wnt11

Summary

Gene Symbol: wnt11
Description: wingless-type MMTV integration site family, member 11
Alias: Slb/Wnt11, cb748, slb, protein Wnt-11, Silberblick/Wnt11, silberblick
Species: zebrafish
Products:     wnt11

Top Publications

  1. Zhu S, Liu L, Korzh V, Gong Z, Low B. RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling. Cell Signal. 2006;18:359-72 pubmed
    ..Injection of rhoA mRNA effectively rescued such defects in wnt5 and wnt11 mutants...
  2. Heisenberg C, Nusslein Volhard C. The function of silberblick in the positioning of the eye anlage in the zebrafish embryo. Dev Biol. 1997;184:85-94 pubmed
    ..Mutations in the recently identified silberblick (slb) gene cause an incomplete separation of the eyes...
  3. Kilian B, Mansukoski H, Barbosa F, Ulrich F, Tada M, Heisenberg C. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech Dev. 2003;120:467-76 pubmed
    ..In zebrafish, slb/wnt11 is required for convergence and extension movements, but not cell fate specification during gastrulation...
  4. Lin F, Sepich D, Chen S, Topczewski J, Yin C, Solnica Krezel L, et al. Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements. J Cell Biol. 2005;169:777-87 pubmed
    ..These findings provide the first evidence that Galpha(12) and Galpha(13) have overlapping and essential roles in distinct cell behaviors that drive vertebrate gastrulation. ..
  5. Yao S, Xie L, Qian M, Yang H, Zhou L, Zhou Q, et al. Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation. FEBS Lett. 2008;582:2325-32 pubmed publisher
    ..In addition, genetic interaction assays indicate that Pnas4 might act in parallel with non-canonical Wnt signal in the regulation of cell movement. Our data suggest that Pnas4 is a key regulator of cell movement during gastrulation. ..
  6. Jopling C, Hertog J. Essential role for Csk upstream of Fyn and Yes in zebrafish gastrulation. Mech Dev. 2007;124:129-36 pubmed
    ..The Csk knock down phenotype was rescued by simultaneous partial knock down of Fyn and Yes. We conclude that Csk acts upstream of Fyn and Yes to control vertebrate gastrulation cell movements. ..
  7. Witzel S, Zimyanin V, Carreira Barbosa F, Tada M, Heisenberg C. Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. J Cell Biol. 2006;175:791-802 pubmed
    b>Wnt11 is a key signal, determining cell polarization and migration during vertebrate gastrulation...
  8. Ciruna B, Jenny A, Lee D, Mlodzik M, Schier A. Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature. 2006;439:220-4 pubmed
    ..These results reveal a function for PCP signalling in coupling cell division and morphogenesis at neurulation and indicate a previously unrecognized mechanism that might underlie NTDs. ..
  9. Heisenberg C, Tada M, Rauch G, Saude L, Concha M, Geisler R, et al. Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature. 2000;405:76-81 pubmed
    ..Here we show that the zebrafish silberblick (slb) locus encodes Wnt11 and that Slb/Wnt11 activity is required for cells to undergo correct convergent ..

More Information

Publications83

  1. Westfall T, Brimeyer R, Twedt J, Gladon J, Olberding A, Furutani Seiki M, et al. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol. 2003;162:889-98 pubmed
    ..We describe genetic interaction between two Wnt/Ca2+ members, Wnt-5 (pipetail) and Wnt-11 (silberblick), and a reduction of Ca2+ release in Wnt-5/pipetail...
  2. Ulrich F, Concha M, Heid P, Voss E, Witzel S, Roehl H, et al. Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation. Development. 2003;130:5375-84 pubmed
    ..In zebrafish, silberblick (slb)/wnt11 regulates normal gastrulation movements by activating a signalling pathway similar to the Frizzled-..
  3. Jopling C, den Hertog J. Fyn/Yes and non-canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements. EMBO Rep. 2005;6:426-31 pubmed
    ..of the Fyn and Yes tyrosine kinases in zebrafish embryos impaired normal CE cell movements, resembling the silberblick and pipetail mutants, caused by mutations in wnt11 and wnt5, respectively...
