wnt5b

Summary

Gene Symbol: wnt5b
Description: wingless-type MMTV integration site family, member 5b
Alias: CHUNP6928, id:ibd5111, pipetail, ppt, wnt-5, wnt5, wnt[b], wu:fk85g06, protein Wnt-5b, pipe tail
Species: zebrafish
Products:     wnt5b

Top Publications

  1. Rauch G, Hammerschmidt M, Blader P, Schauerte H, Strahle U, Ingham P, et al. Wnt5 is required for tail formation in the zebrafish embryo. Cold Spring Harb Symp Quant Biol. 1997;62:227-34 pubmed
    ..Here, we show that the zebrafish pipetail gene is identical to wnt5...
  2. Chang W, Tsai J, Chen B, Fu T. Cloning, expression, purification, and characterization of zebrafish cytosolic serine hydroxymethyltransferase. Protein Expr Purif. 2006;46:212-20 pubmed
    ..Kinetic constants for the natural substrates l-serine and tetrahydrofolate are also comparable to the values obtained previously for the rabbit and human cytosolic enzyme. ..
  3. Stoick Cooper C, Weidinger G, Riehle K, Hubbert C, Major M, Fausto N, et al. Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development. 2007;134:479-89 pubmed
    ..By contrast, overexpression of wnt5b (pipetail) reduces expression of Wnt/beta-catenin target genes, impairs proliferation of progenitors and inhibits fin ..
  4. Hammerschmidt M, Pelegri F, Mullins M, Kane D, Brand M, van Eeden F, et al. Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development. 1996;123:143-51 pubmed
    ..Two genes are required for the development of the posterior end of the body axis. In pipetail mutants, the tailbud fails to move ventrally on the yolk sac after germ ring closure, and the tip of the tail ..
  5. Westfall T, Brimeyer R, Twedt J, Gladon J, Olberding A, Furutani Seiki M, et al. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol. 2003;162:889-98 pubmed
    ..We describe genetic interaction between two Wnt/Ca2+ members, Wnt-5 (pipetail) and Wnt-11 (silberblick), and a reduction of Ca2+ release in Wnt-5/pipetail...
  6. Blum N, Begemann G. Retinoic acid signaling controls the formation, proliferation and survival of the blastema during adult zebrafish fin regeneration. Development. 2012;139:107-16 pubmed publisher
  7. Piotrowski T, Schilling T, Brand M, Jiang Y, Heisenberg C, Beuchle D, et al. Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation. Development. 1996;123:345-56 pubmed
    ..The mutants presented here may be valuable tools for elucidating the genetic mechanisms that underlie the development of the mandibular and the hyoid arches, as well as the process of cartilage differentiation...
  8. Bouzaffour M, Dufourcq P, Lecaudey V, Haas P, Vriz S. Fgf and Sdf-1 pathways interact during zebrafish fin regeneration. PLoS ONE. 2009;4:e5824 pubmed publisher
    ..This observation supports the idea that the regeneration process involves a delicate balance between multiple pathways. ..
  9. Chablais F, Jazwinska A. IGF signaling between blastema and wound epidermis is required for fin regeneration. Development. 2010;137:871-9 pubmed publisher
    ..Thus, IGF signaling upregulated upon fin amputation represents a signal from the blastema to the wound epithelium, a crucial step in appendage regeneration. ..

More Information

Publications77

  1. Kim H, Schleiffarth J, Jessurun J, Sumanas S, Petryk A, Lin S, et al. Wnt5 signaling in vertebrate pancreas development. BMC Biol. 2005;3:23 pubmed
    ..Our results implicate a conserved role of a Wnt5/Fz2 signaling pathway in islet formation during pancreatic development...
  2. Robu M, Larson J, Nasevicius A, Beiraghi S, Brenner C, Farber S, et al. p53 activation by knockdown technologies. PLoS Genet. 2007;3:e78 pubmed
    ..p53 inhibition could potentially be applicable to other systems to suppress off-target effects caused by other knockdown technologies. ..
  3. Jopling C, Hertog J. Essential role for Csk upstream of Fyn and Yes in zebrafish gastrulation. Mech Dev. 2007;124:129-36 pubmed
    ..The Csk knock down phenotype was rescued by simultaneous partial knock down of Fyn and Yes. We conclude that Csk acts upstream of Fyn and Yes to control vertebrate gastrulation cell movements. ..
