vtg4

Summary

Gene Symbol: vtg4
Description: vitellogenin 4
Alias: si:rp71-23d18.3, wu:fb59b02, wu:fb59d07, wu:fb59e10, zgc:136286, zgc:136383, vitellogenin 4, vg4
Species: zebrafish

Top Publications

  1. Wang H, Tan J, Emelyanov A, Korzh V, Gong Z. Hepatic and extrahepatic expression of vitellogenin genes in the zebrafish, Danio rerio. Gene. 2005;356:91-100 pubmed
    ..In situ hybridization experiments confirmed that the extrahepatic expression was actually in adipocytes associated with several organs such as the intestine, ovary, and E2-induced testis. ..
  2. Wang H, Yan T, Tan J, Gong Z. A zebrafish vitellogenin gene (vg3) encodes a novel vitellogenin without a phosvitin domain and may represent a primitive vertebrate vitellogenin gene. Gene. 2000;256:303-10 pubmed
    ..Like other vitellogenins in vertebrates, the phosvitinless vitellogenin is also synthesized mainly in the liver and weakly in the intestine. ..
  3. Kristoffersen B, Nerland A, Nilsen F, Kolarevic J, Finn R. Genomic and proteomic analyses reveal non-neofunctionalized vitellogenins in a basal clupeocephalan, the Atlantic herring, and point to the origin of maturational yolk proteolysis in marine teleosts. Mol Biol Evol. 2009;26:1029-44 pubmed publisher
  4. Eb Levadoux Y, Frelon S, Simon O, Arnaudguilhem C, Lobinski R, Mounicou S. In vivo identification of potential uranium protein targets in zebrafish ovaries after chronic waterborne exposure. Metallomics. 2017;9:525-534 pubmed publisher
    ..Potential U targets were mainly involved in three biological processes: oxidative stress regulation (SOD, GST), cytoskeleton structure (actin) and embryo early development (vtg, initiation factor). ..
  5. Sohn J, Kim S, Koschorreck J, Kho Y, Choi K. Alteration of sex hormone levels and steroidogenic pathway by several low molecular weight phthalates and their metabolites in male zebrafish (Danio rerio) and/or human adrenal cell (H295R) line. J Hazard Mater. 2016;320:45-54 pubmed publisher
    ..Our results show that not only DEP, BBzP, and DiBP, but also their hydrolytic metabolites disrupt sex hormone balances through modulating key steroidogenic genes in the human adrenal cells and in zebrafish. ..
  6. Zhang W, Sheng N, Wang M, Zhang H, Dai J. Zebrafish reproductive toxicity induced by chronic perfluorononanoate exposure. Aquat Toxicol. 2016;175:269-76 pubmed publisher
    ..The results of this study indicate that chronic exposure to PFNA can lead to dysfunction in the HPGL axis and sex hormone synthesis and cause adverse effects on fish reproduction. ..
  7. Sun C, Hu L, Liu S, Gao Z, Zhang S. Functional analysis of domain of unknown function (DUF) 1943, DUF1944 and von Willebrand factor type D domain (VWD) in vitellogenin2 in zebrafish. Dev Comp Immunol. 2013;41:469-76 pubmed publisher
    ..This study also opens a new angle for identification of function of genes of unknown function, which have the domains DUF1943 and DUF1944. ..
  8. Parolini M, Bini L, Magni S, Rizzo A, Ghilardi A, Landi C, et al. Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos. Environ Pollut. 2018;232:603-614 pubmed publisher
    ..Our data confirmed the potential toxicity of low concentrations of COC, BE and EME, and helped to shed light on their MoA on an aquatic vertebrate during early developmental period. ..
  9. Biava P, Canaider S, Facchin F, Bianconi E, Ljungberg L, Rotilio D, et al. Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells. Curr Pharm Biotechnol. 2015;16:782-92 pubmed
    ..In addition we report the data not yet published about a first protein analysis of the SCDSFs and about their role in a pathological condition like neurodegeneration. ..

