vent

Summary

Gene Symbol: vent
Description: ventral expressed homeobox
Alias: vega2, vent1, wu:fe36b11
Species: zebrafish

Top Publications

  1. ncbi A role for MKP3 in axial patterning of the zebrafish embryo
    Michael Tsang
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 131:2769-79. 2004
  2. pmc Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like
    Hyunju Ro
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2425, USA
    Nat Cell Biol 11:1121-7. 2009
  3. ncbi A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish
    Takashi Shimizu
    Department of Molecular Oncology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Mech Dev 118:125-38. 2002
  4. ncbi WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation
    Marie Christine Ramel
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 287:237-48. 2005
  5. ncbi Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox
    Marie Christine Ramel
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
    Development 131:3991-4000. 2004
  6. ncbi Patterning the early zebrafish by the opposing actions of bozozok and vox/vent
    A E Melby
    Department of Biochemistry and Center for Developmental Biology, University of Washington, Seattle 98195 7350, USA
    Dev Biol 224:275-85. 2000
  7. doi Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish
    Saijun Mo
    Key Laboratory of Biodiversity and Conservation of Aquatic Organism, Chinese Academy of Sciences, Wuhan, Hubei 430072, PR China
    Dev Biol 344:210-23. 2010
  8. doi Osteogenic transcription factor Runx2 is a maternal determinant of dorsoventral patterning in zebrafish
    Maria Vega C Flores
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Nat Cell Biol 10:346-52. 2008
  9. ncbi Functional interaction of vega2 and goosecoid homeobox genes in zebrafish
    A Kawahara
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genesis 28:58-67. 2000
  10. ncbi The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish
    Y Imai
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 128:2407-20. 2001

Scientific Experts

  • Z Kozmik
  • Stefan Hans
  • Shunji Jia
  • Marie Christine Ramel
  • Dan Li
  • Huaqin Sun
  • Kevin D Baker
  • Igor B Dawid
  • Arne C Lekven
  • Shu Yu Wu
  • Shimin Lim
  • Jian Meng Cao
  • Heinz Georg Belting
  • Xun Wei Xie
  • Birgit Kagermeier-Schenk
  • Jamie L Seebald
  • Iryna Kozmikova
  • Dachang Tao
  • Wenqian Deng
  • Yongxin Ma
  • Anming Meng
  • Saijun Mo
  • Michael J Jurynec
  • Minyong Chen
  • Hyunju Ro
  • Maria Vega C Flores
  • Sung Kook Hong
  • Norihito Kishimoto
  • Máté Varga
  • Xueying Lin
  • Shingo Maegawa
  • A E Melby
  • Ujwal J Pyati
  • Jared W Ragland
  • Michael Tsang
  • Claudio N Gilardelli
  • Samuel Sidi
  • Takashi Shimizu
  • Cencan Xing
  • Jimann Shin
  • Diane S Sepich
  • Ying Wang
  • De Li Shi
  • Lilianna Solnica-Krezel
  • Xin Hua Feng
  • Pooja Kumari
  • Patrick Gilligan
  • Xia Lin
  • Mu Xiao
  • Helen Ngoc Bao Quach
  • Wei Wu
  • Hong Wei Zhang
  • Shang Qi Li
  • Fangyan Dai
  • Karuna Sampath
  • Y Imai
  • Sinnakaruppan Mathavan
  • Di Wu
  • Yu Xue
  • Wuhan Xiao
  • Christian Hoffmann
  • Jing Xia Liu
  • Daniel P Szeto
  • Wolfgang Driever
  • D Kimelman
  • Manuel Leichsenring
  • Karen Lunde
  • Bo Hu
  • Yunqiang Liu
  • Daria Onichtchouk
  • Akira Kikuchi
  • Günes Ozhan-Kizil
  • Jian Li
  • Cestmir Vlcek
  • Björn Wendik
  • Rebecca Mössner
  • Daniel Wehner
  • Peter Stern
  • Gilbert Weidinger
  • Jana Smolikova
  • Katharina Kirchner
  • Hideki Yamamoto
  • Alexandra Schambony
  • Xiaolin Liao
  • Victor J Thannickal
  • Zongbin Cui
  • Jie Li
  • A Kawahara
  • Yuanyuan Li
  • David Jonah Grunwald