  4. Ulrich F, Krieg M, Schötz E, Link V, Castanon I, Schnabel V, et al. Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin. Dev Cell. 2005;9:555-64 pubmed
    b>Wnt11 plays a central role in tissue morphogenesis during vertebrate gastrulation, but the molecular and cellular mechanisms by which Wnt11 exerts its effects remain poorly understood...
  5. Matsui T, Raya A, Kawakami Y, Callol Massot C, Capdevila J, Rodriguez Esteban C, et al. Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes Dev. 2005;19:164-75 pubmed
    ..We also show that three Wnt noncanonical ligands wnt4a, silberblick/wnt11, and wnt11-related regulate this process by acting in a largely redundant way...
  6. Marlow F, Topczewski J, Sepich D, Solnica Krezel L. Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements. Curr Biol. 2002;12:876-84 pubmed
    ..Moreover, Rho kinase 2 (Rok2) overexpression partially suppresses the slb/wnt11 gastrulation phenotype, and ectopic expression of noncanonical Wnts modulates Rok2 intracellular distribution...
  7. Heisenberg C, Brand M, Jiang Y, Warga R, Beuchle D, van Eeden F, et al. Genes involved in forebrain development in the zebrafish, Danio rerio. Development. 1996;123:191-203 pubmed
    ..The four mutants define three genes: masterblind (mbl), silberblick (slb), and knollnase (kas)...
  8. Pelegri F. Maternal factors in zebrafish development. Dev Dyn. 2003;228:535-54 pubmed
  9. Garriock R, D Agostino S, Pilcher K, Krieg P. Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus. Dev Biol. 2005;279:179-92 pubmed
    b>Wnt11 is a secreted protein that signals through the non-canonical planar cell polarity pathway and is a potent modulator of cell behavior and movement...
  10. Makita R, Mizuno T, Koshida S, Kuroiwa A, Takeda H. Zebrafish wnt11: pattern and regulation of the expression by the yolk cell and No tail activity. Mech Dev. 1998;71:165-76 pubmed
    This study analyzed the spatial and temporal expression pattern of zebrafish wnt11 and the regulation of the expression during zebrafish early development, focusing on the interaction with the no tail (ntl) gene, a zebrafish orthologue ..
  11. Topczewski J, Sepich D, Myers D, Walker C, Amores A, Lele Z, et al. The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension. Dev Cell. 2001;1:251-64 pubmed
    ..Double mutant and overexpression analyses show that Knypek potentiates Wnt11 signaling, mediating convergent extension...
  12. Formstone C, Mason I. Combinatorial activity of Flamingo proteins directs convergence and extension within the early zebrafish embryo via the planar cell polarity pathway. Dev Biol. 2005;282:320-35 pubmed
    ..in the zebrafish gastrula, Fmi1 proteins function in concert with each other and with the vertebrate PCP proteins, Wnt11 and Strabismus, to mediate convergence and extension during gastrulation, without altering early dorso-ventral ..
  13. Li M, Wang X, Zhu J, Zhu S, Hu X, Zhu C, et al. Toxic effects of polychlorinated biphenyls on cardiac development in zebrafish. Mol Biol Rep. 2014;41:7973-83 pubmed publisher
    ..In conclusion, PCBs can induce developmental defects in the zebrafish heart, which may be mediated by abnormal RA signaling. ..
  14. Gerdes J, Liu Y, Zaghloul N, Leitch C, Lawson S, Kato M, et al. Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet. 2007;39:1350-60 pubmed
    ..bbs6), which encode basal body proteins, are required for convergence and extension in zebrafish and interact with wnt11 and wnt5b...
  15. Beis D, Stainier D. In vivo cell biology: following the zebrafish trend. Trends Cell Biol. 2006;16:105-12 pubmed
    ..Although this model system has been predominantly appreciated for its amenability to forward genetics, current advances in imaging technology and an increasing number of transgenic lines are bringing it closer to its full potential. ..
