wnt11r

Summary

Gene Symbol: wnt11r
Description: wingless-type MMTV integration site family, member 11, related
Alias: wu:fk73h04, protein Wnt-11, fk73h04, wnt11-related
Species: zebrafish

Top Publications

  1. Choudhry P, Trede N. DiGeorge syndrome gene tbx1 functions through wnt11r to regulate heart looping and differentiation. PLoS ONE. 2013;8:e58145 pubmed publisher
    ..We show for the first time that wnt11r (wnt11 related), a member of the non-canonical Wnt pathway, and its downstream effector gene alcama (activated leukocyte cell ..
  2. Choe C, Collazo A, Trinh L, Pan L, Moens C, Crump J. Wnt-dependent epithelial transitions drive pharyngeal pouch formation. Dev Cell. 2013;24:296-309 pubmed publisher
    ..To date, the cellular mechanism and segmental nature of such budding have remained elusive. Here, we find that Wnt11r and Wnt4a from the head mesoderm and ectoderm, respectively, play distinct roles in the segmental formation of ..
  3. Matsui T, Raya A, Kawakami Y, Callol Massot C, Capdevila J, Rodriguez Esteban C, et al. Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes Dev. 2005;19:164-75 pubmed
    ..Overall, our results uncover a late, previously unexpected role of noncanonical Wnt signaling in the control of midline assembly of organ precursors during vertebrate embryo development. ..
  4. Garriock R, D Agostino S, Pilcher K, Krieg P. Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus. Dev Biol. 2005;279:179-92 pubmed
    ..Embryos with reduced Wnt11-R activity exhibit aberrant cell-cell contacts within the myocardial wall and defects in fusion of the nascent heart tube. ..
  5. Banerjee S, Gordon L, Donn T, Berti C, Moens C, Burden S, et al. A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration. Development. 2011;138:3287-96 pubmed publisher
    ..Instead, we find that muscle-specific receptor kinase (MuSK) and its putative ligand Wnt11r are crucial for restricting neural crest cell migration to the center of each somite...
  6. Jing L, Lefebvre J, Gordon L, Granato M. Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor. Neuron. 2009;61:721-33 pubmed publisher
    ..Here, we show that Wnt11r binds to the zebrafish unplugged/MuSK ectodomain to organize this central muscle zone...
  7. Nojima H, Rothhämel S, Shimizu T, Kim C, Yonemura S, Marlow F, et al. Syntabulin, a motor protein linker, controls dorsal determination. Development. 2010;137:923-33 pubmed publisher
    ..Our findings suggest that Syntabulin regulates the microtubule-dependent transport of the DDs, and provide evidence for the link between AV and dorsoventral axis formation. ..
  8. Cui S, Capecci L, Matthews R. Disruption of planar cell polarity activity leads to developmental biliary defects. Dev Biol. 2011;351:229-41 pubmed publisher
    ..Our results demonstrate that PCP plays an important role in vertebrate biliary development, interacting with other factors known to be involved in biliary morphogenesis. ..
  9. Anelli V, Villefranc J, Chhangawala S, Martinez McFaline R, Riva E, Nguyen A, et al. Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression. elife. 2017;6: pubmed publisher
    ..These data suggest that expression of TWIST2 plays a role in an early step of BRAFV600E-mediated transformation. ..

More Information

Publications15

  1. Hino H, Nakanishi A, Seki R, Aoki T, Yamaha E, Kawahara A, et al. Roles of maternal wnt8a transcripts in axis formation in zebrafish. Dev Biol. 2018;434:96-107 pubmed publisher
    ..Finally, we re-examined the maternal wnt genes and found that Wnt6a is an alternative candidate DD. ..
  2. Groves J, Hammond C, Hughes S. Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish. Development. 2005;132:4211-22 pubmed
    ..We conclude that Fgf8 drives terminal differentiation of a specific population of lateral muscle precursor cells within the early somite...
  3. Hardy K, Garriock R, Yatskievych T, D Agostino S, Antin P, Krieg P. Non-canonical Wnt signaling through Wnt5a/b and a novel Wnt11 gene, Wnt11b, regulates cell migration during avian gastrulation. Dev Biol. 2008;320:391-401 pubmed publisher
    ..We conclude that non-canonical Wnt signaling, mediated in part by Wnt11b, is important for regulation of gastrulation cell movements in the avian embryo. ..
  4. Gordon L, Gribble K, Syrett C, Granato M. Initiation of synapse formation by Wnt-induced MuSK endocytosis. Development. 2012;139:1023-33 pubmed publisher
    ..Here, we show that in vivo, wnt11r and wnt4a initiate MuSK translocation from muscle membranes to recycling endosomes and that this transition is ..
  5. Choe C, Crump J. Tbx1 controls the morphogenesis of pharyngeal pouch epithelia through mesodermal Wnt11r and Fgf8a. Development. 2014;141:3583-93 pubmed publisher
    ..we show that Tbx1 functions in the mesoderm to promote the morphogenesis of pouch-forming endoderm through wnt11r and fgf8a expression...
  6. Duncan R, Panahi S, Piotrowski T, Dorsky R. Identification of Wnt Genes Expressed in Neural Progenitor Zones during Zebrafish Brain Development. PLoS ONE. 2015;10:e0145810 pubmed publisher
    ..Our data identify 12 specific ligands that can now be tested using loss-of-function approaches. ..