Detail Information

Publications34

  1. ncbi A role for MKP3 in axial patterning of the zebrafish embryo
    Michael Tsang
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 131:2769-79. 2004
    ..Thus, mkp3 encodes a feedback attenuator of the FGF pathway, the expression of which is initiated at an early stage so as to ensure correct FGF signaling levels at the time of axial patterning...
  2. pmc Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like
    Hyunju Ro
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2425, USA
    Nat Cell Biol 11:1121-7. 2009
    ..These studies introduce a ubiquitin ligase, Lnx-l, as a balancing modulator of axial patterning in the zebrafish embryo...
  3. ncbi A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish
    Takashi Shimizu
    Department of Molecular Oncology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Mech Dev 118:125-38. 2002
    ..ved's sequence and expression profile were similar to those of vox/vega1 and vent/vega2. Like Vox/Vega1 and Vent/Vega2, Ved acted as a transcriptional repressor...
  4. ncbi WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation
    Marie Christine Ramel
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 287:237-48. 2005
    ..non-axial mesoderm into multiple D/V fate domains is known to involve zygotic Wnt8 and BMP signaling as well as the Vent/Vox/Ved family of transcriptional repressors, how levels of signaling activity are translated into differential ..
  5. ncbi Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox
    Marie Christine Ramel
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
    Development 131:3991-4000. 2004
    ..suggest that Wnt8 achieves this restriction by regulating the early expression of the transcriptional repressors Vent and Vox. Our data show that vent and vox are direct transcriptional targets of Wnt8/beta-catenin...
  6. ncbi Patterning the early zebrafish by the opposing actions of bozozok and vox/vent
    A E Melby
    Department of Biochemistry and Center for Developmental Biology, University of Washington, Seattle 98195 7350, USA
    Dev Biol 224:275-85. 2000
    ..Both of the zebrafish genes, which we have named vox and vent, are potent ventralizing factors in both zebrafish and Xenopus embryos...
  7. doi Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish
    Saijun Mo
    Key Laboratory of Biodiversity and Conservation of Aquatic Organism, Chinese Academy of Sciences, Wuhan, Hubei 430072, PR China
    Dev Biol 344:210-23. 2010
    ..Thus, maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin...
  8. doi Osteogenic transcription factor Runx2 is a maternal determinant of dorsoventral patterning in zebrafish
    Maria Vega C Flores
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Nat Cell Biol 10:346-52. 2008
    ..Among key zygotic ventralizing factors are the bone morphogenetic proteins (Bmps) and the Vent homeodomain family; the latter act as repressors of dorsal organizer gene transcription...
  9. ncbi Functional interaction of vega2 and goosecoid homeobox genes in zebrafish
    A Kawahara
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genesis 28:58-67. 2000
    ..Here, we describe a novel Vega family homeobox gene, vega2. Expression of vega2 is initiated at the ventral blastoderm margin during blastula stages, and by gastrulation ..
  10. ncbi The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish
    Y Imai
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 128:2407-20. 2001
    ..While the zebrafish genes vox (vega1) and vent (vega2) both have ventralizing activity in overexpression assays, loss-of-function studies are needed to determine ..
  11. doi Dorsal activity of maternal squint is mediated by a non-coding function of the RNA
    Shimin Lim
    Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604
    Development 139:2903-15. 2012
    ..Our findings identify new non-coding functions for the Nodal genes and support a model wherein sqt RNA acts as a scaffold to bind and deliver/sequester maternal factors to future embryonic dorsal...
  12. doi Waif1/5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization
    Birgit Kagermeier-Schenk
    Biotechnology Center and Center for Regenerative Therapies, Technische Universitat Dresden, Tatzberg 47, 01307 Dresden, Germany
    Dev Cell 21:1129-43. 2011
    ..These results suggest that Waif1 modulates pathway selection in Wnt-receiving cells...
  13. doi High mobility group B proteins regulate mesoderm formation and dorsoventral patterning during zebrafish and Xenopus early development
    Jian Meng Cao
    School of Life Sciences, Shandong University, 27 Shanda Nan Road, Jinan 250100, China
    Mech Dev 129:263-74. 2012
    ..Therefore, our results suggest that hmgb genes may function to fine-tune the specification and/or dorsoventral patterning of mesoderm during zebrafish and Xenopus development...
  14. doi Zili antagonizes Bmp signaling to regulate dorsal-ventral patterning during zebrafish early embryogenesis
    Dan Li
    Department of Medical Genetics and Division of Morbid Genomics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Zoolog Sci 28:397-402. 2011
    ..Meanwhile, overexpression of zili produced opposite effects. In conclusion, our results indicate that zili regulates dorsal-ventral patterning by antagonizing Bmp signaling during early embryogenesis in zebrafish...
  15. pmc Chemokine GPCR signaling inhibits β-catenin during zebrafish axis formation
    Shu Yu Wu
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS Biol 10:e1001403. 2012
    ..Our study delineates a novel negative, Gsk3β-independent control mechanism of β-catenin and implicates Ccr7 as a long-hypothesized GPCR regulating vertebrate axis formation...
  16. doi Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos
    Shunji Jia
    State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Dev Cell 22:1065-78. 2012
    ..We conclude that Ppp4c is a critical positive regulator of BMP/Smad signaling during embryonic dorsoventral pattern formation in zebrafish...
  17. doi Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways
    Norihito Kishimoto
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, NSB 393, New Haven, CT 06520, USA
    Dev Cell 14:954-61. 2008