  16. Kai M, Heisenberg C, Tada M. Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation. Development. 2008;135:3043-51 pubmed publisher
    ..miles apart (mil) as a suppressor of defective anterior migration of the prospective prechordal plate in silberblick (slb)/wnt11 mutant embryos, in which E-cadherin-mediated coherence of cell movement is reduced...
  17. Zhang J, Granato M. The zebrafish unplugged gene controls motor axon pathway selection. Development. 2000;127:2099-111 pubmed
    ..These data suggest that unplugged defines a somite-derived signal that elicits differential guidance decisions in motor growth cones. ..
  18. Duncan R, Panahi S, Piotrowski T, Dorsky R. Identification of Wnt Genes Expressed in Neural Progenitor Zones during Zebrafish Brain Development. PLoS ONE. 2015;10:e0145810 pubmed publisher
    ..Our data identify 12 specific ligands that can now be tested using loss-of-function approaches. ..
  19. Song S, Eckerle S, Onichtchouk D, Marrs J, Nitschke R, Driever W. Pou5f1-dependent EGF expression controls E-cadherin endocytosis, cell adhesion, and zebrafish epiboly movements. Dev Cell. 2013;24:486-501 pubmed publisher
    ..We hypothesize that dynamic control of E-cad trafficking is essential to effectively generate new adhesion sites when cells move relative to each other. ..
  20. Bai Y, Tan X, Zhang H, Liu C, Zhao B, Li Y, et al. Ror2 receptor mediates Wnt11 ligand signaling and affects convergence and extension movements in zebrafish. J Biol Chem. 2014;289:20664-76 pubmed
    ..convergence and extension defects and incompletely separated eyes, which is consistent with observations from slb/wnt11 mutants or wnt11 knockdown morphants...
  21. Kida Y, Sato T, Miyasaka K, Suto A, Ogura T. Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord. Proc Natl Acad Sci U S A. 2007;104:6708-13 pubmed
    ..We elucidate the molecular mechanism underlying the CE movement of notochord cells with Daam1 as a dynamic coordinator of endocytosis and cytoskeletal remodeling. ..
  22. Marlow F, Gonzalez E, Yin C, Rojo C, Solnica Krezel L. No tail co-operates with non-canonical Wnt signaling to regulate posterior body morphogenesis in zebrafish. Development. 2004;131:203-16 pubmed
    ..Moreover, we provide genetic evidence for the notion that tail development entails a continuation of mechanisms regulating gastrulation together with mechanisms unique to the posterior body. ..
  23. Stengel R, Rivera Milla E, Sahoo N, Ebert C, Bollig F, Heinemann S, et al. Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. J Biol Chem. 2012;287:35565-75 pubmed publisher
    ..These results reveal an unanticipated basic activity of kcnh1 that is crucial for early embryonic development and patterning. ..
  24. Gritsman K, Zhang J, Cheng S, Heckscher E, Talbot W, Schier A. The EGF-CFC protein one-eyed pinhead is essential for nodal signaling. Cell. 1999;97:121-32 pubmed
    ..Expression of the murine EGF-CFC gene cripto rescues oep mutants. These results suggest a conserved role for EGF-CFC proteins as essential extracellular cofactors for Nodal signaling during vertebrate development. ..
  25. Xu X, He Y, Sun L, Ma S, Luo C. Maternal Vsx1 plays an essential role in regulating prechordal mesendoderm and forebrain formation in zebrafish. Dev Biol. 2014;394:264-76 pubmed publisher
    ..Our results reveal a pivotal role for maternal Vsx1 as a direct transcriptional repressor of ntl expression at the margin of the zebrafish gastrula to ensure directional cell polarization and migration of PME cells. ..
  26. Katoh Y, Katoh M. Comparative genomics on Wnt11 gene. Int J Mol Med. 2005;15:879-83 pubmed
    ..b>WNT11 gene at human chromosome 11q13...
  27. Yao S, Qian M, Deng S, Xie L, Yang H, Xiao C, et al. Kzp controls canonical Wnt8 signaling to modulate dorsoventral patterning during zebrafish gastrulation. J Biol Chem. 2010;285:42086-96 pubmed publisher
    ..Thus, our results provide the first insight into the mechanism involved in the initiation of zygotic canonical Wnt signals by a maternally derived transcription factor. ..
