Gene Symbol: wnt8a
Description: wingless-type MMTV integration site family, member 8a
Alias: wnt-8, wnt8, wnt8.1, wu:fa20e02, wu:fe05d07, protein Wnt-8a ORF1, etID309727.14
Species: zebrafish
Products:     wnt8a

Top Publications

  1. Major M, Camp N, Berndt J, Yi X, Goldenberg S, Hubbert C, et al. Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science. 2007;316:1043-6 pubmed
    ..These data provide a possible mechanistic explanation for the tumor suppressor activity of WTX. ..
  2. Van Raay T, Fortino N, Miller B, Ma H, Lau G, Li C, et al. Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of ?-catenin. PLoS ONE. 2011;6:e18650 pubmed publisher
    ..Given the conserved nature of Nkd1, our results shed light on the negative feedback regulation of Wnt signaling through the Nkd1-mediated negative control of nuclear accumulation of ?-catenin. ..
  3. Ramel M, Buckles G, Baker K, Lekven A. WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation. Dev Biol. 2005;287:237-48 pubmed
    ..the subsequent subdivision of non-axial mesoderm into multiple D/V fate domains is known to involve zygotic Wnt8 and BMP signaling as well as the Vent/Vox/Ved family of transcriptional repressors, how levels of signaling ..
  4. Caron A, Xu X, Lin X. Wnt/?-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. Development. 2012;139:514-24 pubmed publisher
    ..Moreover, our results also prompt a hypothesis that certain developmental effects of the Wnt/?-catenin pathway are due to the activation of Foxj1 and cilia formation...
  5. Shimizu T, Bae Y, Muraoka O, Hibi M. Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Dev Biol. 2005;279:125-41 pubmed
    ..In zebrafish, wnt3a and wnt8 are expressed in overlapping domains in the blastoderm margin and later in the tailbud...
  6. Hayes M, Naito M, Daulat A, Angers S, Ciruna B. Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/?-catenin-dependent cell fate decisions during vertebrate development. Development. 2013;140:1807-18 pubmed publisher
  7. Rhinn M, Lun K, Ahrendt R, Geffarth M, Brand M. Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal. Neural Dev. 2009;4:12 pubmed publisher
    ..Previous studies have shown that gbx1 is a target of Wnt8 graded activity in the early neural plate...
  8. Rhinn M, Lun K, Luz M, Werner M, Brand M. Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling. Development. 2005;132:1261-72 pubmed
    ..of the MHB organizer is tightly linked to overall neuroectodermal posteriorization, and specifically depends on Wnt8 signaling emanating from lateral mesendodermal precursors...
  9. Hu T, Li C, Cao Z, Van Raay T, Smith J, Willert K, et al. Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane. J Biol Chem. 2010;285:13561-8 pubmed publisher
    ..These results provide a mechanism by which NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation. ..

More Information


  1. Momoi A, Yoda H, Steinbeisser H, Fagotto F, Kondoh H, Kudo A, et al. Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8. Mech Dev. 2003;120:477-89 pubmed
    ..b>Wnt8 is a secreted factor that is expressed in non-axial mesoderm...
  2. Goessling W, North T, Loewer S, Lord A, Lee S, Stoick Cooper C, et al. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009;136:1136-47 pubmed publisher
    ..Our work provides in vivo evidence that Wnt activation in stem cells requires PGE2, and suggests the PGE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery. ..
  3. Lekven A, Thorpe C, Waxman J, Moon R. Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. Dev Cell. 2001;1:103-14 pubmed
    In vertebrates, wnt8 has been implicated in the early patterning of the mesoderm. To determine directly the embryonic requirements for wnt8, we generated a chromosomal deficiency in zebrafish that removes the bicistronic wnt8 locus...
  4. Goessling W, North T, Lord A, Ceol C, Lee S, Weidinger G, et al. APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol. 2008;320:161-74 pubmed publisher
    ..These studies reveal an important and time-dependent role for wnt signaling during liver development and regeneration. ..
