol. 2008;198:451-8 pubmed publisher
    ..double in situ hybridization assay of chga with genes expressed in pronephros (Wilms' tumor suppressor 1, wt1), adrenal cortex (side-chain cleavage enzyme, scc), and sympathoadrenal neuron/chromaffin cell (dopamine-beta-..
  38. Perner B, Bates T, Naumann U, Englert C. Function and Regulation of the Wilms' Tumor Suppressor 1 (WT1) Gene in Fish. Methods Mol Biol. 2016;1467:119-28 pubmed publisher
    ..In contrast to mammals, most fish species possess two wt1 paralogs that have been named wt1a and wt1b...
  39. Shima T, Znosko W, Tsang M. The characterization of a zebrafish mid-hindbrain mutant, mid-hindbrain gone (mgo). Dev Dyn. 2009;238:899-907 pubmed publisher
    ..Based on these findings, we propose that the mgo mutation genetically interacts with pax2a required for the initiation of MHB formation. ..
  40. Arif E, Kumari B, Wagner M, Zhou W, Holzman L, Nihalani D. Myo1c is an unconventional myosin required for zebrafish glomerular development. Kidney Int. 2013;84:1154-65 pubmed publisher
    ..Thus, our results demonstrate that Myo1c is necessary for podocyte morphogenesis. ..
  41. Serluca F. Development of the proepicardial organ in the zebrafish. Dev Biol. 2008;315:18-27 pubmed publisher
    ..The molecular markers wt1 and tcf21 are used to identify the epicardial layer in the zebrafish heart, to trace its development and to ..
  42. Mitra S, Lukianov S, Ruiz W, Cianciolo Cosentino C, Sanker S, Traub L, et al. Requirement for a uroplakin 3a-like protein in the development of zebrafish pronephric tubule epithelial cell function, morphogenesis, and polarity. PLoS ONE. 2012;7:e41816 pubmed publisher
  43. Pradhan A, Khalaf H, Ochsner S, Sreenivasan R, Koskinen J, Karlsson M, et al. Activation of NF-?B protein prevents the transition from juvenile ovary to testis and promotes ovarian development in zebrafish. J Biol Chem. 2012;287:37926-38 pubmed publisher
  44. Chen Q, Huang S, Zhao Q, Chen R, Zhang A. Expression and function of the Ets transcription factor pea3 during formation of zebrafish pronephros. Pediatr Nephrol. 2011;26:391-400 pubmed publisher
    ..inhibited zebrafish pronephros development, and these defects were rescued by overexpression of the zebrafish wt1a gene...
  45. Anderson B, Howell D, Soldano K, Garrett M, Katsanis N, Telen M, et al. In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress. PLoS Genet. 2015;11:e1005349 pubmed publisher
  46. Tucker J, Mintzer K, Mullins M. The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis. Dev Cell. 2008;14:108-19 pubmed publisher
    ..We propose that a temporal cue regulates a cell's competence to respond to BMP signaling, allowing the acquisition of a cell's DV and AP identity simultaneously. ..
  47. Kleinjan D, Bancewicz R, Gautier P, Dahm R, Schonthaler H, Damante G, et al. Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence. PLoS Genet. 2008;4:e29 pubmed publisher
  48. Kurita K, Sakai N. Functionally distinctive testicular cell lines of zebrafish to support male germ cell development. Mol Reprod Dev. 2004;67:430-8 pubmed
    ..cells such as phagocytic activity and transcription both of their specific genes, sox9a and Wilms' tumor suppressor WT1, and of the vas gene of germ cells were analyzed in the lines...
  49. Fogelgren B, Lin S, Zuo X, Jaffe K, Park K, Reichert R, et al. The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLoS Genet. 2011;7:e1001361 pubmed publisher
    ..Our work supports a model in which the exocyst is required for the ciliary localization of polycystin-2, thus allowing for polycystin-2 function in cellular processes. ..
  50. Kubota F, Murakami T, Mogi K, Yorifuji H. Cadherin-6 is required for zebrafish nephrogenesis during early development. Int J Dev Biol. 2007;51:123-9 pubmed
    ..Embryos injected with cdh6MOs were subjected to in situ hybridization with probes for the pronephric markers, wt1 and pax2...
  51. Bedell V, Person A, Larson J, McLoon A, Balciunas D, Clark K, et al. The lineage-specific gene ponzr1 is essential for zebrafish pronephric and pharyngeal arch development. Development. 2012;139:793-804 pubmed publisher
    ..Together, this work provides experimental evidence of an additional mechanism that incorporates evolutionarily dynamic, lineage-specific gene families into conserved regulatory gene networks to create functional organ diversity. ..
  52. Tomar R, Mudumana S, Pathak N, Hukriede N, Drummond I. osr1 is required for podocyte development downstream of wt1a. J Am Soc Nephrol. 2014;25:2539-45 pubmed publisher
    ..osr1-deficient pronephric podocyte progenitors express the Wilms' tumor suppressor wt1a but do not undergo glomerular morphogenesis or express the foot process junctional markers nephrin and podocin...
  53. Diep C, Ma D, Deo R, Holm T, Naylor R, Arora N, et al. Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 2011;470:95-100 pubmed publisher
    ..The identification of these cells paves the way to isolating or engineering the equivalent cells in mammals and developing novel renal regenerative therapies. ..
  54. Davidson A, Ernst P, Wang Y, Dekens M, Kingsley P, Palis J, et al. cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature. 2003;425:300-6 pubmed
    ..Taken together, these findings demonstrate that cdx4 regulates hox genes and is necessary for the specification of haematopoietic cell fate during vertebrate embryogenesis. ..