  4. Kilian B, Mansukoski H, Barbosa F, Ulrich F, Tada M, Heisenberg C. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech Dev. 2003;120:467-76 pubmed
    ..To determine if other Wnt genes functionally interact with slb/wnt11, we analysed the role of ppt/wnt5 during zebrafish gastrulation...
  5. Lee Y, Hami D, De Val S, Kagermeier Schenk B, Wills A, Black B, et al. Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. Dev Biol. 2009;331:270-80 pubmed publisher
    ..factor lef1 and the blastemal mitogen shh, while distal subtypes express the Fgf target gene pea3 and wnt5b, an inhibitor of blastemal proliferation...
  6. Jopling C, den Hertog J. Fyn/Yes and non-canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements. EMBO Rep. 2005;6:426-31 pubmed
    ..and Yes tyrosine kinases in zebrafish embryos impaired normal CE cell movements, resembling the silberblick and pipetail mutants, caused by mutations in wnt11 and wnt5, respectively...
  7. von der Hardt S, Bakkers J, Inbal A, Carvalho L, Solnica Krezel L, Heisenberg C, et al. The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Curr Biol. 2007;17:475-87 pubmed
  8. De Rienzo G, Gutzman J, Sive H. Efficient shRNA-mediated inhibition of gene expression in zebrafish. Zebrafish. 2012;9:97-107 pubmed publisher
    ..Using an F0 transgenic approach, this report demonstrates that for two genes, wnt5b and zDisc1, each with described mutant and morphant phenotypes, shRNAs efficiently decrease endogenous RNA levels...
  9. Gu Q, Yang X, He X, Li Q, Cui Z. Generation and characterization of a transgenic zebrafish expressing the reverse tetracycline transactivator. J Genet Genomics. 2013;40:523-31 pubmed publisher
    ..Thus, this rtTA-transgenic zebrafish can be utilized to dissect functions of genes in a temporal manner. ..
  10. Guo L, Yamashita H, Kou I, Takimoto A, Meguro Horike M, Horike S, et al. Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation. PLoS Genet. 2016;12:e1005802 pubmed publisher
    ..In embryos overexpressing lbx1b, wnt5b, a ligand of the non-canonical Wnt/planar cell polarity (PCP) pathway, was significantly downregulated...
  11. Weiser D, Row R, Kimelman D. Rho-regulated myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation. Development. 2009;136:2375-84 pubmed publisher
  12. Pei W, Feldman B. Identification of common and unique modifiers of zebrafish midline bifurcation and cyclopia. Dev Biol. 2009;326:201-11 pubmed publisher
    ..Bifurcations do not appear until the completion of gastrulation and are preceded by gaps in the expression of wnt5b, an essential regulator of dorsal convergence...
  13. Hayes M, Naito M, Daulat A, Angers S, Ciruna B. Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/?-catenin-dependent cell fate decisions during vertebrate development. Development. 2013;140:1807-18 pubmed publisher
  14. Xu J, Zhang Q, Li X, Zhan S, Wang L, Chen D. The effects of copper oxide nanoparticles on dorsoventral patterning, convergent extension, and neural and cardiac development of zebrafish. Aquat Toxicol. 2017;188:130-137 pubmed publisher
    ..narrow the expression of chordin and goosecoid in dorsoventral patterning as well as decrease the transcription of Wnt5 and Wnt11 to result in slower, less directed movements and an abnormal cell shape...
  15. LeClair E, Mui S, Huang A, Topczewska J, Topczewski J. Craniofacial skeletal defects of adult zebrafish Glypican 4 (knypek) mutants. Dev Dyn. 2009;238:2550-63 pubmed publisher
    ..In contrast, gpc4(-/-) larvae never form these domains, suggesting a failure of chondrocyte orientation, though not differentiation. Our findings implicate Gpc4 in the regulation of zebrafish cartilage and bone morphogenesis. ..
  16. Na Y, Seok S, Baek M, Lee H, Kim D, Park S, et al. Protective effects of vitamin E against 3,3',4,4',5-pentachlorobiphenyl (PCB126) induced toxicity in zebrafish embryos. Ecotoxicol Environ Saf. 2009;72:714-9 pubmed publisher
    ..These data give insights into the use of vitamin E to reduce PCB126-mediated toxicity and into the use of zebrafish embryos for exploring mechanisms underlying the oxidative potential of AHR agonists. ..