  5. Ramel M, Buckles G, Lekven A. Conservation of structure and functional divergence of duplicated Wnt8s in pufferfish. Dev Dyn. 2004;231:441-8 pubmed publisher
    The zebrafish wnt8 locus differs from its tetrapod counterparts in that it produces two functionally overlapping but distinct Wnt8 proteins...
  6. Lin X, Xu X. Distinct functions of Wnt/beta-catenin signaling in KV development and cardiac asymmetry. Development. 2009;136:207-17 pubmed publisher
    ..In summary, our results reveal a previously unexpected role of Wnt-Gata4 signaling in the control of asymmetric signal propagation from the LPM to the cardiac field. ..
  7. Ramel M, Lekven A. Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox. Development. 2004;131:3991-4000 pubmed
    ..b>Wnt8 is required for ventral patterning in both Xenopus and zebrafish; however, its mechanism of action remains unclear...
  8. Cavodeassi F, Carreira Barbosa F, Young R, Concha M, Allende M, Houart C, et al. Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway. Neuron. 2005;47:43-56 pubmed
  9. Pelegri F. Maternal factors in zebrafish development. Dev Dyn. 2003;228:535-54 pubmed
  10. Agathon A, Thisse C, Thisse B. The molecular nature of the zebrafish tail organizer. Nature. 2003;424:448-52 pubmed
    ..Loss-of-function experiments reveal that bone morphogenetic protein (BMP), Nodal and Wnt8 signalling pathways are required for tail development...
  11. Thorpe C, Weidinger G, Moon R. Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development. 2005;132:1763-72 pubmed
    ..We show here that both wnt3a and wnt8 are expressed in the zebrafish tailbud and that simultaneous inhibition of both wnt3a and wnt8 using morpholino ..
  12. zhan G, Sezgin E, Wehner D, Pfister A, K hl S, Kagermeier Schenk B, et al. Lypd6 enhances Wnt/?-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains. Dev Cell. 2013;26:331-45 pubmed publisher
    ..lypd6 enhances Wnt signaling in zebrafish and Xenopus embryos and in mammalian cells, and it is required for wnt8-mediated patterning of the mesoderm and neuroectoderm during zebrafish gastrulation...
  13. Kumari P, Gilligan P, Lim S, Tran L, Winkler S, Philp R, et al. An essential role for maternal control of Nodal signaling. elife. 2013;2:e00683 pubmed publisher
    ..Thus, Ybx1 prevents ectopic Nodal activity, revealing a new paradigm in the regulation of Nodal signaling, which is likely to be conserved. DOI:http://dx.doi.org/10.7554/eLife.00683.001. ..
  14. Kelly G, Greenstein P, Erezyilmaz D, Moon R. Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways. Development. 1995;121:1787-99 pubmed
    ..We have identified two zebrafish wnt8 paralogs related to Xwnt-8B and Xwnt-8, respectively...
  15. Fekany Lee K, Gonzalez E, Miller Bertoglio V, Solnica Krezel L. The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways. Development. 2000;127:2333-45 pubmed
    ..The posteriorization of neuroectoderm in boz was correlated with ectopic dorsal wnt8 expression...
  16. Harvey S, Tümpel S, Dubrulle J, Schier A, Smith J. no tail integrates two modes of mesoderm induction. Development. 2010;137:1127-35 pubmed publisher
    ..At later stages in development ntl is required for notochord formation, and our analysis has also led to the identification of the enhancer required for ntl expression in the developing notochord. ..
  17. Wu S, Shin J, Sepich D, Solnica Krezel L. Chemokine GPCR signaling inhibits ?-catenin during zebrafish axis formation. PLoS Biol. 2012;10:e1001403 pubmed publisher
    ..Our study delineates a novel negative, Gsk3?-independent control mechanism of ?-catenin and implicates Ccr7 as a long-hypothesized GPCR regulating vertebrate axis formation. ..
  18. Erter C, Wilm T, Basler N, Wright C, Solnica Krezel L. Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. Development. 2001;128:3571-83 pubmed
    ..We have analyzed the requirement for the specific ventrolaterally expressed Wnt8 ligand in the posteriorization of neural tissue in zebrafish wild-type and Nodal-deficient embryos (Antivin ..