More Information

Publications22

  1. Connolly M, Dutkosky R, Heah T, Sayler G, Henry T. Temporal dynamics of oocyte growth and vitellogenin gene expression in zebrafish (Danio rerio). Zebrafish. 2014;11:107-14 pubmed publisher
    ..Follicular atresia among fish sampled 32 days postspawning highlights the importance of regular spawning in zebrafish and suggests that the event of spawning itself may be integral to the regulation of oocyte development. ..
  2. Jo A, Ji K, Choi K. Endocrine disruption effects of long-term exposure to perfluorodecanoic acid (PFDA) and perfluorotridecanoic acid (PFTrDA) in zebrafish (Danio rerio) and related mechanisms. Chemosphere. 2014;108:360-6 pubmed publisher
    ..Consequences of endocrine disruptions in reproduction performances of the fish warrant further investigation. ..
  3. Babaei F, Ramalingam R, Tavendale A, Liang Y, Yan L, Ajuh P, et al. Novel blood collection method allows plasma proteome analysis from single zebrafish. J Proteome Res. 2013;12:1580-90 pubmed publisher
    ..Twenty-seven gender-dependent plasma proteins are identified and their biochemical importance discussed. Taken together, this novel technique enables analyses that were previously difficult to perform on zebrafish blood. ..
  4. Finn R, Kolarevic J, Kongshaug H, Nilsen F. Evolution and differential expression of a vertebrate vitellogenin gene cluster. BMC Evol Biol. 2009;9:2 pubmed publisher
    ..The differential expression and latent neofunctionalization of vtg genes in acanthomorph teleosts is an adaptive feature associated with oocyte hydration and spawning in the marine environment. ..
  5. Lai Y, Hsieh F, Hsu T. Affinity isolation and mass spectral analysis of 1,10-phenanthroline (OP)-stimulated UV-damaged-DNA binding proteins expressed in zebrafish (Danio rerio) embryos. Fish Physiol Biochem. 2012;38:1117-1129 pubmed publisher
    ..The OP-stimulated fraction produced a much stronger UV-dependent DNA incision activity in the presence than in the absence of OP, suggesting the association of these factors with DNA damage repair under metal-deficient conditions. ..
  6. Park J, Henry T, Menn F, Compton R, Sayler G. No bioavailability of 17?-ethinylestradiol when associated with nC60 aggregates during dietary exposure in adult male zebrafish (Danio rerio). Chemosphere. 2010;81:1227-32 pubmed publisher
    ..Results have implications on the effect of nC(60) on the bioavailability of co-contaminants in organisms during dietary exposure. ..
  7. Liu Q, Klingler R, Wimpee B, Dellinger M, KING HEIDEN T, Grzybowski J, et al. Maternal methylmercury from a wild-caught walleye diet induces developmental abnormalities in zebrafish. Reprod Toxicol. 2016;65:272-282 pubmed publisher
    ..Results from this study provide evidence that food intended for human consumption, with relatively modest levels of MeHg, may induce adverse effects in offspring. ..
  8. Henry T, McPherson J, Rogers E, Heah T, Hawkins S, Layton A, et al. Changes in the relative expression pattern of multiple vitellogenin genes in adult male and larval zebrafish exposed to exogenous estrogens. Comp Biochem Physiol A Mol Integr Physiol. 2009;154:119-26 pubmed publisher
    ..In larval zebrafish, the relative fold change in vtg expression varied according to specific estrogenic substance tested, but the pattern of change (i.e., Vg2A/B > Vg1A/B > VgC) was consistent for each substance that induced vtg. ..
  9. Petushkova N, Kuznetsova G, Larina O, Kisrieva Y, Samenkova N, Trifonova O, et al. One-dimensional proteomic profiling of Danio rerio embryo vitellogenin to estimate quantum dot toxicity. Proteome Sci. 2015;13:17 pubmed publisher
    ..This study demonstrates the possible utility of Vtg profiling in D. rerio embryos as a sensitive diagnostic tool to estimate nanoparticle toxicity. ..
  10. Singh A, Sivadas A, Sabharwal A, Vellarikal S, Jayarajan R, Verma A, et al. Chamber Specific Gene Expression Landscape of the Zebrafish Heart. PLoS ONE. 2016;11:e0147823 pubmed publisher
    ..It is also postulated that this transcriptome atlas will help utilize zebrafish in a better way as a model for studying cardiac development and to explore functional role of gene networks in cardiac disease pathogenesis. ..
  11. Su Y, Li L, Hou J, Wu N, Lin W, Li G. Life-cycle exposure to microcystin-LR interferes with the reproductive endocrine system of male zebrafish. Aquat Toxicol. 2016;175:205-12 pubmed publisher
  12. Meng X, Bartholomew C, Craft J. Differential expression of vitellogenin and oestrogen receptor genes in the liver of zebrafish, Danio rerio. Anal Bioanal Chem. 2010;396:625-30 pubmed publisher
    ..1% of female fish), while ERbeta1 could not be detected. The very low level of expression of ERalpha in males raises questions about the accepted mechanism of oestrogenic induction of VTG in male fish. ..
  13. Miao L, Yuan Y, Cheng F, Fang J, Zhou F, Ma W, et al. Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish. Development. 2017;144:128-138 pubmed publisher
    ..Together, our results indicate that regulation of translational repression and de-repression are essential for precisely controlling protein expression during early oogenesis. ..