    ..Finally, we show that seahorse constrains the canonical Wnt pathway and promotes the noncanonical Wnt pathway during gastrulation. Together, these data suggest that Seahorse may provide a link between ciliary signals and Wnt pathways...
  18. pmc Maternal induction of ventral fate by zebrafish radar
    Samuel Sidi
    Institut National de la Santé et de la Recherche Médicale U368, Ecole Normale Superieure, 75005 Paris, France
    Proc Natl Acad Sci U S A 100:3315-20. 2003
    ..They might further indicate that maternal TGF-betaRdr and WntCa(2+) pathways complementarily specify ventral cell fates, with the former triggering bmps expression and the latter indirectly repressing genes encoding BMP antagonists...
  19. ncbi Functional and hierarchical interactions among zebrafish vox/vent homeobox genes
    Claudio N Gilardelli
    Department of Biology, University of Milan, Milan, Italy
    Dev Dyn 230:494-508. 2004
    ..In Danio rerio (zebrafish), members of the vox/vent gene family (vox/vega1, vent/vega2, and ved) are thought to share expression patterns and functional properties...
  20. ncbi Signals derived from the underlying mesoderm are dispensable for zebrafish neural crest induction
    Jared W Ragland
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195 7420, USA
    Dev Biol 276:16-30. 2004
    ....
  21. ncbi Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development
    Ujwal J Pyati
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Development 132:2333-43. 2005
    ..We conclude that the role of Bmp signaling in the ventral and posterior mesoderm changes as gastrulation proceeds...
  22. pmc Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis
    Xun Wei Xie
    Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, People s Republic of China
    PLoS ONE 6:e24469. 2011
    ..Our studies provide an in vivo model for illustrating function of FOXO transcription factors in embryogenesis...
  23. ncbi Depletion of Med10 enhances Wnt and suppresses Nodal signaling during zebrafish embryogenesis
    Xueying Lin
    Department of Biochemistry and Molecular Biology Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Dev Biol 303:536-48. 2007
    ..Thus, Med10 appears to be a unique MED subunit that differentially transduces information from distinct signaling pathways during zebrafish embryogenesis...
  24. doi Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression
    Heinz Georg Belting
    Developmental Biology, Faculty of Biology, University of Freiburg, Hauptstrasse 1, Freiburg, Germany
    Dev Biol 356:323-36. 2011
    ..Our data reveals a set of direct and indirect interactions of Pou5f1 with the BMP dorsoventral patterning network that serve to fine-tune dorsoventral patterning mechanisms and coordinate patterning with developmental timing...
  25. pmc Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning
    Iryna Kozmikova
    Institute of Molecular Genetics, Prague, Czech Republic
    PLoS ONE 6:e14650. 2011
    ..In the cephalochordate amphioxus, genes encoding Bmps and transcription factors downstream of Bmp signaling such as Vent are expressed in patterns reminiscent of those of their vertebrate orthologues...
  26. doi Zebrafish eve1 regulates the lateral and ventral fates of mesodermal progenitor cells at the onset of gastrulation
    Jamie L Seebald
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    Dev Biol 349:78-89. 2011
    ..of eve1 in MPCs requires the redundant and cooperative functions of Bmp-activated downstream homeobox genes, ved, vent and vox. Inhibition of eve1, ved, vent and vox in double and triple combinations results in dorsalized phenotypes...
  27. doi A direct role for Wnt8 in ventrolateral mesoderm patterning
    Kevin D Baker
    Department of Biology, Texas A and M University, College Station, Texas 77843 3258, USA
    Dev Dyn 239:2828-36. 2010
    ..Thus, Wnt8 and BMP signaling have independent roles during vertebrate ventrolateral mesoderm development that can be identified through loss-of-function analysis...
  28. pmc SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo
    Michael J Jurynec
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Dis Model Mech 3:733-42. 2010
    ..We suggest that modulation of FGF signaling may be a principal function of SHIP2 in mammals...
  29. pmc Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 7:5. 2007
    ..We previously suggested that Foxi1 and Dlx3b may provide competence to form the ear because loss of both foxi1 and dlx3b results in ablation of all otic tissue even in the presence of a fully functional Fgf signaling pathway...
  30. pmc Zili inhibits transforming growth factor-beta signaling by interacting with Smad4
    Huaqin Sun
    Department of Medical Genetics and Division of Morbid Genomics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    J Biol Chem 285:4243-50. 2010
    ..This work shows that zili plays a role in early embryogenesis beyond germ line as a novel negative regulator of TGF-beta signaling, extending the function of Piwi proteins in vertebrates...
  31. pmc G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway
    Minyong Chen
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 284:35040-8. 2009
    ..knock-down, as assessed by decreased abundance of beta-catenin and lowered expression of the Wnt target genes cdx4, vent, and axin2. Expression of GRK5 rescues the diminished beta-catenin and axin2 response caused by GRK5 depletion...
  32. pmc Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo
    Máté Varga
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mech Dev 124:775-91. 2007
    ..from the organizer, the paraxial domain is the result of axial-derived anti-Wnt signals, which relieve the repression that otherwise is set by the Wnt8/beta-catenin/vox,vent pathway on latent germ-ring Nodal/FGF-activated expression.
  33. ncbi smad2 and smad3 are required for mesendoderm induction by transforming growth factor-beta/nodal signals in zebrafish
    Shunji Jia
    Protein Science Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    J Biol Chem 283:2418-26. 2008
    ..Thus, our data reveal that Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning...
  34. pmc Alpha2 macroglobulin-like is essential for liver development in zebrafish
    Sung Kook Hong
    Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA
    PLoS ONE 3:e3736. 2008
    ....