  17. Ling I, Rochard L, Liao E. Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification. Dev Biol. 2017;421:219-232 pubmed publisher
    ..Here we examined the role of the non-canonical Wnt signaling pathway (wls, gpc4, wnt5b and wnt9a) in regulating zebrafish Meckel's cartilage maturation to the onset of osteogenic differentiation...
  18. Sisson B, Dale R, Mui S, Topczewska J, Topczewski J. A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis. Mech Dev. 2015;138 Pt 3:279-90 pubmed publisher
    ..defects they do not display the chondrocyte stacking and intercalation problems seen in glypican 4 (gpc4) and wnt5b mutants...
  19. Blader P, Strahle U, Ingham P. Three Wnt genes expressed in a wide variety of tissues during development of the zebrafish, Danio rerio: developmental and evolutionary perspectives. Dev Genes Evol. 1996;206:3-13 pubmed publisher
    ..In the light of the similarities and differences in the patterns of expression of these genes relative to their homologues in other vertebrates, we speculate on their possible functions. ..
  20. Montero Balaguer M, Lang M, Sachdev S, Knappmeyer C, Stewart R, De La Guardia A, et al. The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish. Dev Dyn. 2006;235:3199-212 pubmed
    ..Further analysis of mosm188 mutants and foxd3 morphants revealed that NC cells are initially formed, suggesting that foxd3 function is required to maintain the pool of NC progenitors. ..
  21. Seo J, Asaoka Y, Nagai Y, Hirayama J, Yamasaki T, Namae M, et al. Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. J Cell Biochem. 2010;110:1022-37 pubmed publisher
    ..Furthermore, non-canonical Wnt signaling may coordinate vertebrate CE movements by triggering Jnk activation that represses the expression of the CE-triggering ligand wnt11. ..
  22. Stewart S, Gomez A, Armstrong B, Henner A, Stankunas K. Sequential and opposing activities of Wnt and BMP coordinate zebrafish bone regeneration. Cell Rep. 2014;6:482-98 pubmed publisher
    ..This hierarchical signaling network model provides a conceptual framework for understanding innate bone repair and regeneration mechanisms and rationally designing regenerative therapeutics. ..
  23. Rochard L, Monica S, Ling I, Kong Y, Roberson S, Harland R, et al. Roles of Wnt pathway genes wls, wnt9a, wnt5b, frzb and gpc4 in regulating convergent-extension during zebrafish palate morphogenesis. Development. 2016;143:2541-7 pubmed publisher
    ..We describe that the chaperon Wls and its ligands Wnt9a and Wnt5b are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb and Gpc4...
  24. Pfefferli C, Muller F, Jazwinska A, Wicky C. Specific NuRD components are required for fin regeneration in zebrafish. BMC Biol. 2014;12:30 pubmed publisher
    ..These results provide in vivo evidence for the involvement of key epigenetic factors in the cellular reprogramming processes occurring during epimorphic regeneration in zebrafish. ..
  25. Pauli A, Montague T, Lennox K, Behlke M, Schier A. Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish. PLoS ONE. 2015;10:e0139504 pubmed publisher
    ..Despite this drawback, quantitation of knockdown efficiency and the ability to degrade lncRNAs make ASOs a useful knockdown reagent in zebrafish. ..
  26. Armas P, Margarit E, Mouguelar V, Allende M, Calcaterra N. Beyond the binding site: in vivo identification of tbx2, smarca5 and wnt5b as molecular targets of CNBP during embryonic development. PLoS ONE. 2013;8:e63234 pubmed publisher
    ..We successfully confirmed that CNBP up-regulates tbx2b and smarca5, and down-regulates wnt5b gene expression...
  27. Freisinger C, Fisher R, Slusarski D. Regulator of g protein signaling 3 modulates wnt5b calcium dynamics and somite patterning. PLoS Genet. 2010;6:e1001020 pubmed publisher
    ..Here, we identify rgs3 as having an overlapping expression pattern with wnt5b in zebrafish and reveal that individual knockdown of either rgs3 or wnt5b gene function produces similar somite ..
  28. Jopling C, van Geemen D, den Hertog J. Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects. PLoS Genet. 2007;3:e225 pubmed
    ..The finding that defective Shp2 signaling induced cell movement defects as early as gastrulation may have implications for the monitoring and diagnosis of Noonan and LEOPARD syndrome...
  29. Kagermeier Schenk B, Wehner D, Ozhan Kizil G, Yamamoto H, Li J, Kirchner K, et al. Waif1/5T4 inhibits Wnt/?-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization. Dev Cell. 2011;21:1129-43 pubmed publisher
    ..These results suggest that Waif1 modulates pathway selection in Wnt-receiving cells. ..