  19. Martin B, Kimelman D. Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formation. Dev Cell. 2008;15:121-33 pubmed publisher
    ..autonomous, and demonstrate that Ntl and Bra are required for and can induce expression of the canonical Wnts wnt8 and wnt3a...
  20. Luz M, Spannl Müller S, Ozhan G, Kagermeier Schenk B, Rhinn M, Weidinger G, et al. Dynamic association with donor cell filopodia and lipid-modification are essential features of Wnt8a during patterning of the zebrafish neuroectoderm. PLoS ONE. 2014;9:e84922 pubmed publisher
    ..Many Wnt proteins are post-translationally modified by addition of lipid adducts. Wnt8a provides a crucial signal for patterning the anteroposterior axis of the developing neural plate in vertebrates...
  21. Tran L, Hino H, Quach H, Lim S, Shindo A, Mimori Kiyosue Y, et al. Dynamic microtubules at the vegetal cortex predict the embryonic axis in zebrafish. Development. 2012;139:3644-52 pubmed publisher
    ..Furthermore, we find that parallel microtubule arrays colocalize with wnt8a RNA, the candidate maternal dorsal factor...
  22. Szeto D, Kimelman D. Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation. Development. 2004;131:3751-60 pubmed
    ..We present a model in which overlapping Wnt and Bmp signals in the ventrolateral region activate the expression of tbx6 and other posterior mesodermal genes, leading to the formation of posterior structures. ..
  23. Seiliez I, Thisse B, Thisse C. FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation. Dev Biol. 2006;290:152-63 pubmed
    ..These phenotypes can be fully rescued by overexpression of Wnt inhibitors or by inactivation of wnt8a. Altogether, foxA3 and goosecoid cooperate to promote formation of anterior neural tissue by protecting, as early ..
  24. Angers S, Thorpe C, Biechele T, Goldenberg S, Zheng N, MacCoss M, et al. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol. 2006;8:348-57 pubmed
  25. Novikov N, Evans T. Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling. Development. 2013;140:3787-98 pubmed publisher
    ..Tmem88a is a novel component of the regulatory mechanism controlling the second phase of biphasic WNT activity essential for embryonic cardiogenesis. ..
  26. Xie X, Liu J, Hu B, Xiao W. Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis. PLoS ONE. 2011;6:e24469 pubmed publisher
    ..Our studies provide an in vivo model for illustrating function of FOXO transcription factors in embryogenesis. ..
  27. Miyake A, Nihno S, Murakoshi Y, Satsuka A, Nakayama Y, Itoh N. Neucrin, a novel secreted antagonist of canonical Wnt signaling, plays roles in developing neural tissues in zebrafish. Mech Dev. 2012;128:577-90 pubmed publisher
    ..Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues and plays roles in neural development in zebrafish. ..
  28. Thorpe C, Moon R. nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development. Development. 2004;131:2899-909 pubmed
    ..We show that overexpressed zebrafish nlk, in concert with wnt8, can downregulate two tcf3 homologs, tcf3a and tcf3b, that repress Wnt targets during neurectodermal patterning...
  29. Li Z, Nie F, Wang S, Li L. Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation. Proc Natl Acad Sci U S A. 2011;108:3116-23 pubmed publisher
    ..Our findings also indicate that H4K20me-1 is a marker for gene transcription activation, at least in canonical Wnt signaling. ..
  30. Lin X, Rinaldo L, Fazly A, Xu X. Depletion of Med10 enhances Wnt and suppresses Nodal signaling during zebrafish embryogenesis. Dev Biol. 2007;303:536-48 pubmed
    ..Thus, Med10 appears to be a unique MED subunit that differentially transduces information from distinct signaling pathways during zebrafish embryogenesis. ..
  31. Narayanan A, Lekven A. Biphasic wnt8a expression is achieved through interactions of multiple regulatory inputs. Dev Dyn. 2012;241:1062-75 pubmed publisher
    Vertebrate axis development depends upon wnt8a transcription in a dynamic pool of mesoderm progenitors at the posterior pole of the gastrulating embryo...