  28. Jopling C, van Geemen D, den Hertog J. Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects. PLoS Genet. 2007;3:e225 pubmed
    ..The finding that defective Shp2 signaling induced cell movement defects as early as gastrulation may have implications for the monitoring and diagnosis of Noonan and LEOPARD syndrome...
  29. Yang H, Zhou Y, Gu J, Xie S, Xu Y, Zhu G, et al. Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae. PLoS ONE. 2013;8:e64058 pubmed publisher
    ..Our study provides ample information for further study about the molecular and cellular mechanisms underlying vertebrate development. ..
  30. Black J, Atabakhsh E, Kim J, Biette K, Van Rechem C, Ladd B, et al. Hypoxia drives transient site-specific copy gain and drug-resistant gene expression. Genes Dev. 2015;29:1018-31 pubmed publisher
    ..These findings have major implications in our understanding of copy number heterogeneity and the emergence of drug resistance genes in cancer. ..
  31. Heisenberg C, Tada M. Zebrafish gastrulation movements: bridging cell and developmental biology. Semin Cell Dev Biol. 2002;13:471-9 pubmed
    ..For instance, several mutants, including silberblick, knypek and trilobite, exhibit defects in morphogenesis during gastrulation...
  32. Mitchell D, Stevens C, Frey R, Hunter S, Ashino R, Kawamura S, et al. Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish. PLoS Genet. 2015;11:e1005483 pubmed publisher
    ..This is the first evidence that an extracellular signal may regulate differential expression of opsin genes in a tandemly duplicated array. ..
  33. Dutta S, Sriskanda S, Boobalan E, Alur R, Elkahloun A, Brooks B. nlz1 is required for cilia formation in zebrafish embryogenesis. Dev Biol. 2015;406:203-11 pubmed publisher
    ..Furthermore, Nlz1 contributes to motile cilia formation by positively regulating Wnt11/presumed non-canonical Wnt signaling...
  34. von der Hardt S, Bakkers J, Inbal A, Carvalho L, Solnica Krezel L, Heisenberg C, et al. The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Curr Biol. 2007;17:475-87 pubmed
  35. Biemar F, Argenton F, Schmidtke R, Epperlein S, Peers B, Driever W. Pancreas development in zebrafish: early dispersed appearance of endocrine hormone expressing cells and their convergence to form the definitive islet. Dev Biol. 2001;230:189-203 pubmed
    ..We discuss our findings on zebrafish pancreatogenesis in the light of evolution of the pancreas in chordates. ..
  36. Hardy K, Garriock R, Yatskievych T, D Agostino S, Antin P, Krieg P. Non-canonical Wnt signaling through Wnt5a/b and a novel Wnt11 gene, Wnt11b, regulates cell migration during avian gastrulation. Dev Biol. 2008;320:391-401 pubmed publisher
    ..uncharacterized chicken Wnt11 gene, Wnt11b, that is orthologous to the frog Wnt11 and zebrafish Wnt11 (silberblick) genes. Chicken Wnt11b is expressed in the primitive streak in a pattern similar to chicken Wnt5a and Wnt5b...
  37. Xu J, Zhang Q, Li X, Zhan S, Wang L, Chen D. The effects of copper oxide nanoparticles on dorsoventral patterning, convergent extension, and neural and cardiac development of zebrafish. Aquat Toxicol. 2017;188:130-137 pubmed publisher
    ..expression of chordin and goosecoid in dorsoventral patterning as well as decrease the transcription of Wnt5 and Wnt11 to result in slower, less directed movements and an abnormal cell shape...
  38. Delgado Olguin P, Brand Arzamendi K, Scott I, Jungblut B, Stainier D, Bruneau B, et al. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. J Biol Chem. 2011;286:12483-94 pubmed publisher
    ..We conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis. ..