  30. Cirone P, Lin S, Griesbach H, Zhang Y, Slusarski D, Crews C. A role for planar cell polarity signaling in angiogenesis. Angiogenesis. 2008;11:347-60 pubmed publisher
    ..In addition, we show that the zebrafish Wnt5 mutant (pipetail (ppt)), which has impaired PCP signaling, displays vascular developmental defects...
  31. Yin A, Korzh S, Winata C, Korzh V, Gong Z. Wnt signaling is required for early development of zebrafish swimbladder. PLoS ONE. 2011;6:e18431 pubmed publisher
    ..We also demonstrated that genes encoding Wnt signaling members Wnt5b, Fz2, Fz7b, Lef1, Tcf3 were expressed in different layers of swimbladder...
  32. Louwette S, Labarque V, Wittevrongel C, Thys C, Metz J, Gijsbers R, et al. Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system. FASEB J. 2012;26:2125-36 pubmed publisher
    ..On the basis of literature evidence that RGS-R4 members interact with the G-protein-modulated Wnt/calcium pathway, Wnt5b- but not Wnt5a-depleted embryos phenocopy all RGS18 knockdown effects...
  33. Heisenberg C, Tada M. Zebrafish gastrulation movements: bridging cell and developmental biology. Semin Cell Dev Biol. 2002;13:471-9 pubmed
    ..The identification of the genes mutated in these lines together with the analysis of the mutant phenotypes has provided new insights into the molecular and cellular mechanisms that underlie vertebrate gastrulation movements. ..
  34. Moeller H, Jenny A, Schaeffer H, Schwarz Romond T, Mlodzik M, Hammerschmidt M, et al. Diversin regulates heart formation and gastrulation movements in development. Proc Natl Acad Sci U S A. 2006;103:15900-5 pubmed
    ..Our data thus demonstrate that Diversin and Dishevelled function together in a mutually dependent fashion in zebrafish gastrulation and organ formation. ..
  35. Lin S, Baye L, Westfall T, Slusarski D. Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement. J Cell Biol. 2010;190:263-78 pubmed publisher
    ..However, Wnt-Ryk signaling during embryogenesis is less well characterized. In this study, we report a role for Wnt5b as an instructive cue to regulate gastrulation movements through Ryk...
  36. Barrallo Gimeno A, Holzschuh J, Driever W, Knapik E. Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function. Development. 2004;131:1463-77 pubmed
  37. Goudevenou K, Martin P, Yeh Y, Jones P, Sablitzky F. Def6 is required for convergent extension movements during zebrafish gastrulation downstream of Wnt5b signaling. PLoS ONE. 2011;6:e26548 pubmed publisher
    ..and shortened body axis with normal cell fate specification, reminiscent of the zebrafish mutants silberblick and pipetail that lack Wnt11 or Wnt5b, respectively...
  38. Haffter P, Granato M, Brand M, Mullins M, Hammerschmidt M, Kane D, et al. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development. 1996;123:1-36 pubmed
    ..Here we give an overview of the spectrum of mutant phenotypes obtained, and discuss the limits and the potentials of a genetic saturation screen in the zebrafish. ..
  39. Young T, Poobalan Y, Tan E, Tao S, Ong S, Wehner P, et al. The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish. Development. 2014;141:3505-16 pubmed publisher
    ..that are coordinated by components of the non-canonical, β-catenin-independent Wnt signaling pathway, including Wnt5b and the transmembrane planar cell polarity (PCP) protein Vangl2...
  40. Oteiza P, Köppen M, Krieg M, Pulgar E, Farias C, Melo C, et al. Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. Development. 2010;137:3459-68 pubmed publisher
    ..Our results reveal a novel role for PCP-dependent cell adhesion in coordinating the supracellular organisation of progenitor cells during vertebrate laterality organ formation. ..
  41. Gauron C, Rampon C, Bouzaffour M, Ipendey E, Teillon J, Volovitch M, et al. Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed. Sci Rep. 2013;3:2084 pubmed publisher
    ..These results implicate oxidative stress in regeneration and provide new insights into the differences between healing and regeneration. ..