  32. Angonin D, Van Raay T. Nkd1 functions as a passive antagonist of Wnt signaling. PLoS ONE. 2013;8:e74666 pubmed publisher
    ..Overexpression of the canonical Wnt/?-catenin ligand Wnt8a in slb or tri mutants resulted in dorsalized embryos, with tri mutants being much more sensitive to Wnt8a than slb ..
  33. Liu J, Zhang D, Xie X, Ouyang G, Liu X, Sun Y, et al. Eaf1 and Eaf2 negatively regulate canonical Wnt/?-catenin signaling. Development. 2013;140:1067-78 pubmed publisher
    ..In summary, our evidence points to a novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt/?-catenin signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity. ..
  34. Dohn T, Waxman J. Distinct phases of Wnt/?-catenin signaling direct cardiomyocyte formation in zebrafish. Dev Biol. 2012;361:364-76 pubmed publisher
  35. Nam M, Kim G, Yun S, Jang J, Kim Y, Choi E, et al. Harmless effects of argon plasma on caudal fin regeneration and embryogenesis of zebrafish: novel biological approaches for safe medical applications of bioplasma. Exp Mol Med. 2017;49:e355 pubmed publisher
    ..Remarkably, Ar-PJ did not affect the expression patterns of Wnt8a and β-Catenin, which play important roles in fin regeneration...
  36. Kenyon E, Campos I, Bull J, Williams P, Stemple D, Clark M. Zebrafish Rab5 proteins and a role for Rab5ab in nodal signalling. Dev Biol. 2015;397:212-24 pubmed publisher
    ..We conclude that rab5ab is essential for nodal signalling and organizer specification in the developing zebrafish embryo. ..
  37. Ro H, Dawid I. Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish. EMBO J. 2011;30:2894-907 pubmed publisher
    ..We propose that the modulation of Tcf3 repressor function by E4f1 assures precise and robust regulation of cdx4 expression in the caudal domain of the embryo. ..
  38. Zhu P, Xu X, Lin X. Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning. Biol Open. 2015;4:1376-86 pubmed publisher
    ..We showed that targeted injection of wnt8a mRNA into a single cell at the 128-cell stage is sufficient to induce ectopic foxj1a expression and ectopic cilia...
  39. Welch E, Pelegri F. Cortical depth and differential transport of vegetally localized dorsal and germ line determinants in the zebrafish embryo. Bioarchitecture. 2014;5:13-26 pubmed publisher
    ..We examined the spatial relationship between the proposed dorsal genes wnt8a and grip2a and the PGC factor dazl at the vegetal cortex...
  40. Fior R, Maxwell A, Ma T, Vezzaro A, Moens C, Amacher S, et al. The differentiation and movement of presomitic mesoderm progenitor cells are controlled by Mesogenin 1. Development. 2012;139:4656-65 pubmed publisher
    ..allows progression of the PSM differentiation program by switching off the progenitor maintenance genes ntl, wnt3a, wnt8 and fgf8 in the future PSM cells as they exit from the tailbud, and subsequently induces expression of PSM markers ..
  41. Lewis J, Bonner J, Modrell M, Ragland J, Moon R, Dorsky R, et al. Reiterated Wnt signaling during zebrafish neural crest development. Development. 2004;131:1299-308 pubmed
    ..regard to identifying which endogenous Wnt is responsible for this initial critical period, we established that wnt8 is expressed in the appropriate time and place to participate in this process...
  42. Yee N, Zhou W, Liang I. Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer. Dis Model Mech. 2011;4:240-54 pubmed publisher
    ..Results of this study indicate that Trpm7 regulates exocrine pancreatic development via the Mg(2+)-sensitive Socs3a pathway, and suggest that aberrant TRPM7-mediated signaling contributes to pancreatic carcinogenesis. ..