  39. Gu Q, Yang X, He X, Li Q, Cui Z. Generation and characterization of a transgenic zebrafish expressing the reverse tetracycline transactivator. J Genet Genomics. 2013;40:523-31 pubmed publisher
    ..Thus, this rtTA-transgenic zebrafish can be utilized to dissect functions of genes in a temporal manner. ..
  40. Khan A, Nakamoto A, Okamoto S, Tai M, Nakayama Y, Kobayashi K, et al. Pou2, a class V POU-type transcription factor in zebrafish, regulates dorsoventral patterning and convergent extension movement at different blastula stages. Mech Dev. 2012;129:219-35 pubmed publisher
    ..Collectively, these data demonstrated that pou2 regulates DV patterning and CE movement in zebrafish embryos at the midblastula and late blastula stages, respectively...
  41. Hino H, Nakanishi A, Seki R, Aoki T, Yamaha E, Kawahara A, et al. Roles of maternal wnt8a transcripts in axis formation in zebrafish. Dev Biol. 2018;434:96-107 pubmed publisher
    ..Finally, we re-examined the maternal wnt genes and found that Wnt6a is an alternative candidate DD. ..
  42. Panàkovà D, Werdich A, Macrae C. Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. Nature. 2010;466:874-8 pubmed publisher
    ..tissue geometry and mechanical inputs, but in contrast we were able to demonstrate that non-canonical Wnt11 signals are required for the genesis of this myocardial electrical gradient...
  43. Weiser D, Row R, Kimelman D. Rho-regulated myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation. Development. 2009;136:2375-84 pubmed publisher
  44. Gong Y, Mo C, Fraser S. Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature. 2004;430:689-93 pubmed
    ..Establishment of this animal-vegetal polarity requires the Wnt pathway components Silberblick/Wnt11, Dishevelled and Strabismus...
  45. Nambiar R, Ignatius M, Henion P. Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration. Mech Dev. 2007;124:682-98 pubmed
    ..Here, we demonstrate novel roles for zebrafish hdac1 in activating non-canonical Wnt/PCP signaling underlying axial extension and in promoting Wnt-independent caudal migration of a subset of hindbrain branchiomotor neurons. ..
  46. Cavodeassi F, Carreira Barbosa F, Young R, Concha M, Allende M, Houart C, et al. Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway. Neuron. 2005;47:43-56 pubmed
    ..Wnt/beta-catenin signaling antagonizes eye specification through the activity of Wnt8b and Fz8a. In contrast, Wnt11 and Fz5 promote eye field development, at least in part, through local antagonism of Wnt/beta-catenin signaling...
  47. Kagermeier Schenk B, Wehner D, Ozhan Kizil G, Yamamoto H, Li J, Kirchner K, et al. Waif1/5T4 inhibits Wnt/?-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization. Dev Cell. 2011;21:1129-43 pubmed publisher
    ..These results suggest that Waif1 modulates pathway selection in Wnt-receiving cells. ..
  48. Caneparo L, Huang Y, Staudt N, Tada M, Ahrendt R, Kazanskaya O, et al. Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek. Genes Dev. 2007;21:465-80 pubmed
    ..Our data therefore indicate that Dkk1 regulates gastrulation movement through interaction with LRP5/6 and Kny and coordinated modulations of Wnt/beta catenin and Wnt/PCP pathways. ..
  49. Philipp M, Fralish G, Meloni A, Chen W, MacInnes A, BARAK L, et al. Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase. Mol Biol Cell. 2008;19:5478-89 pubmed publisher
    ..Together, these data suggest that a GRK functions as a vertebrate kinase for Smoothened, promoting Hedgehog signal transduction during early development. ..
  50. Zhang Y, Shao M, Wang L, Liu Z, Gao M, Liu C, et al. Ethanol exposure affects cell movement during gastrulation and induces split axes in zebrafish embryos. Int J Dev Neurosci. 2010;28:283-8 pubmed publisher
    ..be affected by ethanol exposure, as indicated by the much more scattered expression pattern of chordin, eve1 and wnt11 at the early gastrula stage, and the discontinuous gsc positive cells during migration...