  55. Rider S, Christian H, Mullins L, Howarth A, Macrae C, Mullins J. Zebrafish mesonephric renin cells are functionally conserved and comprise two distinct morphological populations. Am J Physiol Renal Physiol. 2017;312:F778-F790 pubmed publisher
    ..Our studies demonstrate substantive conservation of renin regulation across vertebrates, and ultrastructural studies of renin cells reveal at least two distinct morphologies of mesonephric perivascular ren-expressing cells. ..
  56. Dong L, Pietsch S, Tan Z, Perner B, Sierig R, Kruspe D, et al. Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance. J Am Soc Nephrol. 2015;26:2118-28 pubmed publisher
    The Wilms' tumor suppressor gene 1 (WT1) encodes a zinc finger transcription factor. Mutation of WT1 in humans leads to Wilms' tumor, a pediatric kidney tumor, or other kidney diseases, such as Denys-Drash and Frasier syndromes...
  57. Mo D, Ihrke G, Costa S, Brilli L, Labilloy A, Halfter W, et al. Apical targeting and endocytosis of the sialomucin endolyn are essential for establishment of zebrafish pronephric kidney function. J Cell Sci. 2012;125:5546-54 pubmed publisher
    ..This suggests that both polarized targeting and postendocytic trafficking of endolyn are essential for the protein's proper function in mammalian kidney. ..
  58. Cheng C, Li Y, Marra A, Verdun V, Wingert R. Flat mount preparation for observation and analysis of zebrafish embryo specimens stained by whole mount in situ hybridization. J Vis Exp. 2014;: pubmed publisher
  59. Miceli R, Kroeger P, Wingert R. Molecular Mechanisms of Podocyte Development Revealed by Zebrafish Kidney Research. Cell Dev Biol. 2014;3: pubmed
    ..In this review, we discuss how research using the zebrafish has provided new insights into the molecular regulation of the podocyte lineage during kidney ontogeny, complementing contemporary research in other animal models. ..
  60. Liu C, Garnaas M, Tin A, Kottgen A, Franceschini N, Peralta C, et al. Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet. 2011;7:e1002264 pubmed publisher
    ..We identified several SNPs in association with eGFR in African Ancestry individuals, as well as 3 suggestive loci for UACR and eGFR. Functional genetic studies support a role for kcnq1 in glomerular development in zebrafish. ..
  61. Perner B, Schnerwitzki D, Graf M, Englert C. Analysis of Zebrafish Kidney Development with Time-lapse Imaging Using a Dissecting Microscope Equipped for Optical Sectioning. J Vis Exp. 2016;:e53921 pubmed publisher
    ..Renal defects were triggered by injection of an antisense morpholino oligonucleotide against the Wilms tumor gene wt1a, a factor known to be crucial for kidney development...
  62. Powell R, Bubenshchikova E, Fukuyo Y, Hsu C, Lakiza O, Nomura H, et al. Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish. Mol Med Rep. 2016;14:2665-78 pubmed publisher
    ..In the present study, we demonstrate that wtip expression is identical in wt1a?, tcf21?, and tbx18?positive PE cells, and that Wtip protein localizes to the basal body of PE cells...
  63. Sun D, Zhang Y, Wang C, Hua X, Zhang X, Yan J. Sox9-related signaling controls zebrafish juvenile ovary-testis transformation. Cell Death Dis. 2013;4:e930 pubmed publisher
  64. Dutta S, Sriskanda S, Boobalan E, Alur R, Elkahloun A, Brooks B. nlz1 is required for cilia formation in zebrafish embryogenesis. Dev Biol. 2015;406:203-11 pubmed publisher
    ..Furthermore, Nlz1 contributes to motile cilia formation by positively regulating Wnt11/presumed non-canonical Wnt signaling. Together, our data suggest a novel role of nlz1 in ciliogenesis and the morphogenesis of multiple tissues. ..
  65. Rothschild S, Francescatto L, Drummond I, Tombes R. CaMK-II is a PKD2 target that promotes pronephric kidney development and stabilizes cilia. Development. 2011;138:3387-97 pubmed publisher
    ..We conclude that CaMK-II is a crucial effector of PKD2 Ca²? that both promotes morphogenesis of the pronephric kidney and stabilizes primary cloacal cilia. ..
  66. González Rosa J, Martin V, Peralta M, Torres M, Mercader N. Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish. Development. 2011;138:1663-74 pubmed publisher
    ..This finding suggests that CC-induced damage in zebrafish could provide a valuable model for the study of the mechanisms of scar removal post-MI...
  67. Feiner N, Meyer A, Kuraku S. Evolution of the vertebrate Pax4/6 class of genes with focus on its novel member, the Pax10 gene. Genome Biol Evol. 2014;6:1635-51 pubmed publisher
  68. Chiu C, Chou C, Takada S, Liu Y. Development and fibronectin signaling requirements of the zebrafish interrenal vessel. PLoS ONE. 2012;7:e43040 pubmed publisher
    ..In the context of other developmental endocrinology studies, our results indicate a highly dynamic interrenal-vessel interaction immediately before the onset of stress response in the zebrafish embryo. ..
  69. Pala I, Schartl M, Thorsteinsdóttir S, Coelho M. Sex determination in the Squalius alburnoides complex: an initial characterization of sex cascade elements in the context of a hybrid polyploid genome. PLoS ONE. 2009;4:e6401 pubmed publisher
    ..The hybrid polyploid complex of Squalius alburnoides was used as a model to address this question...