  43. Hayes M, Gao X, Yu L, Paria N, Henkelman R, Wise C, et al. ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease. Nat Commun. 2014;5:4777 pubmed publisher
    ..Our data suggest novel molecular origins of, and genetic links between, congenital and idiopathic forms of disease. ..
  44. Hu S, Wu Z, Yan Y, Li Y. Sox31 is involved in central nervous system anteroposterior regionalization through regulating the organizer activity in zebrafish. Acta Biochim Biophys Sin (Shanghai). 2011;43:387-99 pubmed publisher
    ..Taken together, Sox31 functions as an essential CNS AP patterning determinant and coordinates the CNS AP patterning process with organizer specification. ..
  45. Baker K, Ramel M, Lekven A. A direct role for Wnt8 in ventrolateral mesoderm patterning. Dev Dyn. 2010;239:2828-36 pubmed publisher
    Vertebrate dorsoventral patterning requires both Wnt8 and BMP signaling. Because of their multiple interactions, discerning roles attributable specifically to Wnt8 independent of BMP has been a challenge...
  46. Shao M, Lin Y, Liu Z, Zhang Y, Wang L, Liu C, et al. GSK-3 activity is critical for the orientation of the cortical microtubules and the dorsoventral axis determination in zebrafish embryos. PLoS ONE. 2012;7:e36655 pubmed publisher
    ..that the parallel pattern of cortical microtubules in the vegetal pole region and the directed migration of the Wnt8a mRNA were randomized by either lithium or GSK-3 inhibitor IX treatment...
  47. Patil P, Kibiryeva N, Uechi T, Marshall J, O Brien J, Artman M, et al. scaRNAs regulate splicing and vertebrate heart development. Biochim Biophys Acta. 2015;1852:1619-29 pubmed publisher
    ..Our findings represent a new paradigm for determining the mechanisms underlying congenital cardiac malformations. ..
  48. Fauny J, Thisse B, Thisse C. The entire zebrafish blastula-gastrula margin acts as an organizer dependent on the ratio of Nodal to BMP activity. Development. 2009;136:3811-9 pubmed publisher
  49. Guan R, El Rass S, Spillane D, Lam S, Wang Y, Wu J, et al. rbm47, a novel RNA binding protein, regulates zebrafish head development. Dev Dyn. 2013;242:1395-404 pubmed publisher
    ..Down-regulation of rbm47 resulted in headless and small head phenotypes, which can be rescued by a wnt8a blocking morpholino...
  50. Cao J, Li S, Zhang H, Shi D. High mobility group B proteins regulate mesoderm formation and dorsoventral patterning during zebrafish and Xenopus early development. Mech Dev. 2012;129:263-74 pubmed publisher
    ..Therefore, our results suggest that hmgb genes may function to fine-tune the specification and/or dorsoventral patterning of mesoderm during zebrafish and Xenopus development. ..
  51. Mwafi N, Beretta C, Paolini A, Carl M. Divergent Wnt8a gene expression in teleosts. PLoS ONE. 2014;9:e85303 pubmed publisher
    ..We report the analysis of Wnt8a gene expression in the medakafish and provide a detailed comparison to other vertebrates...
  52. Shinya M, Eschbach C, Clark M, Lehrach H, Furutani Seiki M. Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate. Mech Dev. 2000;98:3-17 pubmed
    ..The nodal gene squint is also required for the maintenance of dkk1 expression. Among the mutually dependent target genes of the pre-MBT Wnt signaling, dkk1 plays an important role in patterning the anterior head of zebrafish. ..
  53. Jia S, Wu D, Xing C, Meng A. Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish. Dev Biol. 2009;333:273-84 pubmed publisher
    ..Thus, Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis. ..
  54. Goering L, Hoshijima K, Hug B, Bisgrove B, Kispert A, Grunwald D. An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm. Proc Natl Acad Sci U S A. 2003;100:9410-5 pubmed
    ..We propose that T-box genes, like Hox genes, often function within gene networks comprised of related family members. ..