  51. Yimlamai D, Konnikova L, Moss L, Jay D. The zebrafish down syndrome cell adhesion molecule is involved in cell movement during embryogenesis. Dev Biol. 2005;279:44-57 pubmed
    ..Its loss results in early morphogenetic defects. dscam knockdown results in impaired cell movement during epiboly as well as in subsequent stages. We propose that migrating cells utilize dscam to remodel the developing embryo. ..
  52. Wu B, Wen S, Hwang S, Huang C, Kuan Y. Control of Wnt5b secretion by Wntless modulates chondrogenic cell proliferation through fine-tuning fgf3 expression. J Cell Sci. 2015;128:2328-39 pubmed publisher
    ..the anteroposterior axis in wnt5b mutants and wntless (wls) morphants, but its expression is normal in wnt9a and wnt11 morphants. Introducing fgf3 mRNAs rescued the cartilage defects in Wnt5b- and Wls-deficient larvae...
  53. Yin C, Solnica Krezel L. Convergence and extension movements mediate the specification and fate maintenance of zebrafish slow muscle precursors. Dev Biol. 2007;304:141-55 pubmed
    ..Our results underscore the significance of precise coordination between cell movements and inductive tissue interactions during cell fate specification. ..
  54. Liu Y, Song G, Liu H, Wang X, Shen Y, Zhou L, et al. Silencing of FABP3 leads to apoptosis-induced mitochondrial dysfunction and stimulates Wnt signaling in zebrafish. Mol Med Rep. 2013;8:806-12 pubmed publisher
    ..5 expression was upregulated in FABP3-MO zebrafish, and Wnt signaling molecules (Wnt1, Wnt5 and Wnt11) were also highly expressed in FABP3-MO zebrafish at 24, 48 and 72 h pf...
  55. Miyasaka K, Kida Y, Sato T, Minami M, Ogura T. Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin. Proc Natl Acad Sci U S A. 2007;104:11274-9 pubmed
    ..Our data highlight Csrp1 as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs. ..
  56. Sisson B, Dale R, Mui S, Topczewska J, Topczewski J. A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis. Mech Dev. 2015;138 Pt 3:279-90 pubmed publisher
    ..Here we demonstrate that while vang-like 2 (vangl2), wnt11 and scribbled (scrib) mutants have severe craniofacial morphogenesis defects they do not display the chondrocyte ..
  57. Heisenberg C, Tada M. Wnt signalling: a moving picture emerges from van gogh. Curr Biol. 2002;12:R126-8 pubmed
  58. Seo J, Asaoka Y, Nagai Y, Hirayama J, Yamasaki T, Namae M, et al. Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. J Cell Biochem. 2010;110:1022-37 pubmed publisher
    ..Surprisingly, Mkk4b morphants displayed marked upregulation of wnt11, which is the triggering ligand of CE and stimulates Jnk activation via the non-canonical Wnt pathway...
  59. Cao J, Li S, Zhang H, Shi D. High mobility group B proteins regulate mesoderm formation and dorsoventral patterning during zebrafish and Xenopus early development. Mech Dev. 2012;129:263-74 pubmed publisher
    ..Therefore, our results suggest that hmgb genes may function to fine-tune the specification and/or dorsoventral patterning of mesoderm during zebrafish and Xenopus development. ..
  60. Harvey S, Sealy I, Kettleborough R, Fényes F, White R, STEMPLE D, et al. Identification of the zebrafish maternal and paternal transcriptomes. Development. 2013;140:2703-10 pubmed publisher
  61. Guo L, Yamashita H, Kou I, Takimoto A, Meguro Horike M, Horike S, et al. Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation. PLoS Genet. 2016;12:e1005802 pubmed publisher
    ..Thus, our study presents a novel pathological feature of LBX1 and its zebrafish homologs in body axis deformation at various stages of embryonic and subsequent growth in zebrafish. ..
  62. Xu X, Shuen W, Chen C, Goudevenou K, Jones P, Sablitzky F. Swap70b is required for convergent and extension cell movement during zebrafish gastrulation linking Wnt11 signalling and RhoA effector function. Dev Biol. 2014;386:191-203 pubmed publisher
    ..While ectopic Swap70b expression robustly rescued Wnt11 morphants, RhoA overexpression was sufficient to rescue Swap70b morphants, establishing Swap70b as a novel member ..