  42. Xu X, Shuen W, Chen C, Goudevenou K, Jones P, Sablitzky F. Swap70b is required for convergent and extension cell movement during zebrafish gastrulation linking Wnt11 signalling and RhoA effector function. Dev Biol. 2014;386:191-203 pubmed publisher
    ..This is distinct from the related Def6a protein that acts downstream of Wnt5b. Def6a/Swap70b morphants resemble Ppt/Slb double mutant embryos suggesting that Swap70b and Def6a delineate Wnt11 ..
  43. Ciruna B, Jenny A, Lee D, Mlodzik M, Schier A. Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature. 2006;439:220-4 pubmed
    ..These results reveal a function for PCP signalling in coupling cell division and morphogenesis at neurulation and indicate a previously unrecognized mechanism that might underlie NTDs. ..
  44. Simões M, Bensimon Brito A, Fonseca M, Farinho A, Valério F, Sousa S, et al. Denervation impairs regeneration of amputated zebrafish fins. BMC Dev Biol. 2014;14:49 pubmed publisher
  45. Zhu S, Liu L, Korzh V, Gong Z, Low B. RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling. Cell Signal. 2006;18:359-72 pubmed
    ..Injection of rhoA mRNA effectively rescued such defects in wnt5 and wnt11 mutants...
  46. Thorimbert V, König D, Marro J, Ruggiero F, Jaźwińska A. Bone morphogenetic protein signaling promotes morphogenesis of blood vessels, wound epidermis, and actinotrichia during fin regeneration in zebrafish. FASEB J. 2015;29:4299-312 pubmed publisher
    ..It organizes the wound epithelium by triggering wnt5b expression and promoting Collagen XIV-A deposition into the basement membrane...
  47. Chen Z, Lee H, Henle S, Cheever T, Ekker S, Henley J. Primary neuron culture for nerve growth and axon guidance studies in zebrafish (Danio rerio). PLoS ONE. 2013;8:e57539 pubmed publisher
    ..Thus, this primary neuron culture model system may be useful for studies of neuronal development, chemotropic axon guidance, and mechanisms underlying inhibition of neural regeneration in vitro, and complement observations made in vivo. ..
  48. Chen Q, Takada R, Takada S. Loss of Porcupine impairs convergent extension during gastrulation in zebrafish. J Cell Sci. 2012;125:2224-34 pubmed publisher
    ..Moreover, porcn interacts genetically with wnt5b and wnt11 in regulating CE...
  49. Gerdes J, Liu Y, Zaghloul N, Leitch C, Lawson S, Kato M, et al. Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet. 2007;39:1350-60 pubmed
    ..encode basal body proteins, are required for convergence and extension in zebrafish and interact with wnt11 and wnt5b. Suppression of bbs1, bbs4 and mkks transcripts results in stabilization of beta-catenin with concomitant ..
  50. Matsui T, Raya A, Kawakami Y, Callol Massot C, Capdevila J, Rodriguez Esteban C, et al. Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes Dev. 2005;19:164-75 pubmed
    ..Overall, our results uncover a late, previously unexpected role of noncanonical Wnt signaling in the control of midline assembly of organ precursors during vertebrate embryo development. ..
  51. Panàkovà D, Werdich A, Macrae C. Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. Nature. 2010;466:874-8 pubmed publisher
    ..The regulation of cellular coupling through such mechanisms may be a general property of non-canonical Wnt signals. ..
  52. Nicenboim J, Malkinson G, Lupo T, Asaf L, Sela Y, Mayseless O, et al. Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature. 2015;522:56-61 pubmed
    ..We further identify Wnt5b as a novel lymphatic inductive signal and show that it also promotes the ‘angioblast-to-lymphatic’ ..
  53. Pelegri F. Maternal factors in zebrafish development. Dev Dyn. 2003;228:535-54 pubmed
  54. Paik E, Mahony S, White R, Price E, DiBiase A, Dorjsuren B, et al. A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis. Stem Cell Reports. 2013;1:425-36 pubmed publisher
    ..These findings suggest that auto- and cross-regulation of Cdx4 and Sall4 establish a stable molecular circuit in the mesoderm that facilitates the activation of the blood-specific program as development proceeds...
  55. Gong Y, Mo C, Fraser S. Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature. 2004;430:689-93 pubmed
    ..Furthermore, we propose that non-canonical Wnt signalling has a conserved role in vertebrate axis elongation, orienting both cell intercalation and mitotic division. ..