  55. Campbell P, Heim A, Smith M, Marlow F. Kinesin-1 interacts with Bucky ball to form germ cells and is required to pattern the zebrafish body axis. Development. 2015;142:2996-3008 pubmed publisher
    ..Interestingly, whereas Syntabulin and wnt8a translocation depend on kif5Ba, grip2a translocation does not, providing evidence for two distinct mechanisms by ..
  56. Mo S, Wang L, Li Q, Li J, Li Y, Thannickal V, et al. Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish. Dev Biol. 2010;344:210-23 pubmed publisher
    ..Thus, maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin. ..
  57. Leichsenring M, Maes J, Mössner R, Driever W, Onichtchouk D. Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science. 2013;341:1005-9 pubmed publisher
    ..Our data position Pou5f1 and SOX-POU sites at the center of the zygotic gene activation network of vertebrates and provide a link between zygotic gene activation and pluripotency control. ..
  58. Sezgin E, Azbazdar Y, Ng X, Teh C, Simons K, Weidinger G, et al. Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments. FEBS J. 2017;284:2513-2526 pubmed publisher
    ..We thus conclude that ordered plasma membrane environments are essential for binding of canonical Wnts to their receptor complexes and downstream signaling activity. ..
  59. Phillips B, Storch E, Lekven A, Riley B. A direct role for Fgf but not Wnt in otic placode induction. Development. 2004;131:923-31 pubmed
    ..However, an alternative model proposes that Fgf must cooperate with Wnt8 to induce otic differentiation. Using a genetic approach in zebrafish, we tested the roles of Fgf3, Fgf8 and Wnt8...
  60. Tu C, Yang T, Huang H, Tsai H. Zebrafish arl6ip1 is required for neural crest development during embryogenesis. PLoS ONE. 2012;7:e32899 pubmed publisher
    ..Although the embryonic expression pattern of ADP ribosylation factor-like 6 interacting protein 1 (Arl6ip1) has been reported, its function in neural crest development is unclear...
  61. Martin B, Kimelman D. Brachyury establishes the embryonic mesodermal progenitor niche. Genes Dev. 2010;24:2778-83 pubmed publisher
    ..Thus, the embryonic mesodermal progenitors uniquely establish their own niche--with Brachyury being essential for creating a domain of high Wnt and low RA signaling--rather than having a niche created by separate support cells. ..
  62. Flowers G, Topczewska J, Topczewski J. A zebrafish Notum homolog specifically blocks the Wnt/?-catenin signaling pathway. Development. 2012;139:2416-25 pubmed publisher
    ..Notum 1a does not interact with Glypican 4, an essential component of the Wnt/planar cell polarity (PCP) pathway. Our results suggest a surprising specific role of Notum in the developing vertebrate embryo. ..
  63. Nasevicius A, Hyatt T, Kim H, Guttman J, Walsh E, Sumanas S, et al. Evidence for a frizzled-mediated wnt pathway required for zebrafish dorsal mesoderm formation. Development. 1998;125:4283-92 pubmed
    ..frizzled cooperatively interacts with the maternally encoded zebrafish wnt8 protein in dorsal mesodermal fate determination...
  64. Ho C, Houart C, Wilson S, Stainier D. A role for the extraembryonic yolk syncytial layer in patterning the zebrafish embryo suggested by properties of the hex gene. Curr Biol. 1999;9:1131-4 pubmed
    ..that Hex functions as a transcriptional repressor and its overexpression led to the downregulation of bmp2b and wnt8 expression and the expansion of chordin expression...
  65. Bischof J, Driever W. Regulation of hhex expression in the yolk syncytial layer, the potential Nieuwkoop center homolog in zebrafish. Dev Biol. 2004;276:552-62 pubmed
    ..In summary, zebrafish hhex appears to be activated by Wnt/beta-catenin in the dorsal YSL, where Boz acts in a permissive way to limit repression of hhex by Vega1 and Vega2. ..
  66. Peng G, Westerfield M. Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists. Development. 2006;133:3191-200 pubmed
    ..Our results demonstrate that Lhx5 is a required factor that promotes forebrain development and inhibits Wnt signaling by activating the transcription of secreted Wnt antagonists. ..