  63. Lobbardi R, Lambert G, Zhao J, Geisler R, Kim H, Rosa F. Fine-tuning of Hh signaling by the RNA-binding protein Quaking to control muscle development. Development. 2011;138:1783-94 pubmed publisher
    ..Thus, our results reveal a new mechanism to ensure muscle cell fate diversity by fine-tuning of the Hh signaling pathway via RNA-binding proteins. ..
  64. Snelson C, Santhakumar K, Halpern M, Gamse J. Tbx2b is required for the development of the parapineal organ. Development. 2008;135:1693-702 pubmed publisher
    ..We conclude that tbx2b functions to specify the correct number of parapineal cells and to regulate their asymmetric migration. ..
  65. Muyskens J, Kimmel C. Tbx16 cooperates with Wnt11 in assembling the zebrafish organizer. Mech Dev. 2007;124:35-42 pubmed
    ..Furthermore, with combined loss of Tbx16 and Wnt11 (Silberblick), coalesence is essentially absent...
  66. Pauli A, Montague T, Lennox K, Behlke M, Schier A. Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish. PLoS ONE. 2015;10:e0139504 pubmed publisher
    ..Despite this drawback, quantitation of knockdown efficiency and the ability to degrade lncRNAs make ASOs a useful knockdown reagent in zebrafish. ..
  67. Pei W, Feldman B. Identification of common and unique modifiers of zebrafish midline bifurcation and cyclopia. Dev Biol. 2009;326:201-11 pubmed publisher
    ..Reciprocally, depletion of Wnt11 or Hsp90b increases cyclopia only...
  68. Ochi H, Pearson B, Chuang P, Hammerschmidt M, Westerfield M. Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened. Dev Biol. 2006;297:127-40 pubmed
    ..These data support a model in which Hhip regulates muscle development both by sequestering Hedgehog and by modulating localization of Smoothened. ..
  69. Lemeer S, Jopling C, Naji F, Ruijtenbeek R, Slijper M, Heck A, et al. Protein-tyrosine kinase activity profiling in knock down zebrafish embryos. PLoS ONE. 2007;2:e581 pubmed
    ..Previously, we demonstrated that Wnt11 knock down phenocopied Fyn/Yes knock down...
  70. Cui S, Capecci L, Matthews R. Disruption of planar cell polarity activity leads to developmental biliary defects. Dev Biol. 2011;351:229-41 pubmed publisher
    ..Our results demonstrate that PCP plays an important role in vertebrate biliary development, interacting with other factors known to be involved in biliary morphogenesis. ..
  71. Choi H, Chang J, Trinh L, Padilla J, Fraser S, Pierce N. Programmable in situ amplification for multiplexed imaging of mRNA expression. Nat Biotechnol. 2010;28:1208-12 pubmed publisher
    ..HCR amplifiers exhibit deep sample penetration, high signal-to-background ratios and sharp signal localization. ..
  72. Kim H, Lee M, Jeong Y, Ro H, Kim D, Shin Y, et al. Ottogi Inhibits Wnt/?-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8. Sci Rep. 2017;7:13278 pubmed publisher
    ..Taken together, our data indicate that OTG functions as a novel negative regulator of Wnt signaling during development by the modulation of cell surface expression of Fz receptor. ..
  73. Macheda M, Sun W, Kugathasan K, Hogan B, Bower N, Halford M, et al. The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling. J Biol Chem. 2012;287:29312-23 pubmed publisher
    ..In zebrafish, gene knockdown using morpholinos revealed a genetic interaction between Ryk and Wnt11 during the PCP pathway-regulated process of embryo convergent extension...
  74. Crosier P, Bardsley A, Horsfield J, Krassowska A, Lavallie E, Collins Racie L, et al. In situ hybridization screen in zebrafish for the selection of genes encoding secreted proteins. Dev Dyn. 2001;222:637-44 pubmed