  56. Yu C, Yao X, Zhao L, Wang P, Zhang Q, Zhao C, et al. Wolf-Hirschhorn Syndrome Candidate 1 (whsc1) Functions as a Tumor Suppressor by Governing Cell Differentiation. Neoplasia. 2017;19:606-616 pubmed publisher
    ..At later stage, these whsc1-/- zebrafishes are inclined to grow tumors in the swim bladder. Our work suggested that whsc1 may function as a tumor suppressor by governing progenitor cell differentiation. ..
  57. Nojima H, Rothhämel S, Shimizu T, Kim C, Yonemura S, Marlow F, et al. Syntabulin, a motor protein linker, controls dorsal determination. Development. 2010;137:923-33 pubmed publisher
    ..Our findings suggest that Syntabulin regulates the microtubule-dependent transport of the DDs, and provide evidence for the link between AV and dorsoventral axis formation. ..
  58. Walsh E, Stainier D. UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish. Science. 2001;293:1670-3 pubmed
    ..The atrioventricular border cells do not differentiate from their neighbors in jekyll mutants, suggesting that Jekyll is required in a cell signaling event that establishes a boundary between the atrium and ventricle. ..
  59. Duncan R, Panahi S, Piotrowski T, Dorsky R. Identification of Wnt Genes Expressed in Neural Progenitor Zones during Zebrafish Brain Development. PLoS ONE. 2015;10:e0145810 pubmed publisher
    ..Our data identify 12 specific ligands that can now be tested using loss-of-function approaches. ..
  60. Lou Q, He J, Hu L, Yin Z. Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish. Biochim Biophys Acta. 2012;1823:1024-32 pubmed publisher
    ..Expression of wnt5b is significantly reduced in lbx2 morphants...
  61. Thorpe C, Weidinger G, Moon R. Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development. 2005;132:1763-72 pubmed
    ..These data place sp5l downstream of wnt3a and wnt8 in a Wnt/beta-catenin signaling pathway that controls tail development in zebrafish. ..
  62. Jantzen C, Annunziato K, Bugel S, Cooper K. PFOS, PFNA, and PFOA sub-lethal exposure to embryonic zebrafish have different toxicity profiles in terms of morphometrics, behavior and gene expression. Aquat Toxicol. 2016;175:160-70 pubmed publisher
    ..PFOS, PFNA, and PFOA exposure resulted in significantly altered responses in terms of morphometric, locomotion, and gene expression endpoints, which could be manifested in field exposed teleosts. ..
  63. Yin C, Solnica Krezel L. Convergence and extension movements mediate the specification and fate maintenance of zebrafish slow muscle precursors. Dev Biol. 2007;304:141-55 pubmed
    ..Our results underscore the significance of precise coordination between cell movements and inductive tissue interactions during cell fate specification. ..
  64. Zhang Y, Yeh J, Mara A, Ju R, Hines J, Cirone P, et al. A chemical and genetic approach to the mode of action of fumagillin. Chem Biol. 2006;13:1001-9 pubmed
    ..morpholino oligonucleotide injection in zebrafish embryos phenocopies gastrulation defects seen in noncanonical Wnt5 loss-of-function zebrafish mutants...
  65. Barresi M, Burton S, Dipietrantonio K, Amsterdam A, Hopkins N, Karlstrom R. Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Dev Dyn. 2010;239:2603-18 pubmed publisher
    ..The genes disrupted in these viral lines have all been identified, providing a powerful new resource for the study of axon guidance, glio- and neurogenesis, and neuron-glial interactions during development of the vertebrate CNS. ..
  66. Yao S, Qian M, Deng S, Xie L, Yang H, Xiao C, et al. Kzp controls canonical Wnt8 signaling to modulate dorsoventral patterning during zebrafish gastrulation. J Biol Chem. 2010;285:42086-96 pubmed publisher
    ..Thus, our results provide the first insight into the mechanism involved in the initiation of zygotic canonical Wnt signals by a maternally derived transcription factor. ..
  67. Miyasaka K, Kida Y, Sato T, Minami M, Ogura T. Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin. Proc Natl Acad Sci U S A. 2007;104:11274-9 pubmed
    ..Our data highlight Csrp1 as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs. ..
  68. Marlow F, Gonzalez E, Yin C, Rojo C, Solnica Krezel L. No tail co-operates with non-canonical Wnt signaling to regulate posterior body morphogenesis in zebrafish. Development. 2004;131:203-16 pubmed
    ..whether genes that regulate cell movements during gastrulation [no tail (ntl)/brachyury, knypek (kny) and pipetail (ppt)/wnt5] interact to regulate posterior body morphogenesis...