ved

Summary

Gene Symbol: ved
Description: ventrally expressed dharma/bozozok antagonist
Alias: cb675, ventrally expressed dharma/bozozok antagonist
Species: zebrafish

Top Publications

  1. Shimizu T, Bae Y, Muraoka O, Hibi M. Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Dev Biol. 2005;279:125-41 pubmed
    ..The ventrally expressed homeobox genes vox, vent, and ved mediated Wnt3a/Wnt8 signaling to restrict the organizer domain...
  2. Ramel M, Buckles G, Baker K, Lekven A. WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation. Dev Biol. 2005;287:237-48 pubmed
    ..mesoderm into multiple D/V fate domains is known to involve zygotic Wnt8 and BMP signaling as well as the Vent/Vox/Ved family of transcriptional repressors, how levels of signaling activity are translated into differential regulation ..
  3. Dal Pra S, Fürthauer M, Van Celst J, Thisse B, Thisse C. Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity. Dev Biol. 2006;298:514-26 pubmed
  4. Flores M, Lam E, Crosier K, Crosier P. Osteogenic transcription factor Runx2 is a maternal determinant of dorsoventral patterning in zebrafish. Nat Cell Biol. 2008;10:346-52 pubmed publisher
    ..maternal Runx2b type2 strongly dorsalizes embryos, due to loss of the earliest zygotic expression of vox, vent and ved, resulting in expansion of dorsal gene expression...
  5. Ro H, Dawid I. Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like. Nat Cell Biol. 2009;11:1121-7 pubmed publisher
    ..These studies introduce a ubiquitin ligase, Lnx-l, as a balancing modulator of axial patterning in the zebrafish embryo. ..
  6. Feng Q, Zou X, Lu L, Li Y, Liu Y, Zhou J, et al. The stress-response gene redd1 regulates dorsoventral patterning by antagonizing Wnt/?-catenin activity in zebrafish. PLoS ONE. 2012;7:e52674 pubmed publisher
    ..These findings have unraveled a novel role of Redd1 in early development by antagonizing Wnt/?-catenin signaling. ..
  7. Baker K, Ramel M, Lekven A. A direct role for Wnt8 in ventrolateral mesoderm patterning. Dev Dyn. 2010;239:2828-36 pubmed publisher
    ..Thus, Wnt8 and BMP signaling have independent roles during vertebrate ventrolateral mesoderm development that can be identified through loss-of-function analysis. ..
  8. Shimizu T, Yamanaka Y, Nojima H, Yabe T, Hibi M, Hirano T. A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish. Mech Dev. 2002;118:125-38 pubmed
    ..We also isolated a novel homeobox gene, ved, whose expression was negatively regulated by dha/boz...
  9. Zhong Y, Lu L, Zhou J, Li Y, Liu Y, Clemmons D, et al. IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos. J Cell Sci. 2011;124:1925-35 pubmed publisher
    ..Knockdown of Igfbp3 enhanced the ventralized phenotype caused by chordin knockdown. These results suggest that Igfbp3 exerts its IGF-independent actions by antagonizing Bmp signaling and that this mechanism is conserved. ..