  67. Griffin K, Kimelman D. One-Eyed Pinhead and Spadetail are essential for heart and somite formation. Nat Cell Biol. 2002;4:821-5 pubmed
    ..We propose that the major role of Spt in somitogenesis is to promote the differentiation of presomitic mesoderm from tailbud progenitors by antagonizing progenitor-type gene expression and behaviour. ..
  68. Nambiar R, Henion P. Sequential antagonism of early and late Wnt-signaling by zebrafish colgate promotes dorsal and anterior fates. Dev Biol. 2004;267:165-80 pubmed
    ..dorsal and anterior patterning phenotypes of the col mutant embryos are selectively rescued by inactivation of Wnt8 function by morpholino translational interference...
  69. Ma Y, Liu X, Liu Z, Wei S, Shang H, Xue Y, et al. The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression. J Neurosci. 2015;35:8493-506 pubmed publisher
    ..interacts with p-Smad2, which is activated by non-Nodal TGF-β signaling, to promote the expression of wnt8a, a critical gene for neural posteriorization...
  70. Stanganello E, Hagemann A, Mattes B, Sinner C, Meyen D, Weber S, et al. Filopodia-based Wnt transport during vertebrate tissue patterning. Nat Commun. 2015;6:5846 pubmed publisher
    ..Here we show that Wnt8a is transported on actin-based filopodia to contact responding cells and activate signalling during neural plate ..
  71. Kim J, Chun H, Kim S, Kim H, Kim Y, Kim M, et al. Normal forebrain development may require continual Wnt antagonism until mid-somitogenesis in zebrafish. Biochem Biophys Res Commun. 2009;381:717-21 pubmed publisher
    ..These results suggest that normal forebrain development requires continual Wnt antagonism from the early gastrula to the mid-somitogenesis stage. ..
  72. Kategaya L, Changkakoty B, Biechele T, Conrad W, Kaykas A, DasGupta R, et al. Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. PLoS ONE. 2009;4:e6129 pubmed publisher
    ..These studies identify Bili as an evolutionarily conserved negative regulator of the Wnt/beta-catenin pathway. ..
  73. Chen J, Gao H, Zhang Y, Zhang Y, Zhou X, Li C, et al. Developmental toxicity of diclofenac and elucidation of gene regulation in zebrafish (Danio rerio). Sci Rep. 2014;4:4841 pubmed publisher
    ..g. down-regulation of Wnt3a and Gata4 and up-regulation of Wnt8a. The alteration of expression of such genes or the regulation of downstream genes could cause defects in the ..
  74. Ding Y, Xi Y, Chen T, Wang J, Tao D, Wu Z, et al. Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J Cell Biol. 2008;182:865-72 pubmed publisher
    ..Therefore, Caprin-2 promotes activation of the canonical Wnt signaling pathway by regulating LRP5/6 phosphorylation. ..
  75. Zhao X, Kuja Panula J, Rouhiainen A, Chen Y, Panula P, Rauvala H. High mobility group box-1 (HMGB1; amphoterin) is required for zebrafish brain development. J Biol Chem. 2011;286:23200-13 pubmed publisher
    ..progenitors and displays fewer cell groups expressing the transcription factor Pax6a in the forebrain and aberrant Wnt8 signaling...
  76. Yabe T, Takada S. Mesogenin causes embryonic mesoderm progenitors to differentiate during development of zebrafish tail somites. Dev Biol. 2012;370:213-22 pubmed publisher
    ..msgn1) and spt failed to differentiate into PSM cells in tail development and show increased expression of wnt8 and ntl. Msgn1 acted in a cell-autonomous manner and as a transcriptional activator in PSM differentiation...
  77. Sorrell M, Dohn T, D Aniello E, Waxman J. Tcf7l1 proteins cell autonomously restrict cardiomyocyte and promote endothelial specification in zebrafish. Dev Biol. 2013;380:199-210 pubmed publisher
    ..This study expands our understanding of the in vivo developmental requirements of Tcf7l1 proteins and the mechanisms directing CM development in vertebrates. ..