More Information

Publications23

  1. Mo S, Wang L, Li Q, Li J, Li Y, Thannickal V, et al. Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish. Dev Biol. 2010;344:210-23 pubmed publisher
    ..Thus, maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin. ..
  2. Kapp L, Abrams E, Marlow F, Mullins M. The integrator complex subunit 6 (Ints6) confines the dorsal organizer in vertebrate embryogenesis. PLoS Genet. 2013;9:e1003822 pubmed publisher
    ..genes, embryos from mutant mothers fail to maintain expression of BMP ligands, fail to fully express vox and ved, two mediators of Wnt8a, display delayed cell movements during gastrulation, and severe dorsalization...
  3. Zhao J, Lambert G, Meijer A, Rosa F. The transcription factor Vox represses endoderm development by interacting with Casanova and Pou2. Development. 2013;140:1090-9 pubmed publisher
    ..Cell fate analysis further shows that Vox plays a key role downstream of BMP signals in regulating the capacity of Nodal to induce endoderm versus mesoderm by modulating the activity of the Casanova/Pou2 regulatory system. ..
  4. Wu S, Shin J, Sepich D, Solnica Krezel L. Chemokine GPCR signaling inhibits ?-catenin during zebrafish axis formation. PLoS Biol. 2012;10:e1001403 pubmed publisher
    ..Our study delineates a novel negative, Gsk3?-independent control mechanism of ?-catenin and implicates Ccr7 as a long-hypothesized GPCR regulating vertebrate axis formation. ..
  5. Schuff M, Siegel D, Philipp M, Bundschu K, Heymann N, Donow C, et al. Characterization of Danio rerio Nanog and functional comparison to Xenopus Vents. Stem Cells Dev. 2012;21:1225-38 pubmed publisher
    ..Depletion of Nanog in zebrafish cannot be rescued by ectopic expression of Xvent, and Xvent depletion in Xenopus cannot be overcome by ectopic expression of zebrafish Nanog...
  6. Fauny J, Thisse B, Thisse C. The entire zebrafish blastula-gastrula margin acts as an organizer dependent on the ratio of Nodal to BMP activity. Development. 2009;136:3811-9 pubmed publisher
  7. Moreno Ayala R, Schnabel D, Salas Vidal E, Lomelí H. PIAS-like protein Zimp7 is required for the restriction of the zebrafish organizer and mesoderm development. Dev Biol. 2015;403:89-100 pubmed publisher
    ..Altogether, our findings indicate that Zimp7 is involved in transcriptional regulation of factors that are essential for patterning in the dorsoventral axis. ..
  8. Winata C, Łapiński M, Pryszcz L, Vaz C, Bin Ismail M, Nama S, et al. Cytoplasmic polyadenylation-mediated translational control of maternal mRNAs directs maternal-to-zygotic transition. Development. 2018;145: pubmed publisher
    ..Our results establish the necessity of CPA for ensuring progression of the MZT. The RNA-seq data generated in this study represent a valuable zebrafish resource for the discovery of novel elements of the early embryonic transcriptome. ..
  9. Rong X, Chen C, Zhou P, Zhou Y, Li Y, Lu L, et al. R-spondin 3 regulates dorsoventral and anteroposterior patterning by antagonizing Wnt/?-catenin signaling in zebrafish embryos. PLoS ONE. 2014;9:e99514 pubmed publisher
    ..Human RSPO3 has similar action when tested in zebrafish embryos. These results suggest that Rspo3 regulates dorsoventral and anteroposterior patterning by negatively regulating the zygotic Wnt/?-catenin signaling in zebrafish embryos. ..
  10. Seebald J, Szeto D. Zebrafish eve1 regulates the lateral and ventral fates of mesodermal progenitor cells at the onset of gastrulation. Dev Biol. 2011;349:78-89 pubmed publisher
    ..role of eve1 in MPCs requires the redundant and cooperative functions of Bmp-activated downstream homeobox genes, ved, vent and vox...
  11. Wei C, Wang H, Zhu Z, Sun Y. Transcriptional factors smad1 and smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5. J Biol Chem. 2014;289:6604-18 pubmed publisher
    ..In conclusion, our study uncovers that smad1 and smad9 act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis. ..
  12. Xie X, Liu J, Hu B, Xiao W. Zebrafish foxo3b negatively regulates canonical Wnt signaling to affect early embryogenesis. PLoS ONE. 2011;6:e24469 pubmed publisher
    ..Our studies provide an in vivo model for illustrating function of FOXO transcription factors in embryogenesis. ..
  13. Phillips B, Kwon H, Melton C, Houghtaling P, Fritz A, Riley B. Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development. Dev Biol. 2006;294:376-90 pubmed
    ..These data suggest that mutual antagonism between Msx and Dlx proteins achieves a balance of function required for normal preplacodal differentiation and placement of the neural-nonneural border. ..
  14. Gilardelli C, Pozzoli O, Sordino P, Matassi G, Cotelli F. Functional and hierarchical interactions among zebrafish vox/vent homeobox genes. Dev Dyn. 2004;230:494-508 pubmed
    ..In Danio rerio (zebrafish), members of the vox/vent gene family (vox/vega1, vent/vega2, and ved) are thought to share expression patterns and functional properties...